Timothy Sutton

  • 2488 Citations
  • 21 h-Index
1988 …2018
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Publications 1988 2018

  • 2488 Citations
  • 21 h-Index
  • 39 Article
  • 1 Review article
2018
3 Citations (Scopus)

Live-Animal Imaging of Renal Function by Multiphoton Microscopy

Dunn, K., Sutton, T. & Sandoval, R. M., Jan 18 2018, In : Current Protocols in Cytometry. 83, p. 12.9.1-12.9.25

Research output: Contribution to journalArticle

Microscopy
Microscopic examination
Animals
Kidney
Fluorescent Dyes
1 Citation (Scopus)

Quantitative Large-Scale Three-Dimensional Imaging of Human Kidney Biopsies: A Bridge to Precision Medicine in Kidney Disease

Winfree, S., Dagher, P., Dunn, K., Eadon, M., Ferkowicz, M., Barwinska, D., Kelly, K., Sutton, T. & Ashkar (El-Achkar), T., Jun 5 2018, (Accepted/In press) In : Nephron. p. 1-6 6 p.

Research output: Contribution to journalArticle

Precision Medicine
Three-Dimensional Imaging
Kidney Diseases
Kidney
Biopsy
2017
7 Citations (Scopus)

Endothelial STAT3 Modulates Protective Mechanisms in a Mouse Ischemia-Reperfusion Model of Acute Kidney Injury

Dube, S., Matam, T., Yen, J., Mang, H. E., Dagher, P., Hato, T. & Sutton, T., Jan 1 2017, In : Journal of Immunology Research. 2017, 4609502.

Research output: Contribution to journalArticle

Acute Kidney Injury
Reperfusion
Ischemia
Kidney
Wounds and Injuries
3 Citations (Scopus)

Large-scale 3-dimensional quantitative imaging of tissues: State-of-the-art and translational implications

Winfree, S., Ferkowicz, M. J., Dagher, P., Kelly, K., Eadon, M., Sutton, T., Markel, T. A., Yoder, M., Dunn, K. & Ashkar (El-Achkar), T., 2017, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

Tissue
Imaging techniques
Research Personnel
Technology
Precision Medicine
4 Citations (Scopus)

Novel roles for mucin 1 in the kidney

Al-Bataineh, M. M., Sutton, T. & Hughey, R. P., Sep 1 2017, In : Current Opinion in Nephrology and Hypertension. 26, 5, p. 384-391 8 p.

Research output: Contribution to journalReview article

Mucin-1
Kidney
Hypoxia-Inducible Factor 1
Catenins
Mucins
10 Citations (Scopus)

Quantitative three-dimensional tissue cytometry to study kidney tissue and resident immune cells

Winfree, S., Khan, S., Micanovic, R., Eadon, M., Kelly, K., Sutton, T., Phillips, C., Dunn, K. & Ashkar (El-Achkar), T., Jul 1 2017, In : Journal of the American Society of Nephrology. 28, 7, p. 2108-2118 11 p.

Research output: Contribution to journalArticle

Kidney
Flow Cytometry
Software
Biopsy
Spatial Analysis
2016
6 Citations (Scopus)

Inhibition of Toll-Like Receptor 4 Signaling Mitigates Microvascular Loss but Not Fibrosis in a Model of Ischemic Acute Kidney Injury

Dagher, P., Hato, T., Mang, H. E., Plotkin, Z., Richardson, Q. V., Massad, M., Mai, E., Kuehl, S. E., Graham, P., Kumar, R. & Sutton, T., Apr 29 2016, In : International Journal of Molecular Sciences. 17, 5

Research output: Contribution to journalArticle

fibrosis
Toll-Like Receptor 4
kidneys
Acute Kidney Injury
Fibrosis
13 Citations (Scopus)

Muc1 enhances the β-catenin protective pathway during ischemia-reperfusion injury

Al-Bataineh, M. M., Kinlough, C. L., Poland, P. A., Pastor-Soler, N. M., Sutton, T., Mang, H. E., Bastacky, S. I., Gendler, S. J., Madsen, C. S., Singh, S., Monga, S. P. & Hughey, R. P., Mar 15 2016, In : American Journal of Physiology - Renal Physiology. 310, 6, p. F569-F579

