Thomas Hurley

  • 5257 Citations
  • 41 h-Index
1979 …2021

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Publications

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Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart

Chen, C. H., Budas, G. R., Churchill, E. N., Disatnik, M. H., Hurley, T. D. & Mochly-Rosen, D., Sep 12 2008, In : Science. 321, 5895, p. 1493-1495 3 p.

Research output: Contribution to journalArticle

490 Scopus citations

A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase

Maile, C. A., Hingst, J. R., Mahalingan, K. K., O'Reilly, A. O., Cleasby, M. E., Mickelson, J. R., McCue, M. E., Anderson, S. M., Hurley, T. D., Wojtaszewski, J. F. P. & Piercy, R. J., Jan 1 2017, In : Biochimica et Biophysica Acta - General Subjects. 1861, 1, p. 3388-3398 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: Synthesis of N-acyl glycinals

Aneetha, H., O'Dell, D. K., Tan, B., Walker, J. M. & Hurley, T. D., Jan 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 1, p. 237-241 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant

Perez-Miller, S., Younus, H., Vanam, R., Chen, C. H., Mochly-Rosen, D. & Hurley, T. D., Feb 1 2010, In : Nature Structural and Molecular Biology. 17, 2, p. 159-164 6 p.

Research output: Contribution to journalArticle

130 Scopus citations

Aldehyde dehydrogenase inhibitors: A comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application

Koppaka, V., Thompson, D. C., Chen, Y., Ellermann, M., Nicolaou, K. C., Juvonen, R. O., Petersen, D., Deitrich, R. A., Hurley, T. D. & Vasiliou Dr., V., Jul 2012, In : Pharmacological Reviews. 64, 3, p. 520-539 20 p.

Research output: Contribution to journalArticle

239 Scopus citations

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH High Melanoma-Initiating Cells

Sarvi, S., Crispin, R., Lu, Y., Zeng, L., Hurley, T. D., Houston, D. R., von Kriegsheim, A., Chen, C. H., Mochly-Rosen, D., Ranzani, M., Mathers, M. E., Xu, X., Xu, W., Adams, D. J., Carragher, N. O., Fujita, M., Schuchter, L., Unciti-Broceta, A., Brunton, V. G. & Patton, E. E., Dec 20 2018, In : Cell Chemical Biology. 25, 12, p. 1456-1469.e6

Research output: Contribution to journalArticle

12 Scopus citations

A multiple reaction monitoring method for absolute quantification of the human liver alcohol dehydrogenase ADH1C1 isoenzyme

Janecki, D. J., Bemis, K. G., Tegeler, T. J., Sanghani, P. C., Zhai, L., Hurley, T. D., Bosron, W. F. & Wang, M., Oct 1 2007, In : Analytical biochemistry. 369, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

85 Scopus citations

A new crystal form of mouse thiamin pyrophosphokinase

Liu, J. Y. & Hurley, T. D., Jun 10 2011, In : International Journal of Biochemistry and Molecular Biology. 2, 2, p. 111-118 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

A novel aldh1a1 inhibitor targets cells with stem cell characteristics in ovarian cancer

Nwani, N. G., Condello, S., Wang, Y., Swetzig, W. M., Barber, E., Hurley, T. & Matei, D., Apr 2019, In : Cancers. 11, 4, 502.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

Chefetz, I., Grimley, E., Yang, K., Hong, L., Vinogradova, E. V., Suciu, R., Kovalenko, I., Karnak, D., Morgan, C. A., Chtcherbinine, M., Buchman, C., Huddle, B., Barraza, S., Morgan, M., Bernstein, K. A., Yoon, E., Lombard, D. B., Bild, A., Mehta, G., Romero, I. & 6 others, Chiang, C. Y., Landen, C., Cravatt, B., Hurley, T. D., Larsen, S. D. & Buckanovich, R. J., Mar 12 2019, In : Cell Reports. 26, 11, p. 3061-3075.e6

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Catalytic contribution of threonine 244 in human ALDH2

González-Segura, L., Ho, K. K., Perez-Miller, S., Weiner, H. & Hurley, T. D., Feb 25 2013, In : Chemico-Biological Interactions. 202, 1-3, p. 32-40 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Catalytic Efficiency of Human Alcohol Dehydrogenases for Retinol Oxidation and Retinal Reduction

Yang, ZN. N., Davis, G. J., Hurley, T. D., Stone, C. L., Li, TK. K. & Bosron, W. F., Jun 1994, In : Alcoholism: Clinical and Experimental Research. 18, 3, p. 587-591 5 p.

