• 3355 Citations
  • 32 h-Index
1974 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Publications

Filter
Article
2019

A Class I Haemophilus ducreyi Strain Containing a Class II hgbA Allele Is Partially Attenuated in Humans: Implications for HGBA vaccine efficacy trials

Leduc, I., Fortney, K. R., Janowicz, D. M., Zwickl, B., Ellinger, S., Katz, B. P., Lin, H., Dong, Q. & Spinola, S. M., Jan 1 2019, In : Infection and immunity. 87, 7, e00112.

Research output: Contribution to journalArticle

Determination of an interaction network between an extracellular bacterial pathogen and the human host

Griesenauer, B., Tran, T. M., Fortney, K. R., Janowicz, D. M., Johnson, P., Gao, H., Barnes, S., Wilson, L. S., Liu, Y. & Spinola, S. M., May 1 2019, In : mBio. 10, 3, e01193-19.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors

Li, Y., Gardner, J. J., Fortney, K. R., Leus, I. V., Bonifay, V., Zgurskaya, H. I., Pletnev, A. A., Zhang, S., Zhang, Z. Y., Gribble, G. W., Spinola, S. M. & Duerfeldt, A. S., Jul 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 14, p. 1836-1841 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Evaluation of CpxRA as a therapeutic target for uropathogenic Escherichia coli infections

Dbeibo, L., van Rensburg, J. J., Smith, S. N., Fortney, K. R., Gangaiah, D., Gao, H., Marzoa, J., Liu, Y., Mobley, H. L. T. & Spinola, S. M., Mar 1 2018, In : Infection and immunity. 86, 3, e00798-17.

Research output: Contribution to journalArticle

6 Scopus citations

Multiple Class i and Class II Haemophilus ducreyi Strains Cause Cutaneous Ulcers in Children on an Endemic Island

Grant, J. C., González-Beiras, C., Amick, K. M., Fortney, K. R., Gangaiah, D., Humphreys, T. L., Mitjà, O., Abecasis, A. & Spinola, S. M., Nov 13 2018, In : Clinical Infectious Diseases. 67, 11, p. 1729-1735 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Both MisR (CpxR) and MisS (CpxA) are required for Neisseria gonorrhoeae infection in a murine model of lower genital tract infection

Gangaiah, D., Raterman, E. L., Wu, H., Fortney, K. R., Gao, H., Liu, Y., Jerse, A. E. & Spinola, S., Sep 1 2017, In : Infection and Immunity. 85, 9, e00307-17.

Research output: Contribution to journalArticle

11 Scopus citations

Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea

Houinei, W., Godornes, C., Kapa, A., Knauf, S., Mooring, E. Q., González-Beiras, C., Watup, R., Paru, R., Advent, P., Bieb, S., Sanz, S., Bassat, Q., Spinola, S. M., Lukehart, S. A. & Mitjà, O., May 10 2017, In : PLoS neglected tropical diseases. 11, 5, e0004958.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Draft whole-genome sequence of Haemophilus ducreyi strain AUSPNG1, isolated from a cutaneousulcer of a child from Papua New Guinea

Gangaiah, D., Marinov, G. K., Roberts, S. A., Robson, J. & Spinola, S. M., 2016, In : Genome Announcements. 4, 1, e01661-15.

Research output: Contribution to journalArticle

6 Scopus citations
6 Scopus citations

Haemophilus ducreyi seeks alternative carbon sources and adapts to nutrient stress and anaerobiosis during experimental infection of human volunteers

Gangaiah, D., Zhang, X., Baker, B., Fortney, K. R., Gao, H., Holley, C. L., Munson, R. S., Liu, Y. & Spinola, S. M., May 1 2016, In : Infection and immunity. 84, 5, p. 1514-1525 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Host Polymorphisms in TLR9 and IL10 Are Associated with the Outcomes of Experimental Haemophilus ducreyi Infection in Human Volunteers

Singer, M., Li, W., Morre, S. A., Ouburg, S. & Spinola, S., Aug 1 2016, In : Journal of Infectious Diseases. 214, 3, p. 489-495 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Development and validation of a high-throughput cell-based screen to identify activators of a bacterial two-component signal transduction system

Van Rensburg, J. J., Fortney, K. R., Chen, L., Krieger, A. J., Lima, B. P., Wolfe, A. J., Katz, B. P., Zhang, Z. Y. & Spinola, S. M., Jul 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 7, p. 3789-3799 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

DksA and (p)ppGpp have unique and overlapping contributions to Haemophilus ducreyi pathogenesis in humans

Holley, C. L., Zhang, X., Fortney, K. R., Ellinger, S., Johnson, P., Baker, B., Liu, Y., Janowicz, D. M., Katz, B. P., Munson, R. S. & Spinola, S. M., Jan 1 2015, In : Infection and immunity. 83, 8, p. 3281-3292 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Haemophilus ducreyi cutaneous ulcer strains are nearly identical to class I genital ulcer strains

Gangaiah, D., Webb, K. M., Humphreys, T. L., Fortney, K. R., Toh, E., Tai, A., Katz, S. S., Pillay, A., Chen, C. Y., Roberts, S. A., Munson, R. S. & Spinola, S. M., 2015, In : PLoS neglected tropical diseases. 9, 7, e0003918.

