Xuening (Neal) Chen

  • Associate Research Professor of Medicine, Nephrology
  • 4027 Citations
  • 29 h-Index
19952019
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Publications 1995 2019

  • 4027 Citations
  • 29 h-Index
  • 68 Article
  • 1 Conference contribution
  • 1 Review article
2019
1 Citation (Scopus)

Effect of ovariectomy on the progression of chronic kidney disease-mineral bone disorder (CKD-MBD) in female Cy/+ rats

Vorland, C. J., Lachcik, P. J., Swallow, E. A., Metzger, C. E., Allen, M., Chen, X. N., Moe, S. & Hill Gallant, K. M., May 28 2019, In : Scientific reports. 9, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Chronic Kidney Disease-Mineral and Bone Disorder
Ovariectomy
Porosity
Kidney Diseases
Phosphorus

Kidney Disease Progression Does Not Decrease Intestinal Phosphorus Absorption in a Rat Model of Chronic Kidney Disease–Mineral Bone Disorder

Vorland, C. J., Biruete, A., Lachcik, P. J., Srinivasan, S., Chen, N. X., Moe, S. M. & Hill Gallant, K. M., Jan 1 2019, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Intestinal Absorption
Kidney Diseases
Phosphorus
Disease Progression
Kidney
1 Citation (Scopus)
Chronic Renal Insufficiency
Blood Vessels
Perfusion
Parathyroid Hormone
Therapeutics
2 Citations (Scopus)

Phosphate Binders and Nonphosphate Effects in the Gastrointestinal Tract

Biruete, A., Hill Gallant, K. M., Lindemann, S. R., Wiese, G. N., Chen, N. X. & Moe, S. M., Jan 1 2019, In : Journal of Renal Nutrition.

Research output: Contribution to journalReview article

Gastrointestinal Tract
Phosphates
Iron
Hyperphosphatemia
Advanced Glycosylation End Products

Skeletal levels of bisphosphonate in the setting of chronic kidney disease are independent of remodeling rate and lower with fractionated dosing

Swallow, E. A., Aref, M. W., Metzger, C. E., Sacks, S., Lehmkuhler, D. R., Chen, X. N., Hammond, M. A., Territo, P., Nickolas, T. L., Moe, S. & Allen, M., Oct 1 2019, In : Bone. 127, p. 419-426 8 p.

Research output: Contribution to journalArticle

zoledronic acid
Diphosphonates
Chronic Renal Insufficiency
Ulna
Bone Remodeling
2 Citations (Scopus)

Time course of rapid bone loss and cortical porosity formation observed by longitudinal μCT in a rat model of CKD

McNerny, E. M. B., Buening, D. T., Aref, M. W., Chen, X. N., Moe, S. & Allen, M., Aug 1 2019, In : Bone. 125, p. 16-24 9 p.

Research output: Contribution to journalArticle

Porosity
Tibia
Bone and Bones
X-Ray Microtomography
Chronic Renal Insufficiency
1 Citation (Scopus)

Voluntary wheel running has beneficial effects in a rat model of CKD-mineral bone disorder (CKD-MBD)

Avin, K. G., Allen, M. R., Chen, N. X., Srinivasan, S., O'Neill, K. D., Troutman, A. D., Mast, G., Swallow, E. A., Brown, M. B., Wallace, J. M., Zimmers, T. A., Warden, S. J. & Moe, S. M., Jan 1 2019, In : Journal of the American Society of Nephrology. 30, 10, p. 1898-1909 12 p.

Research output: Contribution to journalArticle

Running
Minerals
Bone and Bones
Cystic Kidney Diseases
Biochemistry
2018
1 Citation (Scopus)

Effect of dietary phosphorus intake and age on intestinal phosphorus absorption efficiency and phosphorus balance in male rats

Vorland, C. J., Lachcik, P. J., Aromeh, L. O., Moe, S., Chen, X. N. & Hill Gallant, K. M., Jan 1 2018, In : PLoS One. 13, 11, p. e0207601

Research output: Contribution to journalArticle

Dietary Phosphorus
Intestinal Absorption
Phosphorus
Rats
phosphorus
3 Citations (Scopus)

Effects of treadmill running in a rat model of chronic kidney disease

Organ, J., Allen, M., Myers-White, A., Elkhatib, W., O'Neill, K. D., Chen, X. N., Moe, S. & Avin, K. G., Dec 1 2018, In : Biochemistry and Biophysics Reports. 16, p. 19-23 5 p.