Research output: Contribution to journalArticle

138 Scopus citations

cDNA sequence and catalytic properties of a chick embryo alcohol dehydrogenase that oxidizes retinol and 3β,5α-hydroxysteroids

Kedishvili, N. Y., Cough, W. H., Chernoff, E. A. G., Hurley, T. D., Stone, C. L., Bowman, K. D., Popov, K. M., Bosron, W. F. & Li, T. K., Mar 14 1997, In : Journal of Biological Chemistry. 272, 11, p. 7494-7500 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Characterization of human alcohol dehydrogenases containing substitutions at amino acids 47 and 51

Hurley, T. D., Ehrig, T., Edenberg, H. J. & Bosron, W. F., Jun 11 1991, In : Advances in experimental medicine and biology. 284, p. 271-275 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors

Morgan, C. A. & Hurley, T. D., Feb 26 2015, In : Journal of Medicinal Chemistry. 58, 4, p. 1964-1975 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Cimetidine Inhibition of Human Gastric and Liver Alcohol Dehydrogenase Isoenzymes: Identification of Inhibitor Complexes by Kinetics and Molecular Modeling

Stone, C. L., Hurley, T. D., Peggs, C. F., Kedishvili, N. Y., Davis, G. J., Thomasson, H. R., Li, T. K. & Bosron, W. F., Sep 1 1995, In : Biochemistry. 34, 12, p. 4008-4014 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Cloning and expression of a human stomach alcohol dehydrogenase isozyme

Kedishvili, N. Y., Bosron, W. F., Stone, C. L., Peggs, C. F., Thomasson, H. R., Popov, K. M., Carr, L. G., Hurley, T. D., Edenberg, H. J. & Li, T. K., Jan 1 1995, In : Advances in experimental medicine and biology. 372, p. 341-347 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase

Perez-Miller, S. J. & Hurley, T. D., Jun 17 2003, In : Biochemistry. 42, 23, p. 7100-7109 10 p.

Research output: Contribution to journalArticle

128 Scopus citations

Comparative roles of histidine-51 in human β1β1 and threonine-51 in ππ alcohol dehydrogenases

Davis, G. J., Carr, L. G., Hurley, T. D., Li, T. K. & Bosron, W. F., Jun 1994, In : Archives of Biochemistry and Biophysics. 311, 2, p. 307-312 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
18 Scopus citations

Crystallization and preliminary X-ray investigation of bovine liver mitochondrial aldehyde dehydrogenase

Hurley, T. D. & Weiner, H., Oct 20 1992, In : Journal of molecular biology. 227, 4, p. 1255-1257 3 p.

Research output: Contribution to journalArticle

9 Scopus citations
22 Scopus citations

Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin

Gibbons, B. J., Roach, P. J. & Hurley, T. D., Jan 1 2002, In : Journal of molecular biology. 319, 2, p. 463-477 15 p.

Research output: Contribution to journalArticle

99 Scopus citations

Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1

Morgan, C. A. & Hurley, T. D., Jun 5 2015, In : Chemico-Biological Interactions. 234, p. 29-37 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones

Kimble-Hill, A. C., Parajuli, B., Chen, C. H., Mochly-Rosen, D. & Hurley, T. D., Feb 13 2014, In : Journal of Medicinal Chemistry. 57, 3, p. 714-722 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity

Parajuli, B., Georgiadis, T. M., Fishel, M. L. & Hurley, T. D., Mar 21 2014, In : ChemBioChem. 15, 5, p. 701-712 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Differential effects of Mg2+ ions on the individual kinetic steps of human cytosolic and mitochondrial aldehyde dehydrogenases

Ho, K. K., Allali-Hassani, A., Hurley, T. D. & Weiner, H., Jun 7 2005, In : Biochemistry. 44, 22, p. 8022-8029 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Different mutations in the same codon of the proteolipid protein gene, PLP, may help in correlating genotype with phenotype in Pelizaeus-Merzbacher disease/X-linked spastic paraplegia (PMD/SPG2)

Hodes, M. E., Zimmerman, A. W., Aydanian, A., Naidu, S., Miller, N. R., Garcia Oller, J. L., Barker, B., Aleck, K. A., Hurley, T. D. & Dlouhy, S. R., Jan 15 1999, In : American journal of medical genetics. 82, 2, p. 132-139 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Direct detection of glycogenin reaction products during glycogen initiation

Hurley, T. D., Walls, C., Bennett, J. R., Roach, P. J. & Wang, M., Sep 22 2006, In : Biochemical and Biophysical Research Communications. 348, 2, p. 374-378 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase

Tang, B., Frasinyuk, M. S., Chikwana, V. M., Mahalingan, K. K., Morgan, C. A., Segvich, D. M., Bondarenko, S. P., Mrug, G. P., Wyrebek, P., Watt, D. S., Depaoli-Roach, A. A., Roach, P. J. & Hurley, T. D., Apr 9 2020, In : Journal of Medicinal Chemistry. 63, 7, p. 3538-3551 14 p.

