Xuening (Neal) Chen

  • Associate Research Professor of Medicine, Nephrology
  • 4275 Citations
  • 29 h-Index
19952020

Research output per year

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Publications

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Article
2020

Adverse effects of autoclaved diets on the progression of chronic kidney disease and chronic kidney disease-mineral bone disorder in rats

Biruete, A., Srinivasan, S., O'Neill, K. D., Vorland, C. J., Hill Gallant, K. M., Cai, W., Uribarri, J., Johnston, N., Allen, M. R., Chen, N. X. & Moe, S. M., May 1 2020, In : American journal of nephrology. 51, 5, p. 381-389 9 p.

Research output: Contribution to journalArticle

Effect of Advanced Glycation End-Products (AGE) Lowering Drug ALT-711 on Biochemical, Vascular, and Bone Parameters in a Rat Model of CKD-MBD

Chen, N. X., Srinivasan, S., O'Neill, K., Nickolas, T. L., Wallace, J. M., Allen, M. R., Metzger, C. E., Creecy, A., Avin, K. G. & Moe, S. M., Mar 1 2020, In : Journal of Bone and Mineral Research. 35, 3, p. 608-617 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Kidney Disease Progression Does Not Decrease Intestinal Phosphorus Absorption in a Rat Model of Chronic Kidney Disease–Mineral Bone Disorder

Vorland, C. J., Biruete, A., Lachcik, P. J., Srinivasan, S., Chen, N. X., Moe, S. M. & Hill Gallant, K. M., Feb 1 2020, In : Journal of Bone and Mineral Research. 35, 2, p. 333-342 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

N-acetylcysteine (NAC), an anti-oxidant, does not improve bone mechanical properties in a rat model of progressive chronic kidney disease-mineral bone disorder

Allen, M. R., Wallace, J., McNerney, E., Nyman, J., Avin, K., Chen, N. & Moe, S., 2020, In : PloS one. 15, 3, e0230379.

Research output: Contribution to journalArticle

Open Access
2019

Effect of ovariectomy on the progression of chronic kidney disease-mineral bone disorder (CKD-MBD) in female Cy/+ rats

Vorland, C. J., Lachcik, P. J., Swallow, E. A., Metzger, C. E., Allen, M. R., Chen, N. X., Moe, S. M. & Hill Gallant, K. M., Dec 1 2019, In : Scientific reports. 9, 1, 7936.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Parathyroid suppression therapy normalizes chronic kidney disease-induced elevations in cortical bone vascular perfusion: a pilot study

Aref, M. W., Swallow, E. A., Metzger, C. E., Chen, N., Moe, S. M. & Allen, M. R., Aug 1 2019, In : Osteoporosis International. 30, 8, p. 1693-1698 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Skeletal levels of bisphosphonate in the setting of chronic kidney disease are independent of remodeling rate and lower with fractionated dosing

Swallow, E. A., Aref, M. W., Metzger, C. E., Sacks, S., Lehmkuhler, D. R., Chen, N., Hammond, M. A., Territo, P. R., Nickolas, T. L., Moe, S. M. & Allen, M. R., Oct 2019, In : Bone. 127, p. 419-426 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Time course of rapid bone loss and cortical porosity formation observed by longitudinal μCT in a rat model of CKD

McNerny, E. M. B., Buening, D. T., Aref, M. W., Chen, N. X., Moe, S. M. & Allen, M. R., Aug 2019, In : Bone. 125, p. 16-24 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Voluntary wheel running has beneficial effects in a rat model of CKD-mineral bone disorder (CKD-MBD)

Avin, K. G., Allen, M. R., Chen, N. X., Srinivasan, S., O'Neill, K. D., Troutman, A. D., Mast, G., Swallow, E. A., Brown, M. B., Wallace, J. M., Zimmers, T. A., Warden, S. J. & Moe, S. M., Jan 1 2019, In : Journal of the American Society of Nephrology. 30, 10, p. 1898-1909 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Effect of dietary phosphorus intake and age on intestinal phosphorus absorption efficiency and phosphorus balance in male rats

Vorland, C. J., Lachcik, P. J., Aromeh, L. O., Moe, S. M., Chen, N. X. & Hill Gallant, K. M., Nov 2018, In : PloS one. 13, 11, e0207601.

