X. Yang

  • 3542 Citations
  • 33 h-Index
19992020

Research output per year

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Publications

  • 3542 Citations
  • 33 h-Index
  • 65 Article
  • 3 Review article
  • 2 Chapter
  • 2 Comment/debate
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Article
2018

LtpA, a CdnL-type CarD regulator, is important for the enzootic cycle of the Lyme disease pathogen article

Chen, T., Xiang, X., Xu, H., Zhang, X., Zhou, B., Yang, Y., Lou, Y. & Yang, X. F., Dec 1 2018, In : Emerging Microbes and Infections. 7, 1, 126.

Research output: Contribution to journalArticle

2 Scopus citations

Positive and negative regulation of glycerol utilization by the c-di-GMP binding protein plza in borrelia burgdorferi

Zhang, J. J., Chen, T., Yang, Y., Du, J., Li, H., Troxell, B., He, M., Carrasco, S. E., Gomelsky, M. & Yang, X. F., Nov 1 2018, In : Journal of bacteriology. 200, 22, e0024318.

Research output: Contribution to journalArticle

Simulation study of cDNA dataset to investigate possible association of differentially expressed genes of human THP1-monocytic cells in cancer progression affected by bacterial shiga toxins

Muhammad, S. A., Guo, J., Nguyen, T. M., Wu, X., Bai, B., Yang, X. & Chen, J. Y., Mar 1 2018, In : Frontiers in Microbiology. 9, MAR, 380.

Research output: Contribution to journalArticle

The oligopeptide ABC transporter OppA4 negatively regulates the virulence factor OspC production of the Lyme disease pathogen

Zhou, B., Yang, Y., Chen, T., Lou, Y. & Yang, X. F., Jul 2018, In : Ticks and Tick-borne Diseases. 9, 5, p. 1343-1349 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

The sigma factor σ54 is required for the long-term survival of Leptospira biflexa in water

Zhang, J. J., Hu, W. L., Yang, Y., Li, H., Picardeau, M., Yan, J. & Yang, X. F., Jul 2018, In : Molecular Microbiology. 109, 1, p. 63-77 15 p.

Research output: Contribution to journalArticle

Toll-like receptor 3 (TLR3) promotes the resolution of chlamydia muridarum genital tract infection in congenic C57BL/6N mice

Carrasco, S. E., Hu, S., Imai, D. M., Kumar, R., Sandusky, G., Yang, X. & Derbigny, W., Apr 1 2018, In : PLoS One. 13, 4, e0195165.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Investigation of ospC expression variation among Borrelia burgdorferi Strains

Xiang, X., Yang, Y., Du, J., Lin, T., Chen, T., Yang, X. F. & Lou, Y., Apr 20 2017, In : Frontiers in Cellular and Infection Microbiology. 7, APR, 131.

Research output: Contribution to journalArticle

8 Scopus citations

The EbpA-RpoN regulatory pathway of the pathogen Leptospira interrogans is essential for survival in the environment

Hu, W. L., Pappas, C. J., Zhang, J. J., Yang, Y. Y., Yan, J., Picardeau, M. & Yang, X. F., Jan 1 2017, In : Applied and environmental microbiology. 83, 3, e02377-16.

Research output: Contribution to journalArticle

7 Scopus citations

Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages

Xie, D. L., Zheng, M. M., Zheng, Y., Gao, H., Zhang, J., Zhang, T., Guo, J. C., Yang, X. F., Zhong, X. P. & Lou, Y. L., Jul 2017, In : PLoS ONE. 12, 7, e0181454.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Genome reduction of Borrelia burgdorferi: two TCS signaling pathways for two distinct host habitats

Ye, M., Zhou, Y., Lou, Y. & Yang, X. F., Jan 1 2016, In : Science China Life Sciences. 59, 1, p. 19-21 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

HtrA, a temperature- and stationary phase-activated protease involved in maturation of a key microbial virulence determinant, facilitates Borrelia burgdorferi infection in mammalian hosts

Ye, M., Sharma, K., Thakur, M., Smith, A. A., Buyuktanir, O., Xiang, X., Yang, X., Promnares, K., Lou, Y., Yang, X. F. & Pal, U., Jan 1 2016, In : Infection and immunity. 84, 8, p. 2372-2381 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Insight into the dual functions of bacterial enhancer-binding protein Rrp2 of Borrelia burgdorferi

Yin, Y., Yang, Y., Xiang, X., Wang, Q., Yang, Z. N., Blevins, J., Lou, Y. & Frank Yang, X., May 1 2016, In : Journal of bacteriology. 198, 10, p. 1543-1552 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira

