Tatiana Foroud

  • 41759 Citations
  • 101 h-Index
1976 …2021
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Publications 1988 2019

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2019

Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders

Rao, X., Thapa, K. S., Chen, A. B., Lin, H., Gao, H., Reiter, J., Hargreaves, K. A., Ipe, J., Lai, D., Xuei, X., Wang, Y., Gu, H., Kapoor, M., Farris, S. P., Tischfield, J., Foroud, T., Goate, A. M., Skaar, T., Mayfield, R. D., Edenberg, H. & 1 others, Liu, Y., Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Alleles
Single Nucleotide Polymorphism
Alcohols
Genome-Wide Association Study
3' Untranslated Regions
3 Citations (Scopus)

Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

Kapoor, M., Wang, J. C., Farris, S. P., Liu, Y., McClintick, J., Gupta, I., Meyers, J. L., Bertelsen, S., Chao, M., Nurnberger, J., Tischfield, J., Harari, O., Zeran, L., Hesselbrock, V., Bauer, L., Raj, T., Porjesz, B., Agrawal, A., Foroud, T., Edenberg, H. & 2 others, Mayfield, R. D. & Goate, A., Dec 1 2019, In : Translational psychiatry. 9, 1, 89.

Research output: Contribution to journalArticle

Alcoholism
Genome
Alcohol Drinking
Brain
Genes

Angiotensin-related genetic determinants of cardiovascular disease in patients undergoing hemodialysis

Moe, S. M., Long, J., Schwantes-An, T. H. L., Decker, B. S., Wetherill, L., Edenberg, H. J., Xuei, X., Vatta, M., Foroud, T. M. & Chertow, G. M., Nov 1 2019, In : Nephrology Dialysis Transplantation. 34, 11, p. 1924-1931 8 p.

Research output: Contribution to journalArticle

Open Access
Angiotensins
Peptidyl-Dipeptidase A
Renal Dialysis
Cardiovascular Diseases
Single Nucleotide Polymorphism
3 Citations (Scopus)

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), EADB (Alzheimer Disease European DNA biobank), IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB) & The GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, Jan 1 2019, In : Acta Neuropathologica.

Research output: Contribution to journalArticle

Open Access
Lewy Body Disease
Frontotemporal Dementia
Alzheimer Disease
Mutation
Neurodegenerative Diseases
3 Citations (Scopus)

A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease

Alzheimer's Disease Sequencing Project, Mar 1 2019, In : Alzheimer's and Dementia. 15, 3, p. 441-452 12 p.

Research output: Contribution to journalArticle

Open Access
Alzheimer Disease
Hispanic Americans
Genome-Wide Association Study
Case-Control Studies
Alzheimer disease type 2
Open Access
Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Executive Function
Dementia
Clinical Trials

Association of polygenic liability for alcohol dependence and EEG connectivity in adolescence and young adulthood

Meyers, J. L., Chorlian, D. B., Johnson, E. C., Pandey, A. K., Kamarajan, C., Salvatore, J. E., Aliev, F., de Viteri, S. S. S., Zhang, J., Chao, M., Kapoor, M., Hesselbrock, V., Kramer, J., Kuperman, S., Nurnberger, J., Tischfield, J., Goate, A., Foroud, T., Dick, D. M., Edenberg, H. J. & 2 others, Agrawal, A. & Porjesz, B., Oct 2019, In : Brain Sciences. 9, 10, 280.

Research output: Contribution to journalArticle

Open Access
Alcoholism
Electroencephalography
Alcohols
Genome-Wide Association Study
Brain

Cancer outcomes among Parkinson's disease patients with leucine rich repeat kinase 2 mutations, idiopathic Parkinson's disease patients, and nonaffected controls

Agalliu, I., Ortega, R. A., Luciano, M. S., Mirelman, A., Pont-Sunyer, C., Brockmann, K., Vilas, D., Tolosa, E., Berg, D., Warø, B., Glickman, A., Raymond, D., Inzelberg, R., Ruiz-Martinez, J., Mondragon, E., Friedman, E., Hassin-Baer, S., Alcalay, R. N., Mejia-Santana, H., Aasly, J. & 5 others, Foroud, T., Marder, K., Giladi, N., Bressman, S. & Saunders-Pullman, R., Sep 1 2019, In : Movement disorders : official journal of the Movement Disorder Society. 34, 9, p. 1392-1398 7 p.