Research output: Contribution to journalArticle

1 Scopus citations

Effects of treadmill running in a rat model of chronic kidney disease

Organ, J. M., Allen, M. R., Myers-White, A., Elkhatib, W., O'Neill, K. D., Chen, N. X., Moe, S. M. & Avin, K. G., Dec 2018, In : Biochemistry and Biophysics Reports. 16, p. 19-23 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Fibroblast growth factor 23 does not directly influence skeletal muscle cell proliferation and differentiation or ex vivo muscle contractility

Avin, K. G., Vallejo, J. A., Chen, N. X., Wang, K., Touchberry, C. D., Brotto, M., Dallas, S. L., Moe, S. M. & Wacker, M. J., Oct 2 2018, In : American Journal of Physiology - Endocrinology and Metabolism. 315, 4, p. E594-E604

Research output: Contribution to journalArticle

6 Scopus citations

Matrix vesicles induce calcification of recipient vascular smooth muscle cells through multiple signaling pathways

Chen, N. X., O'Neill, K. D. & Moe, S. M., Feb 2018, In : Kidney international. 93, 2, p. 343-354 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Skeletal accumulation of fluorescently tagged zoledronate is higher in animals with early stage chronic kidney disease

Swallow, E. A., Aref, M. W., Chen, N., Byiringiro, I., Hammond, M. A., McCarthy, B. P., Territo, P. R., Kamocka, M. M., Winfree, S., Dunn, K. W., Moe, S. M. & Allen, M. R., Sep 1 2018, In : Osteoporosis International. 29, 9, p. 2139-2146 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Skeletal vascular perfusion is altered in chronic kidney disease

Aref, M. W., Swallow, E. A., Chen, N. X., Moe, S. M. & Allen, M. R., Jun 2018, In : Bone Reports. 8, p. 215-220 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Intracellular calcium increases in vascular smooth muscle cells with progression of chronic kidney disease in a rat model

Rodenbeck, S. D., Zarse, C. A., McKenney-Drake, M. L., Bruning, R. S., Sturek, M., Chen, N. X. & Moe, S. M., Mar 1 2017, In : Nephrology Dialysis Transplantation. 32, 3, p. 450-458 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Calcitriol suppression of parathyroid hormone fails to improve skeletal properties in an animal model of chronic kidney disease

Newman, C. L., Tian, N., Hammond, M. A., Wallace, J. M., Brown, D. M., Chen, N. X., Moe, S. M. & Allen, M. R., Mar 1 2016, In : American journal of nephrology. 43, 1, p. 20-31 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Raloxifene improves skeletal properties in an animal model of cystic chronic kidney disease

Newman, C. L., Creecy, A., Granke, M., Nyman, J. S., Tian, N., Hammond, M. A., Wallace, J. M., Brown, D. M., Chen, N., Moe, S. M. & Allen, M. R., Jan 1 2016, In : Kidney international. 89, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Reduced skeletal muscle function is associated with decreased fiber cross-sectional area in the Cy/+ rat model of progressive kidney disease

Organ, J. M., Srisuwananukorn, A., Price, P., Joll, J. E., Biro, K. C., Rupert, J. E., Chen, N. X., Avin, K. G., Moe, S. M. & Allen, M. R., Feb 1 2016, In : Nephrology Dialysis Transplantation. 31, 2, p. 223-230 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Skeletal muscle regeneration and oxidative stress are altered in chronic kidney disease

Avin, K. G., Chen, N. X., Organ, J. M., Zarse, C., O'Neill, K., Conway, R. G., Konrad, R. J., Bacallao, R. L., Allen, M. R. & Moe, S. M., Aug 1 2016, In : PloS one. 11, 8, e0159411.

Research output: Contribution to journalArticle

24 Scopus citations

Subcutaneous nerve activity and mechanisms of sudden death in a rat model of chronic kidney disease

Zhao, Y., Chen, N. X., Shirazi, J. T., Shen, C., Lin, S. F., Fishbein, M. C., Moe, S. M. & Chen, P. S., May 1 2016, In : Heart Rhythm. 13, 5, p. 1105-1112 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Anti-sclerostin antibody treatment in a rat model of progressive renal osteodystrophy

Moe, S. M., Chen, N. X., Newman, C. L., Organ, J. M., Kneissel, M., Kramer, I., Gattone, V. H. & Allen, M. R., Mar 1 2015, In : Journal of Bone and Mineral Research. 30, 3, p. 539-549 11 p.

