X. Yang

  • 3467 Citations
  • 32 h-Index
19992020
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Publications 1999 2018

  • 3467 Citations
  • 32 h-Index
  • 68 Article
  • 2 Chapter
  • 1 Comment/debate
  • 1 Review article
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Article
2018
2 Citations (Scopus)

LtpA, a CdnL-type CarD regulator, is important for the enzootic cycle of the Lyme disease pathogen article

Chen, T., Xiang, X., Xu, H., Zhang, X., Zhou, B., Yang, Y., Lou, Y. & Yang, X., Dec 1 2018, In : Emerging Microbes and Infections. 7, 1, 126.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Lyme Disease
Ticks
Myxococcus xanthus
Mycobacterium tuberculosis

Positive and negative regulation of glycerol utilization by the c-di-GMP binding protein plza in borrelia burgdorferi

Zhang, J. J., Chen, T., Yang, Y., Du, J., Li, H., Troxell, B., He, M., Carrasco, S. E., Gomelsky, M. & Yang, X., Nov 1 2018, In : Journal of Bacteriology. 200, 22, e0024318.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Cyclic GMP
Glycerol
Ticks
Lyme Disease

Simulation study of cDNA dataset to investigate possible association of differentially expressed genes of human THP1-monocytic cells in cancer progression affected by bacterial shiga toxins

Muhammad, S. A., Guo, J., Nguyen, T. M., Wu, X., Bai, B., Yang, X. & Chen, J. Y., Mar 1 2018, In : Frontiers in Microbiology. 9, MAR, 380.

Research output: Contribution to journalArticle

Shiga Toxins
Complementary DNA
Genes
Neoplasms
NF-kappa B p50 Subunit
1 Citation (Scopus)

The oligopeptide ABC transporter OppA4 negatively regulates the virulence factor OspC production of the Lyme disease pathogen

Zhou, B., Yang, Y., Chen, T., Lou, Y. & Yang, X., Jan 1 2018, (Accepted/In press) In : Ticks and Tick-borne Diseases.

Research output: Contribution to journalArticle

oligopeptides
Oligopeptides
Borrelia burgdorferi
ABC transporters
ATP-Binding Cassette Transporters

The sigma factor σ54 is required for the long-term survival of Leptospira biflexa in water

Zhang, J. J., Hu, W. L., Yang, Y., Li, H., Picardeau, M., Yan, J. & Yang, X., Jan 1 2018, (Accepted/In press) In : Molecular Microbiology.

Research output: Contribution to journalArticle

RNA Polymerase Sigma 54
Leptospira
Nitrogen
Water
Gene Expression Profiling
5 Citations (Scopus)

Toll-like receptor 3 (TLR3) promotes the resolution of chlamydia muridarum genital tract infection in congenic C57BL/6N mice

Carrasco, S. E., Hu, S., Imai, D. M., Kumar, R., Sandusky, G., Yang, X. & Derbigny, W., Apr 1 2018, In : PLoS One. 13, 4, e0195165.

Research output: Contribution to journalArticle

Chlamydia muridarum
Toll-Like Receptor 3
Reproductive Tract Infections
Congenic Mice
Inbred C57BL Mouse
2017
5 Citations (Scopus)

Investigation of ospC expression variation among Borrelia burgdorferi Strains

Xiang, X., Yang, Y., Du, J., Lin, T., Chen, T., Yang, X. & Lou, Y., Apr 20 2017, In : Frontiers in cellular and infection microbiology. 7, APR, 131.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Plasmids
Clone Cells
Lyme Disease
Multiplex Polymerase Chain Reaction
6 Citations (Scopus)

The EbpA-RpoN regulatory pathway of the pathogen Leptospira interrogans is essential for survival in the environment

Hu, W. L., Pappas, C. J., Zhang, J. J., Yang, Y. Y., Yan, J., Picardeau, M. & Yang, X., 2017, In : Applied and Environmental Microbiology. 83, 3, e02377-16.

