Thomas Hurley

  • 5257 Citations
  • 41 h-Index
1979 …2021

Research output per year

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Publications

2020

Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase

Tang, B., Frasinyuk, M. S., Chikwana, V. M., Mahalingan, K. K., Morgan, C. A., Segvich, D. M., Bondarenko, S. P., Mrug, G. P., Wyrebek, P., Watt, D. S., Depaoli-Roach, A. A., Roach, P. J. & Hurley, T. D., Apr 9 2020, In : Journal of Medicinal Chemistry. 63, 7, p. 3538-3551 14 p.

Research output: Contribution to journalArticle

Targeting aldehyde dehydrogenases to eliminate cancer stem cells in gynecologic malignancies

Muralikrishnan, V., Hurley, T. D. & Nephew, K. P., Apr 2020, In : Cancers. 12, 4, 961.

Research output: Contribution to journalReview article

Open Access

The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic

Gentry, M. S., Afawi, Z., Armstrong, D. D., Delgado-Escueta, A., Goldberg, Y. P., Grossman, T. R., Guinovart, J. J., Harris, F., Hurley, T. D., Michelucci, R., Minassian, B. A., Sanz, P., Worby, C. A. & Serratosa, J. M., Feb 2020, In : Epilepsy and Behavior. 103, 106839.

Research output: Contribution to journalArticle

1 Scopus citations
2019

A novel aldh1a1 inhibitor targets cells with stem cell characteristics in ovarian cancer

Nwani, N. G., Condello, S., Wang, Y., Swetzig, W. M., Barber, E., Hurley, T. & Matei, D., Apr 2019, In : Cancers. 11, 4, 502.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

Chefetz, I., Grimley, E., Yang, K., Hong, L., Vinogradova, E. V., Suciu, R., Kovalenko, I., Karnak, D., Morgan, C. A., Chtcherbinine, M., Buchman, C., Huddle, B., Barraza, S., Morgan, M., Bernstein, K. A., Yoon, E., Lombard, D. B., Bild, A., Mehta, G., Romero, I. & 6 others, Chiang, C. Y., Landen, C., Cravatt, B., Hurley, T. D., Larsen, S. D. & Buckanovich, R. J., Mar 12 2019, In : Cell Reports. 26, 11, p. 3061-3075.e6

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2018

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH High Melanoma-Initiating Cells

Sarvi, S., Crispin, R., Lu, Y., Zeng, L., Hurley, T. D., Houston, D. R., von Kriegsheim, A., Chen, C. H., Mochly-Rosen, D., Ranzani, M., Mathers, M. E., Xu, X., Xu, W., Adams, D. J., Carragher, N. O., Fujita, M., Schuchter, L., Unciti-Broceta, A., Brunton, V. G. & Patton, E. E., Dec 20 2018, In : Cell Chemical Biology. 25, 12, p. 1456-1469.e6

Research output: Contribution to journalArticle

12 Scopus citations

Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy

Huddle, B. C., Grimley, E., Buchman, C. D., Chtcherbinine, M., Debnath, B., Mehta, P., Yang, K., Morgan, C. A., Li, S., Felton, J., Sun, D., Mehta, G., Neamati, N., Buckanovich, R. J., Hurley, T. D. & Larsen, S. D., Oct 11 2018, In : Journal of Medicinal Chemistry. 61, 19, p. 8754-8773 20 p.

Research output: Contribution to journalArticle

13 Scopus citations
2017

A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase

Maile, C. A., Hingst, J. R., Mahalingan, K. K., O'Reilly, A. O., Cleasby, M. E., Mickelson, J. R., McCue, M. E., Anderson, S. M., Hurley, T. D., Wojtaszewski, J. F. P. & Piercy, R. J., Jan 1 2017, In : Biochimica et Biophysica Acta - General Subjects. 1861, 1, p. 3388-3398 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives

Buchman, C. D. & Hurley, T. D., Mar 23 2017, In : Journal of Medicinal Chemistry. 60, 6, p. 2439-2455 17 p.

Research output: Contribution to journalArticle

10 Scopus citations

Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells

Li, J., Condello, S., Thomes-Pepin, J., Ma, X., Xia, Y., Hurley, T. D., Matei, D. & Cheng, J. X., Mar 2 2017, In : Cell Stem Cell. 20, 3, p. 303-314.e5

Research output: Contribution to journalArticle

131 Scopus citations

Redox switch for the inhibited state of yeast glycogen synthase mimics regulation by phosphorylation

Mahalingan, K. K., Baskaran, S., Depaoli-Roach, A. A., Roach, P. J. & Hurley, T. D., Jan 1 2017, In : Biochemistry. 56, 1, p. 179-188 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Incorporation of phosphate into glycogen by glycogen synthase

Contreras, C. J., Segvich, D. M., Mahalingan, K., Chikwana, V. M., Kirley, T. L., Hurley, T. D., DePaoli-Roach, A. A. & Roach, P. J., May 1 2016, In : Archives of Biochemistry and Biophysics. 597, p. 21-29 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors

