Tao Lu

  • 1465 Citations
  • 20 h-Index
20002019
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Publications 2000 2019

  • 1465 Citations
  • 20 h-Index
  • 35 Article
  • 3 Review article
  • 1 Chapter
  • 1 Editorial
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Article
2017
8 Citations (Scopus)

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Prabhu, L., Wei, H., Chen, L., Demir, Ö., Sandusky, G., Sun, E., Wang, J., Mo, J., Zeng, L., Fishel, M., Safa, A., Amaro, R., Korc, M., Zhang, Z-Y. & Lu, T., 2017, In : Oncotarget. 8, 25, p. 39963-39977 15 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Pancreatic Neoplasms
Colorectal Neoplasms
Adenocarcinoma
Neoplasms
18 Citations (Scopus)

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB

Chen, M., Liang, J., Ji, H., Yang, Z., Altilia, S., Hu, B., Schronce, A., McDermott, M. S. J., Schools, G. P., Lim, C. U., Oliver, D., Shtutman, M. S., Lu, T., Stark, G. R., Porter, D. C., Broude, E. V. & Roninson, I. B., Sep 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 38, p. 10208-10213 6 p.

Research output: Contribution to journalArticle

Transcription Factors
Phosphotransferases
Genes
Mediator Complex
RNA Polymerase III
3 Citations (Scopus)

Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases

Prabhu, L., Chen, L., Wei, H., Demir, Ö., Safa, A., Zeng, L., Amaro, R. E., O'Neil, B. H., Zhang, Z. Y. & Lu, T., Jan 1 2017, In : Molecular BioSystems. 13, 12, p. 2509-2520 12 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Histones
Methylation
Arginine
Streptavidin
9 Citations (Scopus)

Novel serine 176 phosphorylation of YBX1 activates NF-κB in colon cancer

Martin, M., Hua, L., Wang, B., Wei, H., Prabhu, L., Hartley, A. V., Jiang, G., Liu, Y. & Lu, T., Feb 24 2017, In : Journal of Biological Chemistry. 292, 8, p. 3433-3444 12 p.

Research output: Contribution to journalArticle

Y-Box-Binding Protein 1
Phosphorylation
Colonic Neoplasms
Serine
Neoplasms
2015
12 Citations (Scopus)

Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF-κB in colon cancer

Prabhu, L., Mundade, R., Wang, B., Wei, H., Hartley, A. V., Martin, M., McElyea, K., Temm, C. J., Sandusky, G., Liu, Y. & Lu, T., 2015, In : Oncotarget. 6, 30, p. 29396-29412 17 p.

Research output: Contribution to journalArticle

Y-Box-Binding Protein 1
Colonic Neoplasms
Serine
Phosphorylation
Neoplasms
38 Citations (Scopus)

NF-κB: Regulation by methylation

Lu, T. & Stark, G. R., Sep 15 2015, In : Cancer Research. 75, 18, p. 3692-3695 4 p.

Research output: Contribution to journalArticle

Methylation
Lysine
Arginine
Neoplasms
Mutation
8 Citations (Scopus)

Role of novel serine 316 phosphorylation of the p65 subunit of NF-κB in differential gene regulation

Wang, B., Wei, H., Prabhu, L., Zhao, W., Martin, M., Hartley, A. V. & Lu, T., Aug 14 2015, In : Journal of Biological Chemistry. 290, 33, p. 20336-20347 12 p.

Research output: Contribution to journalArticle

Phosphorylation
Gene expression
Serine
Genes
Alanine
4 Citations (Scopus)

Using Sequential Immunoprecipitation and Mass Spectrometry to Identify Methylation of NF-κB

Lu, T. & Stark, G. R., 2015, In : Methods in molecular biology (Clifton, N.J.). 1280, p. 383-393 11 p.

Research output: Contribution to journalArticle

Immunoprecipitation
Methylation
Cations
Mass Spectrometry
Phosphorylation
2014
59 Citations (Scopus)

Critical role of NF-κB in pancreatic cancer

Prabhu, L., Mundade, R., Korc, M., Loehrer, P. & Lu, T., 2014, In : Oncotarget. 5, 22, p. 10969-10975 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Mutation Rate
Therapeutics
Mutation
8 Citations (Scopus)

DHA2, a synthesized derivative of bisbibenzyl, exerts antitumor activity against ovarian cancer through inhibition of XIAP and Akt/mTOR pathway

Pang, Y., Si, M., Sun, B., Niu, L., Xu, X., Lu, T., Yuan, H. & Lou, H., 2014, In : Food and Chemical Toxicology. 69, p. 163-174 12 p.

