Thomas Hurley

  • 5348 Citations
  • 41 h-Index
1979 …2020

Research output per year

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Publications

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Article
1990
48 Scopus citations
1991

Characterization of human alcohol dehydrogenases containing substitutions at amino acids 47 and 51

Hurley, T. D., Ehrig, T., Edenberg, H. J. & Bosron, W. F., Jun 11 1991, In : Advances in experimental medicine and biology. 284, p. 271-275 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

General Base Catalysis in a Glutamine for Histidine Mutant at Position 51 of Human Liver Alcohol Dehydrogenase

Ehrig, T., Hurley, T. D., Edenberg, H. J. & Bosron, W. F., Jan 1 1991, In : Biochemistry. 30, 4, p. 1062-1068 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

Structure of human β1β1 alcohol dehydrogenase: Catalytic effects of non-active-site substitutions

Hurley, T. D., Bosron, W. F., Hamilton, J. A. & Mario Amzel, L., Jan 1 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 18, p. 8149-8153 5 p.

Research output: Contribution to journalArticle

Open Access
76 Scopus citations
1992

Crystallization and preliminary X-ray investigation of bovine liver mitochondrial aldehyde dehydrogenase

Hurley, T. D. & Weiner, H., Oct 20 1992, In : Journal of molecular biology. 227, 4, p. 1255-1257 3 p.

Research output: Contribution to journalArticle

9 Scopus citations
16 Scopus citations

Tryptophan fluorescence quenching by alkaline pH and ternary complex formation in human β1β1 and horse EE alcohol dehydrogenases

Ehrig, T., Muhoberac, B. B., Hurley, T. D. & Bosron, W. F., Apr 6 1992, In : FEBS Letters. 300, 3, p. 283-285 3 p.

Research output: Contribution to journalArticle

2 Scopus citations
1993

Human alcohol dehydrogenase: Design of a secondary alcohol dehydrogenase using crystallography and mutagenesis

Hurley, T., Bosron, W. F. & Mario Amzel, L., 1993, In : Protein Engineering, Design and Selection. 6, p. 44 1 p.

Research output: Contribution to journalArticle

1994

Catalytic Efficiency of Human Alcohol Dehydrogenases for Retinol Oxidation and Retinal Reduction

Yang, ZN. N., Davis, G. J., Hurley, T. D., Stone, C. L., Li, TK. K. & Bosron, W. F., Jun 1994, In : Alcoholism: Clinical and Experimental Research. 18, 3, p. 587-591 5 p.

Research output: Contribution to journalArticle

138 Scopus citations

Comparative roles of histidine-51 in human β1β1 and threonine-51 in ππ alcohol dehydrogenases

Davis, G. J., Carr, L. G., Hurley, T. D., Li, T. K. & Bosron, W. F., Jun 1994, In : Archives of Biochemistry and Biophysics. 311, 2, p. 307-312 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Structures of three human β alcohol dehydrogenase variants: Correlations with their functional differences

Hurley, T. D., Bosron, W. F., Stone, C. L. & Amzel, L. M., Jun 9 1994, In : Journal of molecular biology. 239, 3, p. 415-429 15 p.

Research output: Contribution to journalArticle

68 Scopus citations
1995

Cimetidine Inhibition of Human Gastric and Liver Alcohol Dehydrogenase Isoenzymes: Identification of Inhibitor Complexes by Kinetics and Molecular Modeling

Stone, C. L., Hurley, T. D., Peggs, C. F., Kedishvili, N. Y., Davis, G. J., Thomasson, H. R., Li, T. K. & Bosron, W. F., Sep 1 1995, In : Biochemistry. 34, 12, p. 4008-4014 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Cloning and expression of a human stomach alcohol dehydrogenase isozyme

Kedishvili, N. Y., Bosron, W. F., Stone, C. L., Peggs, C. F., Thomasson, H. R., Popov, K. M., Carr, L. G., Hurley, T. D., Edenberg, H. J. & Li, T. K., Jan 1 1995, In : Advances in experimental medicine and biology. 372, p. 341-347 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase: Active-site amino acid sequence explains substrate specificity compared with liver isozymes

Kedishvili, N. Y., Bosron, W. F., Stone, C. L., Hurley, T. D., Peggs, C. F., Thomasson, H. R., Popov, K. M., Carr, L. G., Edenberg, H. J. & Li, T. K., Feb 24 1995, In : Journal of Biological Chemistry. 270, 8, p. 3625-3630 6 p.

Research output: Contribution to journalArticle

Open Access
75 Scopus citations

The role of leucine 116 in determining substrate specificity in human B1 alcohol dehydrogenase

Hurley, T. D. & Vessell, D. L., 1995, In : Advances in experimental medicine and biology. 372, p. 321-325 5 p.

Research output: Contribution to journalArticle

5 Scopus citations
1996

Three-dimensional structure of mammalian casein kinase I: Molecular basis for phosphate recognition

Longenecker, K. L., Roach, P. J. & Hurley, T. D., Apr 5 1996, In : Journal of molecular biology. 257, 3, p. 618-631 14 p.