Fouts, D. E., Matthias, M. A., Adhikarla, H., Adler, B., Amorim-Santos, L., Berg, D. E., Bulach, D., Buschiazzo, A., Chang, Y. F., Galloway, R. L., Haake, D. A., Haft, D. H., Hartskeerl, R., Ko, A. I., Levett, P. N., Matsunaga, J., Mechaly, A. E., Monk, J. M., Nascimento, A. L. T., Nelson, K. E. & 9 others, Palsson, B., Peacock, S. J., Picardeau, M., Ricaldi, J. N., Thaipandungpanit, J., Wunder, E. A., Yang, X. F., Zhang, J. J. & Vinetz, J. M., Feb 18 2016, In : PLoS neglected tropical diseases. 10, 2, e0004403.

Research output: Contribution to journalArticle

105 Scopus citations
2015

Acetyl-phosphate is not a global regulatory bridge between virulence and central metabolism in Borrelia burgdorferi

Richards, C. L., Lawrence, K. A., Su, H., Yang, Y., Yang, X. F., Dulebohn, D. P. & Gherardini, F. C., Dec 1 2015, In : PloS one. 10, 12, e0144472.

Research output: Contribution to journalArticle

12 Scopus citations

Borrelia burgdorferi elongation factor EF-Tu is an immunogenic protein during Lyme borreliosis

Carrasco, S. E., Yang, Y., Troxell, B., Yang, X., Pal, U. & Yang, X. F., Sep 2 2015, In : Emerging Microbes and Infections. 4, e54.

Research output: Contribution to journalArticle

11 Scopus citations

Functional study of Treponema pallidum genes using Borrelia burgdorferi as a surrogate system

Yin, Y., Shi, B., Tang, Z., Lou, Y. & Yang, X., Aug 31 2015, In : Chinese Journal of Microbiology and Immunology. 35, 8, p. 568-572 5 p.

Research output: Contribution to journalArticle

MicroRNA expression profiling of human respiratory epithelium affected by invasive candida infection

Muhammad, S. A., Fatima, N., Syed, N. I. H., Wu, X., Yang, X. & Chen, J. Y., Aug 27 2015, In : PLoS One. 10, 8, 0136454.

Research output: Contribution to journalArticle

10 Scopus citations

Outer surface protein OspC is an antiphagocytic factor that protects Borrelia burgdorferi from phagocytosis by macrophages

Carrasco, S. E., Troxell, B., Yang, Y., Brandt, S. L., Li, H., Sandusky, G., Condon, K. W., Serezani, C. H. & Yang, X., 2015, In : Infection and Immunity. 83, 12, p. 4848-4860 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

PCR-based multiple species cell counting for in vitro mixed culture

Huang, R., Zhang, J., Yang, X. F. & Gregory, R. L., May 13 2015, In : PloS one. 10, 5, e0126628.

Research output: Contribution to journalArticle

2 Scopus citations

Transferred interbacterial antagonism genes augment eukaryotic innate immune function

Chou, S., Daugherty, M. D., Peterson, S. B., Biboy, J., Yang, Y., Jutras, B. L., Fritz-Laylin, L. K., Ferrin, M. A., Harding, B. N., Jacobs-Wagner, C., Yang, X. F., Vollmer, W., Malik, H. S. & Mougous, J. D., Feb 5 2015, In : Nature. 518, 7537, p. 98-101 4 p.

Research output: Contribution to journalArticle

33 Scopus citations
2014

Cyclic Di-GMP receptor PlzA controls virulence gene expression through RpoS in Borrelia burgdorferi

He, M., Zhang, J. J., Ye, M., Lou, Y. & Yang, X. F., Jan 1 2014, In : Infection and immunity. 82, 1, p. 445-452 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

DhhP, a cyclic di-AMP phosphodiesterase of Borrelia burgdorferi, is essential for cell growth and virulence

Ye, M., Zhang, J. J., Fang, X., Lawlis, G. B., Troxell, B., Zhou, Y., Gomelsky, M., Lou, Y. & Yang, X. F., May 2014, In : Infection and immunity. 82, 5, p. 1840-1849 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Identification of collagenase as a critical virulence factor for invasiveness and transmission of pathogenic leptospira species

Kassegne, K., Hu, W., Ojcius, D. M., Sun, D., Ge, Y., Zhao, J., Yang, X. F., Li, L. & Yan, J., Jan 1 2014, In : Journal of Infectious Diseases. 209, 7, p. 1105-1115 11 p.