Research output: Contribution to journalArticle

X-Linked Inhibitor of Apoptosis Protein
ovarian neoplasms
Cell death
Ovarian Neoplasms
cell death
50 Citations (Scopus)

Genetic pathways, prevention, and treatment of sporadic colorectal cancer

Mundade, R., Imperiale, T. F., Prabhu, L., Loehrer, P. J. & Lu, T., 2014, In : Oncoscience. 1, 6, p. 400-406 7 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Epigenomics
Colonic Neoplasms
Therapeutics
Neoplasms
93 Citations (Scopus)

Protein arginine methylation of non-histone proteins and its role in diseases

Wei, H., Mundade, R., Lange, K. C. & Lu, T., Jan 1 2014, In : Cell Cycle. 13, 1, p. 32-41 10 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Methylation
Arginine
Proteins
Post Translational Protein Processing
49 Citations (Scopus)

Role of ChIP-seq in the discovery of transcription factor binding sites, differential gene regulation mechanism, epigenetic marks and beyond

Mundade, R., Ozer, H. G., Wei, H., Prabhu, L. & Lu, T., Sep 15 2014, In : Cell Cycle. 13, 18, p. 2847-2852 6 p.

Research output: Contribution to journalArticle

Chromatin Immunoprecipitation
Epigenomics
Transcription Factors
Binding Sites
Genes
2013
35 Citations (Scopus)

PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65.

Zhang, T., Park, K. A., Li, Y., Byun, H. S., Jeon, J., Lee, Y., Hong, J. H., Kim, J. M., Huang, S. M., Choi, S. W., Kim, S. H., Sohn, K. C., Ro, H., Lee, J. H., Lu, T., Stark, G. R., Shen, H. M., Liu, Z. G., Park, J. & Hur, G. M., 2013, In : Nature Communications. 4, 2062.

Research output: Contribution to journalArticle

Homeodomain Proteins
disrupting
Plant Proteins
proteins
Proteins
91 Citations (Scopus)

PRMT5 dimethylates R30 of the p65 subunit to activate NF-?B

Wei, H., Wang, B., Miyagi, M., She, Y., Gopalan, B., Huang, D. B., Ghosh, G., Stark, G. R. & Lu, T., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13516-13521 6 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Methylation
Arginine
Carcinogenesis
Gene Expression
29 Citations (Scopus)

Role of lysine methylation of NF-?B in differential gene regulation

Lu, T., Yang, M., Huang, D. B., Wei, H., Ozer, G. H., Ghosh, G. & Stark, G. R., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13510-13515 6 p.

Research output: Contribution to journalArticle

Methylation
Lysine
Mutation
Genes
Gene Expression
2012
9 Citations (Scopus)
Phosphorylation
Cell death
Islets of Langerhans
Cell Death
Chemical activation
24 Citations (Scopus)

Retigeric Acid b exhibits antitumor activity through suppression of nuclear factor-κB signaling in prostate cancer cells in vitro and in vivo

Liu, Y. Q., Hu, X. Y., Lu, T., Cheng, Y. N., Young, C. Y. F., Yuan, H. Q. & Lou, H. X., May 29 2012, In : PLoS One. 7, 5, e38000.

Research output: Contribution to journalArticle

prostatic neoplasms
Prostatic Neoplasms
Cells
Acids
acids
2011
16 Citations (Scopus)

Effects of imatinib mesylate (gleevec) on human islet NF-kappaB activation and chemokine production in vitro

Mokhtari, D., Li, T., Lu, T. & Welsh, N., Sep 14 2011, In : PLoS One. 6, 9, e24831.

Research output: Contribution to journalArticle

transcription factor NF-kappa B
NF-kappa B
chemokines
Chemokines
Chemical activation
39 Citations (Scopus)

Lysine methylation of promoter-bound transcription factors and relevance to cancer

Stark, G. R., Wang, Y. & Lu, T., Mar 2011, In : Cell Research. 21, 3, p. 375-380 6 p.

Research output: Contribution to journalArticle

Methylation
Lysine
Transcription Factors
Histones
Neoplasms
2010
3 Citations (Scopus)

Activation of cAMP-responsive-element-binding protein by PI3 kinase and p38 MAPK is essential for elevated expression of transforming growth factor β2 in cancer cells

Wan, Y., Yang, M., Kolattukudy, S., Stark, G. R. & Lu, T., Sep 1 2010, In : Journal of Interferon and Cytokine Research. 30, 9, p. 677-681 5 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
p38 Mitogen-Activated Protein Kinases
Phosphatidylinositol 3-Kinases
Cyclic AMP
Protein Kinases
166 Citations (Scopus)

Regulation of NF-κB by NSD1/FBXL11-dependent reversible lysine methylation of p65

Lu, T., Jackson, M. W., Wang, B., Yang, M., Chance, M. R., Miyagi, M., Gudkov, A. V. & Stark, G. R., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 1, p. 46-51 6 p.

Research output: Contribution to journalArticle

Methylation
Lysine
HT29 Cells
Cytoplasmic and Nuclear Receptors
Small Interfering RNA
160 Citations (Scopus)

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

Yang, J., Huang, J., Dasgupta, M., Sears, N., Miyagi, M., Wang, B., Chance, M. R., Chen, X., Du, Y., Wang, Y., An, L., Wang, Q., Lu, T., Zhang, X., Wang, Z. & Stark, G. R., Dec 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21499-21504 6 p.

Research output: Contribution to journalArticle

Histones
Methylation
Enzymes
Interleukin-6
Chromatin Immunoprecipitation
7 Citations (Scopus)

Use of forward genetics to discover novel regulators of NF-kappaB.

