• 3355 Citations
  • 32 h-Index
1974 …2019

Research output per year

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Publications

2005

Trafficking pathways and characterization of CD4 and CD8 cells recruited to the skin of humans experimentally infected with Haemophilus ducreyi

Humphreys, T. L., Baldridge, L. A., Billings, S. D., Campbell, J. J. & Spinola, S. M., Jul 1 2005, In : Infection and immunity. 73, 7, p. 3896-3902 7 p.

Research output: Contribution to journalArticle

18 Scopus citations
2004

Expression of the LspA1 and LspA2 proteins by Haemophilus ducreyi is required for virulence in human volunteers

Janowicz, D. M., Fortney, K. R., Katz, B. P., Latimer, J. L., Deng, K., Hansen, E. J. & Spinola, S. M., Aug 1 2004, In : Infection and immunity. 72, 8, p. 4528-4533 6 p.

Research output: Contribution to journalArticle

39 Scopus citations
2003

CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking

Soler, D., Humphreys, T. L., Spinola, S. M. & Campbell, J. J., Mar 1 2003, In : Blood. 101, 5, p. 1677-1683 7 p.

Research output: Contribution to journalArticle

173 Scopus citations

Differences in Host Susceptibility to Disease Progression in the Human Challenge Model of Haemophilus ducreyi Infection

Spinola, S. M., Bong, C. T. H., Faber, A. L., Fortney, K. R., Bennett, S. L., Townsend, C. A., Zwickl, B. E., Billings, S. D., Humphreys, T. L., Bauer, M. E. & Katz, B. P., Nov 1 2003, In : Infection and immunity. 71, 11, p. 6658-6663 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Haemophilus ducreyi Requires an Intact flp Gene Cluster for Virulence in Humans

Spinola, S. M., Fortney, K. R., Katz, B. P., Latimer, J. L., Mock, J. R., Vakevainen, M. & Hansen, E. J., Dec 1 2003, In : Infection and immunity. 71, 12, p. 7178-7182 5 p.

Research output: Contribution to journalArticle

51 Scopus citations
2002

A superoxide dismutase C mutant of Haemophilus ducreyi is virulent in human volunteers

Bong, C. T. H., Fortney, K. R., Katz, B. P., Hood, A. F., San Mateo, L. R., Kawula, T. H. & Spinola, S. M., Mar 4 2002, In : Infection and immunity. 70, 3, p. 1367-1371 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Evolution of the cutaneous immune response to experimental Haemophilus ducreyi infection and its relevance to HIV-1 acquisition

Humphreys, T. L., Schnizlein-Bick, C. T., Katz, B. P., Baldridge, L. A., Hood, A. F., Hromas, R. A. & Spinola, S. M., Dec 1 2002, In : Journal of Immunology. 169, 11, p. 6316-6323 8 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Haemophilus ducreyi: Clinical disease and pathogenesis

Al-Tawfiq, J. A. & Spinola, S. M., Jan 1 2002, In : Current Opinion in Infectious Diseases. 15, 1, p. 43-47 5 p.

Research output: Contribution to journalReview article

18 Scopus citations

Haemophilus ducreyi: Clinical features, epidemiology, and prospects for disease control

Bong, C. T. H., Bauer, M. E. & Spinola, S. M., Sep 1 2002, In : Microbes and Infection. 4, 11, p. 1141-1148 8 p.

Research output: Contribution to journalReview article

52 Scopus citations

Immunopathogenesis of Haemophilus ducreyi infection (chancroid)

Spinola, S. M., Bauer, M. E. & Munson, R. S., Apr 3 2002, In : Infection and immunity. 70, 4, p. 1667-1676 10 p.

Research output: Contribution to journalShort survey

69 Scopus citations

Men are more susceptible than women to pustule formation in the experimental model of Haemophilus ducreyi infection

Bong, C. T. H., Harezlak, J., Katz, B. P. & Spinola, S. M., Jan 1 2002, In : Sexually transmitted diseases. 29, 2, p. 114-118 5 p.

