William Sullivan

  • 2542 Citations
  • 32 h-Index
19972020

Research output per year

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Publications

2020

Efficacy of guanabenz combination therapy against chronic toxoplasmosis across multiple mouse strains

Martynowicz, J., Stone Doggett, J. & Sullivan, W. J., Sep 2020, In : Antimicrobial Agents and Chemotherapy. 64, 9, e00535-20.

Research output: Contribution to journalArticle

Emerging Therapeutic Targets Against Toxoplasma gondii: Update on DNA Repair Response Inhibitors and Genotoxic Drugs

Angel, S. O., Vanagas, L., Ruiz, D. M., Cristaldi, C., Saldarriaga Cartagena, A. M. & Sullivan, W. J., Jun 12 2020, In : Frontiers in Cellular and Infection Microbiology. 10, 289.

Research output: Contribution to journalReview article

Open Access

Evaluating the GCN5b bromodomain as a novel therapeutic target against the parasite Toxoplasma gondii

Hanquier, J., Gimeno, T., Jeffers, V. & Sullivan, W. J., Apr 2020, In : Experimental Parasitology. 211, 107868.

Research output: Contribution to journalArticle

1 Scopus citations

Mastering Toxoplasma sex and sleep

Sullivan, W. J., Apr 1 2020, In : Nature Microbiology. 5, 4, p. 533-534 2 p.

Research output: Contribution to journalArticle

Toxoplasma gondii AP2XII-2 Contributes to Proper Progression through S-Phase of the Cell Cycle

Srivastava, S., White, M. W. & Sullivan, W. J., Sep 16 2020, In : mSphere. 5, 5

Research output: Contribution to journalArticle

Open Access

Toxoplasma gondii co-opts the unfolded protein response to enhance migration and dissemination of infected host cells

Augusto, L., Martynowicz, J., Amin, P. H., Alakhras, N. S., Kaplan, M. H., Wek, R. C. & Sullivan, W. J., Aug 2020, In : mBio. 11, 4, p. 1-13 13 p., e00915-20.

Research output: Contribution to journalArticle

Open Access
2019

A novel GCN5b lysine acetyltransferase complex associates with distinct transcription factors in the protozoan parasite Toxoplasma gondii

Harris, M. T., Jeffers, V., Martynowicz, J., True, J. D., Mosley, A. L. & Sullivan, W. J., Sep 2019, In : Molecular and Biochemical Parasitology. 232, 111203.

Research output: Contribution to journalArticle

3 Scopus citations

Characterization of protein arginine methyltransferase of TgPRMT5 in Toxoplasma gondii

Liu, M., Li, F. X., Li, C. Y., Li, X. C., Chen, L. F., Wu, K., Yang, P. L., Lai, Z. F., Liu, T. K., Sullivan, W. J., Cui, L. & Chen, X. G., May 8 2019, In : Parasites and Vectors. 12, 1, 221.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Evaluation of ATM Kinase Inhibitor KU-55933 as Potential Anti-Toxoplasma gondii Agent

Munera López, J., Ganuza, A., Bogado, S. S., Muñoz, D., Ruiz, D. M., Sullivan, W. J., Vanagas, L. & Angel, S. O., Jan 1 2019, In : Frontiers in Cellular and Infection Microbiology. 9, 1 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Guanabenz reverses a key behavioral change caused by latent toxoplasmosis in mice by reducing neuroinflammation

Martynowicz, J., Augusto, L., Wek, R. C., Boehm, S. L. & Sullivan, W. J., Mar 1 2019, In : mBio. 10, 2, e00381-19.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Regulation of arginine transport by GCN2 eiF2 kinase is important for replication of the intracellular parasite toxoplasma gondii

Augusto, L., Amin, P. H., Wek, R. C. & Sullivan, W. J., Jun 2019, In : PLoS pathogens. 15, 6, e1007746.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Repositioning of Guanabenz in Conjugation with Gold and Silver Nanoparticles against Pathogenic Amoebae Acanthamoeba castellanii and Naegleria fowleri