Research output: Contribution to journalArticle

Catenins
Reperfusion Injury
Hypoxia-Inducible Factor 1
Kidney
Knockout Mice
8 Citations (Scopus)

Novel application of complementary imaging techniques to examine in vivo glucose metabolism in the kidney

Hato, T., Friedman, A., Mang, H., Plotkin, Z., Dube, S., Hutchins, G., Territo, P., McCarthy, B. P., Riley, A. A., Pichumani, K., Malloy, C. R., Harris, R., Dagher, P. & Sutton, T., Apr 15 2016, In : American Journal of Physiology - Renal Physiology. 310, 8, p. F717-F725

Research output: Contribution to journalArticle

Positron-Emission Tomography
Kidney
Glucose
Glycolysis
Pharmacology
2015
17 Citations (Scopus)

Muc1 is protective during kidney ischemia - Reperfusion injury

Pastor-Soler, N. M., Sutton, T., Mang, H. E., Kinlough, C. L., Gendler, S. J., Madsen, C. S., Bastacky, S. I., Ho, J., Al-Bataineh, M. M., Hallows, K. R., Singh, S., Monga, S. P., Kobayashi, H., Haase, V. H. & Hughey, R. P., Jun 15 2015, In : American Journal of Physiology - Renal Physiology. 308, 12, p. F1452-F1462

Research output: Contribution to journalArticle

Mucin-1
Reperfusion Injury
Kidney
Hypoxia-Inducible Factor 1
Transcription Factors
2014
72 Citations (Scopus)

Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury

Kapitsinou, P. P., Sano, H., Michael, M., Kobayashi, H., Davidoff, O., Bian, A., Yao, B., Zhang, M. Z., Harris, R. C., Duffy, K. J., Erickson-Miller, C. L., Sutton, T. & Haase, V. H., Jun 2 2014, In : Journal of Clinical Investigation. 124, 6, p. 2396-2409 14 p.

Research output: Contribution to journalArticle

Kidney
Wounds and Injuries
Prolyl-Hydroxylase Inhibitors
Fibrosis
Integrin alpha4beta1
2013
56 Citations (Scopus)

p53 is renoprotective after ischemic kidney injury by reducing inflammation

Sutton, T., Hato, T., Mai, E., Yoshimoto, M., Kuehl, S., Anderson, M., Mang, H., Plotkin, Z., Chan, R. & Dagher, P., Dec 28 2013, In : Journal of the American Society of Nephrology. 24, 1, p. 113-124 12 p.

Research output: Contribution to journalArticle

Inflammation
Kidney
Wounds and Injuries
Leukocytes
Anti-Inflammatory Agents
2012
5 Citations (Scopus)
ADAM Proteins
Tissue Inhibitor of Metalloproteinase-3
Pericytes
Kidney Diseases
Blood Vessels

Functional studies in living animals using multiphoton microscopy

Dunn, K. & Sutton, T., 2012, In : ILAR Journal. 53, 1, p. 66-77 12 p.

Research output: Contribution to journalArticle

Microscopy
microscopy
Physiology
Microscopic examination
Animals
12 Citations (Scopus)
Microscopy
Microscopic examination
Animals
Kidney
Fluorescent Dyes
307 Citations (Scopus)

Pathophysiology of acute kidney injury

Basile, D., Anderson, M. & Sutton, T., Apr 2012, In : Comprehensive Physiology. 2, 2, p. 1303-1353 51 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Renal Circulation
Wounds and Injuries
Glomerular Filtration Rate
Chronic Renal Insufficiency
13 Citations (Scopus)

Soluble thrombomodulin reduces inflammation and prevents microalbuminuria induced by chronic endothelial activation in transgenic mice

Rajashekhar, G., Gupta, A., Marin, A., Friedrich, J., Willuweit, A., Berg, D. T., Cramer, M. S., Sandusky, G., Sutton, T., Basile, D., Grinnell, B. W. & Clauss, M., Mar 2012, In : American Journal of Physiology - Renal Physiology. 302, 6

