Subbiah Sivam

  • 1434 Citations
  • 23 h-Index
1978 …2008
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Publications 1978 2008

  • 1434 Citations
  • 23 h-Index
  • 59 Article
  • 1 Conference contribution
2008
5 Citations (Scopus)

L-DOPA-induced activation of striatal p38MAPK and CREB in neonatal dopaminergic denervated rat: Relevance to self-injurious behavior

Sivam, S., Pugazhenthi, S., Pugazhenthi, V. & Brown, H., Feb 1 2008, In : Journal of Neuroscience Research. 86, 2, p. 339-349 11 p.

Research output: Contribution to journalArticle

Corpus Striatum
Self-Injurious Behavior
Dihydroxyphenylalanine
Dopamine
Serotonin
2006
6 Citations (Scopus)
Corpus Striatum
Enkephalins
Oxidopamine
Dopamine Agonists
Substance P
1996
23 Citations (Scopus)

Dopamine, serotonin and tachykinin in self-injurious behavior

Sivam, S., May 24 1996, In : Life Sciences. 58, 26, p. 2367-2375 9 p.

Research output: Contribution to journalArticle

Tachykinins
Self-Injurious Behavior
Dopamine
Serotonin
Biosynthesis
4 Citations (Scopus)

Dopaminergic regulation of postnatal development of dynorphin neurons in rat striatum

Sivam, S., 1996, In : Neuropeptides. 30, 1, p. 103-107 5 p.

Research output: Contribution to journalArticle

Dynorphins
Neurons
Rats
Dopamine
Oxidopamine
7 Citations (Scopus)
Dopamine Uptake Inhibitors
Dynorphins
Tachykinins
Neurokinin A
Gene Expression
1995
18 Citations (Scopus)

Dopaminergic modulation of serotonin metabolism in rat striatum: A study with dopamine uptake inhibitor GBR-12909

Sivam, S., May 19 1995, In : Life Sciences. 56, 26, p. 467-472 6 p.

Research output: Contribution to journalArticle

Dopamine Uptake Inhibitors
Metabolism
3,4-Dihydroxyphenylacetic Acid
Rats
Dopamine
24 Citations (Scopus)

GBR-12909-induced self-injurious behavior: role of dopamine

Sivam, S., Sep 4 1995, In : Brain Research. 690, 2, p. 259-263 5 p.

Research output: Contribution to journalArticle

Self-Injurious Behavior
Dopamine
Oxidopamine
Corpus Striatum
Spiperone
33 Citations (Scopus)

Integration of pharmacology into a problem-based learning curriculum for medical students

Sivam, S., Iatridis, P. G. & Vaughn, S., 1995, In : Medical Education. 29, 4, p. 289-296 8 p.

Research output: Contribution to journalArticle

pharmacology
Problem-Based Learning
Medical Students
medical student
Pharmacology
11 Citations (Scopus)
Corpus Striatum
Dynorphins
Fluoxetine
Serotonin Uptake Inhibitors
Substance P
1993
5 Citations (Scopus)
Clorgyline
Selegiline
Dynorphins
Monoamine Oxidase Inhibitors
Monoamine Oxidase
1992
Neuropeptides
Cysteine
Neurotransmitter Agents
Rats
dynorphin (1-8)
27 Citations (Scopus)
Neurokinin-1 Receptors
Tachykinins
Capsaicin
Spinal Ganglia
Substance P
1991
39 Citations (Scopus)
Enkephalins
Substance P
Basal Ganglia
Dopamine
Brain
33 Citations (Scopus)

Dopamine-dependent postnatal development of enkephalin and tachykinin neurons of rat basal ganglia

Sivam, S., Krause, J. E., Breese, G. R. & Hong, J. S., May 1991, In : Journal of Neurochemistry. 56, 5, p. 1499-1508 10 p.

