Thomas Hurley

  • 5408 Citations
  • 42 h-Index
1979 …2020

Research output per year

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Publications

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Identification and analysis of single-nucleotide polymorphisms in the gemcitabine pharmacologic pathway

Fukunaga, A. K., Marsh, S., Murry, D. J., Hurley, T. D. & McLeod, H. L., Oct 20 2004, In : Pharmacogenomics Journal. 4, 5, p. 307-314 8 p.

Research output: Contribution to journalArticle

81 Scopus citations

Incorporation of phosphate into glycogen by glycogen synthase

Contreras, C. J., Segvich, D. M., Mahalingan, K., Chikwana, V. M., Kirley, T. L., Hurley, T. D., DePaoli-Roach, A. A. & Roach, P. J., May 1 2016, In : Archives of Biochemistry and Biophysics. 597, p. 21-29 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal

Doorn, J. A., Hurley, T. D. & Petersen, D. R., Jan 1 2006, In : Chemical Research in Toxicology. 19, 1, p. 102-110 9 p.

Research output: Contribution to journalArticle

88 Scopus citations

Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives

Buchman, C. D. & Hurley, T. D., Mar 23 2017, In : Journal of Medicinal Chemistry. 60, 6, p. 2439-2455 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

Inhibition of the oxidative metabolism of 3,4-dihydroxyphenylacetaldehyde, a reactive intermediate of dopamine metabolism, by 4-hydroxy-2-nonenal

Florang, V. R., Rees, J. N., Brogden, N. K., Anderson, D. G., Hurley, T. D. & Doorn, J. A., Jan 1 2007, In : NeuroToxicology. 28, 1, p. 76-82 7 p.

Research output: Contribution to journalArticle

45 Scopus citations
52 Scopus citations

Kinetic mechanism of human glutathione-dependent formaldehyde dehydrogenase

Sanghani, P. C., Stone, C. L., Ray, B. D., Pindel, E. V., Hurley, T. D. & Bosron, W. F., Sep 5 2000, In : Biochemistry. 39, 35, p. 10720-10729 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells

Li, J., Condello, S., Thomes-Pepin, J., Ma, X., Xia, Y., Hurley, T. D., Matei, D. & Cheng, J. X., Mar 2 2017, In : Cell Stem Cell. 20, 3, p. 303-314.e5

Research output: Contribution to journalArticle

147 Scopus citations

Methionine-141 directly influences the binding of 4-methylpyrazole in human σσ alcohol dehydrogenase

Xie, P. T. & Hurley, T. D., 1999, In : Protein Science. 8, 12, p. 2639-2644 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1

Sun, Z., Murry, D. J., Sanghani, S. P., Davis, W. I., Kedishvili, N. Y., Zou, Q., Hurley, T. D. & Bosron, W. F., Aug 2004, In : Journal of Pharmacology and Experimental Therapeutics. 310, 2, p. 469-476 8 p.

Research output: Contribution to journalArticle

146 Scopus citations
27 Scopus citations

Multiple conformations of NAD and NADH when bound to human cytosolic and mitochondrial aldehyde dehydrogenase

Hammen, P. K., Allali-Hassani, A., Hallenga, K., Hurley, T. D. & Weiner, H., Jun 4 2002, In : Biochemistry. 41, 22, p. 7156-7168 13 p.

Research output: Contribution to journalArticle

65 Scopus citations

Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen

Baskaran, S., Chikwana, V. M., Contreras, C. J., Davis, K. D., Wilson, W. A., DePaoli-Roach, A. A., Roach, P. J. & Hurley, T. D., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 33999-34006 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes

Morgan, C. A., Parajuli, B., Buchman, C. D., Dria, K. & Hurley, T. D., Jun 5 2015, In : Chemico-Biological Interactions. 234, p. 18-28 11 p.

Research output: Contribution to journalArticle

50 Scopus citations

Order and disorder in mitochondrial aldehyde dehydrogenase

Hurley, T. D., Perez-Miller, S. & Breen, H., Jan 30 2001, In : Chemico-Biological Interactions. 130-132, p. 3-14 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Phosphate incorporation during glycogen synthesis and Lafora disease

Tagliabracci, V. S., Heiss, C., Karthik, C., Contreras, C. J., Glushka, J., Ishihara, M., Azadi, P., Hurley, T. D., Depaoli-Roach, A. A. & Roach, P. J., Mar 2 2011, In : Cell Metabolism. 13, 3, p. 274-282 9 p.

