Tao Lu

  • 1567 Citations
  • 21 h-Index
20002020

Research output per year

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Publications

Aberrant constitutive activation of nuclear factor κB in glioblastoma multiforme drives invasive phenotype

Raychaudhuri, B., Han, Y., Lu, T. & Vogelbaum, M. A., Oct 1 2007, In : Journal of Neuro-Oncology. 85, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

72 Scopus citations

Activation of cAMP-responsive-element-binding protein by PI3 kinase and p38 MAPK is essential for elevated expression of transforming growth factor β2 in cancer cells

Wan, Y., Yang, M., Kolattukudy, S., Stark, G. R. & Lu, T., Sep 1 2010, In : Journal of Interferon and Cytokine Research. 30, 9, p. 677-681 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Prabhu, L., Wei, H., Chen, L., Demir, Ö., Sandusky, G., Sun, E., Wang, J., Mo, J., Zeng, L., Fishel, M., Safa, A., Amaro, R., Korc, M., Zhang, Z. Y. & Lu, T., Jan 1 2017, In : Oncotarget. 8, 25, p. 39963-39977 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

Aging: Cancer - An unlikely couple

Hartley, A. V., Martin, M. & Lu, T., Sep 1 2017, In : Aging. 9, 9, p. 1949-1950 2 p.

Research output: Contribution to journalEditorial

4 Scopus citations

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB

Chen, M., Liang, J., Ji, H., Yang, Z., Altilia, S., Hu, B., Schronce, A., McDermott, M. S. J., Schools, G. P., Lim, C. U., Oliver, D., Shtutman, M. S., Lu, T., Stark, G. R., Porter, D. C., Broude, E. V. & Roninson, I. B., Sep 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 38, p. 10208-10213 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Critical role of NF-κB in pancreatic cancer

Prabhu, L., Mundade, R., Korc, M., Loehrer, P. J. & Lu, T., Jan 1 2014, In : Oncotarget. 5, 22, p. 10969-10975 7 p.

Research output: Contribution to journalReview article

Open Access
68 Scopus citations

Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF-κB in colon cancer

Prabhu, L., Mundade, R., Wang, B., Wei, H., Hartley, A. V., Martin, M., McElyea, K., Temm, C. J., Sandusky, G., Liu, Y. & Lu, T., Jan 1 2015, In : Oncotarget. 6, 30, p. 29396-29412 17 p.

Research output: Contribution to journalArticle

17 Scopus citations
9 Scopus citations

Cytokine overexpression and constitutive NFκB in cancer

Lu, T. & Stark, G. R., Sep 2004, In : Cell Cycle. 3, 9, p. 1114-1117 4 p.

Research output: Contribution to journalReview article

52 Scopus citations

Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases

Prabhu, L., Chen, L., Wei, H., Demir, Ö., Safa, A., Zeng, L., Amaro, R. E., O'Neil, B. H., Zhang, Z. Y. & Lu, T., Jan 1 2017, In : Molecular BioSystems. 13, 12, p. 2509-2520 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

DHA2, a synthesized derivative of bisbibenzyl, exerts antitumor activity against ovarian cancer through inhibition of XIAP and Akt/mTOR pathway

Pang, Y., Si, M., Sun, B., Niu, L., Xu, X., Lu, T., Yuan, H. & Lou, H., Jul 2014, In : Food and Chemical Toxicology. 69, p. 163-174 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Dose-dependent cross-talk between the transforming growth factor-β and interleukin-1 signaling pathways

Lu, T., Tian, L., Han, Y., Vogelbaum, M. & Stark, G. R., Mar 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 11, p. 4365-4370 6 p.

Research output: Contribution to journalArticle

83 Scopus citations

Effects of imatinib mesylate (gleevec) on human islet NF-kappaB activation and chemokine production in vitro

Mokhtari, D., Li, T., Lu, T. & Welsh, N., Sep 14 2011, In : PLoS ONE. 6, 9, e24831.

Research output: Contribution to journalArticle

16 Scopus citations

Genetic heterogeneity and molecular epidemiology of GB virus C/hepatitis G virus in China

An, P., Luo, H., Lu, T., O'Brien, S. J. & Winkler, C., Nov 25 2000, In : Journal of Human Virology. 3, 6, p. 299-305 7 p.