Lu, T. & Stark, G. R., Jun 1 2010, In : Cold Spring Harbor perspectives in biology. 2, 6

Research output: Contribution to journalArticle

Reverse Genetics
NF-kappa B
Signal Transduction
Transcription Factors
Cell Culture Techniques
2009
57 Citations (Scopus)

Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFκB

Lu, T., Jackson, M. W., Singhi, A. D., Kandel, E. S., Yang, M., Zhang, Y., Gudkov, A. V. & Stark, G. R., Sep 22 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 38, p. 16339-16344 6 p.

Research output: Contribution to journalArticle

Insertional Mutagenesis
Leucine
Lysine
Histone Demethylases
Proteins
2008
5 Citations (Scopus)

Transposon-based mutagenesis identifies short RIP1 as an activator of NFκB

Dasgupta, M., Agarwal, M. K., Varley, P., Lu, T., Stark, G. R. & Kandel, E. S., Jul 15 2008, In : Cell Cycle. 7, 14, p. 2249-2256 8 p.

Research output: Contribution to journalArticle

Receptor-Interacting Protein Serine-Threonine Kinases
Mutagenesis
Protein Kinases
Beauty
Gene encoding
2007
69 Citations (Scopus)

Aberrant constitutive activation of nuclear factor κB in glioblastoma multiforme drives invasive phenotype

Raychaudhuri, B., Han, Y., Lu, T. & Vogelbaum, M. A., Oct 2007, In : Journal of Neuro-Oncology. 85, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Glioblastoma
Glioma
Phenotype
Neoplasms
Cell Line
80 Citations (Scopus)

Dose-dependent cross-talk between the transforming growth factor-β and interleukin-1 signaling pathways

Lu, T., Tian, L., Han, Y., Vogelbaum, M. & Stark, G. R., Mar 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 11, p. 4365-4370 6 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Interleukin-1
TNF Receptor-Associated Factor 6
Cytokines
Interleukin-1 Receptors
2005
18 Citations (Scopus)

Mutagenesis by reversible promoter insertion to study the activation of NF-κB

Kandel, E. S., Lu, T., Wan, Y., Agarwal, M. K., Jackson, M. W. & Stark, G. R., May 3 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 18, p. 6425-6430 6 p.

Research output: Contribution to journalArticle

Mutagenesis
Phenotype
Genes
Mutation
Insertional Mutagenesis

Secreted transforming growth factor beta2 activates NF-kappaB, blocks apoptosis, and is essential for the survival of some tumor cells

Lu, T., Burdelya, L. G., Swiatkowski, S. M., Boiko, A. D., Howe, P. H., Stark, G. R., Gudkov, A. V., Loberg, R. D. & Pienta, K. J., Jan 2005, In : Urologic Oncology: Seminars and Original Investigations. 23, 1, p. 75 1 p.

Research output: Contribution to journalArticle

Transforming Growth Factor beta2
NF-kappa B
Apoptosis
Neoplasms
2004
51 Citations (Scopus)

Cytokine overexpression and constitutive NFκB in cancer

Lu, T. & Stark, G. R., Sep 2004, In : Cell Cycle. 3, 9, p. 1114-1117 4 p.

Research output: Contribution to journalArticle

Cytokines
Cell Surface Receptors
Neoplasms
Transcription Factors
Chemical activation
85 Citations (Scopus)

Secreted transforming growth factor β2 activates NF-κB, blocks apoptosis, and is essential for the survival of some tumor cells

Lu, T., Burdelya, L. G., Swiatkowski, S. M., Boiko, A. D., Howe, P. H., Stark, G. R. & Gudkov, A. V., May 4 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 18, p. 7112-7117 6 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Apoptosis
Neoplasms
Tumor Cell Line
Small Interfering RNA
61 Citations (Scopus)

Secretion of cytokines and growth factors as a general cause of constitutive NFκB activation in cancer

Lu, T., Sathe, S. S., Swiatkowski, S. M., Hampole, C. V. & Stark, G. R., Mar 18 2004, In : Oncogene. 23, 12, p. 2138-2145 8 p.

Research output: Contribution to journalArticle

Tumor Cell Line
Intercellular Signaling Peptides and Proteins
Cytokines
Fibroblast Growth Factor 5
Neoplasms
2002
66 Citations (Scopus)

Participation of the conventional calpains in apoptosis

Lu, T., Xu, Y., Mericle, M. T. & Mellgren, R. L., Jun 12 2002, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1590, 1-3, p. 16-26 11 p.

Research output: Contribution to journalArticle

Calpain
Apoptosis
Spectrin
Cricetulus
Ovary
2000

Genetic heterogeneity and molecular epidemiology of GB virus C/hepatitis G virus in China

An, P., Luo, H., Lu, T., O'Brien, S. J. & Winkler, C., 2000, In : Journal of Human Virology. 3, 6, p. 299-305 7 p.

Research output: Contribution to journalArticle

GB virus C
Genetic Heterogeneity
Molecular Epidemiology
China
Hepacivirus