Research output: Contribution to journalArticle

77 Scopus citations

Pyrithiamine as a substrate for thiamine pyrophosphokinase

Liu, J. Y., Timm, D. E. & Hurley, T. D., Mar 10 2006, In : Journal of Biological Chemistry. 281, 10, p. 6601-6607 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Redox switch for the inhibited state of yeast glycogen synthase mimics regulation by phosphorylation

Mahalingan, K. K., Baskaran, S., Depaoli-Roach, A. A., Roach, P. J. & Hurley, T. D., Jan 1 2017, In : Biochemistry. 56, 1, p. 179-188 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Relative inhibitory potency of molinate and metabolites with aldehyde dehydrogenase 2: Implications for the mechanism of enzyme inhibition

Allen, E. M. G., Anderson, D. G. R., Florang, V. R., Khanna, M., Hurley, T. D. & Doorn, J. A., Nov 15 2010, In : Chemical Research in Toxicology. 23, 11, p. 1843-1850 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Requirements for catalysis in mammalian glycogenin

Hurley, T. D., Stout, S., Miner, E., Zhou, J. & Roach, P. J., Jun 24 2005, In : Journal of Biological Chemistry. 280, 25, p. 23892-23899 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells

Parajuli, B., Fishel, M. L. & Hurley, T. D., Jan 23 2014, In : Journal of Medicinal Chemistry. 57, 2, p. 449-461 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Selective alteration of the rate-limiting step in cytosolic aldehyde dehydrogenase through random mutagenesis

Ho, K. K., Hurley, T. D. & Weiner, H., Aug 8 2006, In : Biochemistry. 45, 31, p. 9445-9453 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: Kinetics, crystal structure and pharmacokinetics

Bateman, R. L., Ashworth, J., Witte, J. F., Baker, L. J., Bhanumoorthy, P., Timm, D. E., Hurley, T. D., Grompe, M. & McClard, R. W., Mar 1 2007, In : Biochemical Journal. 402, 2, p. 251-260 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
5 Scopus citations

Structural and functional consequences of coenzyme binding to the inactive Asian variant of mitochondrial aldehyde dehydrogenase: Roles of residues 475 and 487

Larson, H. N., Zhou, J., Chen, Z., Stamler, J. S., Weiner, H. & Hurley, T. D., Apr 27 2007, In : Journal of Biological Chemistry. 282, 17, p. 12940-12950 11 p.

Research output: Contribution to journalArticle

71 Scopus citations

Structural basis for 2'-phosphate incorporation into glycogen by glycogen synthase

Chikwana, V. M., Khanna, M., Baskaran, S., Tagliabracci, V. S., Contreras, C. J., DePaoli-Roach, A., Roach, P. J. & Hurley, T. D., Dec 24 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 52, p. 20976-20981 6 p.

Research output: Contribution to journalArticle

15 Scopus citations
49 Scopus citations

Structural basis for regulation of protein phosphatase 1 by inhibitor-2

Hurley, T. D., Yang, J., Zhang, L., Goodwin, K. D., Zou, Q., Cortese, M., Dunker, A. K. & DePaoli-Roach, A. A., Sep 28 2007, In : Journal of Biological Chemistry. 282, 39, p. 28874-28883 10 p.

Research output: Contribution to journalArticle

131 Scopus citations

Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy

Huddle, B. C., Grimley, E., Buchman, C. D., Chtcherbinine, M., Debnath, B., Mehta, P., Yang, K., Morgan, C. A., Li, S., Felton, J., Sun, D., Mehta, G., Neamati, N., Buckanovich, R. J., Hurley, T. D. & Larsen, S. D., Oct 11 2018, In : Journal of Medicinal Chemistry. 61, 19, p. 8754-8773 20 p.

Research output: Contribution to journalArticle

15 Scopus citations

Structure-function relationships in human Class III alcohol dehydrogenase (formaldehyde dehydrogenase)

Sanghani, P. C., Robinson, H., Bennett-Lovsey, R., Hurley, T. D. & Bosron, W. F., Feb 1 2003, In : Chemico-Biological Interactions. 143-144, p. 195-200 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Structure of human β1β1 alcohol dehydrogenase: Catalytic effects of non-active-site substitutions

Hurley, T. D., Bosron, W. F., Hamilton, J. A. & Mario Amzel, L., Jan 1 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 18, p. 8149-8153 5 p.

Research output: Contribution to journalArticle

Open Access
76 Scopus citations

Structure of human χχ alcohol dehydrogenase: A glutathione-dependent formaldehyde dehydrogenase

Yang, Z. N., Bosron, W. F. & Hurley, T. D., Jan 1 1997, In : Journal of molecular biology. 265, 3, p. 330-343 14 p.

Research output: Contribution to journalArticle

75 Scopus citations

Structure of mitochondrial aldehyde dehydrogenase: The genetic component of ethanol aversion

Steinmetz, C. G., Xie, P., Weiner, H. & Hurley, T. D., Jan 1 1997, In : Structure. 5, 5, p. 701-711 11 p.

