Thomas Hurley

  • 4817 Citations
  • 40 h-Index
1979 …2021
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Publications 1990 2019

  • 4817 Citations
  • 40 h-Index
  • 104 Article
  • 2 Chapter
  • 1 Editorial
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Article
2019
1 Citation (Scopus)

A novel aldh1a1 inhibitor targets cells with stem cell characteristics in ovarian cancer

Nwani, N. G., Condello, S., Wang, Y., Swetzig, W. M., Barber, E., Hurley, T. & Matei, D., Apr 1 2019, In : Cancers. 11, 4, 502.

Research output: Contribution to journalArticle

Open Access
Ovarian Neoplasms
Stem Cells
Aldehyde Dehydrogenase
DNA Damage
Cell Proliferation

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

Chefetz, I., Grimley, E., Yang, K., Hong, L., Vinogradova, E. V., Suciu, R., Kovalenko, I., Karnak, D., Morgan, C. A., Chtcherbinine, M., Buchman, C., Huddle, B., Barraza, S., Morgan, M., Bernstein, K. A., Yoon, E., Lombard, D. B., Bild, A., Mehta, G., Romero, I. & 6 others, Chiang, C. Y., Landen, C., Cravatt, B., Hurley, T., Larsen, S. D. & Buckanovich, R. J., Mar 12 2019, In : Cell Reports. 26, 11, p. 3061-3075.e6

Research output: Contribution to journalArticle

Open Access
Chemotherapy
Neoplastic Stem Cells
Ovarian Neoplasms
Aldehyde Dehydrogenase
Drug Therapy
2018
4 Citations (Scopus)

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells

Sarvi, S., Crispin, R., Lu, Y., Zeng, L., Hurley, T., Houston, D. R., von Kriegsheim, A., Chen, C. H., Mochly-Rosen, D., Ranzani, M., Mathers, M. E., Xu, X., Xu, W., Adams, D. J., Carragher, N. O., Fujita, M., Schuchter, L., Unciti-Broceta, A., Brunton, V. G. & Patton, E. E., Dec 20 2018, In : Cell Chemical Biology. 25, 12, p. 1456-1469.e6

Research output: Contribution to journalArticle

Melanoma
Nitrofurans
Prodrugs
Chemical activation
Neoplasms
4 Citations (Scopus)

Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy

Huddle, B. C., Grimley, E., Buchman, C. D., Chtcherbinine, M., Debnath, B., Mehta, P., Yang, K., Morgan, C. A., Li, S., Felton, J., Sun, D., Mehta, G., Neamati, N., Buckanovich, R. J., Hurley, T. & Larsen, S. D., Oct 11 2018, In : Journal of Medicinal Chemistry. 61, 19, p. 8754-8773 20 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Ovarian Neoplasms
Neoplastic Stem Cells
Protein Isoforms
Drug Therapy
2017
7 Citations (Scopus)

Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives

Buchman, C. D. & Hurley, T., Mar 23 2017, In : Journal of Medicinal Chemistry. 60, 6, p. 2439-2455 17 p.

Research output: Contribution to journalArticle

Ficusin
Coumarins
Aldehyde Dehydrogenase
Isoenzymes
Aldehydes

Redox Switch for the Inhibited State of Yeast Glycogen Synthase Mimics Regulation by Phosphorylation

Mahalingan, K. K., Baskaran, S., De Paoli-Roach, A., Roach, P. & Hurley, T., Jan 10 2017, In : Biochemistry. 56, 1, p. 179-188 10 p.

Research output: Contribution to journalArticle

Glycogen Synthase
Phosphorylation
Yeast
Oxidation-Reduction
Yeasts
2016
5 Citations (Scopus)

A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase

Maile, C. A., Hingst, J. R., Mahalingan, K. K., O'Reilly, A. O., Cleasby, M. E., Mickelson, J. R., McCue, M. E., Anderson, S. M., Hurley, T., Wojtaszewski, J. F. P. & Piercy, R. J., Apr 19 2016, (Accepted/In press) In : Biochimica et Biophysica Acta - General Subjects.