Research output: Contribution to journalArticle

Genetic pathways, prevention, and treatment of sporadic colorectal cancer

Mundade, R., Imperiale, T. F., Prabhu, L., Loehrer, P. J. & Lu, T., Jan 1 2014, In : Oncoscience. 1, 6, p. 400-406 7 p.

Research output: Contribution to journalArticle

57 Scopus citations

Lysine methylation of promoter-bound transcription factors and relevance to cancer

Stark, G. R., Wang, Y. & Lu, T., Mar 1 2011, In : Cell Research. 21, 3, p. 375-380 6 p.

Research output: Contribution to journalReview article

42 Scopus citations

Modulating the modulators: regulation of protein arginine methyltransferases by post-translational modifications

Hartley, A. V. & Lu, T., 2020, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalReview article

Open Access

Mutagenesis by reversible promoter insertion to study the activation of NF-κB

Kandel, E. S., Lu, T., Wan, Y., Agarwal, M. K., Jackson, M. W. & Stark, G. R., May 3 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 18, p. 6425-6430 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

NF-κB: Regulation by methylation

Lu, T. & Stark, G. R., Sep 15 2015, In : Cancer Research. 75, 18, p. 3692-3695 4 p.

Research output: Contribution to journalArticle

40 Scopus citations

NF-κB: Its role in colorectal cancer

Hartley, A., Wei, H., Prabhu, L., Martin, M. & Lu, T., Jan 1 2018, Role of Transcription Factors in Gastrointestinal Malignancies. Springer Singapore, p. 247-260 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Novel serine 176 phosphorylation of YBX1 activates NF-κB in colon cancer

Martin, M., Hua, L., Wang, B., Wei, H., Prabhu, L., Hartley, A. V., Jiang, G., Liu, Y. & Lu, T., Feb 24 2017, In : Journal of Biological Chemistry. 292, 8, p. 3433-3444 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Participation of the conventional calpains in apoptosis

Lu, T., Xu, Y., Mericle, M. T. & Mellgren, R. L., Jun 12 2002, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1590, 1-3, p. 16-26 11 p.

Research output: Contribution to journalArticle

69 Scopus citations

PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65

Zhang, T., Ah Park, K., Li, Y., Sun Byun, H., Jeon, J., Lee, Y., Hee Hong, J., Man Kim, J., Huang, S. M., Choi, S. W., Kim, S. H., Sohn, K. C., Ro, H., Hoon Lee, J., Lu, T., Stark, G. R., Shen, H. M., Liu, Z. G., Park, J. & Min Hur, G., Jun 25 2013, In : Nature communications. 4, 2062.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations

PRMT5 dimethylates R30 of the p65 subunit to activate NF-?B

Wei, H., Wang, B., Miyagi, M., She, Y., Gopalan, B., Huang, D. B., Ghosh, G., Stark, G. R. & Lu, T., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13516-13521 6 p.

Research output: Contribution to journalArticle

99 Scopus citations

PRMTs and miRNAs: functional cooperation in cancer and beyond

Jin, J., Martin, M., Hartley, A. V. & Lu, T., Aug 3 2019, In : Cell Cycle. 18, 15, p. 1676-1686 11 p.

Research output: Contribution to journalReview article

1 Scopus citations

Protein arginine methylation of non-histone proteins and its role in diseases

Wei, H., Mundade, R., Lange, K. C. & Lu, T., Jan 1 2014, In : Cell Cycle. 13, 1, p. 32-41 10 p.

Research output: Contribution to journalArticle

101 Scopus citations

Regulation of a PRMT5/NF-κB axis by phosphorylation of PRMT5 at serine 15 in colorectal cancer

Hartley, A. V., Wang, B., Jiang, G., Wei, H., Sun, M., Prabhu, L., Martin, M., Safa, A., Sun, S., Liu, Y. & Lu, T., May 2 2020, In : International journal of molecular sciences. 21, 10, 3684.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Regulation of NF-κB by NSD1/FBXL11-dependent reversible lysine methylation of p65

Lu, T., Jackson, M. W., Wang, B., Yang, M., Chance, M. R., Miyagi, M., Gudkov, A. V. & Stark, G. R., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 1, p. 46-51 6 p.

Research output: Contribution to journalArticle

170 Scopus citations

Retigeric Acid b exhibits antitumor activity through suppression of nuclear factor-κB signaling in prostate cancer cells in vitro and in vivo

Liu, Y. Q., Hu, X. Y., Lu, T., Cheng, Y. N., Young, C. Y. F., Yuan, H. Q. & Lou, H. X., May 29 2012, In : PloS one. 7, 5, e38000.