Research output: Contribution to journalArticle

51 Scopus citations

Increased Interleukin-17 in Peripheral Blood and Cerebrospinal Fluid of Neurosyphilis Patients

Wang, C., Zhu, L., Gao, Z., Guan, Z., Lu, H., Shi, M., Gao, Y., Xu, H., Yang, X. F. & Zhou, P., Jul 2014, In : PLoS neglected tropical diseases. 8, 7, e3004.

Research output: Contribution to journalArticle

16 Scopus citations

Prioritizing drug targets in Clostridium botulinum with a computational systems biology approach

Muhammad, S. A., Ahmed, S., Ali, A., Huang, H., Wu, X., Yang, X. F., Naz, A. & Chen, J., Jul 2014, In : Genomics. 104, 1, p. 24-35 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Pyruvate protects pathogenic spirochetes from H2O2 killing

Troxel, B., Zhang, J. J., Bourret, T. J., Zeng, M. Y., Blum, J., Gherardini, F., Hassan, H. M. & Yang, X. F., Jan 2 2014, In : PloS one. 9, 1, e84625.

Research output: Contribution to journalArticle

24 Scopus citations
2013

Manganese and zinc regulate virulence determinants in borrelia burgdorferi

Troxell, B., Ye, M., Yang, Y., Carrasco, S. E., Lou, Y. & Frank Yang, X., Aug 1 2013, In : Infection and immunity. 81, 8, p. 2743-2752 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

P53 Signalling Controls Cell Cycle Arrest And Caspase-Independent Apoptosis In Macrophages Infected With Pathogenic Leptospira Species

Hu, W., Ge, Y., Ojcius, D. M., Sun, D., Dong, H., Yang, X. F. & Yan, J., Oct 1 2013, In : Cellular Microbiology. 15, 10, p. 1624-1659 36 p.

Research output: Contribution to journalArticle

46 Scopus citations
2012

Borrelia burgdorferi, a pathogen that lacks iron, encodes manganese-dependent superoxide dismutase essential for resistance to streptonigrin

Troxell, B., Xu, H. & Yang, X. F., Jun 1 2012, In : Journal of Biological Chemistry. 287, 23, p. 19284-19293 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Genome sequence of Borrelia afzelii strain HLj01, isolated from a patient in china

Jiang, B. G., Zheng, Y. C., Tong, Y. G., Jia, N., Huo, Q. B., Fan, H., Ni, X. B., Ma, L., Yang, X. F., Jiang, J. F. & Cao, W. C., Oct 1 2012, In : Journal of bacteriology. 194, 24, p. 7014-7015 2 p.

Research output: Contribution to journalArticle

10 Scopus citations

Immunogenicity of a multi-epitope DNA vaccine against hantavirus

Zhao, C., Sun, Y., Zhao, Y., Wang, S., Yu, T., Du, F., Yang, X. F. & Luo, E., Feb 1 2012, In : Human Vaccines and Immunotherapeutics. 8, 2, p. 208-215 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Immunogenicity of a multi-epitope DNA vaccine against hantavirus

Zhao, C., Sun, Y., Zhao, Y., Wang, S., Yu, T., Du, F., Yang, X. F. & Luo, E., Feb 1 2012, In : Human Vaccines and Immunotherapeutics. 8, 2, p. 198-205 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Leptospiral hemolysins induce proinflammatory cytokines through toll-like receptor 2-and 4-mediated JNK and NF-κB signaling pathways

Wang, H., Wu, Y., Ojcius, D. M., Yang, X. F., Zhang, C., Ding, S., Lin, X. & Yan, J., Aug 1 2012, In : PLoS ONE. 7, 8, e42266.

Research output: Contribution to journalArticle

76 Scopus citations

Rrp2, a prokaryotic enhancer-like binding protein, is essential for viability of Borrelia burgdorferi

Groshong, A. M., Gibbons, N. E., Yang, X. F. & Blevins, J. S., Jul 1 2012, In : Journal of bacteriology. 194, 13, p. 3336-3342 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Three-dimensional structures of pathogenic and saprophytic leptospira species revealed by cryo-electron tomography

Raddi, G., Morado, D. R., Yan, J., Haake, D. A., Yang, X. F. & Liu, J., Mar 1 2012, In : Journal of bacteriology. 194, 6, p. 1299-1306 8 p.

Research output: Contribution to journalArticle

43 Scopus citations
2011

Cyclic di-gmp is essential for the survival of the lyme disease spirochete in ticks

He, M., Ouyang, Z., Troxell, B., Xu, H., Moh, A., Piesman, J., Norgard, M. V., Gomelsky, M. & Yang, X. F., Jun 1 2011, In : PLoS pathogens. 7, 6, e1002133.