Research output: Contribution to journalArticle

Leucine
Parkinson Disease
Phosphotransferases
Mutation
Neoplasms

Efficient region-based test strategy uncovers genetic risk factors for functional outcome in bipolar disorder

Budde, M., Friedrichs, S., Alliey-Rodriguez, N., Ament, S., Badner, J. A., Berrettini, W. H., Bloss, C. S., Byerley, W., Cichon, S., Comes, A. L., Coryell, W., Craig, D. W., Degenhardt, F., Edenberg, H., Foroud, T., Forstner, A. J., Frank, J., Gershon, E. S., Goes, F. S., Greenwood, T. A. & 40 others, Guo, Y., Hipolito, M., Hood, L., Keating, B. J., Koller, D. L., Lawson, W. B., Liu, C., Mahon, P. B., McInnis, M. G., McMahon, F. J., Meier, S. M., Mühleisen, T. W., Murray, S. S., Nievergelt, C. M., Nurnberger, J., Nwulia, E. A., Potash, J. B., Quarless, D., Rice, J., Roach, J. C., Scheftner, W. A., Schork, N. J., Shekhtman, T., Shilling, P. D., Smith, E. N., Streit, F., Strohmaier, J., Szelinger, S., Treutlein, J., Witt, S. H., Zandi, P. P., Zhang, P., Zöllner, S., Bickeböller, H., Falkai, P. G., Kelsoe, J. R., Nöthen, M. M., Rietschel, M., Schulze, T. G. & Malzahn, D., Jan 1 2019, In : European Neuropsychopharmacology. 29, 1, p. 156-170 15 p.

Research output: Contribution to journalArticle

Open Access
Bipolar Disorder
Single Nucleotide Polymorphism
Haplotypes
Genes
Chromosomes, Human, Pair 15
6 Citations (Scopus)

Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

CHD Exome+ Consortium & Consortium for Genetics of Smoking Behaviour, Jun 1 2019, In : Biological Psychiatry. 85, 11, p. 946-955 10 p.

Research output: Contribution to journalArticle

Exome
Meta-Analysis
Smoking
Alcohols
Phenotype
1 Citation (Scopus)

Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI)

The Parkinson's Progression Markers InitiativeSteering Committee, Study Cores, Site Investigators, Coordinators & Industry and Scientific Advisory Board, Jan 1 2019, In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

Spinal Puncture
Parkinson Disease
Safety
Research
Needles

Fibroblast Growth Factor 23 Genotype and Cardiovascular Disease in Patients Undergoing Hemodialysis

Schwantes-An, T. H., Liu, S., Stedman, M., Decker, B., Wetherill, L., Edenberg, H., Vatta, M., Foroud, T., Chertow, G. M. & Moe, S., Jan 1 2019, (Accepted/In press) In : American Journal of Nephrology. p. 125-132 8 p.

Research output: Contribution to journalArticle

Renal Dialysis
Cardiovascular Diseases
Genotype
Heart Failure
Mortality
50 Citations (Scopus)

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Mar 1 2019, In : Nature genetics. 51, 3, p. 414-430 17 p.

Research output: Contribution to journalArticle

Meta-Analysis
Immunity
Alzheimer Disease
Lipids
Serum Amyloid A Protein
3 Citations (Scopus)

Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria

Lai, D., Wetherill, L., Bertelsen, S., Carey, C. E., Kamarajan, C., Kapoor, M., Meyers, J. L., Anokhin, A. P., Bennett, D. A., Bucholz, K. K., Chang, K. K., De Jager, P. L., Dick, D. M., Hesselbrock, V., Kramer, J., Kuperman, S., Nurnberger, J., Raj, T., Schuckit, M., Scott, D. M. & 9 others, Taylor, R. E., Tischfield, J., Hariri, A. R., Edenberg, H., Agrawal, A., Bogdan, R., Porjesz, B., Goate, A. M. & Foroud, T., Jul 1 2019, In : Genes, Brain and Behavior. 18, 6, e12579.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Diagnostic and Statistical Manual of Mental Disorders
Alcoholism
Drinking
Meta-Analysis

Genome-wide association studies of the self-rating of effects of ethanol (SRE)

Lai, D., Wetherill, L., Kapoor, M., Johnson, E. C., Schwandt, M., Ramchandani, V. A., Goldman, D., Joslyn, G., Rao, X., Liu, Y., Farris, S., Mayfield, R. D., Dick, D., Hesselbrock, V., Kramer, J., McCutcheon, V. V., Nurnberger, J., Tischfield, J., Goate, A., Edenberg, H. & 4 others, Porjesz, B., Agrawal, A., Foroud, T. & Schuckit, M., Jan 1 2019, In : Addiction Biology. e12800.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Alcoholism
Ethanol
Alcohols
Drinking
41 Citations (Scopus)

Genome-wide association study identifies 30 loci associated with bipolar disorder

eQTLGen Consortium, BIOS Consortium & the Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, May 1 2019, In : Nature genetics. 51, 5, p. 793-803 11 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Bipolar Disorder
Genome
Neurotransmitter Transport Proteins
Endocannabinoids
1 Citation (Scopus)

Genome-wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward-related ventral striatum activity in African- and European-Americans

