Theodore Cummins

  • 12075 Citations
  • 61 h-Index
1991 …2020

Research output per year

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Publications

  • 12075 Citations
  • 61 h-Index
  • 127 Article
  • 11 Review article
  • 9 Chapter
  • 1 Letter
2020

Differential inhibition of human Nav1.2 resurgent and persistent sodium currents by cannabidiol and GS967

Mason, E. R. & Cummins, T. R., Apr 1 2020, In : International journal of molecular sciences. 21, 7, p. 1-21 21 p., 2454.

Research output: Contribution to journalArticle

Open Access

Distinct functional alterations in SCN8A epilepsy mutant channels

Pan, Y. & Cummins, T. R., Jan 1 2020, In : Journal of Physiology. 598, 2, p. 381-401 21 p.

Research output: Contribution to journalArticle

1 Scopus citations
2 Scopus citations

S-Palmitoylation of the sodium channel Nav1.6 regulates its activity and neuronal excitability

Pan, Y., Xiao, Y., Pei, Z. & Cummins, T. R., May 1 2020, In : Journal of Biological Chemistry. 295, 18, p. 6151-6164 14 p.

Research output: Contribution to journalArticle

Open Access
2019

Astrocytes Regulate the Development and Maturation of Retinal Ganglion Cells Derived from Human Pluripotent Stem Cells

VanderWall, K. B., Vij, R., Ohlemacher, S. K., Sridhar, A., Fligor, C. M., Feder, E. M., Edler, M. C., Baucum, A. J., Cummins, T. R. & Meyer, J. S., Feb 12 2019, In : Stem Cell Reports. 12, 2, p. 201-212 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Extracellular signal-regulated kinases mediate the enhancing effects of inflammatory mediators on resurgent currents in dorsal root ganglion neurons

Wu, B., McDermott, J. S., Krajewski, J. L., Knopp, K. L., Nisenbaum, E. S., Cummins, T. R. & Tan, Z. Y., Mar 1 2019, In : Molecular Pain. 15

Research output: Contribution to journalArticle

Open Access

Hedgehog pathway activation alters ciliary signaling in primary hypothalamic cultures

Bansal, R., Engle, S. E., Antonellis, P. J., Whitehouse, L. S., Baucum, A. J., Cummins, T. R., Reiter, J. F. & Berbari, N. F., May 14 2019, In : Frontiers in Cellular Neuroscience. 13, 266.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Increased resurgent sodium currents in nav1.8 contribute to nociceptive sensory neuron hyperexcitability associated with peripheral neuropathies

Xiao, Y., Barbosa, C., Pei, Z., Xie, W., Strong, J. A., Zhang, J. M. & Cummins, T. R., Feb 20 2019, In : Journal of Neuroscience. 39, 8, p. 1539-1550 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Resurgent and gating pore currents induced by De Novo SCN2A epilepsy mutations

Mason, E. R., Wu, F., Patel, R. R., Xiao, Y., Cannon, S. C. & Cummins, T. R., Jan 1 2019, In : eNeuro. 6, 5, ENEURO.0141-19.2019.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
Open Access
1 Scopus citations
2018

Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells

Thompson, K., Chen, J., Luo, Q., Xiao, Y., Cummins, T. & Bhatwadekar, A., Feb 1 2018, In : PLoS One. 13, 2, e0193280.

Research output: Contribution to journalArticle

7 Scopus citations

A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons

Rush, A. M., Dib-Hajj, S. D., Liu, S., Cummins, T., Black, J. A. & Waxman, S. G., Jan 1 2018, Chasing Men on Fire: The Story of the Search for a Pain Gene. The MIT Press, p. 89-101 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Calcium/calmodulin-dependent protein kinase II regulation of IKs during sustained β-adrenergic receptor stimulation

Shugg, T., Johnson, D. E., Shao, M., Lai, X., Witzmann, F., Cummins, T. R., Rubart-Von-der Lohe, M., Hudmon, A. & Overholser, B. R., Jun 2018, In : Heart Rhythm. 15, 6, p. 895-904 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Characterization of Membrane Patch-Ion Channel Probes for Scanning Ion Conductance Microscopy

Shi, W., Zeng, Y., Zhu, C., Xiao, Y., Cummins, T. R., Hou, J. & Baker, L. A., May 3 2018, In : Small. 14, 18, 1702945.