Research output: Contribution to journalArticle

Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases

Khanna, M., Chen, C. H., Kimble-Hill, A., Parajuli, B., Perez-Miller, S., Baskaran, S., Kim, J., Dria, K., Vasiliou, V., Mochly-Rosen, D. & Hurley, T. D., Dec 16 2011, In : Journal of Biological Chemistry. 286, 50, p. 43486-43494 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors

Buchman, C. D., Mahalingan, K. K. & Hurley, T. D., Jun 5 2015, In : Chemico-Biological Interactions. 234, p. 38-44 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity

Wang, W. L., Chai, S. C., Huang, M., He, H. Z., Hurley, T. D. & Ye, Q. Z., Oct 9 2008, In : Journal of Medicinal Chemistry. 51, 19, p. 6110-6120 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Discovery of novel regulators of aldehyde dehydrogenase isoenzymes

Parajuli, B., Kimble-Hill, A. C., Khanna, M., Ivanova, Y., Meroueh, S. & Hurley, T. D., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 153-158 6 p.

Research output: Contribution to journalArticle

26 Scopus citations
63 Scopus citations

Enrichment of chemical libraries docked to protein conformational ensembles and application to aldehyde dehydrogenase 2

Wang, B., Buchman, C. D., Li, L., Hurley, T. D. & Meroueh, S. O., Jul 28 2014, In : Journal of Chemical Information and Modeling. 54, 7, p. 2105-2116 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Evaluation of the roles of the conserved residues of aldehyde dehydrogenase

Hurley, T. D. & Weiner, H., Dec 1 1999, In : Advances in Experimental Medicine and Biology. 463, p. 45-52 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase: Active-site amino acid sequence explains substrate specificity compared with liver isozymes

Kedishvili, N. Y., Bosron, W. F., Stone, C. L., Hurley, T. D., Peggs, C. F., Thomasson, H. R., Popov, K. M., Carr, L. G., Edenberg, H. J. & Li, T. K., Feb 24 1995, In : Journal of Biological Chemistry. 270, 8, p. 3625-3630 6 p.

Research output: Contribution to journalArticle

Open Access
75 Scopus citations
47 Scopus citations

Expression and purification of functional human glycogen synthase-1 (hGYS1) in insect cells

Khanna, M., Imasaki, T., Chikwana, V. M., Perez-Miller, S., Hunter, G. O., Mosley, A., Takagi, Y. & Hurley, T. D., Jun 20 2013, In : Protein Expression and Purification. 90, 2, p. 78-83 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

General Base Catalysis in a Glutamine for Histidine Mutant at Position 51 of Human Liver Alcohol Dehydrogenase

Ehrig, T., Hurley, T. D., Edenberg, H. J. & Bosron, W. F., Jan 1 1991, In : Biochemistry. 30, 4, p. 1062-1068 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

Genes encoding enzymes involved in ethanol metabolism

Hurley, T. D. & Edenberg, H. J., Dec 1 2011, In : Alcohol Research and Health. 34, 3, p. 339-344 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones

Perez-Miller, S., Zou, Q., Novotny, M. V. & Hurley, T. D., Aug 1 2010, In : Protein Science. 19, 8, p. 1469-1479 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Hominids adapted to metabolize ethanol long before human-directed fermentation

Carrigan, M. A., Uryasev, O., Frye, C. B., Eckman, B. L., Myers, C. R., Hurley, T. D. & Benner, S. A., Jan 13 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 2, p. 458-463 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Human alcohol dehydrogenase: Design of a secondary alcohol dehydrogenase using crystallography and mutagenesis

Hurley, T., Bosron, W. F. & Mario Amzel, L., 1993, In : Protein Engineering, Design and Selection. 6, p. 44 1 p.

Research output: Contribution to journalArticle

16 Scopus citations

Human glutathione-dependent formaldehyde dehydrogenase. Structural changes associated with ternary complex formation

Sanghani, P. C., Bosron, W. F. & Hurley, T. D., Dec 24 2002, In : Biochemistry. 41, 51, p. 15189-15194 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

Human glutathione-dependent formaldehyde dehydrogenase. Structures of apo, binary, and inhibitory ternary complexes

Sanghani, P. C., Robinson, H., Bosron, W. F. & Hurley, T. D., Sep 3 2002, In : Biochemistry. 41, 35, p. 10778-10786 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

Human liver mitochondrial aldehyde dehydrogenase: Three-dimensional structure and the restoration of solubility and activity of chimeric forms

Ni, L., Zhou, J., Hurley, T. D. & Weiner, H., Dec 1 1999, In : Protein Science. 8, 12, p. 2784-2790 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Hydrolysis of capecitabine to 5′-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide

Quinney, S. K., Sanghani, S. P., Davis, W. I., Hurley, T. D., Sun, Z., Murry, D. J. & Bosron, W. F., Jun 1 2005, In : Journal of Pharmacology and Experimental Therapeutics. 313, 3, p. 1011-1016 6 p.

Research output: Contribution to journalArticle

114 Scopus citations