Research output: Contribution to journalArticle

Leptospira interrogans
pathogen
mutants
Survival
pathogens
4 Citations (Scopus)

Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages

Xie, D. L., Zheng, M. M., Zheng, Y., Gao, H., Zhang, J., Zhang, T., Guo, J. C., Yang, X., Zhong, X. P. & Lou, Y. L., Jul 1 2017, In : PLoS One. 12, 7, e0181454.

Research output: Contribution to journalArticle

Vibrio vulnificus
Macrophages
Liver
macrophages
inflammation
2016
3 Citations (Scopus)

Genome reduction of Borrelia burgdorferi: two TCS signaling pathways for two distinct host habitats

Ye, M., Zhou, Y., Lou, Y. & Yang, X., Jan 1 2016, In : Science China Life Sciences. 59, 1, p. 19-21 3 p.

Research output: Contribution to journalArticle

Arthropod Vectors
Lyme disease
host-pathogen interaction
Bacterial Genomes
Host-Pathogen Interactions
15 Citations (Scopus)

HtrA, a temperature- and stationary phase-activated protease involved in maturation of a key microbial virulence determinant, facilitates Borrelia burgdorferi infection in mammalian hosts

Ye, M., Sharma, K., Thakur, M., Smith, A. A., Buyuktanir, O., Xiang, X., Yang, X., Promnares, K., Lou, Y., Yang, X. & Pal, U., 2016, In : Infection and Immunity. 84, 8, p. 2372-2381 10 p.

Research output: Contribution to journalArticle

Borrelia Infections
Borrelia burgdorferi
Virulence
Peptide Hydrolases
Spirochaetales
8 Citations (Scopus)

Insight into the dual functions of bacterial enhancer-binding protein Rrp2 of Borrelia burgdorferi

Yin, Y., Yang, Y., Xiang, X., Wang, Q., Yang, Z. N., Blevins, J., Lou, Y. & Yang, X., May 1 2016, In : Journal of Bacteriology. 198, 10, p. 1543-1552 10 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Carrier Proteins
Growth
RNA Polymerase Sigma 54
Adenosine Triphosphatases
95 Citations (Scopus)

What Makes a Bacterial Species Pathogenic? Comparative Genomic Analysis of the Genus Leptospira

Fouts, D. E., Matthias, M. A., Adhikarla, H., Adler, B., Amorim-Santos, L., Berg, D. E., Bulach, D., Buschiazzo, A., Chang, Y. F., Galloway, R. L., Haake, D. A., Haft, D. H., Hartskeerl, R., Ko, A. I., Levett, P. N., Matsunaga, J., Mechaly, A. E., Monk, J. M., Nascimento, A. L. T., Nelson, K. E. & 9 others, Palsson, B., Peacock, S. J., Picardeau, M., Ricaldi, J. N., Thaipandungpanit, J., Wunder, E. A., Yang, X., Zhang, J. J. & Vinetz, J. M., Feb 18 2016, In : PLoS Neglected Tropical Diseases. 10, 2, e0004403.

Research output: Contribution to journalArticle

Leptospira
Leptospirosis
CRISPR-Cas Systems
Virulence
Autotrophic Processes
2015
11 Citations (Scopus)

Acetyl-phosphate is not a global regulatory bridge between virulence and central metabolism in Borrelia burgdorferi

Richards, C. L., Lawrence, K. A., Su, H., Yang, Y., Yang, X., Dulebohn, D. P. & Gherardini, F. C., Dec 1 2015, In : PLoS One. 10, 12, e0144472.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Metabolism
Virulence
virulence
phosphates
11 Citations (Scopus)

Borrelia burgdorferi elongation factor EF-Tu is an immunogenic protein during Lyme borreliosis

Carrasco, S. E., Yang, Y., Troxell, B., Yang, X., Pal, U. & Yang, X., Sep 2 2015, In : Emerging Microbes and Infections. 4, e54.

