Simon Conway

  • 17085 Citations
  • 63 h-Index
1994 …2020

Research output per year

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Publications

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Article
2020

Cross-talk between transforming growth factor-b and periostin can be targeted for pulmonary fibrosis

Nanri, Y., Nunomura, S., Terasaki, Y., Yoshihara, T., Hirano, Y., Yokosaki, Y., Yamaguchi, Y., Feghali-Bostwick, C., Ajito, K., Murakami, S., Conway, S. J. & Izuhara, K., 2020, In : American journal of respiratory cell and molecular biology. 62, 2, p. 204-216 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Generation of transgenic mice that conditionally express microRNA miR-145

Sawant, D., Klevenow, E., Baeten, J. T., Thomas, S., Manivannan, S., Conway, S. J. & Lilly, B., 2020, (Accepted/In press) In : Genesis.

Research output: Contribution to journalArticle

Periostin forms a functional complex with IgA in human serum

Ono, J., Takai, M., Kamei, A., Nunomura, S., Nanri, Y., Yoshihara, T., Ohta, S., Yasuda, K., Conway, S. J., Yokosaki, Y. & Izuhara, K., Jan 2020, In : Allergology International. 69, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15

Cheng, H., Gottlieb, L., Marchi, E., Kleyner, R., Bhardwaj, P., Rope, A. F., Rosenheck, S., Moutton, S., Philippe, C., Eyaid, W., Alkuraya, F. S., Toribio, J., Mena, R., Prada, C. E., Stessman, H., Bernier, R., Wermuth, M., Kauffmann, B., Blaumeiser, B., Kooy, R. F. & 9 others, Baralle, D., Mancini, G. M. S., Conway, S. J., Xia, F., Chen, Z., Meng, L., Mihajlovic, L., Marmorstein, R. & Lyon, G. J., Mar 27 2020, In : Human molecular genetics. 29, 5, p. 877-878 2 p.

Research output: Contribution to journalArticle

Open Access
2019

Armadillo-like helical domain containing-4 is dynamically expressed in both the first and second heart fields

Conway, S. J., McConnell, R., Simmons, O. & Snider, P. L., Dec 2019, In : Gene Expression Patterns. 34, 119077.

Research output: Contribution to journalArticle

Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart

Huang, S., Chen, B., Su, Y., Alex, L., Humeres, C., Shinde, A. V., Conway, S. J. & Frangogiannis, N. G., Jul 2019, In : Journal of Molecular and Cellular Cardiology. 132, p. 84-97 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Fibroblast Primary Cilia Are Required for Cardiac Fibrosis

Villalobos, E., Criollo, A., Schiattarella, G. G., Altamirano, F., French, K. M., May, H. I., Jiang, N., Nguyen, N. U. N., Romero, D., Roa, J. C., García, L., Diaz-Araya, G., Morselli, E., Ferdous, A., Conway, S. J., Sadek, H. A., Gillette, T. G., Lavandero, S. & Hill, J. A., May 14 2019, In : Circulation. 139, 20, p. 2342-2357 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

Inactivation of Sox9 in fibroblasts reduces cardiac fibrosis and inflammation

Scharf, G. M., Kilian, K., Cordero, J., Wang, Y., Grund, A., Hofmann, M., Froese, N., Wang, X., Kispert, A., Kist, R., Conway, S. J., Geffers, R., Wollert, K. C., Dobreva, G., Bauersachs, J. & Heineke, J., Aug 8 2019, In : JCI Insight. 4, 15, e126721.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Myofibroblast β2 adrenergic signaling amplifies cardiac hypertrophy in mice

Imaeda, A., Tanaka, S., Tonegawa, K., Fuchigami, S., Obana, M., Maeda, M., Kihara, M., Kiyonari, H., Conway, S. J., Fujio, Y. & Nakayama, H., Feb 26 2019, In : Biochemical and Biophysical Research Communications. 510, 1, p. 149-155 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

PAX3 Confers Functional Heterogeneity in Skeletal Muscle Stem Cell Responses to Environmental Stress

Der Vartanian, A., Quétin, M., Michineau, S., Auradé, F., Hayashi, S., Dubois, C., Rocancourt, D., Drayton-Libotte, B., Szegedi, A., Buckingham, M., Conway, S. J., Gervais, M. & Relaix, F., Jun 6 2019, In : Cell Stem Cell. 24, 6, p. 958-973.e9

Research output: Contribution to journalArticle

7 Scopus citations

Periostin-expressing cell-specific transforming growth factor-β inhibition in pulmonary artery prevents pulmonary arterial hypertension

Seki, M., Furukawa, N., Koitabashi, N., Obokata, M., Conway, S. J., Arakawa, H. & Kurabayashi, M., 2019, In : PloS one. 14, 8, e0220795.