Research output: Contribution to journalArticle

20 Scopus citations

Phosphoethanolamine transferase LptA in haemophilus ducreyi modifies lipid a and contributes to human defensin resistance in vitro

Trombley, M. P., Post, D. M. B., Rinker, S. D., Reinders, L. M., Fortney, K. R., Zwickl, B. W., Janowicz, D. M., Baye, F. M., Katz, B. P., Spinola, S. M. & Bauer, M. E., Apr 22 2015, In : PloS one. 10, 4, e0124373.

Research output: Contribution to journalArticle

10 Scopus citations
2014

A (p)ppGpp-null mutant of Haemophilus ducreyi is partially attenuated in humans due to multiple conflicting phenotypes

Holley, C., Gangaiah, D., Li, W., Fortney, K. R., Janowicz, D. M., Ellinger, S., Zwickl, B., Katz, B. P. & Spinola, S. M., 2014, In : Infection and immunity. 82, 8, p. 3492-3502 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Correcting imbalanced reads coverage in bacterial transcriptome sequencing with extreme deep coverage

Zhang, X., Gangaiah, D., Munson, R. S., Spinola, S. M. & Liu, Y., 2014, In : International Journal of Computational Biology and Drug Design. 7, 2-3, p. 195-213 19 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi Hfq contributes to virulence gene regulation as cells enter stationary phase

Gangaiah, D., Labandeira-Rey, M., Zhang, X., Fortney, K. R., Ellinger, S., Zwickl, B., Baker, B., Liu, Y., Janowicz, D. M., Katz, B. P., Brautigam, C. A., Munson, R. S., Hansen, E. J. & Spinola, S. M., Feb 11 2014, In : mBio. 5, 1, e01081-13.

Research output: Contribution to journalArticle

8 Scopus citations

Haemophilus ducreyi RpoE and CpxRA appear To play distinct yet complementary roles in regulation of envelope-related functions

Gangaiah, D., Zhang, X., Baker, B., Fortney, K. R., Liu, Y., Munson, R. S. & Spinola, S. M., Jan 1 2014, In : Journal of bacteriology. 196, 23, p. 4012-4025 14 p.

Research output: Contribution to journalArticle

3 Scopus citations
2013

Activation of CpxRA in Haemophilus ducreyi primarily inhibits the expression of Its targets, including major virulence determinants

Gangaiah, D., Zhang, X., Fortney, K. R., Baker, B., Liu, Y., Munson, R. S. & Spinola, S. M., Aug 1 2013, In : Journal of Bacteriology. 195, 15, p. 3486-3502 17 p.

Research output: Contribution to journalArticle

26 Scopus citations

Carbon storage regulator a contributes to the virulence of haemophilus ducreyi in humans by multiple mechanisms

Gangaiah, D., Li, W., Fortney, K. R., Janowicz, D. M., Ellinger, S., Zwickl, B., Katz, B. P. & Spinola, S. M., Feb 2013, In : Infection and immunity. 81, 2, p. 608-617 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Haemophilus ducreyi infection induces activation of the nlrp3 inflammasome in nonpolarized but not in polarized human macrophages

Li, W., Katz, B. P., Bauer, M. E. & Spinola, S. M., Aug 1 2013, In : Infection and immunity. 81, 8, p. 2997-3008 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

The haemophilus ducreyi fis protein is involved in controlling expression of the lspB-lspA2 operon and other virulence factors

Labandeira-Rey, M., Dodd, D. A., Brautigam, C. A., Fortney, K. R., Spinol, S. M. & Hansena, E. J., Nov 1 2013, In : Infection and immunity. 81, 11, p. 4160-4170 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2012

Haemophilus ducreyi-induced interleukin-10 promotes a mixed M1 and M2 activation program in human macrophages

Li, W., Katz, B. P. & Spinola, S. M., 2012, In : Infection and immunity. 80, 12, p. 4426-4434 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Permeases of the sap transporter are required for cathelicidin resistance and virulence of haemophilus ducreyi in humans