Research output: Contribution to journalArticle

25 Scopus citations

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

Yang, J., Huang, J., Dasgupta, M., Sears, N., Miyagi, M., Wang, B., Chance, M. R., Chen, X., Du, Y., Wang, Y., An, L., Wang, Q., Lu, T., Zhang, X., Wang, Z. & Stark, G. R., Dec 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21499-21504 6 p.

Research output: Contribution to journalArticle

171 Scopus citations

Role of ChIP-seq in the discovery of transcription factor binding sites, differential gene regulation mechanism, epigenetic marks and beyond

Mundade, R., Ozer, H. G., Wei, H., Prabhu, L. & Lu, T., Sep 15 2014, In : Cell Cycle. 13, 18, p. 2847-2852 6 p.

Research output: Contribution to journalReview article

53 Scopus citations

Role of lysine methylation of NF-?B in differential gene regulation

Lu, T., Yang, M., Huang, D. B., Wei, H., Ozer, G. H., Ghosh, G. & Stark, G. R., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13510-13515 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Role of novel serine 316 phosphorylation of the p65 subunit of NF-κB in differential gene regulation

Wang, B., Wei, H., Prabhu, L., Zhao, W., Martin, M., Hartley, A. V. & Lu, T., Aug 14 2015, In : Journal of Biological Chemistry. 290, 33, p. 20336-20347 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Role of post-translational modification of the Y box binding protein 1 in human cancers

Prabhu, L., Hartley, A. V., Martin, M., Warsame, F., Sun, E. & Lu, T., Sep 1 2015, In : Genes and Diseases. 2, 3, p. 240-246 7 p.

Research output: Contribution to journalReview article

8 Scopus citations

Secreted transforming growth factor beta2 activates NF-kappaB, blocks apoptosis, and is essential for the survival of some tumor cells

Lu, T., Burdelya, L. G., Swiatkowski, S. M., Boiko, A. D., Howe, P. H., Stark, G. R., Gudkov, A. V., Loberg, R. D. & Pienta, K. J., Jan 1 2005, In : Urologic Oncology: Seminars and Original Investigations. 23, 1, 1 p.

Research output: Contribution to journalShort survey

Secreted transforming growth factor β2 activates NF-κB, blocks apoptosis, and is essential for the survival of some tumor cells

Lu, T., Burdelya, L. G., Swiatkowski, S. M., Boiko, A. D., Howe, P. H., Stark, G. R. & Gudkov, A. V., May 4 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 18, p. 7112-7117 6 p.

Research output: Contribution to journalArticle

86 Scopus citations

Secretion of cytokines and growth factors as a general cause of constitutive NFκB activation in cancer

Lu, T., Sathe, S. S., Swiatkowski, S. M., Hampole, C. V. & Stark, G. R., Mar 18 2004, In : Oncogene. 23, 12, p. 2138-2145 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Targeting microenvironment in cancer therapeutics

Martin, M., Wei, H. & Lu, T., Aug 1 2016, In : Oncotarget. 7, 32, p. 52575-52583 9 p.

Research output: Contribution to journalReview article

31 Scopus citations

Transposon-based mutagenesis identifies short RIP1 as an activator of NFκB

Dasgupta, M., Agarwal, M. K., Varley, P., Lu, T., Stark, G. R. & Kandel, E. S., Jul 15 2008, In : Cell Cycle. 7, 14, p. 2249-2256 8 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Use of forward genetics to discover novel regulators of NF-kappaB.

Lu, T. & Stark, G. R., Jun 1 2010, In : Cold Spring Harbor perspectives in biology. 2, 6, p. a001966

Research output: Contribution to journalReview article

7 Scopus citations

Using Sequential Immunoprecipitation and Mass Spectrometry to Identify Methylation of NF-κB

Lu, T. & Stark, G. R., Jan 1 2015, In : Methods in Molecular Biology. 1280, p. 383-393 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFκB

Lu, T., Jackson, M. W., Singhi, A. D., Kandel, E. S., Yang, M., Zhang, Y., Gudkov, A. V. & Stark, G. R., Sep 22 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 38, p. 16339-16344 6 p.

Research output: Contribution to journalArticle

58 Scopus citations