Research output: Contribution to journalArticle

Peptide Elongation Factor Tu
Peptide Elongation Factors
Borrelia burgdorferi
Lyme Disease
Proteins
75 Citations (Scopus)

Emerging tick-borne infections in mainland China: An increasing public health threat

Fang, L. Q., Liu, K., Li, X. L., Liang, S., Yang, Y., Yao, H. W., Sun, R. X., Sun, Y., Chen, W. J., Zuo, S. Q., Ma, M. J., Li, H., Jiang, J. F., Liu, W., Yang, X., Gray, G. C., Krause, P. J. & Cao, W. C., Dec 1 2015, In : The Lancet Infectious Diseases. 15, 12, p. 1467-1479 13 p.

Research output: Contribution to journalArticle

Tick-Borne Diseases
Ticks
China
Public Health
Anaplasmataceae

Functional study of Treponema pallidum genes using Borrelia burgdorferi as a surrogate system

Yin, Y., Shi, B., Tang, Z., Lou, Y. & Yang, X., Aug 31 2015, In : Chinese Journal of Microbiology and Immunology. 35, 8, p. 568-572 5 p.

Research output: Contribution to journalArticle

Treponema pallidum
Borrelia burgdorferi
Genes
Genetic Vectors
Sigma Factor
9 Citations (Scopus)

MicroRNA expression profiling of human respiratory epithelium affected by invasive candida infection

Muhammad, S. A., Fatima, N., Syed, N. I. H., Wu, X., Yang, X. & Chen, J. Y., Aug 27 2015, In : PLoS One. 10, 8, 0136454.

Research output: Contribution to journalArticle

respiratory mucosa
Respiratory Mucosa
candidiasis
Candida
MicroRNAs
32 Citations (Scopus)

Outer surface protein OspC is an antiphagocytic factor that protects Borrelia burgdorferi from phagocytosis by macrophages

Carrasco, S. E., Troxell, B., Yang, Y., Brandt, S. L., Li, H., Sandusky, G., Condon, K. W., Serezani, C. H. & Yang, X., 2015, In : Infection and Immunity. 83, 12, p. 4848-4860 13 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Spirochaetales
Phagocytosis
Membrane Proteins
Macrophages
2 Citations (Scopus)

PCR-based multiple species cell counting for in vitro mixed culture

Huang, R., Zhang, J., Yang, X. & Gregory, R., May 13 2015, In : PLoS One. 10, 5, e0126628.

Research output: Contribution to journalArticle

mixed culture
Genes
Polymerase Chain Reaction
Cell Count
Biofilms
31 Citations (Scopus)

Transferred interbacterial antagonism genes augment eukaryotic innate immune function

Chou, S., Daugherty, M. D., Peterson, S. B., Biboy, J., Yang, Y., Jutras, B. L., Fritz-Laylin, L. K., Ferrin, M. A., Harding, B. N., Jacobs-Wagner, C., Yang, X., Vollmer, W., Malik, H. S. & Mougous, J. D., Feb 5 2015, In : Nature. 518, 7537, p. 98-101 4 p.

Research output: Contribution to journalArticle

amidase
Eukaryota
Horizontal Gene Transfer
Ixodes
Genes
2014
26 Citations (Scopus)

Cyclic Di-GMP receptor PlzA controls virulence gene expression through RpoS in Borrelia burgdorferi

He, M., Zhang, J. J., Ye, M., Lou, Y. & Yang, X., Jan 2014, In : Infection and Immunity. 82, 1, p. 445-452 8 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Virulence
Ticks
Gene Expression
Second Messenger Systems
40 Citations (Scopus)

DhhP, a cyclic di-AMP phosphodiesterase of Borrelia burgdorferi, is essential for cell growth and virulence

