Theodore Cummins

  • 11483 Citations
  • 60 h-Index
1991 …2019
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Publications 1991 2019

  • 11483 Citations
  • 60 h-Index
  • 137 Article
  • 9 Chapter
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Article
2019

Astrocytes Regulate the Development and Maturation of Retinal Ganglion Cells Derived from Human Pluripotent Stem Cells

VanderWall, K. B., Vij, R., Ohlemacher, S. K., Sridhar, A., Fligor, C. M., Feder, E. M., Edler, M. C., Baucum, A. J., Cummins, T. & Meyer, J. S., Feb 12 2019, In : Stem Cell Reports. 12, 2, p. 201-212 12 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Retinal Ganglion Cells
Stem cells
Astrocytes
Brain

Energy Metabolism and Mitochondrial Superoxide Anion Production in Pre-symptomatic Striatal Neurons Derived from Human-Induced Pluripotent Stem Cells Expressing Mutant Huntingtin

Hamilton, J., Brustovetsky, T., Sridhar, A., Pan, Y., Cummins, T., Meyer, J. S. & Broustovetski, N., Jan 1 2019, (Accepted/In press) In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Corpus Striatum
Induced Pluripotent Stem Cells
Superoxides
Energy Metabolism
Neurons

Extracellular signal-regulated kinases mediate the enhancing effects of inflammatory mediators on resurgent currents in dorsal root ganglion neurons

Wu, B., McDermott, J. S., Krajewski, J. L., Knopp, K. L., Nisenbaum, E. S., Cummins, T. & Tan, Z. Y., Mar 1 2019, In : Molecular Pain. 15

Research output: Contribution to journalArticle

Open Access
Extracellular Signal-Regulated MAP Kinases
Spinal Ganglia
Neurons
Tetrodotoxin
Protein Kinase C

Hedgehog pathway activation alters ciliary signaling in primary hypothalamic cultures

Bansal, R., Engle, S. E., Antonellis, P. J., Whitehouse, L. S., Baucum, A. J., Cummins, T., Reiter, J. F. & Berbari, N. F., May 14 2019, In : Frontiers in Cellular Neuroscience. 13, 266.

Research output: Contribution to journalArticle

Open Access
Hedgehogs
Cilia
Neurons
Hyperphagia
Feeding Behavior
1 Citation (Scopus)

Increased Resurgent Sodium Currents in Nav1.8 Contribute to Nociceptive Sensory Neuron Hyperexcitability Associated with Peripheral Neuropathies

Xiao, Y., Barbosa, C., Pei, Z., Xie, W., Strong, J. A., Zhang, J. M. & Cummins, T., Feb 20 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 8, p. 1539-1550 12 p.

Research output: Contribution to journalArticle

Nociceptors
Peripheral Nervous System Diseases
Sensory Receptor Cells
Sodium
Diagnosis-Related Groups

Resurgent and Gating Pore Currents Induced by De Novo SCN2A Epilepsy Mutations

Mason, E. R., Wu, F., Patel, R. R., Xiao, Y., Cannon, S. C. & Cummins, T. R., Sep 1 2019, In : eNeuro. 6, 5

Research output: Contribution to journalArticle

Open Access
Epilepsy
Mutation
Electrophysiology
Xenopus
Point Mutation

The Diurnal Rhythm of Insulin Receptor Substrate-1 (IRS-1) and Kir4.1 in Diabetes: Implications for a Clock Gene Bmal1

Luo, Q., Xiao, Y., Alex, A., Cummins, T. & Bhatwadekar, A., May 1 2019, In : Investigative ophthalmology & visual science. 60, 6, p. 1928-1936 9 p.

Research output: Contribution to journalArticle

Open Access
Insulin Receptor Substrate Proteins
Circadian Rhythm
Genes
Insulin
Patch-Clamp Techniques
2018
2 Citations (Scopus)

Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells

Thompson, K., Chen, J., Luo, Q., Xiao, Y., Cummins, T. & Bhatwadekar, A., Feb 1 2018, In : PLoS One. 13, 2, e0193280.