Research output: Contribution to journalArticle

Open Access

Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15

Cheng, H., Gottlieb, L., Marchi, E., Kleyner, R., Bhardwaj, P., Rope, A. F., Rosenheck, S., Moutton, S., Philippe, C., Eyaid, W., Alkuraya, F. S., Toribio, J., Mena, R., Prada, C. E., Stessman, H., Bernier, R., Wermuth, M., Kauffmann, B., Blaumeiser, B., Kooy, R. F. & 9 others, Baralle, D., Mancini, G. M. S., Conway, S. J., Xia, F., Chen, Z., Meng, L., Mihajlovic, L., Marmorstein, R. & Lyon, G. J., Sep 1 2019, In : Human molecular genetics. 28, 17, p. 2900-2919 20 p.

Research output: Contribution to journalArticle

5 Scopus citations

Protective Effects of Activated Myofibroblasts in the Pressure-Overloaded Myocardium Are Mediated Through Smad-Dependent Activation of a Matrix-Preserving Program

Russo, I., Cavalera, M., Huang, S., Su, Y., Hanna, A., Chen, B., Shinde, A. V., Conway, S. J., Graff, J. & Frangogiannis, N. G., Apr 12 2019, In : Circulation research. 124, 8, p. 1214-1227 14 p.

Research output: Contribution to journalArticle

16 Scopus citations
2018

Chemopreventative celecoxib fails to prevent schwannoma formation or sensorineural hearing loss in genetically engineered murine model of neurofibromatosis type 2

Wahle, B. M., Hawley, E. T., He, Y., Smith, A. E., Yuan, J., Masters, A. R., Jones, D. R., Gehlhausen, J. R., Park, S. J., Conway, S. J., Clapp, D. W. & Yates, C. W., 2018, In : Oncotarget. 9, 1, p. 718-725 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Constitutive overexpression of periostin delays wound healing in mouse skin

Nunomura, S., Nanri, Y., Ogawa, M., Arima, K., Mitamura, Y., Yoshihara, T., Hasuwa, H., Conway, S. J. & Izuhara, K., Jan 1 2018, In : Wound Repair and Regeneration. 26, 1, p. 6-15 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Electrical coupling between ventricular myocytes and myofibroblasts in the infarcted mouse heart

Rubart, M., Tao, W., Lu, X. L., Conway, S. J., Reuter, S. P., Lin, S. F. & Soonpaa, M. H., Mar 1 2018, In : Cardiovascular research. 114, 3, p. 389-400 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo

Nakazeki, F., Nishiga, M., Horie, T., Nishi, H., Nakashima, Y., Baba, O., Kuwabara, Y., Nishino, T., Nakao, T., Ide, Y., Koyama, S., Kimura, M., Tsuji, S., Sowa, N., Yoshida, S., Conway, S. J., Yanagita, M., Kimura, T. & Ono, K., Dec 1 2018, In : Scientific reports. 8, 1, 8553.

Research output: Contribution to journalArticle

2 Scopus citations

Megakaryocyte and Osteoblast Interactions Modulate Bone Mass and Hematopoiesis

Alvarez, M. B., Xu, L. L., Childress, P. J., Maupin, K. A., Mohamad, S. F., Chitteti, B. R., Himes, E., Olivos, D. J., Cheng, Y. H., Conway, S. J., Srour, E. F. & Kacena, M. A., May 15 2018, In : Stem Cells and Development. 27, 10, p. 671-682 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Opposing actions of fibroblast and cardiomyocyte smad3 signaling in the infarcted myocardium

Kong, P., Shinde, A. V., Su, Y., Russo, I., Chen, B., Saxena, A., Conway, S. J., Graff, J. M. & Frangogiannis, N. G., Feb 13 2018, In : Circulation. 137, 7, p. 707-724 18 p.