Research output: Contribution to journalArticle

24 Scopus citations
2001

Characterization of Haemophilus ducreyi-specific T-cell lines from lesions of experimentally infected human subjects

Gelfanova, V., Humphreys, T. L. & Spinola, S. M., Jul 5 2001, In : Infection and immunity. 69, 7, p. 4224-4231 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

DsrA-deficient mutant of Haemophilus ducreyi is impaired in its ability to infect human volunteers

Bong, C. T. H., Throm, R. E., Fortney, K. R., Katz, B. P., Hood, A. F., Elkins, C. & Spinola, S. M., Mar 14 2001, In : Infection and immunity. 69, 3, p. 1488-1491 4 p.

Research output: Contribution to journalArticle

61 Scopus citations

Expression of cytolethal distending toxin and hemolysin is not required for pustule formation by Haemophilus ducreyi in human volunteers

Young, R. S., Fortney, K. R., Gelfanova, V., Phillips, C. L., Katz, B. P., Hood, A. F., Latimer, J. L., Munson, J., Hansen, E. J. & Spinola, S. M., Mar 14 2001, In : Infection and immunity. 69, 3, p. 1938-1942 5 p.

Research output: Contribution to journalArticle

47 Scopus citations

Haemophilus ducreyi associates with phagocytes, collagen, and fibrin and remains extracellular throughout infection of human volunteers

Bauer, M. E., Goheen, M. P., Townsend, C. A. & Spinola, S. M., Apr 5 2001, In : Infection and immunity. 69, 4, p. 2549-2557 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

Haemophilus ducreyi lipooligosaccharide mutant defective in expression of β-1,4-glucosyltransferase is virulent in humans

Young, R. S., Filiatrault, M. J., Fortney, K. R., Hood, A. F., Katz, B. P., Munson, J., Campagnari, A. A. & Spinola, S. M., Jun 11 2001, In : Infection and immunity. 69, 6, p. 4180-4184 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Transcription of candidate virulence genes of Haemophilus ducreyi during infection of human volunteers

Throm, R. E. & Spinola, S. M., Mar 14 2001, In : Infection and immunity. 69, 3, p. 1483-1487 5 p.

Research output: Contribution to journalArticle

24 Scopus citations
2000

An isogenic hemoglobin receptor-deficient mutant of Haemophilus ducreyi is attenuated in the human model of experimental infection

Al-Tawfiq, J. A., Fortney, K. R., Katz, B. P., Hood, A. F., Elkins, C. & Spinola, S. M., Apr 19 2000, In : Journal of Infectious Diseases. 181, 3, p. 1049-1054 6 p.

Research output: Contribution to journalArticle

67 Scopus citations

A pilus-deficient mutant of Haemophilus ducreyi is virulent in the human model of experimental infection

Al-Tawfiq, J. A., Bauer, M. E., Fortney, K. R., Katz, B. P., Hood, A. F., Ketterer, M., Apicella, M. A. & Spinola, S. M., Apr 19 2000, In : Journal of Infectious Diseases. 181, 3, p. 1176-1179 4 p.

Research output: Contribution to journalArticle

19 Scopus citations

Cumulative experience with Haemophilus ducreyi 35000 in the human model of experimental infection

Al-Tawfiq, J. A., Harezlak, J., Katz, B. P. & Spinola, S. M., Feb 2000, In : Sexually transmitted diseases. 27, 2, p. 111-114 4 p.

Research output: Contribution to journalArticle

29 Scopus citations

Evaluation of an isogenic major outer membrane protein-deficient mutant in the human model of Haemophilus ducreyi infection

Throm, R. E., Al-Tawfiq, J. A., Fortney, K. R., Katz, B. P., Hood, A. F., Slaughter, C. A., Hansen, E. J. & Spinola, S. M., May 1 2000, In : Infection and immunity. 68, 5, p. 2602-2607 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Expression of peptidoglycan-associated lipoprotein is required for virulence in the human model of Haemophilus ducreyi infection

Fortney, K. R., Young, R. S., Bauer, M. E., Katz, B. P., Hood, A. F., Munson, J. & Spinola, S. M., Jan 1 2000, In : Infection and immunity. 68, 11, p. 6441-6448 8 p.

Research output: Contribution to journalArticle

67 Scopus citations
42 Scopus citations
1999

Binding of Haemophilus ducreyi to extracellular matrix proteins

Bauer, M. E. & Spinola, S. M., May 1999, In : Infection and immunity. 67, 5, p. 2649-2653 5 p.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

Cytolethal distending toxin of Haemophilus ducreyi induces apoptotic death of Jurkat T cells

Gelfanova, V., Hansen, E. J. & Spinola, S. M., Dec 1 1999, In : Infection and immunity. 67, 12, p. 6394-6402 9 p.