Research output: Contribution to journalArticle

Exercise equipment
Chronic Renal Insufficiency
Running
Rats
Muscle
3 Citations (Scopus)

Fibroblast growth factor 23 does not directly influence skeletal muscle cell proliferation and differentiation or ex vivo muscle contractility

Avin, K. G., Vallejo, J. A., Chen, X. N., Wang, K., Touchberry, C. D., Brotto, M., Dallas, S. L., Moe, S. & Wacker, M. J., Oct 2 2018, In : American Journal of Physiology - Endocrinology and Metabolism. 315, 4, p. E594-E604

Research output: Contribution to journalArticle

Muscle Cells
Cell Differentiation
Skeletal Muscle
Cell Proliferation
Muscles
1 Citation (Scopus)

Skeletal accumulation of fluorescently tagged zoledronate is higher in animals with early stage chronic kidney disease

Swallow, E. A., Aref, M. W., Chen, X. N., Byiringiro, I., Hammond, M. A., McCarthy, B. P., Territo, P., Kamocka, M., Winfree, S., Dunn, K., Moe, S. & Allen, M., Jun 11 2018, (Accepted/In press) In : Osteoporosis International. p. 1-8 8 p.

Research output: Contribution to journalArticle

zoledronic acid
Chronic Renal Insufficiency
Tibia
Kidney
Bone and Bones
1 Citation (Scopus)

Skeletal vascular perfusion is altered in chronic kidney disease

Aref, M. W., Swallow, E. A., Chen, X. N., Moe, S. & Allen, M., Jun 1 2018, In : Bone Reports. 8, p. 215-220 6 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Blood Vessels
Perfusion
Bone and Bones
Bone Marrow
2017
7 Citations (Scopus)

Intracellular calcium increases in vascular smooth muscle cells with progression of chronic kidney disease in a rat model

Rodenbeck, S. D., Zarse, C. A., McKenney-Drake, M. L., Bruning, R. S., Sturek, M., Chen, X. N. & Moe, S., Mar 1 2017, In : Nephrology Dialysis Transplantation. 32, 3, p. 450-458 9 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Vascular Smooth Muscle
Smooth Muscle Myocytes
Calcium
Sarcoplasmic Reticulum
17 Citations (Scopus)

Matrix vesicles induce calcification of recipient vascular smooth muscle cells through multiple signaling pathways

Chen, X. N., O'Neill, K. D. & Moe, S., 2017, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Ions
Calcium
alpha-2-HS-Glycoprotein
2016
3 Citations (Scopus)

Calcitriol Suppression of Parathyroid Hormone Fails to Improve Skeletal Properties in an Animal Model of Chronic Kidney Disease

Newman, C. L., Tian, N., Hammond, M. A., Wallace, J. M., Brown, D. M., Chen, X. N., Moe, S. & Allen, M., Feb 17 2016, (Accepted/In press) In : American Journal of Nephrology. p. 20-31 12 p.

Research output: Contribution to journalArticle

Calcitriol
Parathyroid Hormone
Chronic Renal Insufficiency
Animal Models
Bone and Bones
8 Citations (Scopus)

Reduced skeletal muscle function is associated with decreased fiber cross-sectional area in the Cy/+ rat model of progressive kidney disease

Organ, J., Srisuwananukorn, A., Price, P., Joll, J. E., Biro, K. C., Rupert, J. E., Chen, X. N., Avin, K. G., Moe, S. & Allen, M., Feb 1 2016, In : Nephrology Dialysis Transplantation. 31, 2, p. 223-230 8 p.

Research output: Contribution to journalArticle

Kidney Diseases
Chronic Renal Insufficiency
Skeletal Muscle
Torque
Muscles
15 Citations (Scopus)

Skeletal muscle regeneration and oxidative stress are altered in chronic kidney disease

Avin, K. G., Chen, X. N., Organ, J., Zarse, C., O'Neill, K., Conway, R. G., Konrad, R. J., Bacallao, R., Allen, M. & Moe, S., Aug 1 2016, In : PLoS One. 11, 8, e0159411.

Research output: Contribution to journalArticle

Oxidative stress
muscle development
kidney diseases
Chronic Renal Insufficiency
Muscle
7 Citations (Scopus)

Subcutaneous nerve activity and mechanisms of sudden death in a rat model of chronic kidney disease

Zhao, Y., Chen, X. N., Shirazi, J. T., Shen, C., Lin, S-F., Fishbein, M. C., Moe, S. & Chen, P-S., 2016, (Accepted/In press) In : Heart Rhythm.

