Tao Lu

  • 1595 Citations
  • 21 h-Index
20002020

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Publications

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2020

Regulation of a PRMT5/NF-κB axis by phosphorylation of PRMT5 at serine 15 in colorectal cancer

Hartley, A. V., Wang, B., Jiang, G., Wei, H., Sun, M., Prabhu, L., Martin, M., Safa, A., Sun, S., Liu, Y. & Lu, T., May 2 2020, In : International journal of molecular sciences. 21, 10, 3684.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2017

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Prabhu, L., Wei, H., Chen, L., Demir, Ö., Sandusky, G., Sun, E., Wang, J., Mo, J., Zeng, L., Fishel, M., Safa, A., Amaro, R., Korc, M., Zhang, Z. Y. & Lu, T., Jan 1 2017, In : Oncotarget. 8, 25, p. 39963-39977 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB

Chen, M., Liang, J., Ji, H., Yang, Z., Altilia, S., Hu, B., Schronce, A., McDermott, M. S. J., Schools, G. P., Lim, C. U., Oliver, D., Shtutman, M. S., Lu, T., Stark, G. R., Porter, D. C., Broude, E. V. & Roninson, I. B., Sep 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 38, p. 10208-10213 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases

Prabhu, L., Chen, L., Wei, H., Demir, Ö., Safa, A., Zeng, L., Amaro, R. E., O'Neil, B. H., Zhang, Z. Y. & Lu, T., Jan 1 2017, In : Molecular BioSystems. 13, 12, p. 2509-2520 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Novel serine 176 phosphorylation of YBX1 activates NF-κB in colon cancer

Martin, M., Hua, L., Wang, B., Wei, H., Prabhu, L., Hartley, A. V., Jiang, G., Liu, Y. & Lu, T., Feb 24 2017, In : Journal of Biological Chemistry. 292, 8, p. 3433-3444 12 p.

Research output: Contribution to journalArticle

14 Scopus citations
2015

Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF-κB in colon cancer

Prabhu, L., Mundade, R., Wang, B., Wei, H., Hartley, A. V., Martin, M., McElyea, K., Temm, C. J., Sandusky, G., Liu, Y. & Lu, T., 2015, In : Oncotarget. 6, 30, p. 29396-29412 17 p.

Research output: Contribution to journalArticle

17 Scopus citations

NF-κB: Regulation by methylation

Lu, T. & Stark, G. R., Sep 15 2015, In : Cancer Research. 75, 18, p. 3692-3695 4 p.

Research output: Contribution to journalArticle

43 Scopus citations

Role of novel serine 316 phosphorylation of the p65 subunit of NF-κB in differential gene regulation

Wang, B., Wei, H., Prabhu, L., Zhao, W., Martin, M., Hartley, A. V. & Lu, T., Aug 14 2015, In : Journal of Biological Chemistry. 290, 33, p. 20336-20347 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Using Sequential Immunoprecipitation and Mass Spectrometry to Identify Methylation of NF-κB

Lu, T. & Stark, G. R., Jan 1 2015, In : Methods in Molecular Biology. 1280, p. 383-393 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2014

DHA2, a synthesized derivative of bisbibenzyl, exerts antitumor activity against ovarian cancer through inhibition of XIAP and Akt/mTOR pathway

Pang, Y., Si, M., Sun, B., Niu, L., Xu, X., Lu, T., Yuan, H. & Lou, H., Jul 2014, In : Food and Chemical Toxicology. 69, p. 163-174 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Genetic pathways, prevention, and treatment of sporadic colorectal cancer

Mundade, R., Imperiale, T. F., Prabhu, L., Loehrer, P. J. & Lu, T., 2014, In : Oncoscience. 1, 6, p. 400-406 7 p.

Research output: Contribution to journalArticle

59 Scopus citations

Protein arginine methylation of non-histone proteins and its role in diseases

Wei, H., Mundade, R., Lange, K. C. & Lu, T., Jan 1 2014, In : Cell Cycle. 13, 1, p. 32-41 10 p.

Research output: Contribution to journalArticle

104 Scopus citations
2013

PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65

Zhang, T., Ah Park, K., Li, Y., Sun Byun, H., Jeon, J., Lee, Y., Hee Hong, J., Man Kim, J., Huang, S. M., Choi, S. W., Kim, S. H., Sohn, K. C., Ro, H., Hoon Lee, J., Lu, T., Stark, G. R., Shen, H. M., Liu, Z. G., Park, J. & Min Hur, G., Jun 25 2013, In : Nature communications. 4, 2062.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations

PRMT5 dimethylates R30 of the p65 subunit to activate NF-?B

Wei, H., Wang, B., Miyagi, M., She, Y., Gopalan, B., Huang, D. B., Ghosh, G., Stark, G. R. & Lu, T., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13516-13521 6 p.