Research output: Contribution to journalArticle

Advanced Glycosylation End Products
laminin
Laminin
glycation
Down-Regulation
2 Citations (Scopus)

Calcium/calmodulin-dependent protein kinase II regulation of IKs during sustained β-adrenergic receptor stimulation

Shugg, T., Johnson, D. E., Shao, M., Lai, X., Witzmann, F., Cummins, T., Rubart-von der Lohe, M., Hudmon, A. & Overholser, B. R., Jun 1 2018, In : Heart Rhythm. 15, 6, p. 895-904 10 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Adrenergic Receptors
Isoproterenol
Phosphorylation
3 Citations (Scopus)

Characterization of Membrane Patch-Ion Channel Probes for Scanning Ion Conductance Microscopy

Shi, W., Zeng, Y., Zhu, C., Xiao, Y., Cummins, T., Hou, J. & Baker, L. A., May 3 2018, In : Small. 14, 18, 1702945.

Research output: Contribution to journalArticle

Ion Channels
Microscopy
Microscopic examination
Ions
Membranes
2017
4 Citations (Scopus)

FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons

Barbosa, C., Xiao, Y., Johnson, A. J., Xie, W., Strong, J. A., Zhang, J. M. & Cummins, T., Feb 1 2017, In : Pflugers Archiv European Journal of Physiology. 469, 2, p. 195-212 18 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Sensory Receptor Cells
Neurons
Protein Isoforms
Sodium
2016
23 Citations (Scopus)

Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol

Patel, R. R., Barbosa, C., Brustovetsky, T., Broustovetski, N. & Cummins, T., Aug 1 2016, In : Brain. 139, 8, p. 2164-2181 18 p.

Research output: Contribution to journalArticle

Cannabidiol
Sodium Channels
Epilepsy
Voltage-Gated Sodium Channels
Sodium
12 Citations (Scopus)
Lipoylation
arrhythmia
muscle cells
Sodium Channels
NAV1.5 Voltage-Gated Sodium Channel
9 Citations (Scopus)

Membrane patches as ion channel probes for scanning ion conductance microscopy

Shi, W., Zeng, Y., Zhou, L., Xiao, Y., Cummins, T. & Baker, L. A., 2016, In : Faraday Discussions. 193, p. 81-97 17 p.

Research output: Contribution to journalArticle

Ion Channels
Microscopy
Microscopic examination
Ions
membranes
35 Citations (Scopus)

Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration

Ohlemacher, S. K., Sridhar, A., Xiao, Y., Hochstetler, A. E., Sarfarazi, M., Cummins, T. & Meyer, J. S., 2016, (Accepted/In press) In : Stem Cells.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Retinal Ganglion Cells
Induced Pluripotent Stem Cells
Glaucoma
Forensic Anthropology
3 Citations (Scopus)

t-boc synthesis of huwentoxin-i through native chemical ligation incorporating a trifluoromethanesulfonic acid cleavage strategy

Thapa, P., Cabalteja, C. C., Philips, E. E., Espiritu, M. J., Peigneur, S., Mille, B. G., Tytgat, J., Cummins, T. & Bingham, J. P., Sep 1 2016, In : Biopolymers. p. 737-745 9 p.

Research output: Contribution to journalArticle

Ligation
Hydrofluoric Acid
Acids
Hydrogen
Peptides
2 Citations (Scopus)

Unusual Voltage-Gated Sodium Currents as Targets for Pain

Barbosa, C. & Cummins, T., 2016, (Accepted/In press) In : Current Topics in Membranes.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Sodium
Pain
Nociceptors
Sodium Channels
15 Citations (Scopus)

Upregulation of the sodium channel Na v β4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local dorsal root ganglion inflammation

Xie, W., Tan, Z. Y., Barbosa, C., Strong, J. A., Cummins, T. & Zhang, J. M., Apr 1 2016, In : Pain. 157, 4, p. 879-891 13 p.