Research output: Contribution to journalArticle

Glycogen Storage Disease
Glycogen Synthase
Glycogen
Horses
Chemical activation
5 Citations (Scopus)

Incorporation of phosphate into glycogen by glycogen synthase

Contreras, C. J., Segvich, D. M., Mahalingan, K., Chikwana, V. M., Kirley, T. L., Hurley, T., De Paoli-Roach, A. & Roach, P., May 1 2016, In : Archives of Biochemistry and Biophysics. 597, p. 21-29 9 p.

Research output: Contribution to journalArticle

Glycogen Synthase
Glycogen
Phosphates
Phosphorylation
Uridine Diphosphate
85 Citations (Scopus)

Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells

Li, J., Condello, S., Thomes-Pepin, J., Ma, X., Xia, Y., Hurley, T., Matei, D. & Cheng, J. X., Jan 4 2016, (Accepted/In press) In : Cell Stem Cell.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Ovarian Neoplasms
Lipids
Therapeutics
Cell- and Tissue-Based Therapy
2015
21 Citations (Scopus)

Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors

Morgan, C. A. & Hurley, T., Feb 26 2015, In : Journal of Medicinal Chemistry. 58, 4, p. 1964-1975 12 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Aldehydes
Carboxylic Acids
Glycine
Cataract
18 Citations (Scopus)

Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1

Morgan, C. A. & Hurley, T., Jun 5 2015, In : Chemico-Biological Interactions. 234, p. 29-37 9 p.

Research output: Contribution to journalArticle

Assays
Throughput
Aldehyde Dehydrogenase
Esterases
Enzymes
4 Citations (Scopus)

Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors

Buchman, C. D., Mahalingan, K. K. & Hurley, T., Jun 5 2015, In : Chemico-Biological Interactions. 234, p. 38-44 7 p.

Research output: Contribution to journalArticle

Lactones
Isoenzymes
Oxidation
Aldehyde Dehydrogenase
Acetaldehyde
28 Citations (Scopus)

Hominids adapted to metabolize ethanol long before human-directed fermentation

Carrigan, M. A., Uryasev, O., Frye, C. B., Eckman, B. L., Myers, C. R., Hurley, T. & Benner, S. A., Jan 13 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 2, p. 458-463 6 p.

Research output: Contribution to journalArticle

Hominidae
Fermentation
Ethanol
Primates
Fruit
32 Citations (Scopus)

N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes

Morgan, C. A., Parajuli, B., Buchman, C. D., Dria, K. & Hurley, T., Jun 5 2015, In : Chemico-Biological Interactions. 234, p. 18-28 11 p.

Research output: Contribution to journalArticle

Isoenzymes
Substrates
Aldehyde Dehydrogenase
Neoplastic Stem Cells
Cytology
63 Citations (Scopus)

β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids

Condello, S., Morgan, C. A., Nagdas, S., Cao, L., Turek, J., Hurley, T. & Matei, D., Apr 30 2015, In : Oncogene. 34, 18, p. 2297-2308 12 p.

Research output: Contribution to journalArticle

Catenins
Ovarian Neoplasms
Anoikis
Neoplasms
Neoplastic Stem Cells
2014
18 Citations (Scopus)

Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones

Kimble-Hill, A. C., Parajuli, B., Chen, C. H., Mochly-Rosen, D. & Hurley, T., Feb 13 2014, In : Journal of Medicinal Chemistry. 57, 3, p. 714-722 9 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Isoenzymes
X Ray Crystallography
Structure-Activity Relationship
Metabolic Networks and Pathways
23 Citations (Scopus)

Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity

Parajuli, B., Georgiadis, T. M., Fishel, M. & Hurley, T., Mar 21 2014, In : ChemBioChem. 15, 5, p. 701-712 12 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Cytotoxicity
Cyclophosphamide
Cells
Isoenzymes
5 Citations (Scopus)

Enrichment of chemical libraries docked to protein conformational ensembles and application to aldehyde dehydrogenase 2

Wang, B., Buchman, C. D., Li, L., Hurley, T. & Meroueh, S., Jul 28 2014, In : Journal of Chemical Information and Modeling. 54, 7, p. 2105-2116 12 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Aldehydes
Molecular dynamics
Proteins
Crystal structure
24 Citations (Scopus)

Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells

Parajuli, B., Fishel, M. & Hurley, T., Jan 23 2014, In : Journal of Medicinal Chemistry. 57, 2, p. 449-461 13 p.

