Thomas Hurley

  • 4871 Citations
  • 40 h-Index
1979 …2021
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  • 3 Similar Profiles
Alcohol Dehydrogenase Medicine & Life Sciences
Aldehyde Dehydrogenase Medicine & Life Sciences
Isoenzymes Medicine & Life Sciences
Enzymes Medicine & Life Sciences
NAD Medicine & Life Sciences
Coenzymes Medicine & Life Sciences
Liver Chemical Compounds
glutathione-independent formaldehyde dehydrogenase Chemical Compounds

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NIH Grants 1979 2021

Glycogen
Glycogen Synthase
Phosphorylation
Glucose
Glycogen Storage Disease

NRSA Training Core

Hurley, T.

Project: Research project

Aldehyde Dehydrogenase
Neoplastic Stem Cells
Ovarian Neoplasms
Protein Isoforms
Neoplasms
Glycogen Synthase
Glycogen
Glucose-6-Phosphate
Modulators
Yeast
Crystallography
X Ray Crystallography
Research
Organized Financing
Drug Discovery

Publications 1990 2019

  • 4871 Citations
  • 40 h-Index
  • 104 Article
  • 2 Chapter
  • 1 Editorial
1 Citation (Scopus)

A novel aldh1a1 inhibitor targets cells with stem cell characteristics in ovarian cancer

Nwani, N. G., Condello, S., Wang, Y., Swetzig, W. M., Barber, E., Hurley, T. & Matei, D., Apr 1 2019, In : Cancers. 11, 4, 502.

Research output: Contribution to journalArticle

Open Access
Ovarian Neoplasms
Stem Cells
Aldehyde Dehydrogenase
DNA Damage
Cell Proliferation
4 Citations (Scopus)

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

Chefetz, I., Grimley, E., Yang, K., Hong, L., Vinogradova, E. V., Suciu, R., Kovalenko, I., Karnak, D., Morgan, C. A., Chtcherbinine, M., Buchman, C., Huddle, B., Barraza, S., Morgan, M., Bernstein, K. A., Yoon, E., Lombard, D. B., Bild, A., Mehta, G., Romero, I. & 6 others, Chiang, C. Y., Landen, C., Cravatt, B., Hurley, T., Larsen, S. D. & Buckanovich, R. J., Mar 12 2019, In : Cell Reports. 26, 11, p. 3061-3075.e6

Research output: Contribution to journalArticle

Open Access
Chemotherapy
Neoplastic Stem Cells
Ovarian Neoplasms
Aldehyde Dehydrogenase
Drug Therapy
7 Citations (Scopus)

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells

Sarvi, S., Crispin, R., Lu, Y., Zeng, L., Hurley, T., Houston, D. R., von Kriegsheim, A., Chen, C. H., Mochly-Rosen, D., Ranzani, M., Mathers, M. E., Xu, X., Xu, W., Adams, D. J., Carragher, N. O., Fujita, M., Schuchter, L., Unciti-Broceta, A., Brunton, V. G. & Patton, E. E., Dec 20 2018, In : Cell Chemical Biology. 25, 12, p. 1456-1469.e6

Research output: Contribution to journalArticle

Melanoma
Nitrofurans
Prodrugs
Chemical activation
Neoplasms
4 Citations (Scopus)

Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy

Huddle, B. C., Grimley, E., Buchman, C. D., Chtcherbinine, M., Debnath, B., Mehta, P., Yang, K., Morgan, C. A., Li, S., Felton, J., Sun, D., Mehta, G., Neamati, N., Buckanovich, R. J., Hurley, T. & Larsen, S. D., Oct 11 2018, In : Journal of Medicinal Chemistry. 61, 19, p. 8754-8773 20 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Ovarian Neoplasms
Neoplastic Stem Cells
Protein Isoforms
Drug Therapy
7 Citations (Scopus)

Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives

Buchman, C. D. & Hurley, T., Mar 23 2017, In : Journal of Medicinal Chemistry. 60, 6, p. 2439-2455 17 p.

Research output: Contribution to journalArticle

Ficusin
Coumarins
Aldehyde Dehydrogenase
Isoenzymes
Aldehydes