Research output: Contribution to journalArticle

6 Scopus citations

Electrophysiological properties of mutant NaV1.7 sodium channels in a painful inherited neuropathy

Cummins, T., Dib-Hajj, S. D. & Waxman, S. G., Jan 1 2018, Chasing Men on Fire: The Story of the Search for a Pain Gene. The MIT Press, p. 35-43 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gain-of-function mutation in NaV1.7 in familial erythromelalgia induces bursting of sensory neurons

Dib-Hajj, S. D., Rush, A. M., Cummins, T., Hisama, F. M., Novella, S., Tyrrell, L., Marshall, L. & Waxman, S. G., Jan 1 2018, Chasing Men on Fire: The Story of the Search for a Pain Gene. The MIT Press, p. 44-55 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Posttranslational modification of sodium channels

Pei, Z., Pan, Y. & Cummins, T., Jan 1 2018, Handbook of Experimental Pharmacology. Springer New York LLC, p. 101-124 24 p. (Handbook of Experimental Pharmacology; vol. 246).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations
2017

FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons

Barbosa, C., Xiao, Y., Johnson, A. J., Xie, W., Strong, J. A., Zhang, J. M. & Cummins, T. R., Feb 1 2017, In : Pflugers Archiv European Journal of Physiology. 469, 2, p. 195-212 18 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol

Patel, R. R., Barbosa, C., Brustovetsky, T., Brustovetsky, N. & Cummins, T. R., Aug 1 2016, In : Brain. 139, 8, p. 2164-2181 18 p.

Research output: Contribution to journalArticle

42 Scopus citations
18 Scopus citations

Membrane patches as ion channel probes for scanning ion conductance microscopy

Shi, W., Zeng, Y., Zhou, L., Xiao, Y., Cummins, T. R. & Baker, L. A., Jan 1 2016, In : Faraday Discussions. 193, p. 81-97 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration

Ohlemacher, S. K., Sridhar, A., Xiao, Y., Hochstetler, A. E., Sarfarazi, M., Cummins, T. R. & Meyer, J. S., Jun 1 2016, In : STEM CELLS. 34, 6, p. 1553-1562 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

t-boc synthesis of huwentoxin-i through native chemical ligation incorporating a trifluoromethanesulfonic acid cleavage strategy

Thapa, P., Cabalteja, C. C., Philips, E. E., Espiritu, M. J., Peigneur, S., Mille, B. G., Tytgat, J., Cummins, T. R. & Bingham, J. P., Sep 1 2016, In : Biopolymers. p. 737-745 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Unusual Voltage-Gated Sodium Currents as Targets for Pain

Barbosa, C. & Cummins, T., 2016, (Accepted/In press) In : Current Topics in Membranes.

Research output: Contribution to journalArticle

4 Scopus citations

Upregulation of the sodium channel Na v β4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local dorsal root ganglion inflammation

Xie, W., Tan, Z. Y., Barbosa, C., Strong, J. A., Cummins, T. R. & Zhang, J. M., Apr 1 2016, In : Pain. 157, 4, p. 879-891 13 p.

Research output: Contribution to journalArticle

19 Scopus citations
2015
7 Scopus citations
11 Scopus citations

Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons

Barbosa, C., Tan, Z. Y., Wang, R., Xie, W., Strong, J. A., Patel, R. R., Vasko, M. R., Zhang, J. M. & Cummins, T. R., Sep 25 2015, In : Molecular Pain. 11, 1, 60.

Research output: Contribution to journalArticle

21 Scopus citations

Sodium channels in pain pharmacology

Cummins, T. & Waxman, S. G., Jun 1 2015, Pharmacology of Pain. Wolters Kluwer Health Adis (ESP)

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel

Chen, X., Sun, W., Gianaris, N. G., Riley, A. M., Cummins, T. R., Fehrenbacher, J. C. & Obukhov, A. G., Apr 4 2014, In : Journal of Biological Chemistry. 289, 14, p. 9600-9610 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins

Xiao, Y., Blumenthal, K. & Cummins, T. R., Aug 2014, In : Molecular pharmacology. 86, 2, p. 159-167 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III-IV linker

Tan, Z. Y., Priest, B. T., Krajewski, J. L., Knopp, K. L., Nisenbaum, E. S. & Cummins, T. R., Nov 3 2014, In : FEBS Letters. 588, 21, p. 3964-3969 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Substituted N -(biphenyl-4′-yl)methyl (R)-2-acetamido-3- methoxypropionamides: Potent anticonvulsants that affect frequency (Use) dependence and slow inactivation of sodium channels

Lee, H., Park, K. D., Torregrosa, R., Yang, X. F., Dustrude, E. T., Wang, Y., Wilson, S. M., Barbosa, C., Xiao, Y., Cummins, T. R., Khanna, R. & Kohn, H., Jul 24 2014, In : Journal of Medicinal Chemistry. 57, 14, p. 6165-6182 18 p.

Research output: Contribution to journalArticle

6 Scopus citations

Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators

Tan, Z. Y., Piekarz, A. D., Priest, B. T., Knopp, K. L., Krajewski, J. L., McDermott, J. S., Nisenbaum, E. S. & Cummins, T. R., Jan 1 2014, In : Journal of Neuroscience. 34, 21, p. 7190-7197 8 p.