Research output: Contribution to journalArticle

36 Scopus citations

Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin

Duchamp De Lageneste, O., Julien, A., Abou-Khalil, R., Frangi, G., Carvalho, C., Cagnard, N., Cordier, C., Conway, S. J. & Colnot, C., Dec 1 2018, In : Nature communications. 9, 1, 773.

Research output: Contribution to journalArticle

60 Scopus citations

Proteomic profiling of TGFBI-null mouse corneas reveals only minor changes in matrix composition supportive of TGFBI knockdown as therapy against TGFBI-linked corneal dystrophies

Poulsen, E. T., Runager, K., Nielsen, N. S., Lukassen, M. V., Thomsen, K., Snider, P., Simmons, O., Vorum, H., Conway, S. J. & Enghild, J. J., Jan 2018, In : FEBS Journal. 285, 1, p. 101-114 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Sca-1 + cardiac fibroblasts promote development of heart failure

Chen, G., Bracamonte-Baran, W., Diny, N. L., Hou, X., Talor, M. V., Fu, K., Liu, Y., Davogustto, G., Vasquez, H., Taegtmeyer, H., Frazier, O. H., Waisman, A., Conway, S. J., Wan, F. & Čiháková, D., Sep 2018, In : European Journal of Immunology. 48, 9, p. 1522-1538 17 p.

Research output: Contribution to journalArticle

16 Scopus citations

The IL-13/periostin/IL-24 pathway causes epidermal barrier dysfunction in allergic skin inflammation

Mitamura, Y., Nunomura, S., Nanri, Y., Ogawa, M., Yoshihara, T., Masuoka, M., Tsuji, G., Nakahara, T., Hashimoto-Hachiya, A., Conway, S. J., Furue, M. & Izuhara, K., Sep 2018, In : Allergy: European Journal of Allergy and Clinical Immunology. 73, 9, p. 1881-1891 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2017

MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol

Nishiga, M., Horie, T., Kuwabara, Y., Nagao, K., Baba, O., Nakao, T., Nishino, T., Hakuno, D., Nakashima, Y., Nishi, H., Nakazeki, F., Ide, Y., Koyama, S., Kimura, M., Hanada, R., Nakamura, T., Inada, T., Hasegawa, K., Conway, S. J., Kita, T. & 2 others, Kimura, T. & Ono, K., Mar 3 2017, In : Circulation research. 120, 5, p. 835-847 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Notch-TNF signalling is required for development and homeostasis of arterial valves

Wang, Y., Wu, B., Farrar, E., Lui, W., Lu, P., Zhang, D., Alfieri, C. M., Mao, K., Chu, M., Yang, D., Xu, D., Rauchman, M., Taylor, V., Conway, S. J., Yutzey, K. E., Butcher, J. T. & Zhou, B., Mar 1 2017, In : European Heart Journal. 38, 9, p. 675-686 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury

Schwanekamp, J. A., Lorts, A., Sargent, M. A., York, A. J., Grimes, K. M., Fischesser, D. M., Gokey, J. J., Whitsett, J. A., Conway, S. J. & Molkentin, J. D., Jul 2017, In : PloS one. 12, 7, e0181945.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Ataxia telangiectasia mutated in cardiac fibroblasts regulates doxorubicin-induced cardiotoxicity

Zhan, H., Aizawa, K., Sun, J., Tomida, S., Otsu, K., Conway, S. J., McKinnon, P. J., Manabe, I., Komuro, I., Miyagawa, K., Nagai, R. & Suzuki, T., May 1 2016, In : Cardiovascular research. 110, 1, p. 85-95 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Bone Morphogenetic Protein Signaling Is Required for Aortic Valve Calcification

Gomez-Stallons, M. V., Wirrig-Schwendeman, E. E., Hassel, K. R., Conway, S. J. & Yutzey, K. E., Jul 1 2016, In : Arteriosclerosis, thrombosis, and vascular biology. 36, 7, p. 1398-1405 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity

Frame, J. M., Fegan, K. H., Conway, S. J., McGrath, K. E. & Palis, J., Feb 1 2016, In : STEM CELLS. 34, 2, p. 431-444 14 p.