Research output: Contribution to journalArticle

Cyclophosphamide
Aldehyde Dehydrogenase
Xenobiotics
Aldehydes
Neoplasms
2013
2 Citations (Scopus)

Catalytic contribution of threonine 244 in human ALDH2

González-Segura, L., Ho, K. K., Perez-Miller, S., Weiner, H. & Hurley, T., Feb 25 2013, In : Chemico-Biological Interactions. 202, 1-3, p. 32-40 9 p.

Research output: Contribution to journalArticle

Coenzymes
Threonine
Niacinamide
Hydrides
NAD
5 Citations (Scopus)

Expression and purification of functional human glycogen synthase-1 (hGYS1) in insect cells

Khanna, M., Imasaki, T., Chikwana, V. M., Perez-Miller, S., Hunter, G. O., Mosley, A., Takagi, Y. & Hurley, T., 2013, In : Protein Expression and Purification. 90, 2, p. 78-83 6 p.

Research output: Contribution to journalArticle

Glycogen Synthase
Insects
Phosphorylation
Glucose-6-Phosphate
Baculoviridae
23 Citations (Scopus)
Molecular recognition
Free energy
Molecular dynamics
Calorimetry
Ligands
9 Citations (Scopus)

Structural basis for 2'-phosphate incorporation into glycogen by glycogen synthase

Chikwana, V. M., Khanna, M., Baskaran, S., Tagliabracci, V. S., Contreras, C. J., De Paoli-Roach, A., Roach, P. & Hurley, T., Dec 24 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 52, p. 20976-20981 6 p.

Research output: Contribution to journalArticle

Glycogen Synthase
Glycogen
Phosphates
Uridine Diphosphate
Glucose
50 Citations (Scopus)

The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum

Akin, B. L., Hurley, T., Chen, Z. & Jones, L., Oct 18 2013, In : Journal of Biological Chemistry. 288, 42, p. 30181-30191 11 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Pumps
Calcium
Reticulum
Calcium-Transporting ATPases
2012
201 Citations (Scopus)

Aldehyde dehydrogenase inhibitors: A comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application

Koppaka, V., Thompson, D. C., Chen, Y., Ellermann, M., Nicolaou, K. C., Juvonen, R. O., Petersen, D., Deitrich, R. A., Hurley, T. & Vasiliou Dr., V., 2012, In : Pharmacological Reviews. 64, 3, p. 520-539 20 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Substrate Specificity
Pharmacology
Isoenzymes
Aldehydes
243 Citations (Scopus)

Glycogen and its metabolism: Some new developments and old themes

Roach, P., De Paoli-Roach, A., Hurley, T. & Tagliabracci, V. S., Feb 1 2012, In : Biochemical Journal. 441, 3, p. 763-787 25 p.

Research output: Contribution to journalArticle

Glycogen
Metabolism
Glycogen Synthase
Epinephrine
Lafora Disease
10 Citations (Scopus)

The natural history of class I primate alcohol dehydrogenases includes gene duplication, gene loss, and gene conversion

Carrigan, M. A., Uryasev, O., Davis, R. P., Zhai, L., Hurley, T. & Benner, S. A., Jul 31 2012, In : PLoS One. 7, 7, e41175.

Research output: Contribution to journalArticle

Gene Conversion
gene conversion
Gene Duplication
Alcohol Dehydrogenase
alcohol dehydrogenase
2011
2 Citations (Scopus)

A new crystal form of mouse thiamin pyrophosphokinase

Liu, J. Y. & Hurley, T., 2011, In : International Journal of Biochemistry and Molecular Biology. 2, 2, p. 111-118 8 p.