Anwar, A., Mungroo, M. R., Anwar, A., Sullivan, W. J., Khan, N. A. & Siddiqui, R., Dec 13 2019, In : ACS Infectious Diseases. 5, 12, p. 2039-2046 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Simultaneous ribosome profiling of human host cells infected with Toxoplasma gondii

Holmes, M. J., Shah, P., Wek, R. C. & Sullivan, W. J., May 1 2019, In : mSphere. 4, 3, e00292-19.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

TgDrpC, an atypical dynamin-related protein in Toxoplasma gondii, is associated with vesicular transport factors and parasite division

Heredero-Bermejo, I., Varberg, J. M., Charvat, R., Jacobs, K., Garbuz, T., Sullivan, W. J. & Arrizabalaga, G., Jan 2019, In : Molecular Microbiology. 111, 1, p. 46-64 19 p.

Research output: Contribution to journalArticle

7 Scopus citations
2018

A latent ability to persist: differentiation in Toxoplasma gondii

Jeffers, V., Tampaki, Z., Kim, K. & Sullivan, W., Mar 30 2018, (Accepted/In press) In : Cellular and Molecular Life Sciences. p. 1-19 19 p.

Research output: Contribution to journalArticle

23 Scopus citations
5 Scopus citations

Effects of PERK eIF2α Kinase Inhibitor against Toxoplasma gondii

Augusto, L., Martynowicz, J., Staschke, K. A., Wek, R. & Sullivan, W., Nov 1 2018, In : Antimicrobial Agents and Chemotherapy. 62, 11

Research output: Contribution to journalArticle

3 Scopus citations

Elp3 and RlmN: A tale of two mitochondrial tail-anchored radical SAM enzymes in Toxoplasma gondii

Padgett, L. R., Lentini, J. M., Holmes, M. J., Stilger, K. L., Fu, D. & Sullivan, W. J., Jan 2018, In : PloS one. 13, 1, e0189688.

Research output: Contribution to journalArticle

2 Scopus citations

Transcriptional repression by ApiAP2 factors is central to chronic toxoplasmosis

Radke, J. B., Worth, D., Hong, D., Huang, S., Sullivan, W. J., Wilson, E. H. & White, M. W., May 2018, In : PLoS pathogens. 14, 5, e1007035.

Research output: Contribution to journalArticle

20 Scopus citations
2017

Autophagy participates in the unfolded protein response in Toxoplasma gondii

Nguyen, H. M., Berry, L., Sullivan, W. & Besteiro, S., Aug 1 2017, In : FEMS Microbiology Letters. 364, 15, fnx153.

Research output: Contribution to journalLetter

3 Scopus citations

Bromodomains in protozoan parasites: Evolution, function, and opportunities for drug development

Jeffers, V., Yang, C., Huang, S. & Sullivan, W., Mar 1 2017, In : Microbiology and Molecular Biology Reviews. 81, 1, e00047-16.

Research output: Contribution to journalReview article

16 Scopus citations

Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency

Zhang, M., Gallego-Delgado, J., Fernandez-Arias, C., Waters, N. C., Rodriguez, A., Tsuji, M., Wek, R. C., Nussenzweig, V. & Sullivan, W. J., Dec 13 2017, In : Cell Host and Microbe. 22, 6, p. 766-776.e4

Research output: Contribution to journalArticle

33 Scopus citations

Mitochondrial behaviour throughout the lytic cycle of Toxoplasma gondii

Ovciarikova, J., Lemgruber, L., Stilger, K. L., Sullivan, W. J. & Sheiner, L., Feb 16 2017, In : Scientific reports. 7, 42746.

Research output: Contribution to journalArticle

16 Scopus citations

Targeting of tail-anchored membrane proteins to subcellular organelles in Toxoplasma gondii

Padgett, L. R., Arrizabalaga, G. & Sullivan, W. J., Mar 1 2017, In : Traffic. 18, 3, p. 149-158 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

TgPRELID, a mitochondrial protein linked to multidrug resistance in the parasite Toxoplasma gondii

Jeffers, V., Kamau, E. T., Srinivasan, A. R., Harper, J., Sankaran, P., Post, S. E., Varberg, J. M., Sullivan, W. J. & Boyle, J. P., Jan 1 2017, In : mSphere. 2, 1, e00229-16.