Research output: Contribution to journalArticle

61 Scopus citations

Influence of periostin-positive cell-specific Klf5 deletion on aortic thickening in DOCA-salt hypertensive mice

Zempo, H., Suzuki, J. I., Ogawa, M., Watanabe, R., Fujiu, K., Manabe, I., Conway, S. J., Taniyama, Y., Morishita, R., Hirata, Y., Isobe, M. & Nagai, R., Nov 1 2016, In : Hypertension Research. 39, 11, p. 764-768 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Initial suppression of transforming growth factor-β signaling and loss of TGFBI causes early alveolar structural defects resulting in bronchopulmonary dysplasia

Ahlfeld, S. K., Wang, J., Gao, Y., Snider, P. & Conway, S. J., Apr 1 2016, In : American Journal of Pathology. 186, 4, p. 777-793 17 p.

Research output: Contribution to journalArticle

17 Scopus citations

Periostin promotes hepatic fibrosis in mice by modulating hepatic stellate cell activation via αv integrin interaction

Sugiyama, A., Kanno, K., Nishimichi, N., Ohta, S., Ono, J., Conway, S. J., Izuhara, K., Yokosaki, Y. & Tazuma, S., Dec 1 2016, In : Journal of Gastroenterology. 51, 12, p. 1161-1174 14 p.

Research output: Contribution to journalArticle

24 Scopus citations

Restricted Pax3 deletion within the neural tube results in congenital hydrocephalus

Zhou, H. M. & Conway, S. J., Mar 1 2016, In : Journal of Developmental Biology. 4, 1, 7.

Research output: Contribution to journalArticle

2 Scopus citations

Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in Mice

Kaur, H., Takefuji, M., Ngai, C. Y., Carvalho, J., Bayer, J., Wietelmann, A., Poetsch, A., Hoelper, S., Conway, S. J., Möllmann, H., Looso, M., Troidl, C., Offermanns, S. & Wettschureck, N., Jun 10 2016, In : Circulation research. 118, 12, p. 1906-1917 12 p.

Research output: Contribution to journalArticle

67 Scopus citations
2015

A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation

Gehlhausen, J. R., Park, S. J., Hickox, A. E., Shew, M., Staser, K., Rhodes, S. D., Menon, K., Lajiness, J. D., Mwanthi, M., Yang, X., Yuan, J., Territo, P., Hutchins, G., Nalepa, G., Yang, F. C., Conway, S. J., Heinz, M. G., Stemmer-Rachamimov, A., Yates, C. W. & Clapp, D. W., Jan 1 2015, In : Human molecular genetics. 24, 1, p. 1-8 8 p., ddu414.

Research output: Contribution to journalArticle

31 Scopus citations

Distinct Sources of Hematopoietic Progenitors Emerge before HSCs and Provide Functional Blood Cells in the Mammalian Embryo

McGrath, K. E., Frame, J. M., Fegan, K. H., Bowen, J. R., Conway, S. J., Catherman, S. C., Kingsley, P. D., Koniski, A. D. & Palis, J., Jun 30 2015, In : Cell Reports. 11, 12, p. 1892-1904 13 p.

Research output: Contribution to journalArticle

121 Scopus citations

Loss of periostin/OSF-2 in ErbB2/Neu-driven tumors results in androgen receptor-positive molecular apocrine-like tumors with reduced Notch1 activity

Sriram, R., Lo, V., Pryce, B., Antonova, L., Mears, A. J., Daneshmand, M., McKay, B., Conway, S. J., Muller, W. J. & Sabourin, L. A., Dec 14 2015, In : Breast Cancer Research. 17, 1, 7.

Research output: Contribution to journalArticle

11 Scopus citations

Modulation of cardiac fibrosis by Kru ppel-like factor 6 through transcriptional control of thrombospondin 4 in cardiomyocytes

Sawaki, D., Hou, L., Tomida, S., Sun, J., Zhan, H., Aizawa, K., Kyung Son, B., Kariya, T., Takimoto, E., Otsu, K., Conway, S. J., Manabe, I., Komuro, I., Friedman, S. L., Nagai, R. & Suzuki, T., 2015, In : Cardiovascular research. 107, 4, p. 420-430 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis

