Xuening (Neal) Chen

  • Associate Research Professor of Medicine, Nephrology
  • 4063 Citations
  • 29 h-Index
19952019
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Publications 1995 2019

  • 4063 Citations
  • 29 h-Index
  • 69 Article
  • 1 Conference contribution
  • 1 Review article
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Article
1995
19 Citations (Scopus)

Glucocorticoid receptor binding in porcine preadipocytes during development.

Chen, X. N., White, B. D. & Hausman, G. J., Mar 1995, In : Journal of Animal Science. 73, 3, p. 722-727 6 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Swine
swine
gestational age
fetal development
18 Citations (Scopus)
Insulin, Regular, Pork
hypophysectomy
Insulin-Like Growth Factor Binding Proteins
Hypophysectomy
IGF Type 1 Receptor
1996
21 Citations (Scopus)
Insulin-Like Growth Factor Binding Proteins
insulin-like growth factor binding proteins
hormonal regulation
insulin-like growth factor I
Insulin-Like Growth Factor I
1998
326 Citations (Scopus)

Fluid shear-induced mechanical signaling in MC3T3-E1 osteoblasts requires cytoskeleton-integrin interactions

Pavalko, F., Chen, X. N., Turner, C. H., Burr, D., Atkinson, S., Hsieh, Y. F., Qiu, J. & Duncan, R. L., 1998, In : American Journal of Physiology - Cell Physiology. 275, 6 44-6

Research output: Contribution to journalArticle

Osteoblasts
Actinin
Cytoskeleton
Stress Fibers
Integrins
2000
239 Citations (Scopus)

Ca2+ regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts

Chen, X. N., Ryder, K. D., Pavalko, F., Turner, C. H., Burr, D., Qiu, J. & Duncan, R. L., 2000, In : American Journal of Physiology - Cell Physiology. 278, 5 47-5

Research output: Contribution to journalArticle

Osteoblasts
Gene expression
Gadolinium
Gene Expression
Stress Fibers
Cell Physiological Phenomena
Osteoblasts
Physiology
Gene expression
Gene Expression
2001
15 Citations (Scopus)

The role of the synovium and cartilage in the pathogenesis of β2-microglobulin amyloidosis

Moe, S. & Chen, X. N., 2001, In : Seminars in Dialysis. 14, 2, p. 127-130 4 p.

Research output: Contribution to journalArticle

Synovial Membrane
Amyloidosis
Amyloid
Cartilage
Joints
2002
361 Citations (Scopus)

Medial artery calcification in ESRD patients is associated with deposition of bone matrix proteins

Moe, S., O'Neill, K. D., Duan, D., Ahmed, S., Chen, X. N., Leapman, S. B., Fineberg, N. & Kopecky, K., 2002, In : Kidney International. 61, 2, p. 638-647 10 p.

Research output: Contribution to journalArticle

Bone Matrix
Spiral Computed Tomography
Chronic Kidney Failure
Epigastric Arteries
Vascular Calcification
275 Citations (Scopus)

Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells

Chen, X. N., O'Neill, K. D., Duan, D. & Moe, S., 2002, In : Kidney International. 62, 5, p. 1724-1731 8 p.

Research output: Contribution to journalArticle

Osteopontin
Vascular Smooth Muscle
Phosphorus
Smooth Muscle Myocytes
Up-Regulation
18 Citations (Scopus)

Signal transduction of β2m-induced expression of VCAM-1 and COX-2 in synovial fibroblasts

Chen, X. N., O'Neill, K. D., Niwa, T. & Moe, S., 2002, In : Kidney International. 61, 2, p. 414-424 11 p.

Research output: Contribution to journalArticle

Vascular Cell Adhesion Molecule-1
Cyclooxygenase 2
Signal Transduction
Fibroblasts
Phosphatidylinositol 3-Kinase
2003
108 Citations (Scopus)

Arterial calcification in diabetes

Chen, N. X. & Moe, S. M., Feb 2003, In : Current Diabetes Reports. 3, 1, p. 28-32 5 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Osteopontin
Osteoblasts
Chronic Kidney Failure
50 Citations (Scopus)

Calciphylaxis and vascular calcification: A continuum of extra-skeletal osteogenesis

Moe, S. & Chen, X. N., Oct 1 2003, In : Pediatric Nephrology. 18, 10, p. 969-975 7 p.

