• 3355 Citations
  • 32 h-Index
1974 …2019

Research output per year

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Publications

Article

A (p)ppGpp-null mutant of Haemophilus ducreyi is partially attenuated in humans due to multiple conflicting phenotypes

Holley, C., Gangaiah, D., Li, W., Fortney, K. R., Janowicz, D. M., Ellinger, S., Zwickl, B., Katz, B. P. & Spinola, S. M., 2014, In : Infection and immunity. 82, 8, p. 3492-3502 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

A Class I Haemophilus ducreyi Strain Containing a Class II hgbA Allele Is Partially Attenuated in Humans: Implications for HGBA vaccine efficacy trials

Leduc, I., Fortney, K. R., Janowicz, D. M., Zwickl, B., Ellinger, S., Katz, B. P., Lin, H., Dong, Q. & Spinola, S. M., Jan 1 2019, In : Infection and immunity. 87, 7, e00112.

Research output: Contribution to journalArticle

Actinomycosis: A Cause of Pulmonary and Mediastinal Mass Lesions in Children

Spinola, S. M., Bell, R. A. & Henderson, F. W., Apr 1981, In : American Journal of Diseases of Children. 135, 4, p. 336-339 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Activation of CpxRA in Haemophilus ducreyi primarily inhibits the expression of Its targets, including major virulence determinants

Gangaiah, D., Zhang, X., Fortney, K. R., Baker, B., Liu, Y., Munson, R. S. & Spinola, S. M., Aug 1 2013, In : Journal of Bacteriology. 195, 15, p. 3486-3502 17 p.

Research output: Contribution to journalArticle

26 Scopus citations

Activation of the CpxRA system by deletion of cpxA impairs the ability of Haemophilus ducreyi to infect humans

Spinola, S. M., Fortney, K. R., Baker, B., Janowicz, D. M., Zwickl, B., Katz, B. P., Blick, R. J. & Munson, R. S., Sep 1 2010, In : Infection and immunity. 78, 9, p. 3898-3904 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

A DltA mutant of Haemophilus ducreyi is partially attenuated in its ability to cause pustules in human volunteers

Janowicz, D., Leduc, I., Fortney, K. R., Katz, B. P., Elkins, C. & Spinola, S. M., Feb 1 2006, In : Infection and immunity. 74, 2, p. 1394-1397 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

A Haemophilus ducreyi CpxR deletion mutant is virulent in human volunteers

Labandeira-Rey, M., Dodd, D., Fortney, K. R., Zwickl, B., Katz, B. P., Janowicz, D. M., Spinola, S. M. & Hansen, E. J., Jun 15 2011, In : Journal of Infectious Diseases. 203, 12, p. 1859-1865 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Analysis of Haemophilus influenzae type b lipooligosaccharide‐synthesis genes that assemble or expose a 2‐keto‐3‐deoxyoctulosonic acid epitope

Abu Kwaik, Y., McLaughlin, B. E., Apicella, M. A. & Spinola, S. M., Oct 1991, In : Molecular Microbiology. 5, 10, p. 2475-2480 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

An isogenic hemoglobin receptor-deficient mutant of Haemophilus ducreyi is attenuated in the human model of experimental infection

Al-Tawfiq, J. A., Fortney, K. R., Katz, B. P., Hood, A. F., Elkins, C. & Spinola, S. M., Apr 19 2000, In : Journal of Infectious Diseases. 181, 3, p. 1049-1054 6 p.

Research output: Contribution to journalArticle

67 Scopus citations

Antigenuria after Haemophilus influenzae type b polysaccharide immunization: A prospective study

Spinola, S. M., Sheaffer, C. I., Philbrick, K. B. & Gilligan, P. H., Nov 1986, In : The Journal of pediatrics. 109, 5, p. 835-838 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Antigenuria after haemophilus influenzae type b polysaccharide vaccination

Spinola, S. M., Sheaffer, C. I. & Gilligan, P. H., Feb 1986, In : The Journal of pediatrics. 108, 2, p. 247-249 3 p.