Ye, M., Zhang, J. J., Fang, X., Lawlis, G. B., Troxell, B., Zhou, Y., Gomelsky, M., Lou, Y. & Yang, X., 2014, In : Infection and Immunity. 82, 5, p. 1840-1849 10 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Phosphoric Diester Hydrolases
Cyclic AMP
Virulence
Growth
48 Citations (Scopus)

Identification of collagenase as a critical virulence factor for invasiveness and transmission of pathogenic leptospira species

Kassegne, K., Hu, W., Ojcius, D. M., Sun, D., Ge, Y., Zhao, J., Yang, X., Li, L. & Yan, J., 2014, In : Journal of Infectious Diseases. 209, 7, p. 1105-1115 11 p.

Research output: Contribution to journalArticle

Colicins
Leptospira
Virulence Factors
Collagenases
Leptospira interrogans
16 Citations (Scopus)

Increased Interleukin-17 in Peripheral Blood and Cerebrospinal Fluid of Neurosyphilis Patients

Wang, C., Zhu, L., Gao, Z., Guan, Z., Lu, H., Shi, M., Gao, Y., Xu, H., Yang, X. & Zhou, P., 2014, In : PLoS Neglected Tropical Diseases. 8, 7, e3004.

Research output: Contribution to journalArticle

Neurosyphilis
Interleukin-17
Cerebrospinal Fluid
Th17 Cells
Syphilis
14 Citations (Scopus)

Prioritizing drug targets in Clostridium botulinum with a computational systems biology approach

Muhammad, S. A., Ahmed, S., Ali, A., Huang, H., Wu, X., Yang, X., Naz, A. & Chen, J., 2014, In : Genomics. 104, 1, p. 24-35 12 p.

Research output: Contribution to journalArticle

Clostridium botulinum
Systems Biology
Computational Biology
Pharmaceutical Preparations
Proteins
21 Citations (Scopus)

Pyruvate protects pathogenic spirochetes from H2O2 killing

Troxel, B., Zhang, J. J., Bourret, T. J., Zeng, M. Y., Blum, J., Gherardini, F., Hassan, H. M. & Yang, X., Jan 2 2014, In : PLoS One. 9, 1, e84625.

Research output: Contribution to journalArticle

Spirochaetales
Borrelia burgdorferi
Pyruvic Acid
reactive oxygen species
glucose oxidase
2013
22 Citations (Scopus)

Manganese and zinc regulate virulence determinants in borrelia burgdorferi

Troxell, B., Ye, M., Yang, Y., Carrasco, S. E., Lou, Y. & Yang, X., Aug 2013, In : Infection and Immunity. 81, 8, p. 2743-2752 10 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Manganese
Virulence
Zinc
Metals
9 Citations (Scopus)

Metal-dependent gene regulation in the causative agent of lyme disease

Troxell, B. & Yang, X., 2013, In : Frontiers in cellular and infection microbiology. 4, NOV, 79.

Research output: Contribution to journalArticle

Lyme Disease
Borrelia burgdorferi
Metals
Borrelia
Genes
42 Citations (Scopus)

P53 Signalling Controls Cell Cycle Arrest And Caspase-Independent Apoptosis In Macrophages Infected With Pathogenic Leptospira Species

Hu, W., Ge, Y., Ojcius, D. M., Sun, D., Dong, H., Yang, X. & Yan, J., Oct 2013, In : Cellular Microbiology. 15, 10, p. 1624-1659 36 p.

Research output: Contribution to journalArticle

Leptospira
Caspases
Cell Cycle Checkpoints
Apoptosis Inducing Factor
Macrophages
2012
33 Citations (Scopus)

Borrelia burgdorferi, a pathogen that lacks iron, encodes manganese-dependent superoxide dismutase essential for resistance to streptonigrin

Troxell, B., Xu, H. & Yang, X., Jun 1 2012, In : Journal of Biological Chemistry. 287, 23, p. 19284-19293 10 p.