Research output: Contribution to journalArticle

62 Scopus citations

Changes in skeletal collagen cross-links and matrix hydration in high- and low-turnover chronic kidney disease

Allen, M. R., Newman, C. L., Chen, N., Granke, M., Nyman, J. S. & Moe, S. M., Feb 18 2015, In : Osteoporosis International. 26, 3, p. 977-985 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Compromised vertebral structural and mechanical properties associated with progressive kidney disease and the effects of traditional pharmacological interventions

Newman, C. L., Chen, N. X., Smith, E., Smith, M., Brown, D., Moe, S. M. & Allen, M. R., Aug 1 2015, In : Bone. 77, p. 50-56 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Differential miRNA expression in cells and matrix vesicles in vascular smooth muscle cells from rats with kidney disease

Chaturvedi, P., Chen, N. X., O'Neill, K., McClintick, J. N., Moe, S. M. & Janga, S. C., Jun 26 2015, In : PloS one. 10, 6, e0131589.

Research output: Contribution to journalArticle

13 Scopus citations

Low bone turnover in chronic kidney disease is associated with decreased VEGF-A expression and osteoblast differentiation

Chen, N. X., O'Neill, K. D., Allen, M. R., Newman, C. L. & Moe, S. M., Aug 25 2015, In : American journal of nephrology. 41, 6, p. 464-473 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Pathophysiology of Vascular Calcification

Chen, X. N. & Moe, S., Sep 26 2015, In : Current Osteoporosis Reports. 13, 6, p. 372-380 9 p.

Research output: Contribution to journalArticle

43 Scopus citations
2014

A comparison of calcium to zoledronic acid for improvement of cortical bone in an animal model of CKD

Moe, S. M., Chen, N. X., Newman, C. L., Gattone, V. H., Organ, J. M., Chen, X. & Allen, M. R., Apr 2014, In : Journal of Bone and Mineral Research. 29, 4, p. 902-910 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Adipocyte induced arterial calcification is prevented with sodium thiosulfate

Chen, N. X., O'Neill, K., Akl, N. K. & Moe, S. M., Jun 20 2014, In : Biochemical and Biophysical Research Communications. 449, 1, p. 151-156 6 p.

Research output: Contribution to journalArticle

21 Scopus citations
4 Scopus citations

Cortical bone mechanical properties are altered in an animal model of progressive chronic kidney disease

Newman, C. L., Moe, S. M., Chen, N. X., Hammond, M. A., Wallace, J. M., Nyman, J. S. & Allen, M. R., Jun 9 2014, In : PLoS ONE. 9, 6, e99262.

Research output: Contribution to journalArticle

25 Scopus citations

Pathogenesis of arrhythmias in a model of CKD

Hsueh, C. H., Chen, N. X., Lin, S. F., Chen, P. S., Gattone, V. H., Allen, M. R., Fishbein, M. C. & Moe, S. M., Dec 1 2014, In : Journal of the American Society of Nephrology. 25, 12, p. 2812-2821 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2013

Decreased MicroRNA Is Involved in the Vascular Remodeling Abnormalities in Chronic Kidney Disease (CKD)

Chen, N. X., Kiattisunthorn, K., O'Neill, K. D., Chen, X., Moorthi, R. N., Gattone, V. H., Allen, M. R. & Moe, S. M., May 22 2013, In : PLoS ONE. 8, 5, e64558.

Research output: Contribution to journalArticle

64 Scopus citations

Skeletal effects of zoledronic acid in an animal model of chronic kidney disease

Allen, M. R., Chen, N. X., Gattone, V. H., Chen, X., Carr, A. J., Leblanc, P., Brown, D. & Moe, S. M., Apr 2013, In : Osteoporosis International. 24, 4, p. 1471-1481 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Transglutaminase 2 accelerates vascular calcification in chronic kidney disease

Chen, N. X., O'Neill, K., Chen, X., Kiattisunthorn, K., Gattone, V. H. & Moe, S. M., Apr 1 2013, In : American journal of nephrology. 37, 3, p. 191-198 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
2012

Vascular calcification: Pathophysiology and risk factors

Chen, N. X. & Moe, S. M., Jun 1 2012, In : Current hypertension reports. 14, 3, p. 228-237 10 p.