Research output: Contribution to journalArticle

Calciphylaxis
Vascular Calcification
Osteogenesis
Arteries
Tunica Intima
9 Citations (Scopus)

Cellular uptake of β2M and AGE-β2M in synovial fibroblasts and macrophages

O'Neill, K. D., Chen, X. N., Wang, M., Cocklin, R., Zhang, Y. & Moe, S., Jan 1 2003, In : Nephrology Dialysis Transplantation. 18, 1, p. 46-53 8 p.

Research output: Contribution to journalArticle

Endosomes
Fibroblasts
Macrophages
Monocytes
Fluorescent Dyes
67 Citations (Scopus)

Fluid shear-induced NFκB translocation in osteoblasts is mediated by intracellular calcium release

Chen, X. N., Geist, D. J., Genetos, D. C., Pavalko, F. & Duncan, R. L., Sep 1 2003, In : Bone. 33, 3, p. 399-410 12 p.

Research output: Contribution to journalArticle

NF-kappa B
Osteoblasts
Calcium
Type C Phospholipases
Lysine
11 Citations (Scopus)

Identity and localization of advanced glycation end products on human β2-microglobulin using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Cocklin, R. R., Zhang, Y., O'Neill, K. D., Chen, X. N., Moe, S., Bidasee, K. R. & Wang, M., Mar 15 2003, In : Analytical Biochemistry. 314, 2, p. 322-325 4 p.

Research output: Contribution to journalArticle

Advanced Glycosylation End Products
Mass Spectrometry
Lasers
264 Citations (Scopus)

Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels

Moe, S., Duan, D., Doehle, B. P., O'Neill, K. D. & Chen, X. N., Mar 1 2003, In : Kidney International. 63, 3, p. 1003-1011 9 p.

Research output: Contribution to journalArticle

Uremia
Osteoblasts
Blood Vessels
Vascular Smooth Muscle
Smooth Muscle Myocytes
2004
359 Citations (Scopus)

Pathophysiology of vascular calcification in chronic kidney disease

Moe, S. & Chen, X. N., Sep 17 2004, In : Circulation Research. 95, 6, p. 560-567 8 p.

Research output: Contribution to journalArticle

Vascular Calcification
Chronic Renal Insufficiency
Dialysis
Core Binding Factors
alpha-2-HS-Glycoprotein
41 Citations (Scopus)

Vascular Calcification in Chronic Kidney Disease

Chen, N. X. & Moe, S. M., Jan 2004, In : Seminars in Nephrology. 24, 1, p. 61-68 8 p.

Research output: Contribution to journalArticle

Vascular Calcification
Chronic Renal Insufficiency
Osteoblasts
Vascular Smooth Muscle
Smooth Muscle Myocytes
2005
82 Citations (Scopus)

Inflammation and vascular calcification

Moe, S. & Chen, X. N., 2005, In : Blood Purification. 23, 1, p. 64-71 8 p.

Research output: Contribution to journalArticle

Vascular Calcification
Inflammation
Chronic Renal Insufficiency
alpha-2-HS-Glycoprotein
Tunica Intima
287 Citations (Scopus)

Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease (CKD)

Moe, S. M., Reslerova, M., Ketteler, M., O'Neill, K., Duan, D., Koczman, J., Westenfeld, R., Jahnen-Dechent, W. & Chen, N. X., Jun 2005, In : Kidney International. 67, 6, p. 2295-2304 10 p.

Research output: Contribution to journalArticle

alpha-2-HS-Glycoprotein
Vascular Calcification
Osteoprotegerin
Chronic Renal Insufficiency
Vascular Smooth Muscle
2006
100 Citations (Scopus)

High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells

Chen, X. N., Duan, D., O'Neill, K. D. & Moe, S., Dec 1 2006, In : Nephrology Dialysis Transplantation. 21, 12, p. 3435-3442 8 p.