Research output: Contribution to journalArticle

8 Scopus citations

The common parasite Toxoplasma gondii induces prostatic inflammation and microglandular hyperplasia in a mouse model

Colinot, D. L., Garbuz, T., Bosland, M. C., Wang, L., Rice, S. E., Sullivan, W. J., Arrizabalaga, G. & Jerde, T. J., Jul 1 2017, In : Prostate. 77, 10, p. 1066-1075 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Toxoplasma gondii AP2IX-4 regulates gene expression during bradyzoite development

Huang, S., Holmes, M. J., Radke, J. B., Hong, D. P., Liu, T. K., White, M. W. & Sullivan, W. J., Mar 1 2017, In : mSphere. 2, 2, e00054-17.

Research output: Contribution to journalArticle

17 Scopus citations

Translational Control in the Latency of Apicomplexan Parasites

Holmes, M. J., Augusto, L. D. S., Zhang, M., Wek, R. C. & Sullivan, W. J., Dec 2017, In : Trends in Parasitology. 33, 12, p. 947-960 14 p.

Research output: Contribution to journalReview article

18 Scopus citations
2016

An ensemble of specifically targeted proteins stabilizes cortical microtubules in the human parasite toxoplasma gondii

Liu, J., He, Y., Benmerzouga, I., Sullivan, W. J., Morrissette, N. S., Murray, J. M. & Hu, K., Feb 1 2016, In : Molecular Biology of the Cell. 27, 3, p. 549-571 23 p.

Research output: Contribution to journalArticle

12 Scopus citations

Garcinol inhibits GCN5-mediated lysine acetyltransferase activity and prevents replication of the parasite Toxoplasma gondii

Jeffers, V., Gao, H., Checkley, L. A., Liu, Y., Ferdig, M. T. & Sullivan, W. J., Apr 2016, In : Antimicrobial Agents and Chemotherapy. 60, 4, p. 2164-2170 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Phosphorylation of Eukaryotic Initiation Factor-2α during Stress and Encystation in Entamoeba Species

Hendrick, H. M., Welter, B. H., Hapstack, M. A., Sykes, S. E., Sullivan, W. J. & Temesvari, L. A., Dec 8 2016, In : PLoS pathogens. 12, 12, e1006085.

Research output: Contribution to journalArticle

10 Scopus citations

TgATAT-mediated α-tubulin acetylation is required for division of the protozoan parasite Toxoplasma gondii

Varberg, J. M., Padgett, L. R., Arrizabalaga, G. & Sullivan, W. J., Jan 1 2016, In : mSphere. 1, 1, e00088-15.

Research output: Contribution to journalArticle

6 Scopus citations

Trails of discovery: Unbreak my heart: A short history of the defibrillator and CPR

Sullivan, W., 2016, In : Dialogues in Cardiovascular Medicine. 21, 3, p. 217-221 5 p.

Research output: Contribution to journalArticle

2015

Guanabenz repurposed as an antiparasitic with activity against acute and latent toxoplasmosis

Benmerzouga, I., Checkley, L. A., Ferdig, M. T., Arrizabalaga, G., Wek, R. C. & Sullivan, W. J., Nov 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 11, p. 6939-6945 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Preventing friendly fire in the war on microbes

Sullivan, W. & Gilk, S. D., Oct 28 2015, In : Science Translational Medicine. 7, 311, aad4922.

Research output: Contribution to journalArticle

Proteome-wide lysine acetylation in cortical astrocytes and alterations that occur during infection with brain parasite Toxoplasma gondii

Bouchut, A., Chawla, A. R., Jeffers, V., Hudmon, A. & Sullivan, W. J., Mar 18 2015, In : PloS one. 10, 3, e0117966.