Wetherill, L., Lai, D., Johnson, E. C., Anokhin, A., Bauer, L., Bucholz, K. K., Dick, D. M., Hariri, A. R., Hesselbrock, V., Kamarajan, C., Kramer, J., Kuperman, S., Meyers, J. L., Nurnberger, J., Schuckit, M., Scott, D. M., Taylor, R. E., Tischfield, J., Porjesz, B., Goate, A. M. & 4 others, Edenberg, H., Foroud, T., Bogdan, R. & Agrawal, A., Jan 1 2019, In : Genes, Brain and Behavior. e12580.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Reward
African Americans
Alcoholism
Substance-Related Disorders
2 Citations (Scopus)

Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration

ARTFL/LEFFTDS consortium, Jan 1 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Open Access
Frontotemporal Lobar Degeneration
Atrophy
Dementia
Logistic Models
Brain
2 Citations (Scopus)

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ consortium, Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
Genetic Loci
Meta-Analysis
Smoking
Nucleotides
Exome

Persistent Changes in Stress-Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol

Sarkar, D. K., Gangisetty, O., Wozniak, J. R., Eckerle, J. K., Georgieff, M. K., Foroud, T., Wetherill, L., Wertelecki, W., Chambers, C. D., Riley, E., Zymak-Zakutnya, N. & Yevtushok, L., Sep 1 2019, In : Alcoholism: Clinical and Experimental Research. 43, 9, p. 1887-1897 11 p.

Research output: Contribution to journalArticle

Regulator Genes
Pregnant Women
Genes
Alcohols
Pro-Opiomelanocortin
4 Citations (Scopus)

Predicting Alzheimer’s disease progression using multi-modal deep learning approach

for Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific Reports. 9, 1, 1952.

Research output: Contribution to journalArticle

Open Access
Disease Progression
Alzheimer Disease
Learning
Neuroimaging
Area Under Curve
2 Citations (Scopus)

Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics

for the Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2019, In : Scientific Reports. 9, 1, 2235.

Research output: Contribution to journalArticle

Open Access
Disease Progression
Alzheimer Disease
Demography
Complement C1
Prodromal Symptoms

Psychosocial moderation of polygenic risk for cannabis involvement: the role of trauma exposure and frequency of religious service attendance

Meyers, J. L., Salvatore, J. E., Aliev, F., Johnson, E. C., McCutcheon, V. V., Su, J., Kuo, S. I. C., Lai, D., Wetherill, L., Wang, J. C., Chan, G., Hesselbrock, V., Foroud, T., Bucholz, K. K., Edenberg, H. J., Dick, D. M., Porjesz, B. & Agrawal, A., Dec 1 2019, In : Translational psychiatry. 9, 1, 269.

Research output: Contribution to journalArticle

Open Access
Cannabis
Wounds and Injuries
Genome-Wide Association Study
Multifactorial Inheritance
Masks

Telomere Shortening in the Alzheimer's Disease Neuroimaging Initiative Cohort

Nudelman, K. N. H., Lin, J., Lane, K. A., Nho, K., Kim, S., Faber, K. M., Risacher, S. L., Foroud, T., Gao, S., Davis, J. W., Weiner, M. W. & Saykin, A., Jan 1 2019, In : Journal of Alzheimer's Disease. 71, 1, p. 33-43 11 p.

Research output: Contribution to journalArticle

Telomere Shortening
Neuroimaging
Telomere
Alzheimer Disease
Disease Progression

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

The Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dec 1 2019, In : Nature communications. 10, 1, 1766.

Research output: Contribution to journalArticle

Open Access
nervous system disorder
cognition
genetic marker
pathology
risk factor
2 Citations (Scopus)

