Subbiah Sivam

  • 1435 Citations
  • 23 h-Index
1978 …2008
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Publications 1978 2008

  • 1435 Citations
  • 23 h-Index
  • 59 Article
  • 1 Conference contribution
Article
41 Citations (Scopus)

Acute and chronic effects of pentobarbital in relation to postsynaptic GABA receptors: A study with muscimol

Sivam, S., Nabeshima, T. & Ho, I. K., 1982, In : Journal of Neuroscience Research. 7, 1, p. 37-47 11 p.

Research output: Contribution to journalArticle

Muscimol
Pentobarbital
GABA-A Receptors
Picrotoxin
GABA Receptors

Acute toxicity of Soman, Sarin and Tabun: Neurochemical evaluations related to cholinergic, GABAergic and dopamine systems

Sivam, S., Lim, D. K., Hoskins, B. & Ho, I. K., 1984, In : Federation Proceedings. 43, 3

Research output: Contribution to journalArticle

Sarin
Soman
Cholinergic Agents
Dopamine
tabun
22 Citations (Scopus)

Alterations of regional γ-aminobutyric acid receptors in morphine tolerant mice

Sivam, S., Nabeshima, T. & Ho, I. K., Aug 1 1981, In : Biochemical Pharmacology. 30, 15, p. 2187-2190 4 p.

Research output: Contribution to journalArticle

Muscimol
GABA Receptors
Cell Surface Receptors
GABA-A Receptors
Morphine
12 Citations (Scopus)
Opiate Alkaloids
Morphine
Binding Sites
Synaptic Membranes
Membranes
9 Citations (Scopus)

Analgesic cross-tolerance between morphine and opioid peptides

Sivam, S. & Ho, I. K., Sep 1984, In : Psychopharmacology. 84, 1, p. 64-65 2 p.

Research output: Contribution to journalArticle

Opioid Peptides
Morphine
Analgesics
Endorphins
Leucine-2-Alanine Enkephalin
29 Citations (Scopus)

An analysis of GABA receptor changes in the discrete regions of mouse brain after acute and chronic treatments with morphine

Sivam, S., Nabeshima, T. & Ho, I. K., 1982, In : Journal of Neurochemistry. 39, 4, p. 933-939 7 p.

Research output: Contribution to journalArticle

Muscimol
GABA Receptors
Cell Surface Receptors
GABA-A Receptors
Morphine
46 Citations (Scopus)
fluorophosphate
Sarin
Soman
Enzyme activity
Acetylcholinesterase

Anticholinesterase effect of sotalol

Alkondon, M., Sivam, S., Bhatia, S. & Sen, P., 1981, In : Indian Journal of Medical Research. 73, 5, p. 796-800 5 p.

Research output: Contribution to journalArticle

Practolol
Ranidae
Sotalol
Abdominal Muscles
Physostigmine
2 Citations (Scopus)
Opiate Alkaloids
delta Opioid Receptor
mu Opioid Receptor
Analgesia
Morphine
7 Citations (Scopus)

Attenuation of pharmacological effects and increased metabolism of phencyclidine in morphine tolerant mice

Nabeshima, T., Sivam, S. & Ho, I. K., Sep 17 1984, In : European Journal of Pharmacology. 104, 3-4, p. 211-221 11 p.

Research output: Contribution to journalArticle

Phencyclidine
Morphine
Pharmacology
Locomotion
Ataxia
20 Citations (Scopus)

Calcium-dependent GABA release from mouse brain slices following acute and chronic phencyclidine administration

Nabeshima, T., Sivam, S., Norris, J. C. & Ho, I. K., 1981, In : Research Communications in Substances of Abuse. 2, 4, p. 343-354 12 p.