Research output: Contribution to journalArticle

Thiamin Pyrophosphokinase
Thiamine Pyrophosphate
Crystals
Thiamine
Adenosine Triphosphate
37 Citations (Scopus)

Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases

Khanna, M., Chen, C. H., Kimble-Hill, A., Parajuli, B., Perez-Miller, S., Baskaran, S., Kim, J., Dria, K., Vasiliou, V., Mochly-Rosen, D. & Hurley, T., Dec 16 2011, In : Journal of Biological Chemistry. 286, 50, p. 43486-43494 9 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Enzymes
Enzyme Inhibitors
Metabolic Networks and Pathways
Ketones
25 Citations (Scopus)

Discovery of novel regulators of aldehyde dehydrogenase isoenzymes

Parajuli, B., Kimble-Hill, A. C., Khanna, M., Ivanova, Y., Meroueh, S. & Hurley, T., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 153-158 6 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Isoenzymes
Screening
Chemical activation
Oncology
38 Citations (Scopus)

Genes encoding enzymes involved in ethanol metabolism

Hurley, T. & Edenberg, H., 2011, In : Alcohol Research and Health. 34, 3, p. 339-344 6 p.

Research output: Contribution to journalArticle

Acetaldehyde
Ethanol
Alcoholism
Aldehyde Dehydrogenase
Alcohol Dehydrogenase
17 Citations (Scopus)

Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen

Baskaran, S., Chikwana, V. M., Contreras, C. J., Davis, K. D., Wilson, W. A., De Paoli-Roach, A., Roach, P. & Hurley, T., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 33999-34006 8 p.

Research output: Contribution to journalArticle

Glycogen Synthase
Glycogen
Binding Sites
Yeast
Mutation
66 Citations (Scopus)

Phosphate incorporation during glycogen synthesis and Lafora disease

Tagliabracci, V. S., Heiss, C., Karthik, C., Contreras, C. J., Glushka, J., Ishihara, M., Azadi, P., Hurley, T., De Paoli-Roach, A. & Roach, P., Mar 2 2011, In : Cell Metabolism. 13, 3, p. 274-282 9 p.

Research output: Contribution to journalArticle

Lafora Disease
Glycogen
Phosphates
Progressive Myoclonic Epilepsy
Uridine Diphosphate Glucose
2010
110 Citations (Scopus)

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant

Perez-Miller, S., Younus, H., Vanam, R., Chen, C. H., Mochly-Rosen, D. & Hurley, T., Feb 2010, In : Nature Structural and Molecular Biology. 17, 2, p. 159-164 6 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Enzymes
Acrolein
Alcoholic Beverages
Environmental Pollutants
17 Citations (Scopus)

High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones

Perez-Miller, S., Zou, Q., Novotny, M. V. & Hurley, T., Aug 2010, In : Protein Science. 19, 8, p. 1469-1479 11 p.

Research output: Contribution to journalArticle

Pheromones
Nose
Protein Isoforms
X-Rays
X rays
13 Citations (Scopus)

Relative inhibitory potency of molinate and metabolites with aldehyde dehydrogenase 2: Implications for the mechanism of enzyme inhibition

Allen, E. M. G., Anderson, D. G. R., Florang, V. R., Khanna, M., Hurley, T. & Doorn, J. A., Nov 15 2010, In : Chemical Research in Toxicology. 23, 11, p. 1843-1850 8 p.

Research output: Contribution to journalArticle

Enzyme inhibition
Aldehyde Dehydrogenase
Metabolites
Enzymes
Sulfones
43 Citations (Scopus)
Glycogen Synthase
Glucose-6-Phosphate
Phosphorylation
Enzymes
Inteins
33 Citations (Scopus)

Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration

Baraibar, M. A., Muhoberac, B. B., Garringer, H., Hurley, T. & Vidal, R., Jan 15 2010, In : Journal of Biological Chemistry. 285, 3, p. 1950-1956 7 p.

Research output: Contribution to journalArticle

Ferritins
Iron
Apoferritins
Peptides
Inclusion Bodies
2009
17 Citations (Scopus)

Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: Synthesis of N-acyl glycinals

Aneetha, H., O'Dell, D. K., Tan, B., Walker, J. M. & Hurley, T., Jan 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 1, p. 237-241 5 p.

