Thomas Hurley

  • 5408 Citations
  • 42 h-Index
1979 …2020

Research output per year

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Publications

2017

Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives

Buchman, C. D. & Hurley, T. D., Mar 23 2017, In : Journal of Medicinal Chemistry. 60, 6, p. 2439-2455 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells

Li, J., Condello, S., Thomes-Pepin, J., Ma, X., Xia, Y., Hurley, T. D., Matei, D. & Cheng, J. X., Mar 2 2017, In : Cell Stem Cell. 20, 3, p. 303-314.e5

Research output: Contribution to journalArticle

147 Scopus citations

Redox switch for the inhibited state of yeast glycogen synthase mimics regulation by phosphorylation

Mahalingan, K. K., Baskaran, S., Depaoli-Roach, A. A., Roach, P. J. & Hurley, T. D., Jan 1 2017, In : Biochemistry. 56, 1, p. 179-188 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH High Melanoma-Initiating Cells

Sarvi, S., Crispin, R., Lu, Y., Zeng, L., Hurley, T. D., Houston, D. R., von Kriegsheim, A., Chen, C. H., Mochly-Rosen, D., Ranzani, M., Mathers, M. E., Xu, X., Xu, W., Adams, D. J., Carragher, N. O., Fujita, M., Schuchter, L., Unciti-Broceta, A., Brunton, V. G. & Patton, E. E., Dec 20 2018, In : Cell Chemical Biology. 25, 12, p. 1456-1469.e6

Research output: Contribution to journalArticle

15 Scopus citations

Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy

Huddle, B. C., Grimley, E., Buchman, C. D., Chtcherbinine, M., Debnath, B., Mehta, P., Yang, K., Morgan, C. A., Li, S., Felton, J., Sun, D., Mehta, G., Neamati, N., Buckanovich, R. J., Hurley, T. D. & Larsen, S. D., Oct 11 2018, In : Journal of Medicinal Chemistry. 61, 19, p. 8754-8773 20 p.

Research output: Contribution to journalArticle

15 Scopus citations
2019

A novel aldh1a1 inhibitor targets cells with stem cell characteristics in ovarian cancer

Nwani, N. G., Condello, S., Wang, Y., Swetzig, W. M., Barber, E., Hurley, T. & Matei, D., Apr 2019, In : Cancers. 11, 4, 502.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

Chefetz, I., Grimley, E., Yang, K., Hong, L., Vinogradova, E. V., Suciu, R., Kovalenko, I., Karnak, D., Morgan, C. A., Chtcherbinine, M., Buchman, C., Huddle, B., Barraza, S., Morgan, M., Bernstein, K. A., Yoon, E., Lombard, D. B., Bild, A., Mehta, G., Romero, I. & 6 others, Chiang, C. Y., Landen, C., Cravatt, B., Hurley, T. D., Larsen, S. D. & Buckanovich, R. J., Mar 12 2019, In : Cell Reports. 26, 11, p. 3061-3075.e6

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
2020

Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase

Tang, B., Frasinyuk, M. S., Chikwana, V. M., Mahalingan, K. K., Morgan, C. A., Segvich, D. M., Bondarenko, S. P., Mrug, G. P., Wyrebek, P., Watt, D. S., Depaoli-Roach, A. A., Roach, P. J. & Hurley, T. D., Apr 9 2020, In : Journal of Medicinal Chemistry. 63, 7, p. 3538-3551 14 p.

Research output: Contribution to journalArticle

Targeting aldehyde dehydrogenases to eliminate cancer stem cells in gynecologic malignancies

Muralikrishnan, V., Hurley, T. D. & Nephew, K. P., Apr 2020, In : Cancers. 12, 4, 961.

Research output: Contribution to journalReview article

Open Access

The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic

Gentry, M. S., Afawi, Z., Armstrong, D. D., Delgado-Escueta, A., Goldberg, Y. P., Grossman, T. R., Guinovart, J. J., Harris, F., Hurley, T. D., Michelucci, R., Minassian, B. A., Sanz, P., Worby, C. A. & Serratosa, J. M., Feb 2020, In : Epilepsy and Behavior. 103, 106839.

Research output: Contribution to journalArticle

1 Scopus citations