Research output: Contribution to journalArticle

86 Scopus citations
2011

Activation of arterial matrix metalloproteinases leads to vascular calcification in chronic kidney disease

Chen, N. X., O'Neill, K. D., Chen, X., Kiattisunthorn, K., Gattone, V. H. & Moe, S. M., Sep 2011, In : American journal of nephrology. 34, 3, p. 211-219 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Calcimimetics inhibit renal pathology in rodent nephronophthisis

Chen, N. X., Moe, S. M., Eggleston-Gulyas, T., Chen, X., Hoffmeyer, W. D., Bacallao, R. L., Herbert, B. S. & Gattone, V. H., Sep 2 2011, In : Kidney international. 80, 6, p. 612-619 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat

Moe, S. M., Radcliffe, J. S., White, K. E., Gattone, V. H., Seifert, M. F., Chen, X., Aldridge, B. & Chen, N. X., Nov 1 2011, In : Journal of Bone and Mineral Research. 26, 11, p. 2672-2681 10 p.

Research output: Contribution to journalArticle

65 Scopus citations
2010

RhoA/Rho kinase (ROCK) alters fetuin-A uptake and regulates calcification in bovine vascular smooth muscle cells (BVSMC)

Chen, N. X., Chen, X., O'Neill, K. D., Atkinson, S. J. & Moe, S. M., Sep 1 2010, In : American Journal of Physiology - Renal Physiology. 299, 3, p. F674-F680

Research output: Contribution to journalArticle

19 Scopus citations

Verapamil inhibits calcification and matrix vesicle activity of bovine vascular smooth muscle cells

Chen, N. X., Kircelli, F., O'Neill, K. D., Chen, X. & Moe, S. M., Mar 1 2010, In : Kidney international. 77, 5, p. 436-442 7 p.

Research output: Contribution to journalArticle

32 Scopus citations
2009

A rat model of chronic kidney disease-mineral bone disorder

Moe, S. M., Chen, N. X., Seifert, M. F., Sinders, R. M., Duan, D., Chen, X., Liang, Y., Radcliff, J. S., White, K. E. & Gattone, V. H., Jan 2009, In : Kidney international. 75, 2, p. 176-184 9 p.

Research output: Contribution to journalArticle

98 Scopus citations

Calcimimetic inhibits late-stage cyst growth in ADPKD

Gattone, V. H., Chen, N. X., Sinders, R. M., Seifert, M. F., Duan, D., Martin, D., Henley, C. & Moe, S. M., Jul 2009, In : Journal of the American Society of Nephrology. 20, 7, p. 1527-1532 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD)

Moe, S. M., Seifert, M. F., Chen, N. X., Sinders, R. M., Chen, X., Duan, D., Henley, C., Martin, D. & Gattone, V. H., Aug 2009, In : Nephrology Dialysis Transplantation. 24, 8, p. 2371-2377 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
2008

Annexin-mediated matrix vesicle calcification in vascular smooth muscle cells

Chen, N. X., O'Neill, K. D., Chen, X. & Moe, S. M., Nov 1 2008, In : Journal of Bone and Mineral Research. 23, 11, p. 1798-1805 8 p.

Research output: Contribution to journalArticle

93 Scopus citations
2007

Development of progressive aortic vasculopathy in a rat model of aging

Miller, S. J., Watson, W. C., Kerr, K. A., Labarrere, C. A., Chen, N. X., Deeg, M. A. & Unthank, J. L., Nov 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 293, 5, p. H2634-H2643

Research output: Contribution to journalArticle

32 Scopus citations

Fetuin-A uptake in bovine vascular smooth muscle cells is calcium dependent and mediated by annexins

Chen, N. X., O'Neill, K. D., Chen, X., Duan, D., Wang, E., Sturek, M. S., Edwards, J. M. & Moe, S. M., Feb 1 2007, In : American Journal of Physiology - Renal Physiology. 292, 2, p. F599-F606

Research output: Contribution to journalArticle

48 Scopus citations
2006

High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells

Chen, N. X., Duan, D., O'Neill, K. D. & Moe, S. M., Dec 1 2006, In : Nephrology Dialysis Transplantation. 21, 12, p. 3435-3442 8 p.

Research output: Contribution to journalArticle

108 Scopus citations

The mechanisms of uremic serum-induced expression of bone matrix proteins in bovine vascular smooth muscle cells

Chen, N. X., Duan, D., O'Neill, K. D., Wolisi, G. O., Koczman, J. J., LaClair, R. & Moe, S. M., Sep 1 2006, In : Kidney international. 70, 6, p. 1046-1053 8 p.

Research output: Contribution to journalArticle

90 Scopus citations

Uremic vascular calcification

Chen, N. X. & Moe, S. M., Nov 2006, In : Journal of Investigative Medicine. 54, 7, p. 380-384 5 p.

Research output: Contribution to journalArticle

25 Scopus citations