Research output: Contribution to journalArticle

Thrombomodulin
Transgenic Mice
Inflammation
Chronic Renal Insufficiency
Chemokines
37 Citations (Scopus)

The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury

Dagher, P., Mai, E. M., Hato, T., Lee, S. Y., Anderson, M., Karozos, S. C., Mang, H. E., Knipe, N. L., Plotkin, Z. & Sutton, T., Jan 2012, In : American Journal of Physiology - Renal Physiology. 302, 2

Research output: Contribution to journalArticle

Acute Kidney Injury
Fibrosis
Appointments and Schedules
Epithelial-Mesenchymal Transition
Renal Artery
2011
3 Citations (Scopus)

Fueling the fire in acute kidney injury: Endothelial cells collect their Toll

Sutton, T. & Dagher, P., Feb 2011, In : Kidney International. 79, 3, p. 267-269 3 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Acute Kidney Injury
Endothelial Cells
Kidney Medulla
Inflammation
176 Citations (Scopus)

Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury

Basile, D., Friedrich, J. L., Spahic, J., Knipe, N., Mang, H., Leonard, E. C., Changizi-Ashtiyani, S., Bacallao, R., Molitoris, B. & Sutton, T., Mar 1 2011, In : American Journal of Physiology - Renal Physiology. 300, 3

Research output: Contribution to journalArticle

Acute Kidney Injury
Blood Vessels
Endothelial Cells
Vascular Endothelial Growth Factor A
Bromodeoxyuridine
33 Citations (Scopus)

MMP-9 gene deletion mitigates microvascular loss in a model of ischemic acute kidney injury

Lee, S. Y., Hörbelt, M., Mang, H. E., Knipe, N. L., Bacallao, R., Sado, Y. & Sutton, T., Jul 2011, In : American Journal of Physiology - Renal Physiology. 301, 1

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Gene Deletion
Acute Kidney Injury
Vascular Endothelial Growth Factor A
Wounds and Injuries
2009
60 Citations (Scopus)

Alteration of microvascular permeability in acute kidney injury

Sutton, T., Jan 2009, In : Microvascular Research. 77, 1, p. 4-7 4 p.

Research output: Contribution to journalArticle

Capillary Permeability
Acute Kidney Injury
Microvessels
Kidney
Inflammation
2008

Combining microscopy with in vivo imaging

Sutton, T. & Dunn, K., Apr 15 2008, In : Genetic Engineering and Biotechnology News. 28, 8

Research output: Contribution to journalArticle

Microscopic examination
Imaging techniques
Imaging
Intravital Microscopy
27 Citations (Scopus)

Functional studies in living animals using multiphoton microscopy

Dunn, K. & Sutton, T., 2008, In : ILAR Journal. 49, 1, p. 66-77 12 p.

Research output: Contribution to journalArticle

Microscopy
microscopy
Physiology
Microscopic examination
Animals
28 Citations (Scopus)

p53 regulates renal expression of HIF-1α and pVHL under physiological conditions and after ischemia-reperfusion injury

Sutton, T., Wilkinson, J., Mang, H. E., Knipe, N. L., Plotkin, Z., Hosein, M., Zak, K., Wittenborn, J. & Dagher, P., Dec 2008, In : American Journal of Physiology - Renal Physiology. 295, 6

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Reperfusion Injury
Kidney
Extremities
Acute Kidney Injury
63 Citations (Scopus)
Pericytes
Acute Kidney Injury
Kidney
Endothelial Cells
Renal Circulation
2007
108 Citations (Scopus)

Acute and chronic microvascular alterations in a mouse model of ischemic acute kidney injury

Hörbelt, M., Lee, S. Y., Mang, H. E., Knipe, N. L., Sado, Y., Kribben, A. & Sutton, T., Sep 2007, In : American Journal of Physiology - Renal Physiology. 293, 3

Research output: Contribution to journalArticle

Acute Kidney Injury
Wounds and Injuries
Endothelial Cells
Capillary Permeability
Angiopoietin-2
8 Citations (Scopus)
Microscopy
Microscopic examination
Animals
Kidney
Fluorescent Dyes
14 Citations (Scopus)

Organic cation transport in the rat kidney in vivo visualized by time-resolved two-photon microscopy

Hörbelt, M., Wotzlaw, C., Sutton, T., Molitoris, B., Philipp, T., Kribben, A., Fandrey, J. & Pietruck, F., Aug 2007, In : Kidney International. 72, 4, p. 422-429 8 p.