Type 2 diabetes mellitus, brain atrophy, and cognitive decline

Moran, C., Beare, R., Wang, W., Callisaya, M., Srikanth, V., Weiner, M., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Saykin, A. J., Morris, J., Liu, E., Montine, T., Gamst, A., Thomas, R. G. & 234 others, Donohue, M., Walter, S., Gessert, D., Sather, T., Harvey, D., Kornak, J., Dale, A., Bernstein, M., Felmlee, J., Fox, N., Thompson, P., Schuff, N., Alexander, G., Decarli, C., Bandy, D., Koeppe, R. A., Foster, N., Reiman, E. M., Chen, K., Mathis, C., Cairns, N. J., Taylor-Reinwald, L., Trojanowki, J. Q., Shaw, L., Lee, V. M. Y., Korecka, M., Crawford, K., Neu, S., Foroud, T. M., Potkin, S., Shen, L., Kachaturian, Z., Frank, R., Snyder, P. J., Molchan, S., Kaye, J., Quinn, J., Lind, B., Dolen, S., Schneider, L. S., Pawluczyk, S., Spann, B. M., Brewer, J., Vanderswag, H., Heidebrink, J. L., Lord, J. L., Johnson, K., Doody, R. S., Villanueva-Meyer, J., Chowdhury, M., Stern, Y., Honig, L. S., Bell, K. L., Morris, J. C., Ances, B., Carroll, M., Leon, S., Mintun, M. A., Schneider, S., Marson, D., Griffith, R., Clark, D., Grossman, H., Mitsis, E., Romirowsky, A., Detoledo-Morrell, L., Shah, R. C., Duara, R., Varon, D., Roberts, P., Albert, M., Onyike, C., Kielb, S., Rusinek, H., De Leon, M. J., Glodzik, L., De Santi, S., Doraiswamy, P. M., Petrella, J. R., Coleman, R. E., Arnold, S. E., Karlawish, J. H., Wolk, D., Smith, C. D., Jicha, G., Hardy, P., Lopez, O. L., Oakley, M., Simpson, D. M., Porsteinsson, A. P., Goldstein, B. S., Martin, K., Makino, K. M., Ismail, M. S., Brand, C., Mulnard, R. A., Thai, G., McAdams-Ortiz, C., Womack, K., Mathews, D., Quiceno, M., Diaz-Arrastia, R., King, R., Weiner, M., Martin-Cook, K., Devous, M., Levey, A. I., Lah, J. J., Cellar, J. S., Burns, J. M., Anderson, H. S., Swerdlow, R. H., Apostolova, L., Lu, P. H., Bartzokis, G., Silverman, D. H. S., Graff-Radford, N. R., Parfitt, F., Johnson, H., Farlow, M. R., Hake, A. M., Matthews, B. R., Herring, S., Van Dyck, C. H., Carson, R. E., Macavoy, M. G., Chertkow, H., Bergman, H., Hosein, C., Black, S., Stefanovic, B., Caldwell, C., Robin Hsiung, G. Y., Feldman, H., Mudge, B., Assaly, M., Kertesz, A., Rogers, J., Trost, D., Bernick, C., Munic, D., Kerwin, D., Mesulam, M. M., Lipowski, K., Wu, C. K., Johnson, N., Sadowsky, C., Martinez, W., Villena, T., Turner, R. S., Johnson, K., Reynolds, B., Sperling, R. A., Johnson, K. A., Marshall, G., Frey, M., Yesavage, J., Taylor, J. L., Lane, B., Rosen, A., Tinklenberg, J., Sabbagh, M., Belden, C., Jacobson, S., Kowall, N., Killiany, R., Budson, A. E., Norbash, A., Johnson, P. L., Obisesan, T. O., Wolday, S., Bwayo, S. K., Lerner, A., Hudson, L., Ogrocki, P., Fletcher, E., Carmichael, O., Olichney, J., Kittur, S., Borrie, M., Bartha, D. R., Johnson, S., Asthana, S., Carlsson, C. M., Potkin, S. G., Preda, A., Nguyen, D., Tariot, P., Fleisher, A., Reeder, S., Bates, V., Capote, H., Rainka, M., Scharre, D. W., Kataki, M., Zimmerman, E. A., Celmins, D., Brown, A. D., Pearlson, G. D., Blank, K., Anderson, K., Santulli, R. B., Schwartz, E. S., Sink, K. M., Williamson, J. D., Garg, P., Watkins, F., Ott, B. R., Querfurth, H., Tremont, G., Salloway, S., Malloy, P., Correia, S., Rosen, H. J., Miller, B. L., Mintzer, J., Longmire, C. F., Spicer, K., Finger, E., Rachinsky, I., Drost, D., Pomara, N., Hernando, R., Sarrael, A., Schultz, S. K., Boles Ponto, L. L., Shim, H., Smith, K. E., Relkin, N., Chaing, G., Raudin, L., Smith, A., Fargher, K. & Raj, B. A., Feb 19 2019, In : Neurology. 92, 8, p. E823-E830

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Atrophy
Brain
Cognition
Cognitive Reserve
2018

A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework

Schizophrenia and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, Jun 25 2018, In : BMC Genomics. 19, 1, 494.

Research output: Contribution to journalArticle

Genome-Wide Association Study
1 Citation (Scopus)

Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease

for the Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2018, In : Scientific Reports. 8, 1, 13807.

Research output: Contribution to journalArticle

Alzheimer Disease
Metabolic Networks and Pathways
Brain
Fluorodeoxyglucose F18
Occipital Lobe
1 Citation (Scopus)

Collagen COL22A1 maintains vascular stability and mutations in COL22A1 are potentially associated with intracranial aneurysms

Ton, Q. V., Leino, D., Mowery, S. A., Bredemeier, N. O., Lafontant, P. J., Lubert, A., Gurung, S., Farlow, J. L., Foroud, T., Broderick, J. & Sumanas, S., Dec 12 2018, In : Disease models & mechanisms. 11, 12

Research output: Contribution to journalArticle

Intracranial Aneurysm
Blood Vessels
Collagen
Embryonic Structures
Mutation
4 Citations (Scopus)

Combined Face-Brain Morphology and Associated Neurocognitive Correlates in Fetal Alcohol Spectrum Disorders