Research output: Contribution to journalArticle

32 Scopus citations
2013

Structural basis for the modulation of the neuronal Voltage-gated sodium channel Na v 1.6 by calmodulin

Chichili, V. P. R., Xiao, Y., Seetharaman, J., Cummins, T. R. & Sivaraman, J., Aug 28 2013, In : Scientific reports. 3, 2435.

Research output: Contribution to journalArticle

23 Scopus citations

Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin

Rowe, A. H., Xiao, Y., Rowe, M. P., Cummins, T. R. & Zakon, H. H., Jan 1 2013, In : Science. 342, 6157, p. 441-446 6 p.

Research output: Contribution to journalArticle

74 Scopus citations
2012

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

Ashpole, N. M., Herren, A. W., Ginsburg, K. S., Brogan, J. D., Johnson, D. E., Cummins, T. R., Bers, D. M. & Hudmon, A., Jun 8 2012, In : Journal of Biological Chemistry. 287, 24, p. 19856-19869 14 p.

Research output: Contribution to journalArticle

108 Scopus citations
61 Scopus citations

Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+/Ca2+ exchanger

Brittain, M. K., Brustovetsky, T., Sheets, P. L., Brittain, J. M., Khanna, R., Cummins, T. R. & Brustovetsky, N., Apr 1 2012, In : Neurobiology of Disease. 46, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Identification of the benzyloxyphenyl pharmacophore: A structural unit that promotes sodium channel slow inactivation

King, A. M., Yang, X. F., Wang, Y., Dustrude, E. T., Barbosa, C., Due, M. R., Piekarz, A. D., Wilson, S. M., White, F. A., Salomé, C., Cummins, T. R., Khanna, R. & Kohn, H., Dec 19 2012, In : ACS Chemical Neuroscience. 3, 12, p. 1037-1049 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons

Brittain, M. K., Brustovetsky, T., Brittain, J. M., Khanna, R., Cummins, T. R. & Brustovetsky, N., Nov 1 2012, In : Neuropharmacology. 63, 6, p. 974-982 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
8 Scopus citations

The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity

Song, W., Xiao, Y., Chen, H., Ashpole, N. M., Piekarz, A. D., Ma, P., Hudmon, A., Cummins, T. R. & Shou, W., Oct 1 2012, In : Journal of Physiology. 590, 20, p. 5123-5139 17 p.

Research output: Contribution to journalArticle

13 Scopus citations
2011

Common molecular determinants of tarantula huwentoxin-IV inhibition of Na + channel voltage sensors in domains II and IV

Xiao, Y., Jackson, J. O., Liang, S. & Cummins, T. R., Aug 5 2011, In : Journal of Biological Chemistry. 286, 31, p. 27301-27310 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Extended passaging increases the efficiency of neural differentiation from induced pluripotent stem cells

Koehler, K. R., Tropel, P., Theile, J. W., Kondo, T., Cummins, T. R., Viville, S. & Hashino, E., Aug 10 2011, In : BMC Neuroscience. 12, 82.

Research output: Contribution to journalArticle

27 Scopus citations

Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex

Wilson, S. M., Brittain, J. M., Piekarz, A. D., Ballard, C. J., Ripsch, M. S., Cummins, T. R., Hurley, J. H., Khanna, M., Hammes, N. M., Samuels, B. C., White, F. A. & Khanna, R., Jan 1 2011, In : Channels. 5, 5

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide

Theile, J. W. & Cummins, T. R., Oct 1 2011, In : Molecular Pharmacology. 80, 4, p. 724-734 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

Isolation and characterization of CvIV4: A pain inducing α- scorpion toxin

Rowe, A. H., Xiao, Y., Scales, J., Linse, K. D., Rowe, M. P., Cummins, T. R. & Zakon, H. H., Aug 24 2011, In : PLoS ONE. 6, 8, e23520.

Research output: Contribution to journalArticle

18 Scopus citations

KB-R7943, an inhibitor of the reverse Na +/Ca 2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex i

Brustovetsky, T., Brittain, M. K., Sheets, P. L., Cummins, T. R., Pinelis, V. & Brustovetsky, N., Jan 1 2011, In : British Journal of Pharmacology. 162, 1, p. 255-270 16 p.

Research output: Contribution to journalArticle

39 Scopus citations

Lidocaine reduces the transition to slow inactivation in Na v1.7 voltage-gated sodium channels

Sheets, P. L., Jarecki, B. W. & Cummins, T. R., Sep 1 2011, In : British Journal of Pharmacology. 164, 2 B, p. 719-730 12 p.

Research output: Contribution to journalArticle

25 Scopus citations