Research output: Contribution to journalArticle

Streptonigrin
Borrelia burgdorferi
Pathogens
Manganese
Superoxide Dismutase
10 Citations (Scopus)

Genome sequence of Borrelia afzelii strain HLj01, isolated from a patient in china

Jiang, B. G., Zheng, Y. C., Tong, Y. G., Jia, N., Huo, Q. B., Fan, H., Ni, X. B., Ma, L., Yang, X., Jiang, J. F. & Cao, W. C., Oct 2012, In : Journal of Bacteriology. 194, 24, p. 7014-7015 2 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi Group
China
Genome
Lyme Disease
13 Citations (Scopus)

Genome sequence of Borrelia garinii strain NMJW1, isolated from China

Jiang, B., Yao, H., Tong, Y., Yang, X., Huang, Y., Jiang, J. & Cao, W., Dec 2012, In : Journal of Bacteriology. 194, 23, p. 6660-6661 2 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi Group
Ixodes
Base Composition
Transfer RNA
Open Reading Frames
6 Citations (Scopus)

Immunogenicity of a multi-epitope DNA vaccine against hantavirus

Zhao, C., Sun, Y., Zhao, Y., Wang, S., Yu, T., Du, F., Yang, X. & Luo, E., Feb 2012, In : Human vaccines & immunotherapeutics. 8, 2, p. 208-215 8 p.

Research output: Contribution to journalArticle

Hantavirus
Seoul virus
DNA Vaccines
Hantaan virus
Epitopes
7 Citations (Scopus)

Immunogenicity of a multi-epitope DNA vaccine against hantavirus

Zhao, C., Sun, Y., Zhao, Y., Wang, S., Yu, T., Du, F., Yang, X. & Luo, E., Feb 2012, In : Human vaccines & immunotherapeutics. 8, 2, p. 198-205 8 p.

Research output: Contribution to journalArticle

Hantavirus
Seoul virus
DNA Vaccines
Hantaan virus
Epitopes
72 Citations (Scopus)

Leptospiral hemolysins induce proinflammatory cytokines through toll-like receptor 2-and 4-mediated JNK and NF-κB signaling pathways

Wang, H., Wu, Y., Ojcius, D. M., Yang, X., Zhang, C., Ding, S., Lin, X. & Yan, J., Aug 1 2012, In : PLoS One. 7, 8, e42266.

Research output: Contribution to journalArticle

Toll-Like Receptor 2
Toll-Like Receptor 4
Hemolysin Proteins
hemolysins
Cytokines
24 Citations (Scopus)

Rrp2, a prokaryotic enhancer-like binding protein, is essential for viability of Borrelia burgdorferi

Groshong, A. M., Gibbons, N. E., Yang, X. & Blevins, J. S., Jul 2012, In : Journal of Bacteriology. 194, 13, p. 3336-3342 7 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Carrier Proteins
Arthropod Vectors
Thiogalactosides
Sigma Factor
42 Citations (Scopus)

Three-dimensional structures of pathogenic and saprophytic leptospira species revealed by cryo-electron tomography

Raddi, G., Morado, D. R., Yan, J., Haake, D. A., Yang, X. & Liu, J., Mar 2012, In : Journal of Bacteriology. 194, 6, p. 1299-1306 8 p.

Research output: Contribution to journalArticle

Electron Microscope Tomography
Leptospira interrogans
Leptospira
Leptospirosis
Zoonoses
2011
66 Citations (Scopus)

Cyclic di-gmp is essential for the survival of the lyme disease spirochete in ticks

He, M., Ouyang, Z., Troxell, B., Xu, H., Moh, A., Piesman, J., Norgard, M. V., Gomelsky, M. & Yang, X., Jun 2011, In : PLoS Pathogens. 7, 6, e1002133.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Cyclic GMP
Ticks
Glycerol
Operon
2010
14 Citations (Scopus)

Characterization of the highly regulated antigen BBA05 in the enzootic cycle of Borrelia burgdorferi