Suttie, M., Wozniak, J. R., Parnell, S. E., Wetherill, L., Mattson, S. N., Sowell, E. R., Kan, E., Riley, E. P., Jones, K. L., Coles, C., Foroud, T. & Hammond, P., Jan 1 2018, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Fetal Alcohol Spectrum Disorders
Caudate Nucleus
Brain
Corpus Callosum
Alcohols

Detecting significant genotype–phenotype association rules in bipolar disorder: market research meets complex genetics

Breuer, R., Mattheisen, M., Frank, J., Krumm, B., Treutlein, J., Kassem, L., Strohmaier, J., Herms, S., Mühleisen, T. W., Degenhardt, F., Cichon, S., Nöthen, M. M., Karypis, G., Kelsoe, J., Greenwood, T., Nievergelt, C., Shilling, P., Shekhtman, T., Edenberg, H., Craig, D. & 32 others, Szelinger, S., Nurnberger, J., Gershon, E., Alliey-Rodriguez, N., Zandi, P., Goes, F., Schork, N., Smith, E., Koller, D., Zhang, P., Badner, J., Berrettini, W., Bloss, C., Byerley, W., Coryell, W., Foroud, T., Guo, Y., Hipolito, M., Keating, B., Lawson, W., Liu, C., Mahon, P., McInnis, M., Murray, S., Nwulia, E., Potash, J., Rice, J., Scheftner, W., Zöllner, S., McMahon, F. J., Rietschel, M. & Schulze, T. G., Dec 1 2018, In : International Journal of Bipolar Disorders. 6, 1, 24.

Research output: Contribution to journalArticle

Marketing
Bipolar Disorder
Genome-Wide Association Study
Genetic Research
Data Mining
2 Citations (Scopus)

Evaluation of gene-based family-based methods to detect novel genes associated with familial late onset Alzheimer disease

NIA-LOAD family study group & NCRAD, Apr 4 2018, In : Frontiers in Neuroscience. 12, APR, 209.

Research output: Contribution to journalArticle

Genes
Software
Phenotype
Genome-Wide Association Study
Alzheimer disease type 2
1 Citation (Scopus)

Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis

Whitfield, J. B., Masson, S., Liangpunsakul, S., Hyman, J., Mueller, S., Aithal, G., Eyer, F., Gleeson, D., Thompson, A., Stickel, F., Soyka, M., Daly, A. K., Cordell, H. J., Liang, T., Foroud, T., Lumeng, L., Pirmohamed, M., Nalpas, B., Bence, C., Jacquet, J. M. & 12 others, Louvet, A., Moirand, R., Nahon, P., Naveau, S., Perney, P., Podevin, P., Haber, P. S., Seitz, H. K., Day, C. P., Mathurin, P., Morgan, T. M. & Seth, D., Feb 1 2018, In : Alcohol. 66, p. 1-7 7 p.

Research output: Contribution to journalArticle

Alcoholic Liver Cirrhosis
alcoholism
Fibrosis
alcohol
Alcohols
3 Citations (Scopus)

Feasibility and Safety of Multicenter Tissue and Biofluid Sampling for α-Synuclein in Parkinson's Disease: The Systemic Synuclein Sampling Study (S4)

Systemic sSynuclein Sampling study, Jan 1 2018, In : Journal of Parkinson's Disease. 8, 4, p. 517-527 11 p.

Research output: Contribution to journalArticle

Synucleins
Sampling Studies
Parkinson Disease
Safety
Submandibular Gland
49 Citations (Scopus)

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease

Hui, K. Y., Fernandez-Hernandez, H., Hu, J., Schaffner, A., Pankratz, N., Hsu, N. Y., Chuang, L. S., Carmi, S., Villaverde, N., Li, X., Rivas, M., Levine, A. P., Bao, X., Labrias, P. R., Haritunians, T., Ruane, D., Gettler, K., Chen, E., Li, D., Schiff, E. R. & 31 others, Pontikos, N., Barzilai, N., Brant, S. R., Bressman, S., Cheifetz, A. S., Clark, L. N., Daly, M. J., Desnick, R. J., Duerr, R. H., Katz, S., Lencz, T., Myers, R. H., Ostrer, H., Ozelius, L., Payami, H., Peter, Y., Rioux, J. D., Segal, A. W., Scott, W. K., Silverberg, M. S., Vance, J. M., Ubarretxena-Belandia, I., Foroud, T., Atzmon, G., Pe'er, I., Ioannou, Y., McGovern, D. P. B., Yue, Z., Schadt, E. E., Cho, J. H. & Peter, I., Jan 10 2018, In : Science Translational Medicine. 10, 423, eaai7795.