Research output: Contribution to journalArticle

10 Scopus citations

A pilus-deficient mutant of Haemophilus ducreyi is virulent in the human model of experimental infection

Al-Tawfiq, J. A., Bauer, M. E., Fortney, K. R., Katz, B. P., Hood, A. F., Ketterer, M., Apicella, M. A. & Spinola, S. M., Apr 19 2000, In : Journal of Infectious Diseases. 181, 3, p. 1176-1179 4 p.

Research output: Contribution to journalArticle

19 Scopus citations

A superoxide dismutase C mutant of Haemophilus ducreyi is virulent in human volunteers

Bong, C. T. H., Fortney, K. R., Katz, B. P., Hood, A. F., San Mateo, L. R., Kawula, T. H. & Spinola, S. M., Mar 4 2002, In : Infection and immunity. 70, 3, p. 1367-1371 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Binding of Haemophilus ducreyi to extracellular matrix proteins

Bauer, M. E. & Spinola, S. M., May 1999, In : Infection and immunity. 67, 5, p. 2649-2653 5 p.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

Both MisR (CpxR) and MisS (CpxA) are required for Neisseria gonorrhoeae infection in a murine model of lower genital tract infection

Gangaiah, D., Raterman, E. L., Wu, H., Fortney, K. R., Gao, H., Liu, Y., Jerse, A. E. & Spinola, S., Sep 1 2017, In : Infection and Immunity. 85, 9, e00307-17.

Research output: Contribution to journalArticle

11 Scopus citations

Carbon storage regulator a contributes to the virulence of haemophilus ducreyi in humans by multiple mechanisms

Gangaiah, D., Li, W., Fortney, K. R., Janowicz, D. M., Ellinger, S., Zwickl, B., Katz, B. P. & Spinola, S. M., Feb 1 2013, In : Infection and immunity. 81, 2, p. 608-617 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking

Soler, D., Humphreys, T. L., Spinola, S. M. & Campbell, J. J., Mar 1 2003, In : Blood. 101, 5, p. 1677-1683 7 p.

Research output: Contribution to journalArticle

173 Scopus citations

Characterization and sequence analysis of the lsg (LOS synthesis genes) locus from Haemophilus influenzae type b

Mclaughlin, R., Lee, N. G., Abu Kwaik, Y., Spinola, S. M. & Apicella, M. A., Sep 1994, In : Journal of Endotoxin Research. 1, 3, p. 165-174 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Characterization of an 18,000-molecular-weight outer membrane protein of Haemophilus ducreyi that contains a conserved surface-exposed epitope

Spinola, S. M., Griffiths, G. E., Bogdan, J. & Menegus, M. A., Dec 1 1991, In : Infection and immunity. 60, 2, p. 385-391 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Characterization of a novel lipoprotein expressed by Haemophilus ducreyi

Hiltke, T. J., Campagnari, A. A. & Spinola, S. M., Dec 14 1996, In : Infection and immunity. 64, 12, p. 5047-5052 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Characterization of Haemophilus ducreyi-specific T-cell lines from lesions of experimentally infected human subjects

Gelfanova, V., Humphreys, T. L. & Spinola, S. M., Jul 5 2001, In : Infection and immunity. 69, 7, p. 4224-4231 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Characterization of pili expressed by Haemophilus ducreyi

Spinola, S. M., Castellazzo, A., Shero, M. & Apicella, M. A., Dec 1990, In : Microbial Pathogenesis. 9, 6, p. 417-426 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Childhood sarcoidosis

Pattishall, E. N., Strope, G. L., Spinola, S. M. & Denny, F. W., Feb 1986, In : The Journal of pediatrics. 108, 2, p. 169-177 9 p.

Research output: Contribution to journalArticle

111 Scopus citations

Clinical features of experimental human infection with haemophilus ducreyi

Al-Tawfiq, J. A., Thornton, A. C., Fortney, K. A. & Spinola, S. M., Dec 1 1997, In : Clinical Infectious Diseases. 25, 2, 1 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cloning and expression in Escherichia coli of a Haemophilus influenzae type b lipooligosaccharide synthesis gene(s) that encodes a 2-keto-3-deoxyoctulosonic acid epitope

Spinola, S. M., Kwaik, Y. A., Lesse, A. J., Campagnari, A. A. & Apicella, M. A., Jan 1 1990, In : Infection and immunity. 58, 6, p. 1558-1564 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Comparison of enzyme immunoassays for antibodies to Haemophilus ducreyi in a community outbreak of chancroid in the United States