Research output: Contribution to journalArticle

Core Binding Factor Alpha 1 Subunit
Vascular Smooth Muscle
Smooth Muscle Myocytes
Vascular Calcification
Glucose
87 Citations (Scopus)

The mechanisms of uremic serum-induced expression of bone matrix proteins in bovine vascular smooth muscle cells

Chen, X. N., Duan, D., O'Neill, K. D., Wolisi, G. O., Koczman, J. J., LaClair, R. & Moe, S., Sep 2006, In : Kidney International. 70, 6, p. 1046-1053 8 p.

Research output: Contribution to journalArticle

Bone Matrix
Vascular Smooth Muscle
Smooth Muscle Myocytes
Serum
Bone Morphogenetic Protein 2
25 Citations (Scopus)

Uremic vascular calcification

Chen, X. N. & Moe, S., Nov 2006, In : Journal of Investigative Medicine. 54, 7, p. 380-384 5 p.

Research output: Contribution to journalArticle

Vascular Calcification
Core Binding Factors
alpha-2-HS-Glycoprotein
Vascular Smooth Muscle
Smooth Muscle Myocytes
2007
32 Citations (Scopus)

Development of progressive aortic vasculopathy in a rat model of aging

Miller, S., Watson, W. C., Kerr, K. A., Labarrere, C. A., Chen, X. N., Deeg, M. A. & Unthank, J. L., Nov 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 293, 5

Research output: Contribution to journalArticle

Blood Vessels
Tunica Intima
Pathology
8-epi-prostaglandin F2alpha
Osteopontin
46 Citations (Scopus)

Fetuin-A uptake in bovine vascular smooth muscle cells is calcium dependent and mediated by annexins

Chen, X. N., O'Neill, K. D., Chen, X., Duan, D., Wang, E., Sturek, M., Edwards, J. M. & Moe, S., Feb 2007, In : American Journal of Physiology - Renal Physiology. 292, 2

Research output: Contribution to journalArticle

alpha-2-HS-Glycoprotein
Annexins
Vascular Smooth Muscle
Smooth Muscle Myocytes
Calcium
2008
85 Citations (Scopus)
Annexins
Vascular Smooth Muscle
Smooth Muscle Myocytes
Collagen
alpha-2-HS-Glycoprotein
300 Citations (Scopus)

Mechanisms of vascular calcification in chronic kidney disease

Moe, S. & Chen, X. N., Feb 2008, In : Journal of the American Society of Nephrology. 19, 2, p. 213-216 4 p.

Research output: Contribution to journalArticle

Vascular Calcification
Chronic Renal Insufficiency
Body Burden
Risk Management
Chondrocytes
2009
90 Citations (Scopus)

A rat model of chronic kidney disease-mineral bone disorder

Moe, S., Chen, X. N., Seifert, M. F., Sinders, R. M., Duan, D., Chen, X., Liang, Y., Radcliff, J. S., White, K. & Gattone, V. H., Jan 2009, In : Kidney International. 75, 2, p. 176-184 9 p.

Research output: Contribution to journalArticle

Chronic Kidney Disease-Mineral and Bone Disorder
Phosphorus
Chronic Renal Insufficiency
Caseins
Diet
34 Citations (Scopus)

Calcimimetic inhibits late-stage cyst growth in ADPKD

Gattone, V. H., Chen, X. N., Sinders, R. M., Seifert, M. F., Duan, D., Martin, D., Henley, C. & Moe, S., Jul 2009, In : Journal of the American Society of Nephrology. 20, 7, p. 1527-1532 6 p.

Research output: Contribution to journalArticle

N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine
Autosomal Dominant Polycystic Kidney
Cysts
Calcium
Growth
30 Citations (Scopus)

R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD)

Moe, S., Seifert, M. F., Chen, X. N., Sinders, R. M., Chen, X., Duan, D., Henley, C., Martin, D. & Gattone, V. H., Aug 2009, In : Nephrology Dialysis Transplantation. 24, 8, p. 2371-2377 7 p.