Xu, H., He, M., Pang, X., Xu, Z. C., Piesman, J. & Yang, X., Jan 2010, In : Infection and Immunity. 78, 1, p. 100-107 8 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Ticks
Antigens
Lipoproteins
Mammals
17 Citations (Scopus)

Involvement of p300 in constitutive and HIV-1 Tat-activated expression of glial fibrillary acidic protein in astrocytes

Zou, W., Wang, Z., Liu, Y., Fan, Y., Zhou, B. Y., Yang, X. & He, J. J., Oct 2010, In : GLIA. 58, 13, p. 1640-1648 9 p.

Research output: Contribution to journalArticle

Glial Fibrillary Acidic Protein
Astrocytes
HIV-1
HIV Infections
Up-Regulation
65 Citations (Scopus)

Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in borrelia burgdorferi

Xu, H., Caimano, M. J., Lin, T., He, M., Radolf, J. D., Norris, S. J., Gheradini, F., Wolfe, A. J. & Yang, X., Sep 2010, In : PLoS Pathogens. 6, 9, e01104.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Acetates
RNA Polymerase Sigma 54
Phosphate Acetyltransferase
Acetate Kinase
30 Citations (Scopus)

Role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi

Xu, H., He, M., He, J. J. & Yang, X., Jul 2010, In : Infection and Immunity. 78, 7, p. 2910-2918 9 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Ticks
Lipoproteins
Mammals
Spirochaetales
2009
47 Citations (Scopus)

A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi

Ouyang, Z., He, M., Oman, T., Yang, X. & Norgard, M. V., Mar 3 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 9, p. 3449-3454 6 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Manganese
Virulence
Metals
Ticks
37 Citations (Scopus)

Rrp2, a σ 54-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner

Blevins, J. S., Xu, H., He, M., Norgard, M. V., Reitzer, L. & Yang, X., Apr 2009, In : Journal of Bacteriology. 191, 8, p. 2902-2905 4 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Genome
DNA
Infection
2008
25 Citations (Scopus)

Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) in Borrelia burgdorferi

He, M., Oman, T., Xu, H., Blevins, J., Norgard, M. V. & Yang, X., Dec 2008, In : Molecular Microbiology. 70, 6, p. 1453-1464 12 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Lipoproteins
Phenotype
Down-Regulation
Clone Cells
15 Citations (Scopus)

Differential expression of a putative CarD-like transcriptional regulator, LtpA, in Borrelia burgdorferi

Yang, X., Goldberg, M. S., He, M., Xu, H., Blevins, J. S. & Norgard, M. V., Oct 2008, In : Infection and Immunity. 76, 10, p. 4439-4444 6 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Temperature
Down-Regulation
Gene Expression
Arthropod Vectors
82 Citations (Scopus)

Essential role of the response regulator Rrp2 in the infectious cycle of Borrelia burgdorferi

Boardman, B. K., He, M., Ouyang, Z., Xu, H., Pang, X. & Yang, X., Sep 2008, In : Infection and Immunity. 76, 9, p. 3844-3853 10 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Ticks
Infection
RNA Polymerase Sigma 54
Lipoproteins
2007
68 Citations (Scopus)

Evidence that RpoS (σS) in Borrelia burgdorferi is controlled directly by RpoN (σ54/σN)

Smith, A. H., Blevins, J. S., Bachlani, G. N., Yang, X. & Norgard, M. V., Mar 2007, In : Journal of Bacteriology. 189, 5, p. 2139-2144 6 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Sigma Factor
Trans-Activators
Virulence Factors
Molecular Biology
19 Citations (Scopus)

Regulation of expression of the fibronectin-binding protein BBK32 in Borrelia burgdorferi

He, M., Boardman, B. K., Yan, D. & Yang, X., Nov 2007, In : Journal of Bacteriology. 189, 22, p. 8377-8380 4 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi
Fibronectins
Carrier Proteins
Ligands
Gene Expression