Research output: Contribution to journalArticle

Crohn Disease
Parkinson Disease
Genes
Phosphotransferases
Haplotypes

Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease

International Genomics of Alzheimer's Project (IGAP), ARUK Consortium & GERAD/PERADES, CHARGE, ADGC, EADI, Jan 1 2018, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 595-598 4 p.

Research output: Contribution to journalArticle

Cholesterol Ester Transfer Proteins
HDL Cholesterol
Alzheimer Disease
Genes
Single Nucleotide Polymorphism
12 Citations (Scopus)

Genetic risk for schizophrenia and psychosis in Alzheimer disease

Demichele-Sweet, M. A. A., Weamer, E. A., Klei, L., Vrana, D. T., Hollingshead, D. J., Seltman, H. J., Sims, R., Foroud, T., Hernandez, I., Moreno-Grau, S., Tárraga, L., Boada, M., Ruiz, A., Williams, J., Mayeux, R., Lopez, O. L., Sibille, E. L., Kamboh, M. I., Devlin, B. & Sweet, R. A., Apr 1 2018, In : Molecular Psychiatry. 23, 4, p. 963-972 10 p.

Research output: Contribution to journalArticle

Psychotic Disorders
Schizophrenia
Alzheimer Disease
Single Nucleotide Polymorphism
Delusions
3 Citations (Scopus)

Genetic variants associated with circulating fibroblast growth factor 23

Robinson-Cohen, C., Bartz, T. M., Lai, D., Alp Ikizler, T., Peacock, M., Imel, E., Michos, E. D., Foroud, T., Akesson, K., Taylor, K. D., Malmgren, L., Matsushita, K., Nethander, M., Eriksson, J., Ohlsson, C., Mellström, D., Wolf, M., Ljunggren, O., McGuigan, F., Rotter, J. I. & 7 others, Karlsson, M., Econs, M., Ix, J. H., Lutsey, P. L., Psaty, B. M., De Boer, I. H. & Kestenbaum, B. R., Oct 1 2018, In : Journal of the American Society of Nephrology. 29, 10, p. 2583-2592 10 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Vitamin D
Phosphates
Genes
Kidney
2 Citations (Scopus)

Genome-wide association analysis identifies new candidate risk loci for familial intracranial aneurysm in the French-Canadian population

Zhou, S., Gan-Or, Z., Ambalavanan, A., Lai, D., Xie, P., Bourassa, C. V., Strong, S., Ross, J. P., Dionne-Laporte, A., Spiegelman, D., Dupré, N., Foroud, T., Xiong, L., Dion, P. A. & Rouleau, G. A., Dec 1 2018, In : Scientific Reports. 8, 1, 4356.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Intracranial Aneurysm
Population
Founder Effect
Exome
6 Citations (Scopus)

Genome-wide association study identifies a novel locus for cannabis dependence

Agrawal, A., Chou, Y. L., Carey, C. E., Baranger, D. A. A., Zhang, B., Sherva, R., Wetherill, L., Kapoor, M., Wang, J. C., Bertelsen, S., Anokhin, A. P., Hesselbrock, V., Kramer, J., Lynskey, M. T., Meyers, J. L., Nurnberger, J., Rice, J. P., Tischfield, J., Bierut, L. J., Degenhardt, L. & 16 others, Farrer, L. A., Gelernter, J., Hariri, A. R., Heath, A. C., Kranzler, H. R., Madden, P. A. F., Martin, N. G., Montgomery, G. W., Porjesz, B., Wang, T., Whitfield, J. B., Edenberg, H., Foroud, T., Goate, A. M., Bogdan, R. & Nelson, E. C., May 1 2018, In : Molecular Psychiatry. 23, 5, p. 1293-1302 10 p.

Research output: Contribution to journalArticle

Marijuana Abuse
Genome-Wide Association Study
Cannabis
Genome
Single Nucleotide Polymorphism
64 Citations (Scopus)

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium douglas.ruderfer@vanderbilt.edu, Psychosis Endophenotypes International Consortium & Wellcome Trust Case-Control Consortium, Jun 14 2018, In : Cell. 173, 7, p. 1705-1715.e16

Research output: Contribution to journalArticle

Dissection
Bipolar Disorder
Schizophrenia
Genes
Potassium
7 Citations (Scopus)

Immunohistochemical method and histopathology judging for the systemic synuclein sampling study (S4)

Beach, T. G., Serrano, G. E., Kremer, T., Canamero, M., Dziadek, S., Sade, H., Derkinderen, P., Corbillé, A. G., Letournel, F., Munoz, D. G., White, C. L., Schneider, J., Crary, J. F., Sue, L. I., Adler, C. H., Glass, M. J., Intorcia, A. J., Walker, J. E., Foroud, T., Coffey, C. S. & 13 others, Ecklund, D., Riss, H., Goßmann, J., König, F., Kopil, C. M., Arnedo, V., Riley, L., Linder, C., Dave, K. D., Jennings, D., Seibyl, J., Mollenhauer, B. & Chahine, L., Jan 1 2018, In : Journal of Neuropathology and Experimental Neurology. 77, 9, p. 793-802 10 p.