Research output: Contribution to journalArticle

Tachykinins
Enkephalins
Basal Ganglia
Neurons
Rats
1990
14 Citations (Scopus)
Dihydroxyphenylalanine
Dopaminergic Neurons
Substance P
Messenger RNA
Oxidopamine

Deprenyl increases striatal enkephalin levels and preproenkephalin mRNA abundance

Sivam, S., 1990, New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. Van Ree, J. M., Mulder, A. H., Wiegant, V. M., Van Wimersma Greidanus, T. B., Van Ree, J. M., Mulder, A. H., Wiegant, V. M. & Van Wimersma Greidanus, T. B. (eds.). Elsevier Science Publishers B.V., p. 357 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Selegiline
Corpus Striatum
Methionine Enkephalin
Enkephalins
Clorgyline
Tachykinins
Enkephalins
Denervation
Basal Ganglia
24 Citations (Scopus)
Tachykinins
Enkephalins
Denervation
Basal Ganglia
Dopamine
1989
147 Citations (Scopus)
Dynorphins
Cocaine
Enkephalins
Corpus Striatum
Dopamine
36 Citations (Scopus)
Self-Injurious Behavior
Dopamine D1 Receptors
Denervation
Substance P
Oxidopamine
35 Citations (Scopus)

Lithium increases rat striatal beta- and gamma-preprotachykinin messenger RNAs

Sivam, S., Krause, J. E., Takeuchi, K., Li, S., McGinty, J. F. & Hong, J. S., 1989, In : Journal of Pharmacology and Experimental Therapeutics. 248, 3, p. 1297-1301 5 p.

Research output: Contribution to journalArticle

Corpus Striatum
Lithium
Messenger RNA
Substance P
Haloperidol
1988
2 Citations (Scopus)

Effects and mechanism of action of lithium chloride on gastric acid secretion in rats

Guglietta, A., Irons, B. J., Lazarus, L. H. & Sivam, S., 1988, In : Gastroenterology. 95, 6, p. 1454-1459 6 p.

Research output: Contribution to journalArticle

Lithium Chloride
Gastric Acid
Lithium
Stomach
Opioid Receptors
35 Citations (Scopus)

Lithium increases dynorphin A(1-8) and prodynorphin mRNA levels in the basal ganglia of rats

Sivam, S., Takeuchi, K., Li, S., Douglass, J., Civelli, O., Calvetta, L., Herbert, E., McGinty, J. F. & Hong, J. S., 1988, In : Molecular Brain Research. 3, 2, p. 155-163 9 p.

Research output: Contribution to journalArticle

dynorphin (1-8)
Basal Ganglia
Lithium
Messenger RNA
Haloperidol
87 Citations (Scopus)

Regulation of the metabolism of striatal dynorphin by the dopaminergic system

Li, S. J., Sivam, S., McGinty, J. F., Jiang, H. K., Douglass, J., Calavetta, L. & Hong, J. S., 1988, In : Journal of Pharmacology and Experimental Therapeutics. 246, 1, p. 403-408 6 p.

Research output: Contribution to journalArticle

Corpus Striatum
Dynorphins
Injections
dynorphin (1-8)
Neurons
1987
52 Citations (Scopus)

Dopaminergic regulation of tachykinin metabolism in the striatonigral pathway

Li, S. J., Sivam, S., McGinty, J. F., Huang, Y. S. & Hong, J. S., 1987, In : Journal of Pharmacology and Experimental Therapeutics. 243, 2, p. 792-798 7 p.

Research output: Contribution to journalArticle

Tachykinins
Neurokinin A
Corpus Striatum
Dopamine Receptors
Substantia Nigra
10 Citations (Scopus)

GABA and dopamine interaction in the basal ganglia: dopaminergic supersensitivity following chronic elevation of brain γ-aminobutyric acid levels

Sivam, S., Hudson, P. M., Tilson, H. A. & Hong, J. S., May 26 1987, In : Brain Research. 412, 1, p. 29-35 7 p.

Research output: Contribution to journalArticle

Aminobutyrates
Basal Ganglia
gamma-Aminobutyric Acid
Dopamine
Aminooxyacetic Acid
16 Citations (Scopus)

Lithium and haloperidol differentially alter the dynorphin A (1-8) and enkephalin levels in the neurointermediate lobe of rat pituitary

Sivam, S., Smith, D. R., Takeuchi, K. & Hong, J. S., 1987, In : Neuropeptides. 10, 3, p. 291-298 8 p.