Research output: Contribution to journalArticle

Photons
Cations
Microscopy
Fluorescence
Kidney
2006
8 Citations (Scopus)

Imaging vascular pathology

Sutton, T., Hörbelt, M. & Sandoval, R. M., Mar 2006, In : Nephron. Physiology. 103, 2

Research output: Contribution to journalArticle

Blood Vessels
Pathology
Kidney
Intravital Microscopy
2005
102 Citations (Scopus)

Minocycline reduces renal microvascular leakage in a rat model of ischemic renal injury

Sutton, T., Kelly, K., Mang, H. E., Plotkin, Z., Sandoval, R. M. & Dagher, P., Jan 2005, In : American Journal of Physiology - Renal Physiology. 288, 1 57-1

Research output: Contribution to journalArticle

Minocycline
Reperfusion Injury
Kidney
Capillary Permeability
Wounds and Injuries
2004
245 Citations (Scopus)

Endothelial injury and dysfunction: Role in the extension phase of acute renal failure

Molitoris, B. A. & Sutton, T. A., Aug 2004, In : Kidney International. 66, 2, p. 496-499 4 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Kidney
Wounds and Injuries
Blood Vessels
Endothelial Cells
97 Citations (Scopus)

Minocycline inhibits apoptosis and inflammation in a rat model of ischemic renal injury

Kelly, K., Sutton, T., Weathered, N., Ray, N., Caldwell, E. J., Plotkin, Z. & Dagher, P., Oct 2004, In : American Journal of Physiology - Renal Physiology. 287, 4 56-4

Research output: Contribution to journalArticle

Minocycline
Apoptosis
Inflammation
Kidney
Ischemia
2003
234 Citations (Scopus)
Endothelium
Ischemia
Kidney
Wounds and Injuries
Acute Kidney Injury
2002
92 Citations (Scopus)

Endothelial injury and dysfunction in ischemic acute renal failure

Molitoris, B., Sandoval, R. & Sutton, T., 2002, In : Critical Care Medicine. 30, 5 SUPPL.

Research output: Contribution to journalArticle

Acute Kidney Injury
Endothelial Cells
Wounds and Injuries
Actins
P-Selectin
387 Citations (Scopus)

Microvascular endothelial injury and dysfunction during ischemic acute renal failure

Sutton, T., Fisher, C. J. & Molitoris, B., 2002, In : Kidney International. 62, 5, p. 1539-1549 11 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Kidney
Wounds and Injuries
Blood Vessels
Endothelial Cells
2001
25 Citations (Scopus)

Rho-kinase regulates myosin II activation in MDCK cells during recovery after ATP depletion

Sutton, T., Mang, H. E. & Atkinson, S. J., 2001, In : American Journal of Physiology - Renal Physiology. 281, 5 50-5

Research output: Contribution to journalArticle

Myosin Type II
rho-Associated Kinases
Madin Darby Canine Kidney Cells
Stress Fibers
Adenosine Triphosphate
1998
137 Citations (Scopus)

Mechanisms of cellular injury in ischemic acute renal failure

Sutton, T. & Molitoris, B., 1998, In : Seminars in Nephrology. 18, 5, p. 490-497 8 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Actin Cytoskeleton
Cell Communication
Wounds and Injuries
Cell Polarity
1990
38 Citations (Scopus)
Myosin Light Chains
Phosphorylation
Vascular Smooth Muscle
Protein Kinase C
Muscle
1988
29 Citations (Scopus)

Phosphorylation of two sites on smooth muscle myosin. Effects on contraction of glycerinated vascular smooth muscle

Haeberle, J. R., Sutton, T. & Trockman, B. A., 1988, In : Journal of Biological Chemistry. 263, 9, p. 4424-4429 6 p.

Research output: Contribution to journalArticle

Smooth Muscle Myosins
Phosphorylation
Vascular Smooth Muscle
Muscle
Phosphoserine