Thomas Hurley

  • 4871 Citations
  • 40 h-Index
1979 …2021
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Publications 1990 2019

  • 4871 Citations
  • 40 h-Index
  • 104 Article
  • 2 Chapter
  • 1 Editorial
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470 Citations (Scopus)

Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart

Chen, C. H., Budas, G. R., Churchill, E. N., Disatnik, M. H., Hurley, T. & Mochly-Rosen, D., Sep 12 2008, In : Science. 321, 5895, p. 1493-1495 3 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Ischemia
Enzyme Activation
Aldehydes
Proteomics
5 Citations (Scopus)

A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase

Maile, C. A., Hingst, J. R., Mahalingan, K. K., O'Reilly, A. O., Cleasby, M. E., Mickelson, J. R., McCue, M. E., Anderson, S. M., Hurley, T., Wojtaszewski, J. F. P. & Piercy, R. J., Apr 19 2016, (Accepted/In press) In : Biochimica et Biophysica Acta - General Subjects.

Research output: Contribution to journalArticle

Glycogen Storage Disease
Glycogen Synthase
Glycogen
Horses
Chemical activation
17 Citations (Scopus)

Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: Synthesis of N-acyl glycinals

Aneetha, H., O'Dell, D. K., Tan, B., Walker, J. M. & Hurley, T., Jan 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 1, p. 237-241 5 p.

Research output: Contribution to journalArticle

Alcohol Dehydrogenase
Lipids
Oxidation
Physiological Phenomena
Endocannabinoids
110 Citations (Scopus)

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant

Perez-Miller, S., Younus, H., Vanam, R., Chen, C. H., Mochly-Rosen, D. & Hurley, T., Feb 2010, In : Nature Structural and Molecular Biology. 17, 2, p. 159-164 6 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Enzymes
Acrolein
Alcoholic Beverages
Environmental Pollutants
201 Citations (Scopus)

Aldehyde dehydrogenase inhibitors: A comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application

Koppaka, V., Thompson, D. C., Chen, Y., Ellermann, M., Nicolaou, K. C., Juvonen, R. O., Petersen, D., Deitrich, R. A., Hurley, T. & Vasiliou Dr., V., 2012, In : Pharmacological Reviews. 64, 3, p. 520-539 20 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Substrate Specificity
Pharmacology
Isoenzymes
Aldehydes
7 Citations (Scopus)

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells

Sarvi, S., Crispin, R., Lu, Y., Zeng, L., Hurley, T., Houston, D. R., von Kriegsheim, A., Chen, C. H., Mochly-Rosen, D., Ranzani, M., Mathers, M. E., Xu, X., Xu, W., Adams, D. J., Carragher, N. O., Fujita, M., Schuchter, L., Unciti-Broceta, A., Brunton, V. G. & Patton, E. E., Dec 20 2018, In : Cell Chemical Biology. 25, 12, p. 1456-1469.e6

Research output: Contribution to journalArticle

Melanoma
Nitrofurans
Prodrugs
Chemical activation
Neoplasms
84 Citations (Scopus)

A multiple reaction monitoring method for absolute quantification of the human liver alcohol dehydrogenase ADH1C1 isoenzyme

Janecki, D. J., Bemis, K. G., Tegeler, T. J., Sanghani, P. C., Zhai, L., Hurley, T., Bosron, W. F. & Wang, M., Oct 1 2007, In : Analytical Biochemistry. 369, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

Alcohol Dehydrogenase
Liver
Isoenzymes
Monitoring
Isotopes
2 Citations (Scopus)

A new crystal form of mouse thiamin pyrophosphokinase

Liu, J. Y. & Hurley, T., 2011, In : International Journal of Biochemistry and Molecular Biology. 2, 2, p. 111-118 8 p.

Research output: Contribution to journalArticle

Thiamin Pyrophosphokinase
Thiamine Pyrophosphate
Crystals
Thiamine
Adenosine Triphosphate
1 Citation (Scopus)

A novel aldh1a1 inhibitor targets cells with stem cell characteristics in ovarian cancer

Nwani, N. G., Condello, S., Wang, Y., Swetzig, W. M., Barber, E., Hurley, T. & Matei, D., Apr 1 2019, In : Cancers. 11, 4, 502.