Research output: Contribution to journalArticle

100 Scopus citations

X-ray structure of human β3β3 alcohol dehydrogenase. The contribution of ionic interactions to coenzyme binding

Davis, G. J., Bosron, W. F., Stone, C. L., Owusu-Dekyi, K. & Hurley, T. D., Aug 5 1996, In : Journal of Biological Chemistry. 271, 29, p. 17057-17061 5 p.

Research output: Contribution to journalArticle

39 Scopus citations
1997

cDNA sequence and catalytic properties of a chick embryo alcohol dehydrogenase that oxidizes retinol and 3β,5α-hydroxysteroids

Kedishvili, N. Y., Cough, W. H., Chernoff, E. A. G., Hurley, T. D., Stone, C. L., Bowman, K. D., Popov, K. M., Bosron, W. F. & Li, T. K., Mar 14 1997, In : Journal of Biological Chemistry. 272, 11, p. 7494-7500 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Structure of human χχ alcohol dehydrogenase: A glutathione-dependent formaldehyde dehydrogenase

Yang, Z. N., Bosron, W. F. & Hurley, T. D., Jan 1 1997, In : Journal of molecular biology. 265, 3, p. 330-343 14 p.

Research output: Contribution to journalArticle

75 Scopus citations

Structure of mitochondrial aldehyde dehydrogenase: The genetic component of ethanol aversion

Steinmetz, C. G., Xie, P., Weiner, H. & Hurley, T. D., Jan 1 1997, In : Structure. 5, 5, p. 701-711 11 p.

Research output: Contribution to journalArticle

Open Access
275 Scopus citations

Studies on the regulation of the mitochondrial α-ketoacid dehydrogenase complexes and their kinases

Harris, R. A., Hawes, J. W., Popov, K. M., Zhao, Y., Shimomura, Y., Sato, J., Jaskiewicz, J. & Hurley, T. D., Sep 15 1997, In : Advances in Enzyme Regulation. 37, p. 271-293 23 p.

Research output: Contribution to journalArticle

85 Scopus citations

The potential roles of the conserved amino acids in human liver mitochondrial aldehyde dehydrogenase

Sheikh, S., Ni, L., Hurley, T. D. & Weiner, H., Aug 12 1997, In : Journal of Biological Chemistry. 272, 30, p. 18817-18822 6 p.

Research output: Contribution to journalArticle

69 Scopus citations

Three-dimensional structures of human alcohol dehydrogenase isoenzymes reveal the molecular basis for their functional diversity

Hurley, T. D., Steinmetz, C. G., Xie, P. & Yang, Z. N., Apr 1 1997, In : Advances in experimental medicine and biology. 414, p. 291-302 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

X-ray structure of human class IV σσ alcohol dehydrogenase. Structural basis for substrate specificity

Xie, P., Parsons, S. H., Speckhard, D. C., Bosron, W. F. & Hurley, T. D., 1997, In : Journal of Biological Chemistry. 272, 30, p. 18558-18563 6 p.

Research output: Contribution to journalArticle

71 Scopus citations
1998
22 Scopus citations
1999

Different mutations in the same codon of the proteolipid protein gene, PLP, may help in correlating genotype with phenotype in Pelizaeus-Merzbacher disease/X-linked spastic paraplegia (PMD/SPG2)

Hodes, M. E., Zimmerman, A. W., Aydanian, A., Naidu, S., Miller, N. R., Garcia Oller, J. L., Barker, B., Aleck, K. A., Hurley, T. D. & Dlouhy, S. R., Jan 15 1999, In : American journal of medical genetics. 82, 2, p. 132-139 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Evaluation of the roles of the conserved residues of aldehyde dehydrogenase

Hurley, T. D. & Weiner, H., 1999, In : Advances in experimental medicine and biology. 463, p. 45-52 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Human liver mitochondrial aldehyde dehydrogenase: Three-dimensional structure and the restoration of solubility and activity of chimeric forms

Ni, L., Zhou, J., Hurley, T. D. & Weiner, H., Dec 1 1999, In : Protein Science. 8, 12, p. 2784-2790 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Methionine-141 directly influences the binding of 4-methylpyrazole in human σσ alcohol dehydrogenase

Xie, P. T. & Hurley, T. D., Jan 1 1999, In : Protein Science. 8, 12, p. 2639-2644 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

The pH-dependent binding of NADH and subsequent enzyme isomerization of human liver β3β3 alcohol dehydrogenase

Stone, C. L., Jipping, M. B., Owusu-Dekyi, K., Hurley, T. D., Li, T. K. & Bosron, W. F., May 4 1999, In : Biochemistry. 38, 18, p. 5829-5835 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Three-dimensional structure of mitochondrial aldehyde dehydrogenase: Mechanistic implications

Hurley, T. D., Steinmetz, C. G. & Weiner, H., Jan 1 1999, In : Advances in experimental medicine and biology. 463, p. 15-25 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
2000
18 Scopus citations
52 Scopus citations

Kinetic mechanism of human glutathione-dependent formaldehyde dehydrogenase

Sanghani, P. C., Stone, C. L., Ray, B. D., Pindel, E. V., Hurley, T. D. & Bosron, W. F., Sep 5 2000, In : Biochemistry. 39, 35, p. 10720-10729 10 p.