Research output: Contribution to journalArticle

Sodium Channels
Spinal Ganglia
Hypersensitivity
Up-Regulation
Small Interfering RNA
2015
7 Citations (Scopus)
Voltage-Gated Sodium Channels
Sodium Channels
Anticonvulsants
Protein Isoforms
Seizures
9 Citations (Scopus)

Human Nav1.6 channels generate larger resurgent currents than human Nav1.1 channels, but the Navβ4 peptide does not protect either isoform from use-dependent reduction

Patel, R. R., Barbosa, C., Xiao, Y. & Cummins, T., Jul 16 2015, In : PLoS One. 10, 7, e0133485.

Research output: Contribution to journalArticle

action potentials
inactivation
Protein Isoforms
GABAergic Neurons
Action Potentials
15 Citations (Scopus)

Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons

Barbosa, C., Tan, Z. Y., Wang, R., Xie, W., Strong, J. A., Patel, R. R., Vasko, M., Zhang, J. M. & Cummins, T., Sep 25 2015, In : Molecular Pain. 11, 1, 60.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Spinal Ganglia
Sodium
Neurons
Voltage-Gated Sodium Channels
2014
19 Citations (Scopus)

Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel

Chen, X., Sun, W., Gianaris, N. G., Riley, A. M., Cummins, T., Fehrenbacher, J. & Obukhov, A., Apr 4 2014, In : Journal of Biological Chemistry. 289, 14, p. 9600-9610 11 p.

Research output: Contribution to journalArticle

Modulators
Capsaicin
Chemical activation
Eye Pain
Toothache
21 Citations (Scopus)

Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins

Xiao, Y., Blumenthal, K. & Cummins, T., 2014, In : Molecular Pharmacology. 86, 2, p. 159-167 9 p.

Research output: Contribution to journalArticle

Biological Toxins
Sodium Channels
Sea Anemones
Voltage-Gated Sodium Channels
Ion Channels
11 Citations (Scopus)

Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III-IV linker

Tan, Z. Y., Priest, B. T., Krajewski, J. L., Knopp, K. L., Nisenbaum, E. S. & Cummins, T., Nov 3 2014, In : FEBS Letters. 588, 21, p. 3964-3969 6 p.

Research output: Contribution to journalArticle

Sodium Channels
Phosphorylation
Serine
Protein Kinase C
Sodium
6 Citations (Scopus)

Substituted N -(biphenyl-4′-yl)methyl (R)-2-acetamido-3- methoxypropionamides: Potent anticonvulsants that affect frequency (Use) dependence and slow inactivation of sodium channels

Lee, H., Park, K. D., Torregrosa, R., Yang, X. F., Dustrude, E. T., Wang, Y., Wilson, S. M., Barbosa, C., Xiao, Y., Cummins, T., Khanna, R. & Kohn, H., Jul 24 2014, In : Journal of Medicinal Chemistry. 57, 14, p. 6165-6182 18 p.

Research output: Contribution to journalArticle

Sodium Channels
Anticonvulsants
Rodentia
Pharmacology
Pharmaceutical Preparations
27 Citations (Scopus)

Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators

Tan, Z. Y., Piekarz, A. D., Priest, B. T., Knopp, K. L., Krajewski, J. L., McDermott, J. S., Nisenbaum, E. S. & Cummins, T., 2014, In : Journal of Neuroscience. 34, 21, p. 7190-7197 8 p.

Research output: Contribution to journalArticle

Sodium Channels
Tetrodotoxin
Spinal Ganglia
Sensory Receptor Cells
Neurons
2013
18 Citations (Scopus)

Structural basis for the modulation of the neuronal Voltage-gated sodium channel Na v 1.6 by calmodulin

Chichili, V. P. R., Xiao, Y., Seetharaman, J., Cummins, T. & Sivaraman, J., 2013, In : Scientific Reports. 3, 2435.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Calmodulin
Alanine
Action Potentials
Axons
61 Citations (Scopus)

Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin

Rowe, A. H., Xiao, Y., Rowe, M. P., Cummins, T. & Zakon, H. H., 2013, In : Science. 342, 6157, p. 441-446 6 p.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Scorpions
Grasshoppers
Pain
Venoms
2012
102 Citations (Scopus)