Research output: Contribution to journalArticle

Open Access
Ovarian Neoplasms
Stem Cells
Aldehyde Dehydrogenase
DNA Damage
Cell Proliferation
4 Citations (Scopus)

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

Chefetz, I., Grimley, E., Yang, K., Hong, L., Vinogradova, E. V., Suciu, R., Kovalenko, I., Karnak, D., Morgan, C. A., Chtcherbinine, M., Buchman, C., Huddle, B., Barraza, S., Morgan, M., Bernstein, K. A., Yoon, E., Lombard, D. B., Bild, A., Mehta, G., Romero, I. & 6 others, Chiang, C. Y., Landen, C., Cravatt, B., Hurley, T., Larsen, S. D. & Buckanovich, R. J., Mar 12 2019, In : Cell Reports. 26, 11, p. 3061-3075.e6

Research output: Contribution to journalArticle

Open Access
Chemotherapy
Neoplastic Stem Cells
Ovarian Neoplasms
Aldehyde Dehydrogenase
Drug Therapy
2 Citations (Scopus)

Catalytic contribution of threonine 244 in human ALDH2

González-Segura, L., Ho, K. K., Perez-Miller, S., Weiner, H. & Hurley, T., Feb 25 2013, In : Chemico-Biological Interactions. 202, 1-3, p. 32-40 9 p.

Research output: Contribution to journalArticle

Coenzymes
Threonine
Niacinamide
Hydrides
NAD
135 Citations (Scopus)

Catalytic efficiency of human alcohol dehydrogenases for retinol oxidation and retinal reduction

Yang, Z. N., Davis, G. J., Hurley, T., Stone, C. L., Li, T. K. & Bosron, W. F., 1994, In : Alcoholism: Clinical and Experimental Research. 18, 3, p. 587-591 5 p.

Research output: Contribution to journalArticle

Alcohol Dehydrogenase
Vitamin A
Oxidation
Isoenzymes
Retinoids
32 Citations (Scopus)

cDNA sequence and catalytic properties of a chick embryo alcohol dehydrogenase that oxidizes retinol and 3β,5α-hydroxysteroids

Kedishvili, N. Y., Cough, W. H., Chernoff, E. A. G., Hurley, T., Stone, C. L., Bowman, K. D., Popov, K. M., Bosron, W. F. & Li, T. K., Mar 14 1997, In : Journal of Biological Chemistry. 272, 11, p. 7494-7500 7 p.

Research output: Contribution to journalArticle

Hydroxysteroids
Alcohol Dehydrogenase
Chick Embryo
Vitamin A
Complementary DNA
2 Citations (Scopus)

Characterization of human alcohol dehydrogenases containing substitutions at amino acids 47 and 51

Hurley, T., Ehrig, T., Edenberg, H. & Bosron, W. F., 1991, In : Advances in Experimental Medicine and Biology. 284, p. 271-275 5 p.

Research output: Contribution to journalArticle

Alcohol Dehydrogenase
Amino Acid Substitution
Site-Directed Mutagenesis
Recombinant Proteins
Histidine
21 Citations (Scopus)

Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors

Morgan, C. A. & Hurley, T., Feb 26 2015, In : Journal of Medicinal Chemistry. 58, 4, p. 1964-1975 12 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Aldehydes
Carboxylic Acids
Glycine
Cataract
22 Citations (Scopus)

Cimetidine inhibition of human gastric and liver alcohol dehydrogenase isoenzymes: Identification of inhibitor complexes by kinetics and molecular modeling

Stone, C. L., Hurley, T., Peggs, C. F., Kedishvili, N. Y., Davis, G. J., Thomasson, H. R., Li, T. K. & Bosron, W. F., 1995, In : Biochemistry. 34, 12, p. 4008-4014 7 p.