Research output: Contribution to journalArticle

dynorphin (1-8)
Enkephalins
Haloperidol
Lithium
Rats
111 Citations (Scopus)

Neonatal and adult 6-hydroxydopamine-induced lesions differentially alter tachykinin and enkephalin gene expression

Sivam, S., Breese, G. R., Krause, J. E., Napier, T. C., Mueller, R. A. & Hong, J. S., 1987, In : Journal of Neurochemistry. 49, 5, p. 1623-1633 11 p.

Research output: Contribution to journalArticle

Tachykinins
Enkephalins
Oxidopamine
Gene expression
Rats
1986
9 Citations (Scopus)

Dopaminergic regulation of proenkephalin-A gene expression in the basal ganglia.

Sivam, S., Breese, G. R., Napier, T. C., Mueller, R. A. & Hong, J. S., 1986, In : NIDA research monograph. 75, p. 389-392 4 p.

Research output: Contribution to journalArticle

Enkephalins
Basal Ganglia
Gene Expression
Oxidopamine
Corpus Striatum
27 Citations (Scopus)
Enkephalins
gamma-Aminobutyric Acid
Messenger RNA
Aminooxyacetic Acid
Brain
56 Citations (Scopus)

Proenkephalin-A gene regulation in the rat striatum: Influence of lithium and haloperidol

Sivam, S., Strunk, C., Smith, D. R. & Hong, J. S., 1986, In : Molecular Pharmacology. 30, 2, p. 186-191 6 p.

Research output: Contribution to journalArticle

Haloperidol
Enkephalins
Lithium
Genes
Messenger RNA
65 Citations (Scopus)

Regulation of the concentration of dynorphin A1-8 in the striatonigral pathway by the dopaminergic system

Li, S., Sivam, S. & Hong, J. S., Nov 29 1986, In : Brain Research. 398, 2, p. 390-392 3 p.

Research output: Contribution to journalArticle

Dynorphins
Apomorphine
Substantia Nigra
Corpus Striatum
Injections
1985
54 Citations (Scopus)

GABA in morphine analgesia and tolerance

Sivam, S. & Ho, I. K., Jul 22 1985, In : Life Sciences. 37, 3, p. 199-208 10 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Analgesia
gamma-Aminobutyric Acid
Morphine
Analgesics
1984

Acute toxicity of Soman, Sarin and Tabun: Neurochemical evaluations related to cholinergic, GABAergic and dopamine systems

Sivam, S., Lim, D. K., Hoskins, B. & Ho, I. K., 1984, In : Federation Proceedings. 43, 3

Research output: Contribution to journalArticle

Sarin
Soman
Cholinergic Agents
Dopamine
tabun
9 Citations (Scopus)

Analgesic cross-tolerance between morphine and opioid peptides

Sivam, S. & Ho, I. K., Sep 1984, In : Psychopharmacology. 84, 1, p. 64-65 2 p.

Research output: Contribution to journalArticle

Opioid Peptides
Morphine
Analgesics
Endorphins
Leucine-2-Alanine Enkephalin
46 Citations (Scopus)
fluorophosphate
Sarin
Soman
Enzyme activity
Acetylcholinesterase
2 Citations (Scopus)
Opiate Alkaloids
delta Opioid Receptor
mu Opioid Receptor
Analgesia
Morphine
7 Citations (Scopus)

Attenuation of pharmacological effects and increased metabolism of phencyclidine in morphine tolerant mice

Nabeshima, T., Sivam, S. & Ho, I. K., Sep 17 1984, In : European Journal of Pharmacology. 104, 3-4, p. 211-221 11 p.

Research output: Contribution to journalArticle

Phencyclidine
Morphine
Pharmacology
Locomotion
Ataxia
7 Citations (Scopus)

Roles of dopamine and GABA in neurotoxicity of organophosphorus cholinesterase inhibitors

Ho, I. K., Fernando, J. C. R., Sivam, S. & Hoskins, B., 1984, In : Proceedings of the Western Pharmacology Society. VOL. 27, p. 177-180 4 p.