Research output: Contribution to journalArticle

Phencyclidine
gamma-Aminobutyric Acid
Calcium
Brain
Corpus Striatum
2 Citations (Scopus)
Posterior Hypothalamus
Blood pressure
Microinjections
Ouabain
Electric Stimulation
148 Citations (Scopus)
Dynorphins
Cocaine
Enkephalins
Corpus Striatum
Dopamine
14 Citations (Scopus)
Dihydroxyphenylalanine
Dopaminergic Neurons
Substance P
Messenger RNA
Oxidopamine
36 Citations (Scopus)
Self-Injurious Behavior
Dopamine D1 Receptors
Denervation
Substance P
Oxidopamine
23 Citations (Scopus)

Development of dispositional tolerance to phencyclidine by osmotic minipump in the mouse

Toshitaka, N., Sivam, S., Tai, C. Y. & Ho, I. K., 1982, In : Journal of Pharmacological Methods. 7, 3, p. 239-253 15 p.

Research output: Contribution to journalArticle

Phencyclidine
Ataxia
Cytochromes b5
Inbred ICR Mouse
Phosphoric Monoester Hydrolases
17 Citations (Scopus)

Diisopropylfluorophosphate and GABA synaptic function: Effect on levels, enzymes, release and uptake in the rat striatum

Sivam, S., Nabeshima, T., Lim, D. K., Hoskins, B. & Ho, I. K., 1983, In : Research Communications in Chemical Pathology and Pharmacology. 42, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

Isoflurophate
gamma-Aminobutyric Acid
Rats
Enzymes
4-Aminobutyrate Transaminase
23 Citations (Scopus)

Dopamine, serotonin and tachykinin in self-injurious behavior

Sivam, S., May 24 1996, In : Life Sciences. 58, 26, p. 2367-2375 9 p.

Research output: Contribution to journalArticle

Tachykinins
Self-Injurious Behavior
Dopamine
Serotonin
Biosynthesis
39 Citations (Scopus)
Enkephalins
Substance P
Basal Ganglia
Dopamine
Brain
33 Citations (Scopus)

Dopamine-dependent postnatal development of enkephalin and tachykinin neurons of rat basal ganglia

Sivam, S., Krause, J. E., Breese, G. R. & Hong, J. S., May 1991, In : Journal of Neurochemistry. 56, 5, p. 1499-1508 10 p.

Research output: Contribution to journalArticle

Tachykinins
Enkephalins
Basal Ganglia
Neurons
Rats
18 Citations (Scopus)

Dopaminergic modulation of serotonin metabolism in rat striatum: A study with dopamine uptake inhibitor GBR-12909

Sivam, S., May 19 1995, In : Life Sciences. 56, 26, p. 467-472 6 p.

Research output: Contribution to journalArticle

Dopamine Uptake Inhibitors
Metabolism
3,4-Dihydroxyphenylacetic Acid
Rats
Dopamine
4 Citations (Scopus)

Dopaminergic regulation of postnatal development of dynorphin neurons in rat striatum

Sivam, S., 1996, In : Neuropeptides. 30, 1, p. 103-107 5 p.

Research output: Contribution to journalArticle

Dynorphins
Neurons
Rats
Dopamine
Oxidopamine
9 Citations (Scopus)

Dopaminergic regulation of proenkephalin-A gene expression in the basal ganglia.

Sivam, S., Breese, G. R., Napier, T. C., Mueller, R. A. & Hong, J. S., 1986, In : NIDA research monograph. 75, p. 389-392 4 p.

Research output: Contribution to journalArticle

Enkephalins
Basal Ganglia
Gene Expression
Oxidopamine
Corpus Striatum
7 Citations (Scopus)
Dopamine Uptake Inhibitors
Dynorphins
Tachykinins
Neurokinin A
Gene Expression
52 Citations (Scopus)

Dopaminergic regulation of tachykinin metabolism in the striatonigral pathway

Li, S. J., Sivam, S., McGinty, J. F., Huang, Y. S. & Hong, J. S., 1987, In : Journal of Pharmacology and Experimental Therapeutics. 243, 2, p. 792-798 7 p.

Research output: Contribution to journalArticle

Tachykinins
Neurokinin A
Corpus Striatum
Dopamine Receptors
Substantia Nigra
90 Citations (Scopus)

Effect of acute and chronic cholinesterase inhibition with diisopropylfluorophosphate on muscarinic, dopamine, and GABA receptors of the rat striatum

Sivam, S., Norris, J. C., Lim, D. K., Hoskins, B. & Ho, I. K., 1983, In : Journal of Neurochemistry. 40, 5, p. 1414-1422 9 p.

