Steven Johnson

  • 1309 Citations
  • 17 h-Index
20052019
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  • 1 Similar Profiles
Prealbumin Medicine & Life Sciences
Chaperonins Medicine & Life Sciences
Chaperonin 10 Chemical Compounds
Phosphotransferases Medicine & Life Sciences
Stabilization Chemical Compounds
Toxoplasma Medicine & Life Sciences
Kinetics Chemical Compounds
Amyloid Medicine & Life Sciences

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Publications 2005 2019

  • 1309 Citations
  • 17 h-Index
  • 23 Article
  • 3 Review article
  • 1 Chapter

A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78

Ambrose, A. J., Zerio, C. J., Sivinski, J., Schmidlin, C. J., Shi, T., Ross, A. B., Widrick, K. J., Johnson, S., Zhang, D. D. & Chapman, E., Jul 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 14, p. 1689-1693 5 p.

Research output: Contribution to journalArticle

Hexachlorophene
HSP70 Heat-Shock Proteins
Assays
Throughput
Substrates

Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB)inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections

Washburn, A., Abdeen, S., Ovechkina, Y., Ray, A. M., Stevens, M., Chitre, S., Sivinski, J., Park, Y., Johnson, J., Hoang, Q., Chapman, E., Parish, T. & Johnson, S., Jan 1 2019, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Polypharmacology
Chaperonins
Mycobacterium Infections
Protein Tyrosine Phosphatases
Mycobacterium tuberculosis
1 Citation (Scopus)

HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules

Stevens, M., Abdeen, S., Salim, N., Ray, A. M., Washburn, A., Chitre, S., Sivinski, J., Park, Y., Hoang, Q., Chapman, E. & Johnson, S., May 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 9, p. 1106-1112 7 p.

Research output: Contribution to journalArticle

Open Access
Chaperonin 10
Chaperonins
Biological Products
Molecules
Pharmaceutical Preparations

Parkinson’s disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics

Wu, C. X., Liao, J., Park, Y., Reed, X., Engel, V. A., Hoang, N. C., Takagi, Y., Johnson, S., Wang, M., Federici, M., Jeremy Nichols, R., Sanishvili, R., Cookson, M. R. & Hoang, Q., Jan 1 2019, In : Journal of Biological Chemistry. 294, 15, p. 5907-5913 7 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
ras Proteins
Leucine
Parkinson Disease
Conformations
2 Citations (Scopus)

Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus

Kunkle, T., Abdeen, S., Salim, N., Ray, A. M., Stevens, M., Ambrose, A. J., Victorino, J., Park, Y., Hoang, Q., Chapman, E. & Johnson, S., Dec 13 2018, In : Journal of Medicinal Chemistry. 61, 23, p. 10651-10664 14 p.

Research output: Contribution to journalArticle

Biofilms
Hydroxyl Radical
Staphylococcus aureus
Vancomycin
Methicillin-Resistant Staphylococcus aureus