Research output: Contribution to journalArticle

Synucleins
Sampling Studies
Glass
Parkinson Disease
Pathology
22 Citations (Scopus)

Improving genetic prediction by leveraging genetic correlations among human diseases and traits

Maier, R. M., Zhu, Z., Lee, S. H., Trzaskowski, M., Ruderfer, D. M., Stahl, E. A., Ripke, S., Wray, N. R., Yang, J., Visscher, P. M., Robinson, M. R., Forstner, A. J., Mcquillin, A., Trubetskoy, V., Wang, W., Wang, Y., Coleman, J. R. I., Gaspar, H. A., De Leeuw, C. A., Whitehead Pavlides, J. M. & 221 others, Olde Loohuis, L. M., Pers, T. H., Lee, P. H., Charney, A. W., Dobbyn, A. L., Huckins, L., Boocock, J., Giambartolomei, C., Roussos, P., Mullins, N., Awasthi, S., Agerbo, E., Als, T. D., Pedersen, C. B., Grove, J., Kupka, R., Regeer, E. J., Anjorin, A., Casas, M., Mahon, P. B., Allardyce, J., Escott-Price, V., Forty, L., Fraser, C., Kogevinas, M., Frank, J., Streit, F., Strohmaier, J., Treutlein, J., Witt, S. H., Kennedy, J. L., Strauss, J. S., Garnham, J., O'donovan, C., Slaney, C., Steinberg, S., Thorgeirsson, T. E., Hautzinger, M., Steffens, M., Perlis, R. H., Sánchez-Mora, C., Hipolito, M., Lawson, W. B., Nwulia, E. A., Levy, S. E., Foroud, T., Jamain, S., Young, A. H., Mckay, J. D., Albani, D., Zandi, P., Potash, J. B., Zhang, P., Raymond Depaulo, J., Bergen, S. E., Juréus, A., Karlsson, R., Kandaswamy, R., Mcguffin, P., Rivera, M., Lissowska, J., Cruceanu, C., Lucae, S., Cervantes, P., Budde, M., Gade, K., Heilbronner, U., Pedersen, M. G., Morris, D. W., Weickert, C. S., Weickert, T. W., Macintyre, D. J., Lawrence, J., Elvsåshagen, T., Smeland, O. B., Djurovic, S., Xi, S., Green, E. K., Czerski, P. M., Hauser, J., Xu, W., Vedder, H., Oruc, L., Spijker, A. T., Gordon, S. D., Medland, S. E., Curtis, D., Mühleisen, T. W., Badner, J., Scheftner, W. A., Sigurdsson, E., Schork, N. J., Schatzberg, A. F., Bækvad-Hansen, M., Bybjerg-Grauholm, J., Hansen, C. S., Knowles, J. A., Szelinger, S., Montgomery, G. W., Boks, M., Adolfsson, A. N., Hoffmann, P., Bauer, M., Pfennig, A., Leber, M., Kittel-Schneider, S., Reif, A., Del-Favero, J., Fischer, S. B., Herms, S., Reinbold, C. S., Degenhardt, F., Koller, A. C., Maaser, A., Ori, A., Dale, A. M., Fan, C. C., Greenwood, T. A., Nievergelt, C. M., Shehktman, T., Shilling, P. D., Byerley, W., Bunney, W., Alliey-Rodriguez, N., Clarke, T. K., Liu, C., Coryell, W., Akil, H., Burmeister, M., Flickinger, M., Li, J. Z., Mcinnis, M. G., Meng, F., Thompson, R. C., Watson, S. J., Zollner, S., Guan, W., Green, M. J., Craig, D., Sobell, J. L., Milani, L., Gordon-Smith, K., Knott, S. V., Perry, A., Parra, J. G., Mayoral, F., Rivas, F., Rice, J. P., Barchas, J. D., Børglum, A. D., Mortensen, P. B., Mors, O., Grigoroiu-Serbanescu, M., Bellivier, F., Etain, B., Leboyer, M., Ramos-Quiroga, J. A., Agartz, I., Amin, F., Azevedo, M. H., Bass, N., Black, D. W., Blackwood, D. H. R., Bruggeman, R., Buccola, N. G., Choudhury, K., Cloninger, C. R., Corvin, A., Craddock, N., Daly, M. J., Datta, S., Donohoe, G. J., Duan, J., Dudbridge, F., Fanous, A., Freedman, R., Freimer, N. B., Friedl, M., Gill, M., Gurling, H., De Haan, L., Hamshere, M. L., Hartmann, A. M., Holmans, P. A., Kahn, R. S., Keller, M. C., Kenny, E., Kirov, G. K., Krabbendam, L., Krasucki, R., Lencz, T., Levinson, D. F., Lieberman, J. A., Lin, D. Y., Linszen, D. H., Magnusson, P. K. E., Maier, W., Malhotra, A. K., Mattheisen, M., Mattingsdal, M., Mccarroll, S. A., Medeiros, H., Melle, I., Milanova, V., Myin-Germeys, I., Neale, B. M., Ophoff, R. A., Owen, M. J., Pimm, J., Purcell, S. M., Puri, V., Quested, D. J., Rossin, L., Sanders, A. R., Shi, J., Sklar, P., St Clair, D., Stroup, T. S., Van Os, J., Wiersma, D. & Zammit, S., Dec 1 2018, In : Nature Communications. 9, 1, 02769-6.