Research output: Contribution to journalArticle

Alcohol Dehydrogenase
Lipids
Oxidation
Physiological Phenomena
Endocannabinoids
2008
451 Citations (Scopus)

Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart

Chen, C. H., Budas, G. R., Churchill, E. N., Disatnik, M. H., Hurley, T. & Mochly-Rosen, D., Sep 12 2008, In : Science. 321, 5895, p. 1493-1495 3 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Ischemia
Enzyme Activation
Aldehydes
Proteomics
34 Citations (Scopus)

Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity

Wang, W. L., Chai, S. C., Huang, M., He, H. Z., Hurley, T. & Ye, Q., Oct 9 2008, In : Journal of Medicinal Chemistry. 51, 19, p. 6110-6120 11 p.

Research output: Contribution to journalArticle

Aminopeptidases
Methionine
Escherichia coli
Metals
Ions
2007
83 Citations (Scopus)

A multiple reaction monitoring method for absolute quantification of the human liver alcohol dehydrogenase ADH1C1 isoenzyme

Janecki, D. J., Bemis, K. G., Tegeler, T. J., Sanghani, P. C., Zhai, L., Hurley, T., Bosron, W. F. & Wang, M., Oct 1 2007, In : Analytical Biochemistry. 369, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

Alcohol Dehydrogenase
Liver
Isoenzymes
Monitoring
Isotopes
41 Citations (Scopus)

Inhibition of the oxidative metabolism of 3,4-dihydroxyphenylacetaldehyde, a reactive intermediate of dopamine metabolism, by 4-hydroxy-2-nonenal

Florang, V. R., Rees, J. N., Brogden, N. K., Anderson, D. G., Hurley, T. & Doorn, J. A., Jan 2007, In : NeuroToxicology. 28, 1, p. 76-82 7 p.

Research output: Contribution to journalArticle

Enzyme inhibition
Metabolism
Dopamine
Oxidative stress
Oxidative Stress
9 Citations (Scopus)

Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: Kinetics, crystal structure and pharmacokinetics

Bateman, R. L., Ashworth, J., Witte, J. F., Baker, L. J., Bhanumoorthy, P., Timm, D. E., Hurley, T., Grompe, M. & McClard, R. W., Mar 1 2007, In : Biochemical Journal. 402, 2, p. 251-260 10 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Crystal structure
Tyrosinemias
Kinetics
Enzymes
5 Citations (Scopus)
Aminopeptidases
Methionine
Escherichia coli
Enzymes
Drug Design
62 Citations (Scopus)

Structural and functional consequences of coenzyme binding to the inactive Asian variant of mitochondrial aldehyde dehydrogenase: Roles of residues 475 and 487

Larson, H. N., Zhou, J., Chen, Z., Stamler, J. S., Weiner, H. & Hurley, T., Apr 27 2007, In : Journal of Biological Chemistry. 282, 17, p. 12940-12950 11 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Coenzymes
Enzymes
Catalytic Domain
Apoenzymes
121 Citations (Scopus)

Structural basis for regulation of protein phosphatase 1 by inhibitor-2

Hurley, T., Yang, J., Zhang, L., Goodwin, K. D., Zou, Q., Cortese, M., Dunker, A. & De Paoli-Roach, A., Sep 28 2007, In : Journal of Biological Chemistry. 282, 39, p. 28874-28883 10 p.

Research output: Contribution to journalArticle

Protein Phosphatase 1
Phosphoprotein Phosphatases
Metal ions
Crystal structure
Amino Acids
34 Citations (Scopus)

Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase

González-Segura, L., Witte, J. F., McClard, R. W. & Hurley, T., Dec 11 2007, In : Biochemistry. 46, 49, p. 14075-14086 12 p.

Research output: Contribution to journalArticle

Orotate Phosphoribosyltransferase
Orotic Acid
Apoenzymes
Diphosphates
Enzymes
2006
11 Citations (Scopus)

Direct detection of glycogenin reaction products during glycogen initiation

Hurley, T., Walls, C., Bennett, J. R., Roach, P. & Wang, M., Sep 22 2006, In : Biochemical and Biophysical Research Communications. 348, 2, p. 374-378 5 p.

Research output: Contribution to journalArticle

Glycogen
Reaction products
Assays
1,4-alpha-Glucan Branching Enzyme
Glucose