Research output: Contribution to journalArticle

Isoflurophate
GABA Receptors
Cholinesterases
Dopamine Receptors
Muscarinic Receptors
17 Citations (Scopus)
Phencyclidine
Morphine
Opiate Alkaloids
Liver
Aniline Hydroxylase
2 Citations (Scopus)

Effects and mechanism of action of lithium chloride on gastric acid secretion in rats

Guglietta, A., Irons, B. J., Lazarus, L. H. & Sivam, S., 1988, In : Gastroenterology. 95, 6, p. 1454-1459 6 p.

Research output: Contribution to journalArticle

Lithium Chloride
Gastric Acid
Lithium
Stomach
Opioid Receptors
5 Citations (Scopus)

Effects of acute and continuous administration of pentobarbital on phencyclidine response

Tai, C. Y., Nabeshima, T., Sivam, S. & Ho, I. K., 1981, In : Research Communications in Substances of Abuse. 2, 3, p. 239-252 14 p.

Research output: Contribution to journalArticle

Phencyclidine
Pentobarbital
Ataxia
Brain
Serum
10 Citations (Scopus)

GABA and dopamine interaction in the basal ganglia: dopaminergic supersensitivity following chronic elevation of brain γ-aminobutyric acid levels

Sivam, S., Hudson, P. M., Tilson, H. A. & Hong, J. S., May 26 1987, In : Brain Research. 412, 1, p. 29-35 7 p.

Research output: Contribution to journalArticle

Aminobutyrates
Basal Ganglia
gamma-Aminobutyric Acid
Dopamine
Aminooxyacetic Acid
36 Citations (Scopus)

Gabaergic drugs, morphine and morphine tolerance: A study in relation to nociception and gastrointestinal transit in mice

Sivam, S. & Ho, I. K., 1983, In : Neuropharmacology. 22, 6, p. 767-774 8 p.

Research output: Contribution to journalArticle

Gastrointestinal Transit
Nociception
Morphine
Pharmaceutical Preparations
Muscimol
27 Citations (Scopus)
Enkephalins
gamma-Aminobutyric Acid
Messenger RNA
Aminooxyacetic Acid
Brain
54 Citations (Scopus)

GABA in morphine analgesia and tolerance

Sivam, S. & Ho, I. K., Jul 22 1985, In : Life Sciences. 37, 3, p. 199-208 10 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Analgesia
gamma-Aminobutyric Acid
Morphine
Analgesics
24 Citations (Scopus)

GBR-12909-induced self-injurious behavior: role of dopamine

Sivam, S., Sep 4 1995, In : Brain Research. 690, 2, p. 259-263 5 p.

Research output: Contribution to journalArticle

Self-Injurious Behavior
Dopamine
Oxidopamine
Corpus Striatum
Spiperone
5 Citations (Scopus)
Clorgyline
Selegiline
Dynorphins
Monoamine Oxidase Inhibitors
Monoamine Oxidase
21 Citations (Scopus)

Influence of morphine dependence on GABA-stimulated benzodiazepine binding to mouse brain synaptic membranes

Sivam, S. & Ho, I. K., Apr 23 1982, In : European Journal of Pharmacology. 79, 3-4, p. 335-336 2 p.

Research output: Contribution to journalArticle

Morphine Dependence
Drug Receptors
Flunitrazepam
Synaptic Membranes
Inbred ICR Mouse
33 Citations (Scopus)

Integration of pharmacology into a problem-based learning curriculum for medical students

Sivam, S., Iatridis, P. G. & Vaughn, S., 1995, In : Medical Education. 29, 4, p. 289-296 8 p.

Research output: Contribution to journalArticle

pharmacology
Problem-Based Learning
Medical Students
medical student
Pharmacology
4 Citations (Scopus)

Interaction of ouabain and propranolol in the central nervous system. Neurally-mediated effects on the cardiovascular system

Sivam, S., Seth, S. D., Nayar, U. & Manchanda, S. C., 1982, In : Pharmacology. 25, 5, p. 286-293 8 p.