Morgan, C. A. & Hurley, T. D., Feb 26 2015, In : Journal of Medicinal Chemistry. 58, 4, p. 1964-1975 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1

Morgan, C. A. & Hurley, T. D., Jun 5 2015, In : Chemico-Biological Interactions. 234, p. 29-37 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors

Buchman, C. D., Mahalingan, K. K. & Hurley, T. D., Jun 5 2015, In : Chemico-Biological Interactions. 234, p. 38-44 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Hominids adapted to metabolize ethanol long before human-directed fermentation

Carrigan, M. A., Uryasev, O., Frye, C. B., Eckman, B. L., Myers, C. R., Hurley, T. D. & Benner, S. A., Jan 13 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 2, p. 458-463 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes

Morgan, C. A., Parajuli, B., Buchman, C. D., Dria, K. & Hurley, T. D., Jun 5 2015, In : Chemico-Biological Interactions. 234, p. 18-28 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids

Condello, S., Morgan, C. A., Nagdas, S., Cao, L., Turek, J., Hurley, T. D. & Matei, D., Apr 30 2015, In : Oncogene. 34, 18, p. 2297-2308 12 p.

Research output: Contribution to journalArticle

83 Scopus citations
2014

Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones

Kimble-Hill, A. C., Parajuli, B., Chen, C. H., Mochly-Rosen, D. & Hurley, T. D., Feb 13 2014, In : Journal of Medicinal Chemistry. 57, 3, p. 714-722 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity

Parajuli, B., Georgiadis, T. M., Fishel, M. L. & Hurley, T. D., Mar 21 2014, In : ChemBioChem. 15, 5, p. 701-712 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Enrichment of chemical libraries docked to protein conformational ensembles and application to aldehyde dehydrogenase 2

Wang, B., Buchman, C. D., Li, L., Hurley, T. D. & Meroueh, S. O., Jul 28 2014, In : Journal of Chemical Information and Modeling. 54, 7, p. 2105-2116 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells

Parajuli, B., Fishel, M. L. & Hurley, T. D., Jan 23 2014, In : Journal of Medicinal Chemistry. 57, 2, p. 449-461 13 p.

Research output: Contribution to journalArticle

33 Scopus citations
2013

Catalytic contribution of threonine 244 in human ALDH2

González-Segura, L., Ho, K. K., Perez-Miller, S., Weiner, H. & Hurley, T. D., Feb 25 2013, In : Chemico-Biological Interactions. 202, 1-3, p. 32-40 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Expression and purification of functional human glycogen synthase-1 (hGYS1) in insect cells

Khanna, M., Imasaki, T., Chikwana, V. M., Perez-Miller, S., Hunter, G. O., Mosley, A., Takagi, Y. & Hurley, T. D., Jun 20 2013, In : Protein Expression and Purification. 90, 2, p. 78-83 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
25 Scopus citations

Structural basis for 2'-phosphate incorporation into glycogen by glycogen synthase

Chikwana, V. M., Khanna, M., Baskaran, S., Tagliabracci, V. S., Contreras, C. J., DePaoli-Roach, A., Roach, P. J. & Hurley, T. D., Dec 24 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 52, p. 20976-20981 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum

Akin, B. L., Hurley, T. D., Chen, Z. & Jones, L. R., Oct 18 2013, In : Journal of Biological Chemistry. 288, 42, p. 30181-30191 11 p.

Research output: Contribution to journalArticle

57 Scopus citations
2012

Aldehyde dehydrogenase inhibitors: A comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application

Koppaka, V., Thompson, D. C., Chen, Y., Ellermann, M., Nicolaou, K. C., Juvonen, R. O., Petersen, D., Deitrich, R. A., Hurley, T. D. & Vasiliou Dr., V., Jul 2012, In : Pharmacological Reviews. 64, 3, p. 520-539 20 p.

Research output: Contribution to journalArticle

239 Scopus citations

Genes encoding enzymes involved in ethanol metabolism

Hurley, T. & Edenberg, H., 2012, In : Alcohol research : current reviews. 34, 3, p. 339-344 6 p.

Research output: Contribution to journalEditorial

38 Scopus citations

Glycogen and its metabolism: Some new developments and old themes

Roach, P. J., Depaoli-Roach, A. A., Hurley, T. D. & Tagliabracci, V. S., Feb 1 2012, In : Biochemical Journal. 441, 3, p. 763-787 25 p.

Research output: Contribution to journalReview article

276 Scopus citations

The natural history of class I primate alcohol dehydrogenases includes gene duplication, gene loss, and gene conversion

Carrigan, M. A., Uryasev, O., Davis, R. P., Zhai, L. M., Hurley, T. D. & Benner, S. A., Jul 31 2012, In : PLoS ONE. 7, 7, e41175.