Research output: Contribution to journalArticle

78 Scopus citations

Effect of normal and immune sera on Haemophilus ducreyi 35000HP and its isogenic MOMP and LOS mutants

Hiltke, T. J., Bauer, M. E., Klesney-Tait, J., Hansen, E. J., Munson, R. S. & Spinola, S. M., Feb 1999, In : Microbial Pathogenesis. 26, 2, p. 93-102 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Experimental infection of human volunteers with Haemophilus ducreyi does not confer protection against subsequent challenge

Al-Tawfiq, J. A., Palmer, K. L., Chen, C. Y., Haley, J. C., Katz, B. P., Hood, A. F. & Spinola, S. M., May 5 1999, In : Journal of Infectious Diseases. 179, 5, p. 1283-1287 5 p.

Research output: Contribution to journalArticle

34 Scopus citations

Expression of sialylated or paragloboside-like lipooligosaccharides are not required for pustule formation by Haemophilus ducreyi in human volunteers

Young, R. S., Fortney, K., Haley, J. C., Hood, A. F., Campagnari, A. A., Wang, J., Bozue, J. A., Munson, R. S. & Spinola, S. M., Dec 1 1999, In : Infection and immunity. 67, 12, p. 6335-6340 6 p.

Research output: Contribution to journalArticle

26 Scopus citations
1998

Evaluation of an isogenic hemolysin-deficient mutant in the human model of Haemophilus ducreyi infection

Palmer, K. L., Thornton, A. C., Fortney, K. R., Hood, A. F., Munson, R. S. & Spinola, S. M., Jan 1 1998, In : Journal of Infectious Diseases. 178, 1, p. 191-199 9 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Haemophilus ducreyi is susceptible to protegrin

Fortney, K., Totten, P. A., Lehrer, R. I. & Spinola, S. M., Oct 1998, In : Antimicrobial Agents and Chemotherapy. 42, 10, p. 2690-2693 4 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Prevention of experimental Haemophilus ducreyi infection: A randomized, controlled clinical trial

Thornton, A. C., O'Mara, E. M., Sorensen, S. J., Hiltke, T. J., Fortney, K., Katz, B., Shoup, R. E., Hood, A. F. & Spinola, S. M., Jan 1 1998, In : Journal of Infectious Diseases. 177, 6, p. 1608-1613 6 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Standardization of the experimental model of Haemophilus ducreyi infection in human subjects

Al-Tawfiq, J. A., Thornton, A. C., Katz, B. P., Fortney, K. R., Todd, K. D., Hood, A. F. & Spinola, S. M., Dec 18 1998, In : Journal of Infectious Diseases. 178, 6, p. 1684-1687 4 p.

Research output: Contribution to journalArticle

99 Scopus citations

The immune response to Haemophilus ducreyi resembles a delayed-type hypersensitivity reaction throughout experimental infection of human subjects

Palmer, K. L., Schnizlein-Bick, C. T., Orazi, A., John, K., Chen, C. Y., Hood, A. F. & Spinola, S. M., Dec 18 1998, In : Journal of Infectious Diseases. 178, 6, p. 1688-1697 10 p.

Research output: Contribution to journalArticle

50 Scopus citations
1997

Clinical features of experimental human infection with haemophilus ducreyi

Al-Tawfiq, J. A., Thornton, A. C., Fortney, K. A. & Spinola, S. M., Dec 1 1997, In : Clinical Infectious Diseases. 25, 2, 1 p.

Research output: Contribution to journalArticle

Comparison of enzyme immunoassays for antibodies to Haemophilus ducreyi in a community outbreak of chancroid in the United States

Chen, C. Y., Mertz, K. J., Spinola, S. M. & Morse, S. A., Jan 1 1997, In : Journal of Infectious Diseases. 175, 6, p. 1390-1395 6 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

The major outer membrane protein of Haemophilus ducreyi consists of two OmpA homologs

Klesney-Tait, J., Hiltke, T. J., Maciver, I., Spinola, S. M., Radolf, J. D. & Hansen, E. J., Jan 1 1997, In : Journal of bacteriology. 179, 5, p. 1764-1773 10 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations
1996