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

Ashpole, N. M., Herren, A. W., Ginsburg, K. S., Brogan, J. D., Johnson, D. E., Cummins, T., Bers, D. M. & Hudmon, A., Jun 8 2012, In : Journal of Biological Chemistry. 287, 24, p. 19856-19869 14 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Phosphorylation
Sodium Channels
Brugada Syndrome
Heart Failure
48 Citations (Scopus)
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Calcium Signaling
Glutamic Acid
Calcium
20 Citations (Scopus)

Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+/Ca2+ exchanger

Brittain, M. K., Brustovetsky, T., Sheets, P., Brittain, J. M., Khanna, R., Cummins, T. & Broustovetski, N., Apr 2012, In : Neurobiology of Disease. 46, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Calcium
Neurons
Memantine
Glutamic Acid
8 Citations (Scopus)

Identification of the benzyloxyphenyl pharmacophore: A structural unit that promotes sodium channel slow inactivation

King, A. M., Yang, X. F., Wang, Y., Dustrude, E. T., Barbosa, C., Due, M. R., Piekarz, A. D., Wilson, S. M., White, F., Salomé, C., Cummins, T., Khanna, R. & Kohn, H., Dec 19 2012, In : ACS Chemical Neuroscience. 3, 12, p. 1037-1049 13 p.

Research output: Contribution to journalArticle

Electrophysiology
Stereoselectivity
Acetylation
Sodium Channels
Clamping devices
16 Citations (Scopus)

Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons

Brittain, M. K., Brustovetsky, T., Brittain, J. M., Khanna, R., Cummins, T. & Broustovetski, N., Nov 2012, In : Neuropharmacology. 63, 6, p. 974-982 9 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
N-Methylaspartate
Calcium
Neurons
Glutamate Receptors
6 Citations (Scopus)
Voltage-Gated Sodium Channels
Polyamines
Muscle
Myocardium
Modulation
13 Citations (Scopus)

The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity

Song, W., Xiao, Y., Chen, H., Ashpole, N. M., Piekarz, A. D., Ma, P., Hudmon, A., Cummins, T. & Shou, W., Oct 2012, In : Journal of Physiology. 590, 20, p. 5123-5139 17 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Sodium Channels
Lidocaine
Action Potentials
Cardiac Myocytes
2011
35 Citations (Scopus)

Common molecular determinants of tarantula huwentoxin-IV inhibition of Na + channel voltage sensors in domains II and IV

Xiao, Y., Jackson, J. O., Liang, S. & Cummins, T., Aug 5 2011, In : Journal of Biological Chemistry. 286, 31, p. 27301-27310 10 p.

Research output: Contribution to journalArticle

Sodium Channels
Voltage-Gated Sodium Channels
Chemical activation
Sensors
Electric potential
25 Citations (Scopus)

Extended passaging increases the efficiency of neural differentiation from induced pluripotent stem cells

Koehler, K. R., Tropel, P., Theile, J. W., Kondo, T., Cummins, T., Viville, S. & Hashino, E., Aug 10 2011, In : BMC Neuroscience. 12, 82.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Neurons
Embryoid Bodies
Cell Line
Embryonic Stem Cells
28 Citations (Scopus)

Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex

Wilson, S. M., Brittain, J. M., Piekarz, A. D., Ballard, C. J., Ripsch, M. S., Cummins, T., Hurley, J., Khanna, M., Hammes, N. M., Samuels, B. C., White, F. & Khanna, R., Sep 2011, In : Channels. 5, 5

Research output: Contribution to journalArticle

N-Type Calcium Channels
Chronic Pain
Peptides
Drug therapy
Pain
44 Citations (Scopus)

Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide

Theile, J. W. & Cummins, T., Oct 2011, In : Molecular Pharmacology. 80, 4, p. 724-734 11 p.

Research output: Contribution to journalArticle

Riluzole
Carbamazepine
Sodium
Erythromelalgia
Peptides
17 Citations (Scopus)

Isolation and characterization of CvIV4: A pain inducing α- scorpion toxin

Rowe, A. H., Xiao, Y., Scales, J., Linse, K. D., Rowe, M. P., Cummins, T. & Zakon, H. H., Aug 24 2011, In : PLoS One. 6, 8, e23520.