Research output: Contribution to journalArticle

14 Scopus citations
2011

A new crystal form of mouse thiamin pyrophosphokinase

Liu, J. Y. & Hurley, T. D., Jun 10 2011, In : International Journal of Biochemistry and Molecular Biology. 2, 2, p. 111-118 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases

Khanna, M., Chen, C. H., Kimble-Hill, A., Parajuli, B., Perez-Miller, S., Baskaran, S., Kim, J., Dria, K., Vasiliou, V., Mochly-Rosen, D. & Hurley, T. D., Dec 16 2011, In : Journal of Biological Chemistry. 286, 50, p. 43486-43494 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Discovery of novel regulators of aldehyde dehydrogenase isoenzymes

Parajuli, B., Kimble-Hill, A. C., Khanna, M., Ivanova, Y., Meroueh, S. & Hurley, T. D., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 153-158 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Genes encoding enzymes involved in ethanol metabolism

Hurley, T. D. & Edenberg, H. J., Dec 1 2011, In : Alcohol Research and Health. 34, 3, p. 339-344 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen

Baskaran, S., Chikwana, V. M., Contreras, C. J., Davis, K. D., Wilson, W. A., DePaoli-Roach, A. A., Roach, P. J. & Hurley, T. D., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 33999-34006 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Phosphate incorporation during glycogen synthesis and Lafora disease

Tagliabracci, V. S., Heiss, C., Karthik, C., Contreras, C. J., Glushka, J., Ishihara, M., Azadi, P., Hurley, T. D., Depaoli-Roach, A. A. & Roach, P. J., Mar 2 2011, In : Cell Metabolism. 13, 3, p. 274-282 9 p.

Research output: Contribution to journalArticle

76 Scopus citations
2010

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant

Perez-Miller, S., Younus, H., Vanam, R., Chen, C. H., Mochly-Rosen, D. & Hurley, T. D., Feb 1 2010, In : Nature Structural and Molecular Biology. 17, 2, p. 159-164 6 p.

Research output: Contribution to journalArticle

130 Scopus citations

High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones

Perez-Miller, S., Zou, Q., Novotny, M. V. & Hurley, T. D., Aug 1 2010, In : Protein Science. 19, 8, p. 1469-1479 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Relative inhibitory potency of molinate and metabolites with aldehyde dehydrogenase 2: Implications for the mechanism of enzyme inhibition

Allen, E. M. G., Anderson, D. G. R., Florang, V. R., Khanna, M., Hurley, T. D. & Doorn, J. A., Nov 15 2010, In : Chemical Research in Toxicology. 23, 11, p. 1843-1850 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
48 Scopus citations
37 Scopus citations
2009

Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: Synthesis of N-acyl glycinals

Aneetha, H., O'Dell, D. K., Tan, B., Walker, J. M. & Hurley, T. D., Jan 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 1, p. 237-241 5 p.

Research output: Contribution to journalArticle

18 Scopus citations
2008

Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart

Chen, C. H., Budas, G. R., Churchill, E. N., Disatnik, M. H., Hurley, T. D. & Mochly-Rosen, D., Sep 12 2008, In : Science. 321, 5895, p. 1493-1495 3 p.

Research output: Contribution to journalArticle

490 Scopus citations

Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity

Wang, W. L., Chai, S. C., Huang, M., He, H. Z., Hurley, T. D. & Ye, Q. Z., Oct 9 2008, In : Journal of Medicinal Chemistry. 51, 19, p. 6110-6120 11 p.

Research output: Contribution to journalArticle

35 Scopus citations
2007

A multiple reaction monitoring method for absolute quantification of the human liver alcohol dehydrogenase ADH1C1 isoenzyme

Janecki, D. J., Bemis, K. G., Tegeler, T. J., Sanghani, P. C., Zhai, L., Hurley, T. D., Bosron, W. F. & Wang, M., Oct 1 2007, In : Analytical biochemistry. 369, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

85 Scopus citations

Inhibition of the oxidative metabolism of 3,4-dihydroxyphenylacetaldehyde, a reactive intermediate of dopamine metabolism, by 4-hydroxy-2-nonenal

Florang, V. R., Rees, J. N., Brogden, N. K., Anderson, D. G., Hurley, T. D. & Doorn, J. A., Jan 1 2007, In : NeuroToxicology. 28, 1, p. 76-82 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: Kinetics, crystal structure and pharmacokinetics

Bateman, R. L., Ashworth, J., Witte, J. F., Baker, L. J., Bhanumoorthy, P., Timm, D. E., Hurley, T. D., Grompe, M. & McClard, R. W., Mar 1 2007, In : Biochemical Journal. 402, 2, p. 251-260 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Structural analysis of inhibition of E. coli methionine aminopeptidase: Implication of loop adaptability in selective inhibition of bacterial enzymes

Ma, Z. Q., Xie, S. X., Huang, Q. Q., Nan, F. J., Hurley, T. D. & Ye, Q. Z., Dec 1 2007, In : BMC Structural Biology. 7, 84.

Research output: Contribution to journalArticle

5 Scopus citations