Thomas Hurley

  • 5224 Citations
  • 41 h-Index
1979 …2021

Research output per year

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NIH Grants

  • NRSA Training Core

    Hurley, T.

    Project: Research project

  • Publications

    The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic

    Gentry, M. S., Afawi, Z., Armstrong, D. D., Delgado-Escueta, A., Goldberg, Y. P., Grossman, T. R., Guinovart, J. J., Harris, F., Hurley, T. D., Michelucci, R., Minassian, B. A., Sanz, P., Worby, C. A. & Serratosa, J. M., Feb 2020, In : Epilepsy and Behavior. 103, 106839.

    Research output: Contribution to journalArticle

  • A novel aldh1a1 inhibitor targets cells with stem cell characteristics in ovarian cancer

    Nwani, N. G., Condello, S., Wang, Y., Swetzig, W. M., Barber, E., Hurley, T. & Matei, D., Apr 2019, In : Cancers. 11, 4, 502.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

    Chefetz, I., Grimley, E., Yang, K., Hong, L., Vinogradova, E. V., Suciu, R., Kovalenko, I., Karnak, D., Morgan, C. A., Chtcherbinine, M., Buchman, C., Huddle, B., Barraza, S., Morgan, M., Bernstein, K. A., Yoon, E., Lombard, D. B., Bild, A., Mehta, G., Romero, I. & 6 others, Chiang, C. Y., Landen, C., Cravatt, B., Hurley, T. D., Larsen, S. D. & Buckanovich, R. J., Mar 12 2019, In : Cell Reports. 26, 11, p. 3061-3075.e6

    Research output: Contribution to journalArticle

    Open Access
  • 9 Scopus citations

    ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH High Melanoma-Initiating Cells

    Sarvi, S., Crispin, R., Lu, Y., Zeng, L., Hurley, T. D., Houston, D. R., von Kriegsheim, A., Chen, C. H., Mochly-Rosen, D., Ranzani, M., Mathers, M. E., Xu, X., Xu, W., Adams, D. J., Carragher, N. O., Fujita, M., Schuchter, L., Unciti-Broceta, A., Brunton, V. G. & Patton, E. E., Dec 20 2018, In : Cell Chemical Biology. 25, 12, p. 1456-1469.e6

    Research output: Contribution to journalArticle

  • 12 Scopus citations

    Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy

    Huddle, B. C., Grimley, E., Buchman, C. D., Chtcherbinine, M., Debnath, B., Mehta, P., Yang, K., Morgan, C. A., Li, S., Felton, J., Sun, D., Mehta, G., Neamati, N., Buckanovich, R. J., Hurley, T. D. & Larsen, S. D., Oct 11 2018, In : Journal of Medicinal Chemistry. 61, 19, p. 8754-8773 20 p.

    Research output: Contribution to journalArticle

  • 12 Scopus citations