Research output: Contribution to journalArticle

Sudden Death
Chronic Renal Insufficiency
Heart Rate
Chemical Sympathectomy
Atrioventricular Block
2015
51 Citations (Scopus)

Anti-sclerostin antibody treatment in a rat model of progressive renal osteodystrophy

Moe, S., Chen, X. N., Newman, C. L., Organ, J., Kneissel, M., Kramer, I., Gattone, V. H. & Allen, M., Mar 1 2015, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 30, 3, p. 499-509 11 p.

Research output: Contribution to journalArticle

Chronic Kidney Disease-Mineral and Bone Disorder
Parathyroid Hormone
Anti-Idiotypic Antibodies
Chronic Renal Insufficiency
zoledronic acid
14 Citations (Scopus)

Changes in skeletal collagen cross-links and matrix hydration in high- and low-turnover chronic kidney disease

Allen, M., Newman, C. L., Chen, X. N., Granke, M., Nyman, J. S. & Moe, S., 2015, In : Osteoporosis International. 26, 3, p. 977-985 9 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Collagen
Bone and Bones
Bone Remodeling
Kidney
14 Citations (Scopus)

Compromised vertebral structural and mechanical properties associated with progressive kidney disease and the effects of traditional pharmacological interventions

Newman, C. L., Chen, X. N., Smith, E., Smith, M., Brown, D., Moe, S. & Allen, M., Aug 1 2015, In : Bone. 77, p. 50-56 7 p.

Research output: Contribution to journalArticle

Kidney Diseases
Pharmacology
Anti-Idiotypic Antibodies
Bone and Bones
zoledronic acid
8 Citations (Scopus)

Differential miRNA expression in cells and matrix vesicles in vascular smooth muscle cells from rats with kidney disease

Chaturvedi, P., Chen, X. N., O'Neill, K., McClintick, J., Moe, S. & Janga, S. C., Jun 26 2015, In : PLoS One. 10, 6, e0131589.

Research output: Contribution to journalArticle

Kidney Diseases
kidney diseases
MicroRNAs
microRNA
Vascular Smooth Muscle
7 Citations (Scopus)

Low Bone Turnover in Chronic Kidney Disease Is Associated with Decreased VEGF-A Expression and Osteoblast Differentiation

Chen, X. N., O''Neill, K. D., Allen, M., Newman, C. L. & Moe, S., Aug 25 2015, In : American Journal of Nephrology. 41, p. 464-473 10 p.

Research output: Contribution to journalArticle

Bone Remodeling
Osteoblasts
Chronic Renal Insufficiency
Vascular Endothelial Growth Factor A
Osteogenesis
32 Citations (Scopus)

Pathophysiology of Vascular Calcification

Chen, X. N. & Moe, S., Sep 26 2015, In : Current Osteoporosis Reports. 13, 6, p. 372-380 9 p.

Research output: Contribution to journalArticle

Vascular Calcification
alpha-2-HS-Glycoprotein
Hyperphosphatemia
Hypercalcemia
Chronic Renal Insufficiency
8 Citations (Scopus)

Raloxifene improves skeletal properties in an animal model of cystic chronic kidney disease

Newman, C. L., Creecy, A., Granke, M., Nyman, J. S., Tian, N., Hammond, M. A., Wallace, J. M., Brown, D. M., Chen, X. N., Moe, S. & Allen, M., Oct 21 2015, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

Cystic Kidney Diseases
Chronic Renal Insufficiency
Animal Models
Bone Density Conservation Agents
Bone and Bones
2014
36 Citations (Scopus)
zoledronic acid
Chronic Renal Insufficiency
Animal Models
Calcium
Secondary Hyperparathyroidism
20 Citations (Scopus)

Adipocyte induced arterial calcification is prevented with sodium thiosulfate

Chen, X. N., O'Neill, K., Akl, N. K. & Moe, S., Jun 20 2014, In : Biochemical and Biophysical Research Communications. 449, 1, p. 151-156 6 p.

Research output: Contribution to journalArticle

Adipocytes
Phosphorus
Muscle
Osteoblasts
Vascular Smooth Muscle
4 Citations (Scopus)
zoledronic acid
Diphosphonates
Kidney Diseases
Chronic Renal Insufficiency
Calcium
21 Citations (Scopus)

Cortical bone mechanical properties are altered in an animal model of progressive chronic kidney disease

Newman, C. L., Moe, S., Chen, X. N., Hammond, M. A., Wallace, J. M., Nyman, J. S. & Allen, M., Jun 9 2014, In : PLoS One. 9, 6, e99262.