Research output: Contribution to journalArticle

N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine
Chronic Kidney Disease-Mineral and Bone Disorder
Calcium
Phosphorus
Parathyroid Hormone
2010
19 Citations (Scopus)
alpha-2-HS-Glycoprotein
rho-Associated Kinases
Vascular Smooth Muscle
Smooth Muscle Myocytes
Vascular Calcification
30 Citations (Scopus)

Verapamil inhibits calcification and matrix vesicle activity of bovine vascular smooth muscle cells

Chen, X. N., Kircelli, F., O'Neill, K. D., Chen, X. & Moe, S., Mar 2010, In : Kidney International. 77, 5, p. 436-442 7 p.

Research output: Contribution to journalArticle

Verapamil
Vascular Smooth Muscle
Smooth Muscle Myocytes
Nifedipine
Dihydropyridines
2011
46 Citations (Scopus)

Activation of arterial matrix metalloproteinases leads to vascular calcification in chronic kidney disease

Chen, X. N., O'Neill, K. D., Chen, X., Kiattisunthorn, K., Gattone, V. H. & Moe, S., Sep 2011, In : American Journal of Nephrology. 34, 3, p. 211-219 9 p.

Research output: Contribution to journalArticle

Vascular Calcification
Matrix Metalloproteinases
Chronic Renal Insufficiency
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
18 Citations (Scopus)

Calcimimetics inhibit renal pathology in rodent nephronophthisis

Chen, X. N., Moe, S., Eggleston-Gulyas, T., Chen, X., Hoffmeyer, W. D., Bacallao, R., Herbert, B-S. & Gattone, V. H., Sep 2 2011, In : Kidney International. 80, 6, p. 612-619 8 p.

Research output: Contribution to journalArticle

N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine
Cysts
Rodentia
Pathology
Kidney
60 Citations (Scopus)
Chronic Kidney Disease-Mineral and Bone Disorder
Phosphates
Phosphorus
Kidney
Bone and Bones
2012
75 Citations (Scopus)

Vascular calcification: Pathophysiology and risk factors

Chen, X. N. & Moe, S., Jun 2012, In : Current Hypertension Reports. 14, 3, p. 228-237 10 p.

Research output: Contribution to journalArticle

Vascular Calcification
Coronary Vessels
Chronic Renal Insufficiency
Tunica Intima
Advanced Glycosylation End Products
2013
56 Citations (Scopus)

Decreased MicroRNA Is Involved in the Vascular Remodeling Abnormalities in Chronic Kidney Disease (CKD)

Chen, X. N., Kiattisunthorn, K., O'Neill, K. D., Chen, X., Moorthi, R., Gattone, V. H., Allen, M. & Moe, S., May 22 2013, In : PLoS One. 8, 5, e64558.

Research output: Contribution to journalArticle

kidney diseases
MicroRNAs
Chronic Renal Insufficiency
microRNA
blood vessels
24 Citations (Scopus)

Skeletal effects of zoledronic acid in an animal model of chronic kidney disease

Allen, M., Chen, X. N., Gattone, V. H., Chen, X., Carr, A. J., Leblanc, P., Brown, D. & Moe, S., Apr 2013, In : Osteoporosis International. 24, 4, p. 1471-1481 11 p.

Research output: Contribution to journalArticle

zoledronic acid
Chronic Renal Insufficiency
Animal Models
Kidney Diseases
Diphosphonates
19 Citations (Scopus)

Transglutaminase 2 accelerates vascular calcification in chronic kidney disease

Chen, X. N., O'Neill, K., Chen, X., Kiattisunthorn, K., Gattone, V. H. & Moe, S., Apr 2013, In : American Journal of Nephrology. 37, 3, p. 191-198 8 p.

Research output: Contribution to journalArticle

Vascular Calcification
Chronic Renal Insufficiency
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cystamine
2014
37 Citations (Scopus)
zoledronic acid
Chronic Renal Insufficiency
Animal Models
Calcium
Secondary Hyperparathyroidism
20 Citations (Scopus)

Adipocyte induced arterial calcification is prevented with sodium thiosulfate

Chen, X. N., O'Neill, K., Akl, N. K. & Moe, S., Jun 20 2014, In : Biochemical and Biophysical Research Communications. 449, 1, p. 151-156 6 p.