Research output: Contribution to journalArticle

103 Scopus citations

Role of lysine methylation of NF-?B in differential gene regulation

Lu, T., Yang, M., Huang, D. B., Wei, H., Ozer, G. H., Ghosh, G. & Stark, G. R., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13510-13515 6 p.

Research output: Contribution to journalArticle

29 Scopus citations
2012
9 Scopus citations

Retigeric Acid b exhibits antitumor activity through suppression of nuclear factor-κB signaling in prostate cancer cells in vitro and in vivo

Liu, Y. Q., Hu, X. Y., Lu, T., Cheng, Y. N., Young, C. Y. F., Yuan, H. Q. & Lou, H. X., May 29 2012, In : PloS one. 7, 5, e38000.

Research output: Contribution to journalArticle

25 Scopus citations
2011

Effects of imatinib mesylate (gleevec) on human islet NF-kappaB activation and chemokine production in vitro

Mokhtari, D., Li, T., Lu, T. & Welsh, N., Sep 14 2011, In : PLoS ONE. 6, 9, e24831.

Research output: Contribution to journalArticle

16 Scopus citations
2010

Activation of cAMP-responsive-element-binding protein by PI3 kinase and p38 MAPK is essential for elevated expression of transforming growth factor β2 in cancer cells

Wan, Y., Yang, M., Kolattukudy, S., Stark, G. R. & Lu, T., Sep 1 2010, In : Journal of Interferon and Cytokine Research. 30, 9, p. 677-681 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Regulation of NF-κB by NSD1/FBXL11-dependent reversible lysine methylation of p65

Lu, T., Jackson, M. W., Wang, B., Yang, M., Chance, M. R., Miyagi, M., Gudkov, A. V. & Stark, G. R., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 1, p. 46-51 6 p.

Research output: Contribution to journalArticle

171 Scopus citations

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

Yang, J., Huang, J., Dasgupta, M., Sears, N., Miyagi, M., Wang, B., Chance, M. R., Chen, X., Du, Y., Wang, Y., An, L., Wang, Q., Lu, T., Zhang, X., Wang, Z. & Stark, G. R., Dec 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21499-21504 6 p.

Research output: Contribution to journalArticle

173 Scopus citations
2009

Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFκB

Lu, T., Jackson, M. W., Singhi, A. D., Kandel, E. S., Yang, M., Zhang, Y., Gudkov, A. V. & Stark, G. R., Sep 22 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 38, p. 16339-16344 6 p.

Research output: Contribution to journalArticle

59 Scopus citations
2008

Transposon-based mutagenesis identifies short RIP1 as an activator of NFκB

Dasgupta, M., Agarwal, M. K., Varley, P., Lu, T., Stark, G. R. & Kandel, E. S., Jul 15 2008, In : Cell Cycle. 7, 14, p. 2249-2256 8 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2007

Aberrant constitutive activation of nuclear factor κB in glioblastoma multiforme drives invasive phenotype

Raychaudhuri, B., Han, Y., Lu, T. & Vogelbaum, M. A., Oct 1 2007, In : Journal of Neuro-Oncology. 85, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

73 Scopus citations

Dose-dependent cross-talk between the transforming growth factor-β and interleukin-1 signaling pathways

Lu, T., Tian, L., Han, Y., Vogelbaum, M. & Stark, G. R., Mar 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 11, p. 4365-4370 6 p.

Research output: Contribution to journalArticle

83 Scopus citations
2005

Mutagenesis by reversible promoter insertion to study the activation of NF-κB

Kandel, E. S., Lu, T., Wan, Y., Agarwal, M. K., Jackson, M. W. & Stark, G. R., May 3 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 18, p. 6425-6430 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
2004

Secreted transforming growth factor β2 activates NF-κB, blocks apoptosis, and is essential for the survival of some tumor cells

Lu, T., Burdelya, L. G., Swiatkowski, S. M., Boiko, A. D., Howe, P. H., Stark, G. R. & Gudkov, A. V., May 4 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 18, p. 7112-7117 6 p.

Research output: Contribution to journalArticle

87 Scopus citations

Secretion of cytokines and growth factors as a general cause of constitutive NFκB activation in cancer

Lu, T., Sathe, S. S., Swiatkowski, S. M., Hampole, C. V. & Stark, G. R., Mar 18 2004, In : Oncogene. 23, 12, p. 2138-2145 8 p.

Research output: Contribution to journalArticle

61 Scopus citations
2002

Participation of the conventional calpains in apoptosis

Lu, T., Xu, Y., Mericle, M. T. & Mellgren, R. L., Jun 12 2002, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1590, 1-3, p. 16-26 11 p.

Research output: Contribution to journalArticle

71 Scopus citations
2000

Genetic heterogeneity and molecular epidemiology of GB virus C/hepatitis G virus in China

An, P., Luo, H., Lu, T., O'Brien, S. J. & Winkler, C., Nov 25 2000, In : Journal of Human Virology. 3, 6, p. 299-305 7 p.

Research output: Contribution to journalArticle