Characterization of a novel lipoprotein expressed by Haemophilus ducreyi

Hiltke, T. J., Campagnari, A. A. & Spinola, S. M., Dec 14 1996, In : Infection and immunity. 64, 12, p. 5047-5052 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Fine tangled pili expressed by Haemophilus ducreyi are a novel class of pili

Brentjens, R. J., Ketterer, M., Apicella, M. A. & Spinola, S. M., Feb 1996, In : Journal of bacteriology. 178, 3, p. 808-816 9 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations

Haemophilus ducreyi elicits a cutaneous infiltrate of CD4 cells during experimental human infection

Spinola, S. M., Orazi, A., Arno, J. N., Fortney, K., Kotylo, P., Chen, C. Y., Campagnari, A. A. & Hood, A. F., Jan 1 1996, In : Journal of Infectious Diseases. 173, 2, p. 394-402 9 p.

Research output: Contribution to journalArticle

Open Access
105 Scopus citations

The conserved 18,000-molecular-weight outer membrane protein of Haemophilus ducreyi has homology to PAL

Spinola, S. M., Hiltke, T. J., Fortney, K. & Shanks, K. L., Jun 1 1996, In : Infection and immunity. 64, 6, p. 1950-1955 6 p.

Research output: Contribution to journalArticle

39 Scopus citations
1994

Characterization and sequence analysis of the lsg (LOS synthesis genes) locus from Haemophilus influenzae type b

Mclaughlin, R., Lee, N. G., Abu Kwaik, Y., Spinola, S. M. & Apicella, M. A., Sep 1994, In : Journal of Endotoxin Research. 1, 3, p. 165-174 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Experimental human infection with haemophilus ducreyi

Spinola, S. M., Wild, L. M., Apicella, M. A., Gaspari, A. A. & Campagnari, A. A., May 1994, In : Journal of Infectious Diseases. 169, 5, p. 1146-1150 5 p.

Research output: Contribution to journalArticle

109 Scopus citations

Haemophilus ducreyi adheres to human keratinocytes

Brentjens, R. J., Spinola, S. M. & Campagnari, A. A., Mar 1994, In : Microbial Pathogenesis. 16, 3, p. 243-247 5 p.

Research output: Contribution to journalArticle

24 Scopus citations
1993

The major outer membrane protein of Haemophilus ducreyi is a member of the OmpA family of proteins

Spinola, S. M., Griffiths, G. E., Shanks, K. L. & Blake, M. S., Jan 1 1993, In : Infection and immunity. 61, 4, p. 1346-1351 6 p.

Research output: Contribution to journalArticle

30 Scopus citations
1992
4 Scopus citations

Expression of Pili by Haemophilus ducreyi

Castellazzo, A., Shero, M., Apicella, M. A. & Spinola, S. M., Jun 1992, In : Journal of Infectious Diseases. 165, p. S198

Research output: Contribution to journalArticle

6 Scopus citations

Generation of lipooligosaccharide mutants of Haemophilus influenzae type b

McLaughlin, R., Spinola, S. M. & Apicella, M. A., Jan 1 1992, In : Journal of bacteriology. 174, 20, p. 6455-6459 5 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Lipooligosaccharides (LOS) of some Haemophilus species mimic human glycosphingolipids, and some LOS are sialylated

Mandrell, R. E., McLaughlin, R., Kwaik, Y. A., Lesse, A., Yamasaki, R., Gibson, B., Spinola, S. M. & Apicella, M. A., Jan 1 1992, In : Infection and immunity. 60, 4, p. 1322-1328 7 p.

Research output: Contribution to journalArticle

138 Scopus citations
1991

Analysis of Haemophilus influenzae type b lipooligosaccharide‐synthesis genes that assemble or expose a 2‐keto‐3‐deoxyoctulosonic acid epitope

Abu Kwaik, Y., McLaughlin, B. E., Apicella, M. A. & Spinola, S. M., Oct 1991, In : Molecular Microbiology. 5, 10, p. 2475-2480 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Characterization of an 18,000-molecular-weight outer membrane protein of Haemophilus ducreyi that contains a conserved surface-exposed epitope

Spinola, S. M., Griffiths, G. E., Bogdan, J. & Menegus, M. A., Dec 1 1991, In : Infection and immunity. 60, 2, p. 385-391 7 p.

Research output: Contribution to journalArticle

24 Scopus citations