Research output: Contribution to journalArticle

kidney diseases
Chronic Renal Insufficiency
mechanical properties
Bone
Animals
19 Citations (Scopus)

Pathogenesis of arrhythmias in a model of CKD

Hsueh, C. H., Chen, X. N., Lin, S-F., Chen, P-S., Gattone, V. H., Allen, M., Fishbein, M. C. & Moe, S., Dec 1 2014, In : Journal of the American Society of Nephrology. 25, 12, p. 2812-2821 10 p.

Research output: Contribution to journalArticle

Cardiac Arrhythmias
Calcium
MicroRNAs
Action Potentials
Voltage-Sensitive Dye Imaging
2013
54 Citations (Scopus)

Decreased MicroRNA Is Involved in the Vascular Remodeling Abnormalities in Chronic Kidney Disease (CKD)

Chen, X. N., Kiattisunthorn, K., O'Neill, K. D., Chen, X., Moorthi, R., Gattone, V. H., Allen, M. & Moe, S., May 22 2013, In : PLoS One. 8, 5, e64558.

Research output: Contribution to journalArticle

kidney diseases
MicroRNAs
Chronic Renal Insufficiency
microRNA
blood vessels
24 Citations (Scopus)

Skeletal effects of zoledronic acid in an animal model of chronic kidney disease

Allen, M., Chen, X. N., Gattone, V. H., Chen, X., Carr, A. J., Leblanc, P., Brown, D. & Moe, S., Apr 2013, In : Osteoporosis International. 24, 4, p. 1471-1481 11 p.

Research output: Contribution to journalArticle

zoledronic acid
Chronic Renal Insufficiency
Animal Models
Kidney Diseases
Diphosphonates
18 Citations (Scopus)

Transglutaminase 2 accelerates vascular calcification in chronic kidney disease

Chen, X. N., O'Neill, K., Chen, X., Kiattisunthorn, K., Gattone, V. H. & Moe, S., Apr 2013, In : American Journal of Nephrology. 37, 3, p. 191-198 8 p.

Research output: Contribution to journalArticle

Vascular Calcification
Chronic Renal Insufficiency
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cystamine
2012
75 Citations (Scopus)

Vascular calcification: Pathophysiology and risk factors

Chen, X. N. & Moe, S., Jun 2012, In : Current Hypertension Reports. 14, 3, p. 228-237 10 p.

Research output: Contribution to journalArticle

Vascular Calcification
Coronary Vessels
Chronic Renal Insufficiency
Tunica Intima
Advanced Glycosylation End Products
2011
45 Citations (Scopus)

Activation of arterial matrix metalloproteinases leads to vascular calcification in chronic kidney disease

Chen, X. N., O'Neill, K. D., Chen, X., Kiattisunthorn, K., Gattone, V. H. & Moe, S., Sep 2011, In : American Journal of Nephrology. 34, 3, p. 211-219 9 p.

Research output: Contribution to journalArticle

Vascular Calcification
Matrix Metalloproteinases
Chronic Renal Insufficiency
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
17 Citations (Scopus)

Calcimimetics inhibit renal pathology in rodent nephronophthisis

Chen, X. N., Moe, S., Eggleston-Gulyas, T., Chen, X., Hoffmeyer, W. D., Bacallao, R., Herbert, B-S. & Gattone, V. H., Sep 2 2011, In : Kidney International. 80, 6, p. 612-619 8 p.

Research output: Contribution to journalArticle

N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine
Cysts
Rodentia
Pathology
Kidney
58 Citations (Scopus)
Chronic Kidney Disease-Mineral and Bone Disorder
Phosphates
Phosphorus
Kidney
Bone and Bones
2010
18 Citations (Scopus)
alpha-2-HS-Glycoprotein
rho-Associated Kinases
Vascular Smooth Muscle
Smooth Muscle Myocytes
Vascular Calcification
29 Citations (Scopus)

Verapamil inhibits calcification and matrix vesicle activity of bovine vascular smooth muscle cells

Chen, X. N., Kircelli, F., O'Neill, K. D., Chen, X. & Moe, S., Mar 2010, In : Kidney International. 77, 5, p. 436-442 7 p.

Research output: Contribution to journalArticle

Verapamil
Vascular Smooth Muscle
Smooth Muscle Myocytes
Nifedipine
Dihydropyridines
2009
89 Citations (Scopus)

A rat model of chronic kidney disease-mineral bone disorder

Moe, S., Chen, X. N., Seifert, M. F., Sinders, R. M., Duan, D., Chen, X., Liang, Y., Radcliff, J. S., White, K. & Gattone, V. H., Jan 2009, In : Kidney International. 75, 2, p. 176-184 9 p.