Research output: Contribution to journalArticle

Adipocytes
Phosphorus
Muscle
Osteoblasts
Vascular Smooth Muscle
4 Citations (Scopus)
zoledronic acid
Diphosphonates
Kidney Diseases
Chronic Renal Insufficiency
Calcium
22 Citations (Scopus)

Cortical bone mechanical properties are altered in an animal model of progressive chronic kidney disease

Newman, C. L., Moe, S., Chen, X. N., Hammond, M. A., Wallace, J. M., Nyman, J. S. & Allen, M., Jun 9 2014, In : PLoS One. 9, 6, e99262.

Research output: Contribution to journalArticle

kidney diseases
Chronic Renal Insufficiency
mechanical properties
Bone
Animals
19 Citations (Scopus)

Pathogenesis of arrhythmias in a model of CKD

Hsueh, C. H., Chen, X. N., Lin, S-F., Chen, P-S., Gattone, V. H., Allen, M., Fishbein, M. C. & Moe, S., Dec 1 2014, In : Journal of the American Society of Nephrology. 25, 12, p. 2812-2821 10 p.

Research output: Contribution to journalArticle

Cardiac Arrhythmias
Calcium
MicroRNAs
Action Potentials
Voltage-Sensitive Dye Imaging
2015
54 Citations (Scopus)

Anti-sclerostin antibody treatment in a rat model of progressive renal osteodystrophy

Moe, S., Chen, X. N., Newman, C. L., Organ, J., Kneissel, M., Kramer, I., Gattone, V. H. & Allen, M., Mar 1 2015, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 30, 3, p. 499-509 11 p.

Research output: Contribution to journalArticle

Chronic Kidney Disease-Mineral and Bone Disorder
Parathyroid Hormone
Anti-Idiotypic Antibodies
Chronic Renal Insufficiency
zoledronic acid
15 Citations (Scopus)

Changes in skeletal collagen cross-links and matrix hydration in high- and low-turnover chronic kidney disease

Allen, M., Newman, C. L., Chen, X. N., Granke, M., Nyman, J. S. & Moe, S., 2015, In : Osteoporosis International. 26, 3, p. 977-985 9 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Collagen
Bone and Bones
Bone Remodeling
Kidney
14 Citations (Scopus)

Compromised vertebral structural and mechanical properties associated with progressive kidney disease and the effects of traditional pharmacological interventions

Newman, C. L., Chen, X. N., Smith, E., Smith, M., Brown, D., Moe, S. & Allen, M., Aug 1 2015, In : Bone. 77, p. 50-56 7 p.

Research output: Contribution to journalArticle

Kidney Diseases
Pharmacology
Anti-Idiotypic Antibodies
Bone and Bones
zoledronic acid
8 Citations (Scopus)

Differential miRNA expression in cells and matrix vesicles in vascular smooth muscle cells from rats with kidney disease

Chaturvedi, P., Chen, X. N., O'Neill, K., McClintick, J., Moe, S. & Janga, S. C., Jun 26 2015, In : PLoS One. 10, 6, e0131589.

Research output: Contribution to journalArticle

Kidney Diseases
kidney diseases
MicroRNAs
microRNA
Vascular Smooth Muscle
7 Citations (Scopus)

Low Bone Turnover in Chronic Kidney Disease Is Associated with Decreased VEGF-A Expression and Osteoblast Differentiation

Chen, X. N., O''Neill, K. D., Allen, M., Newman, C. L. & Moe, S., Aug 25 2015, In : American Journal of Nephrology. 41, p. 464-473 10 p.

Research output: Contribution to journalArticle

Bone Remodeling
Osteoblasts
Chronic Renal Insufficiency
Vascular Endothelial Growth Factor A
Osteogenesis
34 Citations (Scopus)

Pathophysiology of Vascular Calcification

Chen, X. N. & Moe, S., Sep 26 2015, In : Current Osteoporosis Reports. 13, 6, p. 372-380 9 p.

Research output: Contribution to journalArticle

Vascular Calcification
alpha-2-HS-Glycoprotein
Hyperphosphatemia
Hypercalcemia
Chronic Renal Insufficiency