Research output: Contribution to journalArticle

Molecular modeling
Alcohol Dehydrogenase
Cimetidine
Liver
Isoenzymes
2 Citations (Scopus)

Cloning and expression of a human stomach alcohol dehydrogenase isozyme

Kedishvili, N. Y., Bosron, W. F., Stone, C. L., Peggs, C. F., Thomasson, H. R., Popov, K. M., Carr, L. G., Hurley, T., Edenberg, H. & Li, T. K., 1995, In : Advances in Experimental Medicine and Biology. 372, p. 341-347 7 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Bacteriophage lambda
Amino Acid Sequence Homology
Oligonucleotide Probes
Alcohol Dehydrogenase
122 Citations (Scopus)

Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase

Perez-Miller, S. J. & Hurley, T., Jun 17 2003, In : Biochemistry. 42, 23, p. 7100-7109 10 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Coenzymes
Isomerization
Catalysis
NAD
20 Citations (Scopus)

Comparative Roles of Histidine-51 in Human β1β1 and Threonine-51 in ππ Alcohol Dehydrogenases

Davis, G. J., Carr, L. G., Hurley, T., Li, T. K. & Bosron, W. F., Jun 1994, In : Archives of Biochemistry and Biophysics. 311, 2, p. 307-312 6 p.

Research output: Contribution to journalArticle

Alcohol Dehydrogenase
Threonine
Histidine
Ethanol
Protons
17 Citations (Scopus)
Aldehyde Dehydrogenase
Liver
NAD
Arginine
Mutation
9 Citations (Scopus)

Crystallization and preliminary X-ray investigation of bovine liver mitochondrial aldehyde dehydrogenase

Hurley, T. & Weiner, H., Oct 20 1992, In : Journal of Molecular Biology. 227, 4, p. 1255-1257 3 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Liver Mitochondrion
Crystallization
X-Ray Diffraction
NAD
20 Citations (Scopus)
Casein Kinase I
Catalytic Domain
Dimers
Protein Kinases
Escherichia coli
92 Citations (Scopus)

Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin

Gibbons, B. J., Roach, P. & Hurley, T., 2002, In : Journal of Molecular Biology. 319, 2, p. 463-477 15 p.

Research output: Contribution to journalArticle

Glycogen
Uridine Diphosphate Glucose
Glucose
Glycosyltransferases
4 alpha-glucanotransferase
18 Citations (Scopus)

Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1

Morgan, C. A. & Hurley, T., Jun 5 2015, In : Chemico-Biological Interactions. 234, p. 29-37 9 p.

Research output: Contribution to journalArticle

Assays
Throughput
Aldehyde Dehydrogenase
Esterases
Enzymes
18 Citations (Scopus)

Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones

Kimble-Hill, A. C., Parajuli, B., Chen, C. H., Mochly-Rosen, D. & Hurley, T., Feb 13 2014, In : Journal of Medicinal Chemistry. 57, 3, p. 714-722 9 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Isoenzymes
X Ray Crystallography
Structure-Activity Relationship
Metabolic Networks and Pathways
23 Citations (Scopus)

Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity

Parajuli, B., Georgiadis, T. M., Fishel, M. & Hurley, T., Mar 21 2014, In : ChemBioChem. 15, 5, p. 701-712 12 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Cytotoxicity
Cyclophosphamide
Cells
Isoenzymes
25 Citations (Scopus)

Differential effects of Mg2+ ions on the individual kinetic steps of human cytosolic and mitochondrial aldehyde dehydrogenases

Ho, K. K., Allali-Hassani, A., Hurley, T. & Weiner, H., Jun 7 2005, In : Biochemistry. 44, 22, p. 8022-8029 8 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Isoenzymes
Ions
NAD
Kinetics
27 Citations (Scopus)

Different mutations in the same codon of the proteolipid protein gene, PLP, may help in correlating genotype with phenotype in Pelizaeus-Merzbacher disease/X-linked spastic paraplegia (PMD/SPG2)

Hodes, M. E., Zimmerman, A. W., Aydanian, A., Naidu, S., Miller, N. R., Garcia Oller, J. L., Barker, B., Aleck, K. A., Hurley, T. & Dlouhy, S., Jan 15 1999, In : American Journal of Medical Genetics. 82, 2, p. 132-139 8 p.