Research output: Contribution to journalArticle

53 Scopus citations
2001

Order and disorder in mitochondrial aldehyde dehydrogenase

Hurley, T. D., Perez-Miller, S. & Breen, H., Jan 30 2001, In : Chemico-Biological Interactions. 130-132, p. 3-14 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Three-dimensional structures of the three human class I alcohol dehydrogenases

Niederhut, M. S., Gibbons, B. J., Perez-Miller, S. & Hurley, T. D., Apr 5 2001, In : Protein Science. 10, 4, p. 697-706 10 p.

Research output: Contribution to journalArticle

44 Scopus citations
2002

Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin

Gibbons, B. J., Roach, P. J. & Hurley, T. D., Jan 1 2002, In : Journal of molecular biology. 319, 2, p. 463-477 15 p.

Research output: Contribution to journalArticle

99 Scopus citations

Human glutathione-dependent formaldehyde dehydrogenase. Structural changes associated with ternary complex formation

Sanghani, P. C., Bosron, W. F. & Hurley, T. D., Dec 24 2002, In : Biochemistry. 41, 51, p. 15189-15194 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

Human glutathione-dependent formaldehyde dehydrogenase. Structures of apo, binary, and inhibitory ternary complexes

Sanghani, P. C., Robinson, H., Bosron, W. F. & Hurley, T. D., Sep 3 2002, In : Biochemistry. 41, 35, p. 10778-10786 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

Multiple conformations of NAD and NADH when bound to human cytosolic and mitochondrial aldehyde dehydrogenase

Hammen, P. K., Allali-Hassani, A., Hallenga, K., Hurley, T. D. & Weiner, H., Jun 4 2002, In : Biochemistry. 41, 22, p. 7156-7168 13 p.

Research output: Contribution to journalArticle

64 Scopus citations
2003

Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase

Perez-Miller, S. J. & Hurley, T. D., Jun 17 2003, In : Biochemistry. 42, 23, p. 7100-7109 10 p.

Research output: Contribution to journalArticle

128 Scopus citations

Structure-function relationships in human Class III alcohol dehydrogenase (formaldehyde dehydrogenase)

Sanghani, P. C., Robinson, H., Bennett-Lovsey, R., Hurley, T. D. & Bosron, W. F., Feb 1 2003, In : Chemico-Biological Interactions. 143-144, p. 195-200 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
2004

Identification and analysis of single-nucleotide polymorphisms in the gemcitabine pharmacologic pathway

Fukunaga, A. K., Marsh, S., Murry, D. J., Hurley, T. D. & McLeod, H. L., Oct 20 2004, In : Pharmacogenomics Journal. 4, 5, p. 307-314 8 p.

Research output: Contribution to journalArticle

81 Scopus citations

Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1

Sun, Z., Murry, D. J., Sanghani, S. P., Davis, W. I., Kedishvili, N. Y., Zou, Q., Hurley, T. D. & Bosron, W. F., Aug 2004, In : Journal of Pharmacology and Experimental Therapeutics. 310, 2, p. 469-476 8 p.

Research output: Contribution to journalArticle

145 Scopus citations

Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors

Gibbons, B. J. & Hurley, T. D., Oct 5 2004, In : Biochemistry. 43, 39, p. 12555-12562 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Suicide gene therapy: Conversion of ethanol to acetaldehyde mediated by human beta 2 alcohol dehydrogenase

Savage, P., Cowburn, P., Clemens, D., Hurley, T., Laguda, B., Martin-Duque, P., Vassaux, G. & Lemoine, N. R., Dec 1 2004, In : Cancer gene therapy. 11, 12, p. 774-781 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2005

Differential effects of Mg2+ ions on the individual kinetic steps of human cytosolic and mitochondrial aldehyde dehydrogenases

Ho, K. K., Allali-Hassani, A., Hurley, T. D. & Weiner, H., Jun 7 2005, In : Biochemistry. 44, 22, p. 8022-8029 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
64 Scopus citations

Hydrolysis of capecitabine to 5′-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide

Quinney, S. K., Sanghani, S. P., Davis, W. I., Hurley, T. D., Sun, Z., Murry, D. J. & Bosron, W. F., Jun 1 2005, In : Journal of Pharmacology and Experimental Therapeutics. 313, 3, p. 1011-1016 6 p.

Research output: Contribution to journalArticle

118 Scopus citations

Requirements for catalysis in mammalian glycogenin

Hurley, T. D., Stout, S., Miner, E., Zhou, J. & Roach, P. J., Jun 24 2005, In : Journal of Biological Chemistry. 280, 25, p. 23892-23899 8 p.

Research output: Contribution to journalArticle

24 Scopus citations