Research output: Contribution to journalArticle

Parasympathetic Nervous System
Organophosphorus Compounds
Isoflurophate
Cholinesterase Inhibitors
Nervous System Diseases
1983
17 Citations (Scopus)

Diisopropylfluorophosphate and GABA synaptic function: Effect on levels, enzymes, release and uptake in the rat striatum

Sivam, S., Nabeshima, T., Lim, D. K., Hoskins, B. & Ho, I. K., 1983, In : Research Communications in Chemical Pathology and Pharmacology. 42, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

Isoflurophate
gamma-Aminobutyric Acid
Rats
Enzymes
4-Aminobutyrate Transaminase
90 Citations (Scopus)

Effect of acute and chronic cholinesterase inhibition with diisopropylfluorophosphate on muscarinic, dopamine, and GABA receptors of the rat striatum

Sivam, S., Norris, J. C., Lim, D. K., Hoskins, B. & Ho, I. K., 1983, In : Journal of Neurochemistry. 40, 5, p. 1414-1422 9 p.

Research output: Contribution to journalArticle

Isoflurophate
GABA Receptors
Cholinesterases
Dopamine Receptors
Muscarinic Receptors
17 Citations (Scopus)
Phencyclidine
Morphine
Opiate Alkaloids
Liver
Aniline Hydroxylase
36 Citations (Scopus)

Gabaergic drugs, morphine and morphine tolerance: A study in relation to nociception and gastrointestinal transit in mice

Sivam, S. & Ho, I. K., 1983, In : Neuropharmacology. 22, 6, p. 767-774 8 p.

Research output: Contribution to journalArticle

Gastrointestinal Transit
Nociception
Morphine
Pharmaceutical Preparations
Muscimol

Mechanism of tolerance development to pentobarbital in relation to GABA-ergic neuronal and dispositional functions in mice

Nabeshima, T., Kameyama, T., Sivam, S. & Ho, I. K., 1983, In : Journal of Pharmacobio-Dynamics. 6, 3

Research output: Contribution to journalArticle

1982
41 Citations (Scopus)

Acute and chronic effects of pentobarbital in relation to postsynaptic GABA receptors: A study with muscimol

Sivam, S., Nabeshima, T. & Ho, I. K., 1982, In : Journal of Neuroscience Research. 7, 1, p. 37-47 11 p.

Research output: Contribution to journalArticle

Muscimol
Pentobarbital
GABA-A Receptors
Picrotoxin
GABA Receptors
12 Citations (Scopus)
Opiate Alkaloids
Morphine
Binding Sites
Synaptic Membranes
Membranes
29 Citations (Scopus)

An analysis of GABA receptor changes in the discrete regions of mouse brain after acute and chronic treatments with morphine

Sivam, S., Nabeshima, T. & Ho, I. K., 1982, In : Journal of Neurochemistry. 39, 4, p. 933-939 7 p.

Research output: Contribution to journalArticle

Muscimol
GABA Receptors
Cell Surface Receptors
GABA-A Receptors
Morphine
23 Citations (Scopus)

Development of dispositional tolerance to phencyclidine by osmotic minipump in the mouse

Toshitaka, N., Sivam, S., Tai, C. Y. & Ho, I. K., 1982, In : Journal of Pharmacological Methods. 7, 3, p. 239-253 15 p.

Research output: Contribution to journalArticle

Phencyclidine
Ataxia
Cytochromes b5
Inbred ICR Mouse
Phosphoric Monoester Hydrolases
21 Citations (Scopus)

Influence of morphine dependence on GABA-stimulated benzodiazepine binding to mouse brain synaptic membranes

Sivam, S. & Ho, I. K., Apr 23 1982, In : European Journal of Pharmacology. 79, 3-4, p. 335-336 2 p.

Research output: Contribution to journalArticle

Morphine Dependence
Drug Receptors
Flunitrazepam
Synaptic Membranes
Inbred ICR Mouse
4 Citations (Scopus)

Interaction of ouabain and propranolol in the central nervous system. Neurally-mediated effects on the cardiovascular system

Sivam, S., Seth, S. D., Nayar, U. & Manchanda, S. C., 1982, In : Pharmacology. 25, 5, p. 286-293 8 p.

Research output: Contribution to journalArticle

Ouabain
Cardiovascular System
Propranolol
Central Nervous System
Local Anesthetics