Research output: Contribution to journalArticle

Scorpions
Scorpiones
Venoms
venoms
pain
32 Citations (Scopus)

KB-R7943, an inhibitor of the reverse Na +/Ca 2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex i

Brustovetsky, T., Brittain, M. K., Sheets, P., Cummins, T., Pinelis, V. & Broustovetski, N., Jan 2011, In : British Journal of Pharmacology. 162, 1, p. 255-270 16 p.

Research output: Contribution to journalArticle

Sodium-Calcium Exchanger
N-Methyl-D-Aspartate Receptors
Mitochondria
Neurons
NAD
24 Citations (Scopus)

Lidocaine reduces the transition to slow inactivation in Na v1.7 voltage-gated sodium channels

Sheets, P., Jarecki, B. W. & Cummins, T., Sep 2011, In : British Journal of Pharmacology. 164, 2 B, p. 719-730 12 p.

Research output: Contribution to journalArticle

Voltage-Gated Sodium Channels
Lidocaine
Pain
Mutation
Tetrodotoxin
52 Citations (Scopus)

Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navβ4 peptide-mediated resurgent sodium currents

Theile, J. W., Jarecki, B. W., Piekarz, A. D. & Cummins, T., Feb 2011, In : Journal of Physiology. 589, 3, p. 597-608 12 p.

Research output: Contribution to journalArticle

Erythromelalgia
Sodium
Peptides
Mutation
HEK293 Cells
70 Citations (Scopus)
Voltage-Gated Sodium Channel Blockers
Neuralgia
Sodium Channels
Pain
Sodium Channel Blockers
15 Citations (Scopus)

Vasodilatation in the rat dorsal hindpaw induced by activation of sensory neurons is reduced by paclitaxel

Gracias, N. G., Cummins, T., Kelley, M., Basile, D., Iqbal, T. & Vasko, M., Jan 2011, In : NeuroToxicology. 32, 1, p. 140-149 10 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Paclitaxel
Vasodilation
Neurons
Rats
2010
79 Citations (Scopus)

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents

Jarecki, B. W., Piekarz, A. D., Jackson, J. O. & Cummins, T., Jan 4 2010, In : Journal of Clinical Investigation. 120, 1, p. 369-378 10 p.

Research output: Contribution to journalArticle

Channelopathies
Voltage-Gated Sodium Channels
Sodium
Muscles
Mutation
56 Citations (Scopus)

In Silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation

Wang, Y., Brittain, J. M., Jarecki, B. W., Park, K. D., Wilson, S. M., Wang, B., Hale, R., Meroueh, S., Cummins, T. & Khanna, R., Aug 13 2010, In : Journal of Biological Chemistry. 285, 33, p. 25296-25307 12 p.

Research output: Contribution to journalArticle

Sodium Channels
Computer Simulation
Binding Sites
Voltage-Gated Sodium Channels
Alanine
361 Citations (Scopus)

Sodium channels in normal and pathological pain

Dib-Hajj, S. D., Cummins, T., Black, J. A. & Waxman, S. G., 2010, In : Annual Review of Neuroscience. 33, p. 325-347 23 p.

Research output: Contribution to journalArticle

Sodium Channels
Pain
Voltage-Gated Sodium Channels
Nervous System Trauma
Somatoform Disorders
70 Citations (Scopus)

The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation

Xiao, Y., Blumenthal, K., Jackson, J. O., Liang, S. & Cummins, T., Dec 2010, In : Molecular Pharmacology. 78, 6, p. 1124-1134 11 p.

Research output: Contribution to journalArticle

Sodium Channels
Inhibitory Concentration 50
Mutation
NAV1.7 Voltage-Gated Sodium Channel
Spider Venoms
2009
16 Citations (Scopus)

Alternative splicing of NaV1.7 exon 5 increases the impact of the painful PEPD mutant channel I1461T

Jarecki, B. W., Sheets, P., Xiao, Y., Jackson, J. O. & Cummins, T., Jul 2009, In : Channels. 3, 4

Research output: Contribution to journalArticle

Alternative Splicing
Architectural Accessibility
Exons
Erythromelalgia
Chemical activation