Research output: Contribution to journalArticle

Chronic Kidney Disease-Mineral and Bone Disorder
Phosphorus
Chronic Renal Insufficiency
Caseins
Diet
33 Citations (Scopus)

Calcimimetic inhibits late-stage cyst growth in ADPKD

Gattone, V. H., Chen, X. N., Sinders, R. M., Seifert, M. F., Duan, D., Martin, D., Henley, C. & Moe, S., Jul 2009, In : Journal of the American Society of Nephrology. 20, 7, p. 1527-1532 6 p.

Research output: Contribution to journalArticle

N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine
Autosomal Dominant Polycystic Kidney
Cysts
Calcium
Growth
30 Citations (Scopus)

R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD)

Moe, S., Seifert, M. F., Chen, X. N., Sinders, R. M., Chen, X., Duan, D., Henley, C., Martin, D. & Gattone, V. H., Aug 2009, In : Nephrology Dialysis Transplantation. 24, 8, p. 2371-2377 7 p.

Research output: Contribution to journalArticle

N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine
Chronic Kidney Disease-Mineral and Bone Disorder
Calcium
Phosphorus
Parathyroid Hormone
2008
85 Citations (Scopus)
Annexins
Vascular Smooth Muscle
Smooth Muscle Myocytes
Collagen
alpha-2-HS-Glycoprotein
296 Citations (Scopus)

Mechanisms of vascular calcification in chronic kidney disease

Moe, S. & Chen, X. N., Feb 2008, In : Journal of the American Society of Nephrology. 19, 2, p. 213-216 4 p.

Research output: Contribution to journalArticle

Vascular Calcification
Chronic Renal Insufficiency
Body Burden
Risk Management
Chondrocytes
2007
32 Citations (Scopus)

Development of progressive aortic vasculopathy in a rat model of aging

Miller, S., Watson, W. C., Kerr, K. A., Labarrere, C. A., Chen, X. N., Deeg, M. A. & Unthank, J. L., Nov 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 293, 5

Research output: Contribution to journalArticle

Blood Vessels
Tunica Intima
Pathology
8-epi-prostaglandin F2alpha
Osteopontin
46 Citations (Scopus)

Fetuin-A uptake in bovine vascular smooth muscle cells is calcium dependent and mediated by annexins

Chen, X. N., O'Neill, K. D., Chen, X., Duan, D., Wang, E., Sturek, M., Edwards, J. M. & Moe, S., Feb 2007, In : American Journal of Physiology - Renal Physiology. 292, 2

Research output: Contribution to journalArticle

alpha-2-HS-Glycoprotein
Annexins
Vascular Smooth Muscle
Smooth Muscle Myocytes
Calcium
2006
96 Citations (Scopus)

High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells

Chen, X. N., Duan, D., O'Neill, K. D. & Moe, S., Dec 1 2006, In : Nephrology Dialysis Transplantation. 21, 12, p. 3435-3442 8 p.

Research output: Contribution to journalArticle

Core Binding Factor Alpha 1 Subunit
Vascular Smooth Muscle
Smooth Muscle Myocytes
Vascular Calcification
Glucose
87 Citations (Scopus)

The mechanisms of uremic serum-induced expression of bone matrix proteins in bovine vascular smooth muscle cells

Chen, X. N., Duan, D., O'Neill, K. D., Wolisi, G. O., Koczman, J. J., LaClair, R. & Moe, S., Sep 2006, In : Kidney International. 70, 6, p. 1046-1053 8 p.

Research output: Contribution to journalArticle

Bone Matrix
Vascular Smooth Muscle
Smooth Muscle Myocytes
Serum
Bone Morphogenetic Protein 2
25 Citations (Scopus)

Uremic vascular calcification

Chen, X. N. & Moe, S., Nov 2006, In : Journal of Investigative Medicine. 54, 7, p. 380-384 5 p.

Research output: Contribution to journalArticle

Vascular Calcification
Core Binding Factors
alpha-2-HS-Glycoprotein
Vascular Smooth Muscle
Smooth Muscle Myocytes
2005
82 Citations (Scopus)

Inflammation and vascular calcification

Moe, S. & Chen, X. N., 2005, In : Blood Purification. 23, 1, p. 64-71 8 p.

Research output: Contribution to journalArticle

Vascular Calcification
Inflammation
Chronic Renal Insufficiency
alpha-2-HS-Glycoprotein
Tunica Intima