Research output: Contribution to journalArticle

Phenotype
Precision Medicine
Genome-Wide Association Study
Genomics
predictions
4 Citations (Scopus)

L1 coupling to ankyrin and the spectrin-actin cytoskeleton modulates ethanol inhibition of L1 adhesion and ethanol teratogenesis

Dou, X., Menkari, C., Mitsuyama, R., Foroud, T., Wetherill, L., Hammond, P., Suttie, M., Chen, X., Chen, S. Y. & Charness, M. E., Mar 1 2018, In : FASEB Journal. 32, 3, p. 1364-1374 11 p.

Research output: Contribution to journalArticle

Ankyrins
Teratogenesis
Spectrin
Actin Cytoskeleton
Actins
16 Citations (Scopus)

Longitudinal change of clinical and biological measures in early Parkinson's disease: Parkinson's progression markers initiative cohort

Simuni, T., Siderowf, A., Lasch, S., Coffey, C. S., Caspell-Garcia, C., Jennings, D., Tanner, C. M., Trojanowski, J. Q., Shaw, L. M., Seibyl, J., Schuff, N., Singleton, A., Kieburtz, K., Toga, A. W., Mollenhauer, B., Galasko, D., Chahine, L. M., Weintraub, D., Foroud, T., Tosun, D. & 6 others, Poston, K., Arnedo, V., Frasier, M., Sherer, T., Chowdhury, S. & Marek, K., Jan 1 2018, (Accepted/In press) In : Movement Disorders.

Research output: Contribution to journalArticle

Dopamine Plasma Membrane Transport Proteins
Parkinson Disease
Disease Progression
Corpus Striatum
Sample Size
5 Citations (Scopus)

Meta-Analysis of Genetic Influences on Initial Alcohol Sensitivity

Edwards, A. C., Deak, J. D., Gizer, I. R., Lai, D., Chatzinakos, C., Wilhelmsen, K. P., Lindsay, J., Heron, J., Hickman, M., Webb, B. T., Bacanu, S. A., Foroud, T., Kendler, K. S., Dick, D. M. & Schuckit, M. A., Jan 1 2018, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Meta-Analysis
Genes
Alcohols
Single Nucleotide Polymorphism
Polymorphism
4 Citations (Scopus)

Ondansetron blocks wild-type and p.F503l variant small-conductance Ca2+-activated K+ channels

Ko, J. S., Guo, S., Hassel, J., Celestino-Soper, P., Lynnes, T. C., Tisdale, J. E., Zheng, J. J., Taylor, S. E., Foroud, T., Murray, M., Kovacs, R., Li, X., Lin, S-F., Chen, Z., Vatta, M., Chen, P-S. & Rubart-von der Lohe, M., Aug 1 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 315, 2, p. H375-H388

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Ondansetron
Long QT Syndrome
Serotonin 5-HT3 Receptor Antagonists
Receptors, Serotonin, 5-HT3
11 Citations (Scopus)

Racial disparities in adverse pregnancy outcomes and psychosocial stress

Eunice Kennedy Shriver National Institute of Child Health and Human Development Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b) Network, Feb 1 2018, In : Obstetrics and Gynecology. 131, 2, p. 328-335 8 p.

Research output: Contribution to journalArticle

Pregnancy Outcome
Premature Birth
Gestational Age
Pregnancy
Parturition
22 Citations (Scopus)

Sex-specific association of apolipoprotein e with cerebrospinal fluid levels of tau

Alzheimer's Disease Genetics Consortium and the Alzheimer's Disease Neuroimaging Initiative, Aug 1 2018, In : JAMA Neurology. 75, 8, p. 989-998 10 p.

Research output: Contribution to journalArticle

Apolipoproteins
Apolipoproteins E
Cerebrospinal Fluid
Alzheimer Disease
Neurofibrillary Tangles
13 Citations (Scopus)

Sex-specific genetic predictors of Alzheimer’s disease biomarkers

Alzheimer’s Disease Neuroimaging Initiative (ADNI) & The Alzheimer Disease Genetics Consortium (Adgc), Jul 2 2018, (Accepted/In press) In : Acta Neuropathologica. p. 1-16 16 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Biomarkers
Genome-Wide Association Study
Amyloid
Endophenotypes