Research output: Contribution to journalArticle

Open Access
275 Scopus citations

Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors

Gibbons, B. J. & Hurley, T. D., Oct 5 2004, In : Biochemistry. 43, 39, p. 12555-12562 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Structures of three human β alcohol dehydrogenase variants: Correlations with their functional differences

Hurley, T. D., Bosron, W. F., Stone, C. L. & Amzel, L. M., Jun 9 1994, In : Journal of molecular biology. 239, 3, p. 415-429 15 p.

Research output: Contribution to journalArticle

68 Scopus citations

Studies on the regulation of the mitochondrial α-ketoacid dehydrogenase complexes and their kinases

Harris, R. A., Hawes, J. W., Popov, K. M., Zhao, Y., Shimomura, Y., Sato, J., Jaskiewicz, J. & Hurley, T. D., Sep 15 1997, In : Advances in Enzyme Regulation. 37, p. 271-293 23 p.

Research output: Contribution to journalArticle

85 Scopus citations

Suicide gene therapy: Conversion of ethanol to acetaldehyde mediated by human beta 2 alcohol dehydrogenase

Savage, P., Cowburn, P., Clemens, D., Hurley, T., Laguda, B., Martin-Duque, P., Vassaux, G. & Lemoine, N. R., Dec 1 2004, In : Cancer gene therapy. 11, 12, p. 774-781 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase

González-Segura, L., Witte, J. F., McClard, R. W. & Hurley, T. D., Dec 11 2007, In : Biochemistry. 46, 49, p. 14075-14086 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic

Gentry, M. S., Afawi, Z., Armstrong, D. D., Delgado-Escueta, A., Goldberg, Y. P., Grossman, T. R., Guinovart, J. J., Harris, F., Hurley, T. D., Michelucci, R., Minassian, B. A., Sanz, P., Worby, C. A. & Serratosa, J. M., Feb 2020, In : Epilepsy and Behavior. 103, 106839.

Research output: Contribution to journalArticle

1 Scopus citations

The natural history of class I primate alcohol dehydrogenases includes gene duplication, gene loss, and gene conversion

Carrigan, M. A., Uryasev, O., Davis, R. P., Zhai, L. M., Hurley, T. D. & Benner, S. A., Jul 31 2012, In : PLoS ONE. 7, 7, e41175.

Research output: Contribution to journalArticle

14 Scopus citations

The pH-dependent binding of NADH and subsequent enzyme isomerization of human liver β3β3 alcohol dehydrogenase

Stone, C. L., Jipping, M. B., Owusu-Dekyi, K., Hurley, T. D., Li, T. K. & Bosron, W. F., May 4 1999, In : Biochemistry. 38, 18, p. 5829-5835 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

The potential roles of the conserved amino acids in human liver mitochondrial aldehyde dehydrogenase

Sheikh, S., Ni, L., Hurley, T. D. & Weiner, H., Aug 12 1997, In : Journal of Biological Chemistry. 272, 30, p. 18817-18822 6 p.

Research output: Contribution to journalArticle

69 Scopus citations

The role of leucine 116 in determining substrate specificity in human B1 alcohol dehydrogenase

Hurley, T. D. & Vessell, D. L., 1995, In : Advances in experimental medicine and biology. 372, p. 321-325 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum

Akin, B. L., Hurley, T. D., Chen, Z. & Jones, L. R., Oct 18 2013, In : Journal of Biological Chemistry. 288, 42, p. 30181-30191 11 p.

Research output: Contribution to journalArticle

60 Scopus citations

Three-dimensional structure of mammalian casein kinase I: Molecular basis for phosphate recognition

Longenecker, K. L., Roach, P. J. & Hurley, T. D., Apr 5 1996, In : Journal of molecular biology. 257, 3, p. 618-631 14 p.

Research output: Contribution to journalArticle

100 Scopus citations

Three-dimensional structure of mitochondrial aldehyde dehydrogenase: Mechanistic implications

Hurley, T. D., Steinmetz, C. G. & Weiner, H., Jan 1 1999, In : Advances in experimental medicine and biology. 463, p. 15-25 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Three-dimensional structures of human alcohol dehydrogenase isoenzymes reveal the molecular basis for their functional diversity

Hurley, T. D., Steinmetz, C. G., Xie, P. & Yang, Z. N., Apr 1 1997, In : Advances in experimental medicine and biology. 414, p. 291-302 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Three-dimensional structures of the three human class I alcohol dehydrogenases

Niederhut, M. S., Gibbons, B. J., Perez-Miller, S. & Hurley, T. D., Apr 5 2001, In : Protein Science. 10, 4, p. 697-706 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Tryptophan fluorescence quenching by alkaline pH and ternary complex formation in human β1β1 and horse EE alcohol dehydrogenases

Ehrig, T., Muhoberac, B. B., Hurley, T. D. & Bosron, W. F., Apr 6 1992, In : FEBS Letters. 300, 3, p. 283-285 3 p.

Research output: Contribution to journalArticle

2 Scopus citations
37 Scopus citations