Arima, K., Ohta, S., Takagi, A., Shiraishi, H., Masuoka, M., Ontsuka, K., Suto, H., Suzuki, S., Yamamoto, K. I., Ogawa, M., Simmons, O., Yamaguchi, Y., Toda, S., Aihara, M., Conway, S. J., Ikeda, S. & Izuhara, K., Jan 1 2015, In : Allergology International. 64, 1, p. 41-48 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Persistent Noggin arrests cardiomyocyte morphogenesis and results in early in utero lethality

Simmons, O., Snider, P., Wang, J., Schwartz, R. J., Chen, Y. & Conway, S. J., Mar 1 2015, In : Developmental Dynamics. 244, 3, p. 457-467 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Relationship of structural to functional impairment during alveolar-capillary membrane development

Ahlfeld, S. K., Gao, Y., Conway, S. J. & Tepper, R. S., Apr 1 2015, In : American Journal of Pathology. 185, 4, p. 913-919 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
2014
9 Scopus citations

Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair

Furtado, M. B., Costa, M. W., Pranoto, E. A., Salimova, E., Pinto, A. R., Lam, N. T., Park, A., Snider, P., Chandran, A., Harvey, R. P., Boyd, R., Conway, S. J., Pearson, J., Kaye, D. M. & Rosenthal, N. A., Apr 25 2014, In : Circulation research. 114, 9, p. 1422-1434 13 p.

Research output: Contribution to journalArticle

114 Scopus citations

HDAC1 and HDAC2 control the specification of neural crest cells into peripheral glia

Jacob, C., Lötscher, P., Engler, S., Baggiolini, A., Tavares, S. V., Brügger, V., John, N., Büchmann-Møller, S., Snider, P. L., Conway, S. J., Yamaguchi, T., Matthias, P., Sommer, L., Mantei, N. & Suter, U., Jan 1 2014, In : Journal of Neuroscience. 34, 17, p. 6112-6122 11 p.

Research output: Contribution to journalArticle

47 Scopus citations

Inhibition of periostin expression protects against the development of renal inflammation and fibrosis

Mael-Ainin, M., Abed, A., Conway, S. J., Dussaule, J. C. & Chatziantoniou, C., Aug 1 2014, In : Journal of the American Society of Nephrology. 25, 8, p. 1724-1736 13 p.

Research output: Contribution to journalArticle

52 Scopus citations

Loss of β-catenin promotes chondrogenic differentiation of aortic valve interstitial cells

Fang, M., Alfieri, C. M., Hulin, A., Conway, S. J. & Yutzey, K. E., Dec 11 2014, In : Arteriosclerosis, thrombosis, and vascular biology. 34, 12, p. 2601-2608 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Neurofibromin-deficient myeloid cells are critical mediators of aneurysm formation in vivo

Li, F., Downing, B. D., Smiley, L. C., Mund, J. A., DiStasi, M. R., Bessler, W. K., Sarchet, K. N., Hinds, D. M., Kamendulis, L. M., Hingtgen, C. M., Case, J., Clapp, D. W., Conway, S. J., Stansfield, B. K. & Ingram, D. A., Jan 1 2014, In : Circulation. 129, 11, p. 1213-1224 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Pax3 expression enhances PDGF-B-induced brainstem gliomagenesis and characterizes a subset of brainstem glioma

Misuraca, K. L., Barton, K. L., Chung, A., Diaz, A. K., Conway, S. J., Corcoran, D. L., Baker, S. J. & Becher, O. J., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 134.

Research output: Contribution to journalArticle

16 Scopus citations

Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1α/IL-6 loop

Taniguchi, K., Arima, K., Masuoka, M., Ohta, S., Shiraishi, H., Ontsuka, K., Suzuki, S., Inamitsu, M., Yamamoto, K. I., Simmons, O., Toda, S., Conway, S. J., Hamasaki, Y. & Izuhara, K., Jan 1 2014, In : Journal of Investigative Dermatology. 134, 5, p. 1295-1304 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Periostin promotes renal cyst growth and interstitial fibrosis in polycystic kidney disease

Wallace, D. P., White, C., Savinkova, L., Nivens, E., Reif, G. A., Pinto, C. S., Raman, A., Parnell, S. C., Conway, S. J. & Fields, T. A., Apr 2014, In : Kidney international. 85, 4, p. 845-854 10 p.

Research output: Contribution to journalArticle

37 Scopus citations