Research output: Contribution to journalArticle

66 Scopus citations
2010

Characterization of the highly regulated antigen BBA05 in the enzootic cycle of Borrelia burgdorferi

Xu, H., He, M., Pang, X., Xu, Z. C., Piesman, J. & Yang, X. F., Jan 1 2010, In : Infection and immunity. 78, 1, p. 100-107 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Involvement of p300 in constitutive and HIV-1 Tat-activated expression of glial fibrillary acidic protein in astrocytes

Zou, W., Wang, Z., Liu, Y., Fan, Y., Zhou, B. Y., Yang, X. F. & He, J. J., Oct 1 2010, In : Glia. 58, 13, p. 1640-1648 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in borrelia burgdorferi

Xu, H., Caimano, M. J., Lin, T., He, M., Radolf, J. D., Norris, S. J., Gheradini, F., Wolfe, A. J. & Yang, X. F., Sep 1 2010, In : PLoS pathogens. 6, 9, e01104.

Research output: Contribution to journalArticle

65 Scopus citations

Role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi

Xu, H., He, M., He, J. J. & Yang, X. F., Jul 1 2010, In : Infection and immunity. 78, 7, p. 2910-2918 9 p.

Research output: Contribution to journalArticle

30 Scopus citations
2009

A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi

Ouyang, Z., He, M., Oman, T., Yang, X. F. & Norgard, M. V., Mar 3 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 9, p. 3449-3454 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

Rrp2, a σ 54-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner

Blevins, J. S., Xu, H., He, M., Norgard, M. V., Reitzer, L. & Yang, X. F., Apr 1 2009, In : Journal of bacteriology. 191, 8, p. 2902-2905 4 p.

Research output: Contribution to journalArticle

37 Scopus citations
2008

Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) in Borrelia burgdorferi

He, M., Oman, T., Xu, H., Blevins, J., Norgard, M. V. & Yang, X. F., Dec 1 2008, In : Molecular Microbiology. 70, 6, p. 1453-1464 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Differential expression of a putative CarD-like transcriptional regulator, LtpA, in Borrelia burgdorferi

Yang, X. F., Goldberg, M. S., He, M., Xu, H., Blevins, J. S. & Norgard, M. V., Oct 1 2008, In : Infection and immunity. 76, 10, p. 4439-4444 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Essential role of the response regulator Rrp2 in the infectious cycle of Borrelia burgdorferi

Boardman, B. K., He, M., Ouyang, Z., Xu, H., Pang, X. & Yang, X. F., Sep 1 2008, In : Infection and immunity. 76, 9, p. 3844-3853 10 p.

Research output: Contribution to journalArticle

82 Scopus citations
2007

Evidence that RpoS (σS) in Borrelia burgdorferi is controlled directly by RpoN (σ54N)

Smith, A. H., Blevins, J. S., Bachlani, G. N., Yang, X. F. & Norgard, M. V., Mar 1 2007, In : Journal of bacteriology. 189, 5, p. 2139-2144 6 p.

Research output: Contribution to journalArticle

68 Scopus citations

Regulation of expression of the fibronectin-binding protein BBK32 in Borrelia burgdorferi

He, M., Boardman, B. K., Yan, D. & Yang, X. F., Nov 1 2007, In : Journal of bacteriology. 189, 22, p. 8377-8380 4 p.

Research output: Contribution to journalArticle

19 Scopus citations
2006

The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum

Deka, R. K., Brautigam, C. A., Yang, X. F., Blevins, J. S., Machius, M., Tomchick, D. R. & Norgard, M. V., Mar 24 2006, In : Journal of Biological Chemistry. 281, 12, p. 8072-8081 10 p.

Research output: Contribution to journalArticle

42 Scopus citations
2005

Analysis of the ospC regulatory element controlled by the RpoN-RpoS regulatory pathway in Borrelia burgdorferi

Yang, X. F., Lybecker, M. C., Pal, U., Alani, S. M., Blevins, J., Revel, A. T., Samuels, D. S. & Norgard, M. V., Jul 1 2005, In : Journal of bacteriology. 187, 14, p. 4822-4829 8 p.

Research output: Contribution to journalArticle

75 Scopus citations

The Lyme disease agent exploits a tick protein to infect the mammalian host

Ramamoorthi, N., Narasimhan, S., Pal, U., Bao, F., Yang, X. F., Fish, D., Anguita, J., Norgard, M. V., Kantor, F. S., Anderson, J. F., Koski, R. A. & Fikrig, E., Jul 28 2005, In : Nature. 436, 7050, p. 573-577 5 p.

Research output: Contribution to journalArticle

309 Scopus citations