Rinker, S. D., Gu, X., Fortney, K. R., Zwickl, B. W., Katz, B. P., Janowicz, D. M., Spinola, S. M. & Bauer, M. E., Nov 1 2012, In : Journal of Infectious Diseases. 206, 9, p. 1407-1414 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Sialylation of lipooligosaccharides is dispensable for the virulence of haemophilus ducreyi in humans

Spinola, S. M., Li, W., Fortney, K. R., Janowicz, D. M., Zwickl, B., Katz, B. P. & Munson, R. S., Feb 1 2012, In : Infection and immunity. 80, 2, p. 679-687 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
2011

A Haemophilus ducreyi CpxR deletion mutant is virulent in human volunteers

Labandeira-Rey, M., Dodd, D., Fortney, K. R., Zwickl, B., Katz, B. P., Janowicz, D. M., Spinola, S. M. & Hansen, E. J., Jun 15 2011, In : Journal of Infectious Diseases. 203, 12, p. 1859-1865 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
16 Scopus citations
2010

Activation of the CpxRA system by deletion of cpxA impairs the ability of Haemophilus ducreyi to infect humans

Spinola, S. M., Fortney, K. R., Baker, B., Janowicz, D. M., Zwickl, B., Katz, B. P., Blick, R. J. & Munson, R. S., Sep 1 2010, In : Infection and immunity. 78, 9, p. 3898-3904 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Haemophilus ducreyi SapA contributes to cathelicidin resistance and virulence in humans

Mount, K. L. B., Townsend, C. A., Rinker, S. D., Gu, X., Fortney, K. R., Zwickl, B. W., Janowicz, D. M., Spinola, S. M., Katz, B. P. & Bauer, M. E., Mar 1 2010, In : Infection and immunity. 78, 3, p. 1176-1184 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Role played by CD4+FOXP3+ regulatory T cells in suppression of host responses to Haemophilus ducreyi during experimental infection of human volunteers

Li, W., Tenner-Racz, K., Racz, P., Janowicz, D. M., Fortney, K. R., Katz, B. P. & Spinola, S. M., Jun 15 2010, In : Journal of Infectious Diseases. 201, 12, p. 1839-1848 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2009

A fibrinogen-binding lipoprotein contributes to the virulence of Haemophilus ducreyi in humans

Bauer, M. E., Townsend, C. A., Doster, R. S., Fortney, K. R., Zwickl, B. W., Katz, B. P., Spinola, S. M. & Janowicz, D. M., Mar 1 2009, In : Journal of Infectious Diseases. 199, 5, p. 684-692 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Experimental infection of human volunteers with Haemophilus ducreyi: Fifteen years of clinical data and experience

Janowicz, D. M., Ofner, S., Katz, B. P. & Spinola, S. M., Jun 1 2009, In : Journal of Infectious Diseases. 199, 11, p. 1671-1679 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

Inactivation of the haemophilus ducreyi luxS gene affects the virulence of this pathogen in human subjects

Labandeira-Rey, M., Janowicz, D. M., Blick, R. J., Fortney, K. R., Zwickl, B., Katz, B. P., Spinola, S. M. & Hansen, E. J., Aug 1 2009, In : Journal of Infectious Diseases. 200, 3, p. 409-416 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mechanism of human natural killer cell activation by haemophilus ducreyi

Li, W., Janowicz, D. M., Fortney, K. R., Katz, B. P. & Spinola, S. M., Aug 15 2009, In : Journal of Infectious Diseases. 200, 4, p. 590-598 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2008

Evaluation of the repertoire of the TonB-dependent receptors of Haemophilus ducreyi for their role in virulence in humans

Leduc, I., Banks, K. E., Fortney, K. R., Patterson, K. B., Billings, S. D., Katz, B. P., Spinola, S. M. & Elkins, C., Apr 15 2008, In : Journal of Infectious Diseases. 197, 8, p. 1103-1109 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Identification of Haemophilus ducreyi genes expressed during human infection

Bauer, M. E., Fortney, K. R., Harrison, A., Janowicz, D. M., Munson, R. S. & Spinola, S. M., Apr 1 2008, In : Microbiology. 154, 4, p. 1152-1160 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Outer membrane protein DsrA is the major fibronectin-binding determinant of Haemophilus ducreyi

Leduc, I., White, C. D., Nepluev, I., Throm, R. E., Spinola, S. M. & Elkins, C., Apr 1 2008, In : Infection and immunity. 76, 4, p. 1608-1616 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

The enterobacterial common antigen-like gene cluster of Haemophilus ducreyi contributes to virulence in humans

Banks, K. E., Fortney, K. R., Baker, B., Billings, S. D., Katz, B. P., Munson, R. S. & Spinola, S. M., Jun 1 2008, In : Journal of Infectious Diseases. 197, 11, p. 1531-1536 6 p.