Research output: Contribution to journalArticle

Ouabain
Cardiovascular System
Propranolol
Central Nervous System
Local Anesthetics
5 Citations (Scopus)

L-DOPA-induced activation of striatal p38MAPK and CREB in neonatal dopaminergic denervated rat: Relevance to self-injurious behavior

Sivam, S., Pugazhenthi, S., Pugazhenthi, V. & Brown, H., Feb 1 2008, In : Journal of Neuroscience Research. 86, 2, p. 339-349 11 p.

Research output: Contribution to journalArticle

Corpus Striatum
Self-Injurious Behavior
Dihydroxyphenylalanine
Dopamine
Serotonin
16 Citations (Scopus)

Lithium and haloperidol differentially alter the dynorphin A (1-8) and enkephalin levels in the neurointermediate lobe of rat pituitary

Sivam, S., Smith, D. R., Takeuchi, K. & Hong, J. S., 1987, In : Neuropeptides. 10, 3, p. 291-298 8 p.

Research output: Contribution to journalArticle

dynorphin (1-8)
Enkephalins
Haloperidol
Lithium
Rats
35 Citations (Scopus)

Lithium increases dynorphin A(1-8) and prodynorphin mRNA levels in the basal ganglia of rats

Sivam, S., Takeuchi, K., Li, S., Douglass, J., Civelli, O., Calvetta, L., Herbert, E., McGinty, J. F. & Hong, J. S., 1988, In : Molecular Brain Research. 3, 2, p. 155-163 9 p.

Research output: Contribution to journalArticle

dynorphin (1-8)
Basal Ganglia
Lithium
Messenger RNA
Haloperidol
35 Citations (Scopus)

Lithium increases rat striatal beta- and gamma-preprotachykinin messenger RNAs

Sivam, S., Krause, J. E., Takeuchi, K., Li, S., McGinty, J. F. & Hong, J. S., 1989, In : Journal of Pharmacology and Experimental Therapeutics. 248, 3, p. 1297-1301 5 p.

Research output: Contribution to journalArticle

Corpus Striatum
Lithium
Messenger RNA
Substance P
Haloperidol

Mechanism of tolerance development to pentobarbital in relation to GABA-ergic neuronal and dispositional functions in mice

Nabeshima, T., Kameyama, T., Sivam, S. & Ho, I. K., 1983, In : Journal of Pharmacobio-Dynamics. 6, 3

Research output: Contribution to journalArticle

6 Citations (Scopus)

Metoprolol: a new cardioselective beta adrenoceptor antagonist in experimental cardiac arrhythmias

Sivam, S. & Seth, S. D., 1978, In : Indian Journal of Medical Research. 68, 1, p. 176-182 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Nature of antagonism of centrogenic ouabain arrhythmias by propranolol

Sivam, S., Seth, S. D. S., Nayer, U. & Manchanda, S. C., 1978, In : Journal of Molecular and Cellular Cardiology. 10, SUPPL.1, p. 111 1 p.

Research output: Contribution to journalArticle

Neuropeptides
Cysteine
Neurotransmitter Agents
Rats
dynorphin (1-8)
111 Citations (Scopus)

Neonatal and adult 6-hydroxydopamine-induced lesions differentially alter tachykinin and enkephalin gene expression

Sivam, S., Breese, G. R., Krause, J. E., Napier, T. C., Mueller, R. A. & Hong, J. S., 1987, In : Journal of Neurochemistry. 49, 5, p. 1623-1633 11 p.

Research output: Contribution to journalArticle

Tachykinins
Enkephalins
Oxidopamine
Gene expression
Rats
2 Citations (Scopus)

Neurally induced digitalis arrhythmias and adrenoreceptors

Sivam, S., Seth, S. D., Nayar, U. & Manchanda, S. C., 1980, In : European Journal of Pharmacology. 68, 2, p. 107-115 9 p.

Research output: Contribution to journalArticle

Digitalis
Cardiac Arrhythmias
Ouabain
Tachycardia
Blood Vessels
Tachykinins
Enkephalins
Denervation
Basal Ganglia
6 Citations (Scopus)
Corpus Striatum
Enkephalins
Oxidopamine
Dopamine Agonists
Substance P