Research output: Contribution to journalArticle

Pelizaeus-Merzbacher Disease
Proteolipids
Paraplegia
Codon
Genotype
11 Citations (Scopus)

Direct detection of glycogenin reaction products during glycogen initiation

Hurley, T., Walls, C., Bennett, J. R., Roach, P. & Wang, M., Sep 22 2006, In : Biochemical and Biophysical Research Communications. 348, 2, p. 374-378 5 p.

Research output: Contribution to journalArticle

Glycogen
Reaction products
Assays
1,4-alpha-Glucan Branching Enzyme
Glucose
37 Citations (Scopus)

Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases

Khanna, M., Chen, C. H., Kimble-Hill, A., Parajuli, B., Perez-Miller, S., Baskaran, S., Kim, J., Dria, K., Vasiliou, V., Mochly-Rosen, D. & Hurley, T., Dec 16 2011, In : Journal of Biological Chemistry. 286, 50, p. 43486-43494 9 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Enzymes
Enzyme Inhibitors
Metabolic Networks and Pathways
Ketones
4 Citations (Scopus)

Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors

Buchman, C. D., Mahalingan, K. K. & Hurley, T., Jun 5 2015, In : Chemico-Biological Interactions. 234, p. 38-44 7 p.

Research output: Contribution to journalArticle

Lactones
Isoenzymes
Oxidation
Aldehyde Dehydrogenase
Acetaldehyde
34 Citations (Scopus)

Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity

Wang, W. L., Chai, S. C., Huang, M., He, H. Z., Hurley, T. & Ye, Q., Oct 9 2008, In : Journal of Medicinal Chemistry. 51, 19, p. 6110-6120 11 p.

Research output: Contribution to journalArticle

Aminopeptidases
Methionine
Escherichia coli
Metals
Ions
25 Citations (Scopus)

Discovery of novel regulators of aldehyde dehydrogenase isoenzymes

Parajuli, B., Kimble-Hill, A. C., Khanna, M., Ivanova, Y., Meroueh, S. & Hurley, T., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 153-158 6 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Isoenzymes
Screening
Chemical activation
Oncology
60 Citations (Scopus)

Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant

Larson, H. N., Weiner, H. & Hurley, T., Aug 26 2005, In : Journal of Biological Chemistry. 280, 34, p. 30550-30556 7 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Coenzymes
Dimers
Crystal structure
Binding Sites
5 Citations (Scopus)

Enrichment of chemical libraries docked to protein conformational ensembles and application to aldehyde dehydrogenase 2

Wang, B., Buchman, C. D., Li, L., Hurley, T. & Meroueh, S., Jul 28 2014, In : Journal of Chemical Information and Modeling. 54, 7, p. 2105-2116 12 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Aldehydes
Molecular dynamics
Proteins
Crystal structure
4 Citations (Scopus)

Evaluation of the roles of the conserved residues of aldehyde dehydrogenase

Hurley, T. & Weiner, H., 1999, In : Advances in Experimental Medicine and Biology. 463, p. 45-52 8 p.

Research output: Contribution to journalArticle

Recombinant Fusion Proteins
Mutagenesis
Aldehyde Dehydrogenase
Conserved Sequence
Threonine
75 Citations (Scopus)

Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase: Active-site amino acid sequence explains substrate specificity compared with liver isozymes

Kedishvili, N. Y., Bosron, W. F., Stone, C. L., Hurley, T., Peggs, C. F., Thomasson, H. R., Popov, K. M., Carr, L. G., Edenberg, H. & Li, T. K., Feb 24 1995, In : Journal of Biological Chemistry. 270, 8, p. 3625-3630 6 p.

Research output: Contribution to journalArticle

Alcohol Dehydrogenase
Substrate Specificity
Liver
Isoenzymes
Amino Acid Sequence
47 Citations (Scopus)
Alcohol Dehydrogenase
Amino Acid Substitution
Substitution reactions
Amino Acids
Kinetics
5 Citations (Scopus)

Expression and purification of functional human glycogen synthase-1 (hGYS1) in insect cells

Khanna, M., Imasaki, T., Chikwana, V. M., Perez-Miller, S., Hunter, G. O., Mosley, A., Takagi, Y. & Hurley, T., 2013, In : Protein Expression and Purification. 90, 2, p. 78-83 6 p.