Research output: Contribution to journalArticle

25 Scopus citations
2007

Dysregulated immune profiles for skin and dendritic cells are associated with increased host susceptibility to Haemophilus ducreyi infection in human volunteers

Humphreys, T. L., Li, L., Li, X., Janowicz, D. M., Fortney, K. R., Zhao, Q., Li, W., McClintick, J., Katz, B. P., Wilkes, D. S., Edenberg, H. J. & Spinola, S. M., Dec 1 2007, In : Infection and immunity. 75, 12, p. 5686-5697 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Experimental infection with Haemophilus ducreyi in persons who are infected with HIV does not cause local or augment systemic viral replication

Janowicz, D. M., Tenner-Racz, K., Racz, P., Humphreys, T. L., Schnizlein-Bick, C., Fortney, K. R., Zwickl, B., Katz, B. P., Campbell, J. J., Ho, D. D. & Spinola, S. M., May 15 2007, In : Journal of Infectious Diseases. 195, 10, p. 1443-1451 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Haemophilus ducreyi partially activates human myeloid dendritic cells

Banks, K. E., Humphreys, T. L., Li, W., Katz, B. P., Wilkes, D. S. & Spinola, S. M., Dec 1 2007, In : Infection and immunity. 75, 12, p. 5678-5685 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
2006

A DltA mutant of Haemophilus ducreyi is partially attenuated in its ability to cause pustules in human volunteers

Janowicz, D., Leduc, I., Fortney, K. R., Katz, B. P., Elkins, C. & Spinola, S. M., Feb 1 2006, In : Infection and immunity. 74, 2, p. 1394-1397 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Expression of Haemophilus ducreyi collagen binding outer membrane protein NcaA is required for virulence in swine and human challenge models of chancroid

Fulcher, R. A., Cole, L. E., Janowicz, D. M., Toffer, K. L., Fortney, K. R., Katz, B. P., Orndorff, P. E., Spinola, S. M. & Kawula, T. H., May 2006, In : Infection and immunity. 74, 5, p. 2651-2658 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Expression of OmpP2A and OmpP2B is not required for pustule formation by Haemophilus ducreyi in human volunteers

Janowicz, D., Luke, N. R., Fortney, K. R., Katz, B. P., Campagnari, A. A. & Spinola, S. M., Mar 1 2006, In : Microbial Pathogenesis. 40, 3, p. 110-115 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Localization of Haemophilus ducreyi in naturally acquired chancroidal ulcers

Bauer, M. E., Townsend, C. A., Ronald, A. R. & Spinola, S. M., Aug 1 2006, In : Microbes and Infection. 8, 9-10, p. 2465-2468 4 p.

Research output: Contribution to journalArticle

46 Scopus citations
2005

Trafficking pathways and characterization of CD4 and CD8 cells recruited to the skin of humans experimentally infected with Haemophilus ducreyi

Humphreys, T. L., Baldridge, L. A., Billings, S. D., Campbell, J. J. & Spinola, S. M., Jul 1 2005, In : Infection and immunity. 73, 7, p. 3896-3902 7 p.

Research output: Contribution to journalArticle

18 Scopus citations
2004

Expression of the LspA1 and LspA2 proteins by Haemophilus ducreyi is required for virulence in human volunteers

Janowicz, D. M., Fortney, K. R., Katz, B. P., Latimer, J. L., Deng, K., Hansen, E. J. & Spinola, S. M., Aug 1 2004, In : Infection and immunity. 72, 8, p. 4528-4533 6 p.

Research output: Contribution to journalArticle

39 Scopus citations
2003

CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking

Soler, D., Humphreys, T. L., Spinola, S. M. & Campbell, J. J., Mar 1 2003, In : Blood. 101, 5, p. 1677-1683 7 p.

Research output: Contribution to journalArticle

173 Scopus citations

Differences in Host Susceptibility to Disease Progression in the Human Challenge Model of Haemophilus ducreyi Infection

Spinola, S. M., Bong, C. T. H., Faber, A. L., Fortney, K. R., Bennett, S. L., Townsend, C. A., Zwickl, B. E., Billings, S. D., Humphreys, T. L., Bauer, M. E. & Katz, B. P., Nov 1 2003, In : Infection and immunity. 71, 11, p. 6658-6663 6 p.

Research output: Contribution to journalArticle

32 Scopus citations