Chen, C. Y., Mertz, K. J., Spinola, S. M. & Morse, S. A., Jan 1 1997, In : Journal of Infectious Diseases. 175, 6, p. 1390-1395 6 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Conserved lipoprotein H.8 of pathogenic Neisseria consists entirely of pentapeptide repeats

Woods, J. P., Spinola, S. M., Strobel, S. M. & Cannon, J. G., Jan 1989, In : Molecular Microbiology. 3, 1, p. 43-48 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Correcting imbalanced reads coverage in bacterial transcriptome sequencing with extreme deep coverage

Zhang, X., Gangaiah, D., Munson, R. S., Spinola, S. M. & Liu, Y., 2014, In : International Journal of Computational Biology and Drug Design. 7, 2-3, p. 195-213 19 p.

Research output: Contribution to journalArticle

Cumulative experience with Haemophilus ducreyi 35000 in the human model of experimental infection

Al-Tawfiq, J. A., Harezlak, J., Katz, B. P. & Spinola, S. M., Feb 2000, In : Sexually transmitted diseases. 27, 2, p. 111-114 4 p.

Research output: Contribution to journalArticle

29 Scopus citations

Cytolethal distending toxin of Haemophilus ducreyi induces apoptotic death of Jurkat T cells

Gelfanova, V., Hansen, E. J. & Spinola, S. M., Dec 1 1999, In : Infection and immunity. 67, 12, p. 6394-6402 9 p.

Research output: Contribution to journalArticle

78 Scopus citations

Determination of an interaction network between an extracellular bacterial pathogen and the human host

Griesenauer, B., Tran, T. M., Fortney, K. R., Janowicz, D. M., Johnson, P., Gao, H., Barnes, S., Wilson, L. S., Liu, Y. & Spinola, S. M., May 1 2019, In : mBio. 10, 3, e01193-19.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Development and validation of a high-throughput cell-based screen to identify activators of a bacterial two-component signal transduction system

Van Rensburg, J. J., Fortney, K. R., Chen, L., Krieger, A. J., Lima, B. P., Wolfe, A. J., Katz, B. P., Zhang, Z. Y. & Spinola, S. M., Jul 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 7, p. 3789-3799 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Differences in Host Susceptibility to Disease Progression in the Human Challenge Model of Haemophilus ducreyi Infection

Spinola, S. M., Bong, C. T. H., Faber, A. L., Fortney, K. R., Bennett, S. L., Townsend, C. A., Zwickl, B. E., Billings, S. D., Humphreys, T. L., Bauer, M. E. & Katz, B. P., Nov 1 2003, In : Infection and immunity. 71, 11, p. 6658-6663 6 p.

Research output: Contribution to journalArticle

32 Scopus citations
48 Scopus citations

DksA and (p)ppGpp have unique and overlapping contributions to Haemophilus ducreyi pathogenesis in humans

Holley, C. L., Zhang, X., Fortney, K. R., Ellinger, S., Johnson, P., Baker, B., Liu, Y., Janowicz, D. M., Katz, B. P., Munson, R. S. & Spinola, S. M., Jan 1 2015, In : Infection and immunity. 83, 8, p. 3281-3292 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Draft whole-genome sequence of Haemophilus ducreyi strain AUSPNG1, isolated from a cutaneousulcer of a child from Papua New Guinea

Gangaiah, D., Marinov, G. K., Roberts, S. A., Robson, J. & Spinola, S., 2016, In : Genome Announcements. 4, 1, e01661-15.

Research output: Contribution to journalArticle

6 Scopus citations

DsrA-deficient mutant of Haemophilus ducreyi is impaired in its ability to infect human volunteers

Bong, C. T. H., Throm, R. E., Fortney, K. R., Katz, B. P., Hood, A. F., Elkins, C. & Spinola, S. M., Mar 14 2001, In : Infection and immunity. 69, 3, p. 1488-1491 4 p.