Research output: Contribution to journalArticle

Glycogen Synthase
Insects
Phosphorylation
Glucose-6-Phosphate
Baculoviridae
46 Citations (Scopus)

General Base Catalysis in a Glutamine for Histidine Mutant at Position 51 of Human Liver Alcohol Dehydrogenase

Ehrig, T., Hurley, T., Edenberg, H. & Bosron, W. F., 1991, In : Biochemistry. 30, 4, p. 1062-1068 7 p.

Research output: Contribution to journalArticle

Alcohol Dehydrogenase
Glutamine
Catalysis
Histidine
Liver
38 Citations (Scopus)

Genes encoding enzymes involved in ethanol metabolism

Hurley, T. & Edenberg, H., 2011, In : Alcohol Research and Health. 34, 3, p. 339-344 6 p.

Research output: Contribution to journalArticle

Acetaldehyde
Ethanol
Alcoholism
Aldehyde Dehydrogenase
Alcohol Dehydrogenase
243 Citations (Scopus)

Glycogen and its metabolism: Some new developments and old themes

Roach, P., De Paoli-Roach, A., Hurley, T. & Tagliabracci, V. S., Feb 1 2012, In : Biochemical Journal. 441, 3, p. 763-787 25 p.

Research output: Contribution to journalArticle

Glycogen
Metabolism
Glycogen Synthase
Epinephrine
Lafora Disease
17 Citations (Scopus)

High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones

Perez-Miller, S., Zou, Q., Novotny, M. V. & Hurley, T., Aug 2010, In : Protein Science. 19, 8, p. 1469-1479 11 p.

Research output: Contribution to journalArticle

Pheromones
Nose
Protein Isoforms
X-Rays
X rays
28 Citations (Scopus)

Hominids adapted to metabolize ethanol long before human-directed fermentation

Carrigan, M. A., Uryasev, O., Frye, C. B., Eckman, B. L., Myers, C. R., Hurley, T. & Benner, S. A., Jan 13 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 2, p. 458-463 6 p.

Research output: Contribution to journalArticle

Hominidae
Fermentation
Ethanol
Primates
Fruit

Human alcohol dehydrogenase: Design of a secondary alcohol dehydrogenase using crystallography and mutagenesis

Hurley, T., Bosron, W. F. & Mario Amzel, L., 1993, In : Protein Engineering, Design and Selection. 6, p. 44 1 p.

Research output: Contribution to journalArticle

Mutagenesis
Crystallography
Alcohol Dehydrogenase
Alcohols
isopropanol dehydrogenase (NADP)
16 Citations (Scopus)
Alcohol Dehydrogenase
Alcoholism
Alcohols
Amino Acids
Oxidation
43 Citations (Scopus)

Human glutathione-dependent formaldehyde dehydrogenase. Structural changes associated with ternary complex formation

Sanghani, P. C., Bosron, W. F. & Hurley, T., Dec 24 2002, In : Biochemistry. 41, 51, p. 15189-15194 6 p.

Research output: Contribution to journalArticle

glutathione-independent formaldehyde dehydrogenase
Coenzymes
Glutathione
Zinc
Catalytic Domain
56 Citations (Scopus)

Human glutathione-dependent formaldehyde dehydrogenase. Structures of apo, binary, and inhibitory ternary complexes

Sanghani, P. C., Robinson, H., Bosron, W. F. & Hurley, T., Sep 3 2002, In : Biochemistry. 41, 35, p. 10778-10786 9 p.

Research output: Contribution to journalArticle

glutathione-independent formaldehyde dehydrogenase
Glutathione
Zinc
Catalytic Domain
Substrates
63 Citations (Scopus)

Human liver mitochondrial aldehyde dehydrogenase: Three-dimensional structure and the restoration of solubility and activity of chimeric forms

Ni, L., Zhou, J., Hurley, T. & Weiner, H., 1999, In : Protein Science. 8, 12, p. 2784-2790 7 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Liver
Solubility
Restoration
Isoenzymes