Research output: Contribution to journalArticle

12 Scopus citations

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs

Herman, J. D., Pepper, L. R., Cortese, J. F., Estiu, G., Galinsky, K., Zuzarte-Luis, V., Derbyshire, E. R., Ribacke, U., Lukens, A. K., Santos, S. A., Patel, V., Clish, C. B., Sullivan, W. J., Zhou, H., Bopp, S. E., Schimmel, P., Lindquist, S., Clardy, J., Mota, M. M., Keller, T. L. & 4 others, Whitman, M., Wiest, O., Wirth, D. F. & Mazitschek, R., May 20 2015, In : Science translational medicine. 7, 288

Research output: Contribution to journalArticle

32 Scopus citations
2014

Canonical histone H2Ba and H2A.X dimerize in an opposite genomic localization to H2A.Z/H2B.Z dimers in Toxoplasma gondii

Bogado, S. S., Dalmasso, M. C., Ganuza, A., Kim, K., Sullivan, W. J., Angel, S. O. & Vanagas, L., Oct 2014, In : Molecular and Biochemical Parasitology. 197, 1-2, p. 36-42 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Characterization of TgPuf1, a member of the Puf family RNA-binding proteins from Toxoplasma gondii

Liu, M., Miao, J., Liu, T., Sullivan, W. J., Cui, L. & Chen, X., Mar 31 2014, In : Parasites and Vectors. 7, 1, 141.

Research output: Contribution to journalArticle

5 Scopus citations

GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma gondii

Konrad, C., Wek, R. C. & Sullivan, W. J., Feb 1 2014, In : International Journal for Parasitology. 44, 2, p. 139-146 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Lysine Acetyltransferase GCN5b Interacts with AP2 Factors and Is Required for Toxoplasma gondii Proliferation

Wang, J., Dixon, S. E., Ting, L. M., Liu, T. K., Jeffers, V., Croken, M. M., Calloway, M., Cannella, D., Ali Hakimi, M., Kim, K. & Sullivan, W. J., Jan 1 2014, In : PLoS pathogens. 10, 1, e1003830.

Research output: Contribution to journalArticle

34 Scopus citations
2013

ApiAP2 transcription factor restricts development of the Toxoplasma tissue cyst

Radke, J. B., Lucas, O., De Silva, E. K., Ma, Y., Sullivan, W. J., Weiss, L. M., Llinas, M. & White, M. W., Apr 23 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 17, p. 6871-6876 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in toxoplasma gondii

Stilger, K. L. & Sullivan, W. J., Aug 30 2013, In : Journal of Biological Chemistry. 288, 35, p. 25318-25329 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii

Sullivan, W. J., Radke, J. B., Kim, K. & White, M. W., Sep 1 2013, Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods: Second Edition. Elsevier Ltd., p. 613-645 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development

Miao, J., Lawrence, M., Jeffers, V., Zhao, F., Parker, D., Ge, Y., Sullivan, W. J. & Cui, L., Aug 1 2013, In : Molecular Microbiology. 89, 4, p. 660-675 16 p.

Research output: Contribution to journalArticle

53 Scopus citations
23 Scopus citations

Perturbations of PlasmodiumPuf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility

Lindner, S. E., Mikolajczak, S. A., Vaughan, A. M., Moon, W., Joyce, B. R., Sullivan, W. J. & Kappe, S. H. I., Jul 1 2013, In : Cellular Microbiology. 15, 7, p. 1266-1283 18 p.

Research output: Contribution to journalArticle

40 Scopus citations

Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii

Xue, B., Jeffers, V., Sullivan, W. J. & Uversky, V. N., Apr 2013, In : Molecular BioSystems. 9, 4, p. 645-657 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

The histone code of Toxoplasma gondii comprises conserved and unique posttranslational modifications

Nardelli, S. C., Che, F. Y., Silmon de Monerri, N. C., Xiao, H., Nieves, E., Madrid-Aliste, C., Angel, S. O., Sullivan, W. J., Angeletti, R. H., Kim, K. & Weiss, L. M., Dec 10 2013, In : mBio. 4, 6, e00922-13.

Research output: Contribution to journalArticle

41 Scopus citations