Research output: Contribution to journalArticle

61 Scopus citations

Dysregulated immune profiles for skin and dendritic cells are associated with increased host susceptibility to Haemophilus ducreyi infection in human volunteers

Humphreys, T. L., Li, L., Li, X., Janowicz, D. M., Fortney, K. R., Zhao, Q., Li, W., McClintick, J., Katz, B. P., Wilkes, D. S., Edenberg, H. J. & Spinola, S. M., Dec 1 2007, In : Infection and immunity. 75, 12, p. 5686-5697 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Effect of normal and immune sera on Haemophilus ducreyi 35000HP and its isogenic MOMP and LOS mutants

Hiltke, T. J., Bauer, M. E., Klesney-Tait, J., Hansen, E. J., Munson, R. S. & Spinola, S. M., Feb 1999, In : Microbial Pathogenesis. 26, 2, p. 93-102 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Epidemiology of colonization by nontypable Haemophilus influenzae in children: A longitudinal study

Spinola, S. M., Peacock, J., Denny, F. W., Smith, D. L. & Cannon, J. G., Jan 1 1986, In : Journal of Infectious Diseases. 154, 1, p. 100-109 10 p.

Research output: Contribution to journalArticle

69 Scopus citations

Evaluation of an isogenic hemolysin-deficient mutant in the human model of Haemophilus ducreyi infection

Palmer, K. L., Thornton, A. C., Fortney, K. R., Hood, A. F., Munson, R. S. & Spinola, S. M., Jan 1 1998, In : Journal of Infectious Diseases. 178, 1, p. 191-199 9 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Evaluation of an isogenic major outer membrane protein-deficient mutant in the human model of Haemophilus ducreyi infection

Throm, R. E., Al-Tawfiq, J. A., Fortney, K. R., Katz, B. P., Hood, A. F., Slaughter, C. A., Hansen, E. J. & Spinola, S. M., May 1 2000, In : Infection and immunity. 68, 5, p. 2602-2607 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Evaluation of CpxRA as a therapeutic target for uropathogenic Escherichia coli infections

Dbeibo, L., van Rensburg, J. J., Smith, S. N., Fortney, K. R., Gangaiah, D., Gao, H., Marzoa, J., Liu, Y., Mobley, H. L. T. & Spinola, S. M., Mar 1 2018, In : Infection and immunity. 86, 3, e00798-17.

Research output: Contribution to journalArticle

6 Scopus citations

Evaluation of the repertoire of the TonB-dependent receptors of Haemophilus ducreyi for their role in virulence in humans

Leduc, I., Banks, K. E., Fortney, K. R., Patterson, K. B., Billings, S. D., Katz, B. P., Spinola, S. M. & Elkins, C., Apr 15 2008, In : Journal of Infectious Diseases. 197, 8, p. 1103-1109 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Evolution of the cutaneous immune response to experimental Haemophilus ducreyi infection and its relevance to HIV-1 acquisition

Humphreys, T. L., Schnizlein-Bick, C. T., Katz, B. P., Baldridge, L. A., Hood, A. F., Hromas, R. A. & Spinola, S. M., Dec 1 2002, In : Journal of Immunology. 169, 11, p. 6316-6323 8 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Experimental human infection with haemophilus ducreyi

Spinola, S. M., Wild, L. M., Apicella, M. A., Gaspari, A. A. & Campagnari, A. A., May 1994, In : Journal of Infectious Diseases. 169, 5, p. 1146-1150 5 p.

Research output: Contribution to journalArticle

109 Scopus citations
56 Scopus citations

Experimental infection of human volunteers with Haemophilus ducreyi does not confer protection against subsequent challenge

Al-Tawfiq, J. A., Palmer, K. L., Chen, C. Y., Haley, J. C., Katz, B. P., Hood, A. F. & Spinola, S. M., May 5 1999, In : Journal of Infectious Diseases. 179, 5, p. 1283-1287 5 p.

Research output: Contribution to journalArticle

34 Scopus citations

Experimental infection with Haemophilus ducreyi in persons who are infected with HIV does not cause local or augment systemic viral replication

Janowicz, D. M., Tenner-Racz, K., Racz, P., Humphreys, T. L., Schnizlein-Bick, C., Fortney, K. R., Zwickl, B., Katz, B. P., Campbell, J. J., Ho, D. D. & Spinola, S. M., May 15 2007, In : Journal of Infectious Diseases. 195, 10, p. 1443-1451 9 p.

Research output: Contribution to journalArticle

11 Scopus citations