Xuening (Neal) Chen

  • Associate Research Professor of Medicine, Nephrology
  • 4063 Citations
  • 29 h-Index
19952019
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Publications 1995 2019

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37 Citations (Scopus)

A comparison of calcium to zoledronic acid for improvement of cortical bone in an animal model of CKD

Moe, S. M., Chen, N. X., Newman, C. L., Gattone, V. H., Organ, J. M., Chen, X. & Allen, M. R., Apr 2014, In : Journal of Bone and Mineral Research. 29, 4, p. 902-910 9 p.

Research output: Contribution to journalArticle

zoledronic acid
Chronic Renal Insufficiency
Animal Models
Calcium
Secondary Hyperparathyroidism
46 Citations (Scopus)

Activation of arterial matrix metalloproteinases leads to vascular calcification in chronic kidney disease

Chen, N. X., O'Neill, K. D., Chen, X., Kiattisunthorn, K., Gattone, V. H. & Moe, S. M., Sep 1 2011, In : American Journal of Nephrology. 34, 3, p. 211-219 9 p.

Research output: Contribution to journalArticle

Vascular Calcification
Matrix Metalloproteinases
Chronic Renal Insufficiency
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
20 Citations (Scopus)

Adipocyte induced arterial calcification is prevented with sodium thiosulfate

Chen, N. X., O'Neill, K., Akl, N. K. & Moe, S. M., Jun 20 2014, In : Biochemical and Biophysical Research Communications. 449, 1, p. 151-156 6 p.

Research output: Contribution to journalArticle

Adipocytes
Phosphorus
Muscle
Osteoblasts
Vascular Smooth Muscle
4 Citations (Scopus)
zoledronic acid
Diphosphonates
Kidney Diseases
Chronic Renal Insufficiency
Calcium
85 Citations (Scopus)

Annexin-mediated matrix vesicle calcification in vascular smooth muscle cells

Chen, N. X., O'Neill, K. D., Chen, X. & Moe, S. M., Nov 1 2008, In : Journal of Bone and Mineral Research. 23, 11, p. 1798-1805 8 p.

Research output: Contribution to journalArticle

Annexins
Vascular Smooth Muscle
Smooth Muscle Myocytes
Collagen
alpha-2-HS-Glycoprotein
54 Citations (Scopus)

Anti-sclerostin antibody treatment in a rat model of progressive renal osteodystrophy

Moe, S. M., Chen, N. X., Newman, C. L., Organ, J. M., Kneissel, M., Kramer, I., Gattone, V. H. & Allen, M. R., Mar 1 2015, In : Journal of Bone and Mineral Research. 30, 3, p. 539-549 11 p.

Research output: Contribution to journalArticle

Chronic Kidney Disease-Mineral and Bone Disorder
Parathyroid Hormone
Anti-Idiotypic Antibodies
Chronic Renal Insufficiency
zoledronic acid
90 Citations (Scopus)

A rat model of chronic kidney disease-mineral bone disorder

Moe, S. M., Chen, N. X., Seifert, M. F., Sinders, R. M., Duan, D., Chen, X., Liang, Y., Radcliff, J. S., White, K. E. & Gattone, V. H., Jan 1 2009, In : Kidney international. 75, 2, p. 176-184 9 p.

Research output: Contribution to journalArticle

Chronic Kidney Disease-Mineral and Bone Disorder
Phosphorus
Chronic Renal Insufficiency
Caseins
Diet
239 Citations (Scopus)

Ca2+ regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts

Chen, N. X., Ryder, K. D., Pavalko, F. M., Turner, C. H., Burr, D. B., Qiu, J. & Duncan, R. L., Jun 22 2000, In : American Journal of Physiology - Cell Physiology. 278, 5 47-5, p. C989-C997

Research output: Contribution to journalArticle

Osteoblasts
Gene expression
Gadolinium
Gene Expression
Stress Fibers
34 Citations (Scopus)

Calcimimetic inhibits late-stage cyst growth in ADPKD

Gattone, V. H., Chen, N. X., Sinders, R. M., Seifert, M. F., Duan, D., Martin, D., Henley, C. & Moe, S. M., Jul 1 2009, In : Journal of the American Society of Nephrology. 20, 7, p. 1527-1532 6 p.

Research output: Contribution to journalArticle

N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine
Autosomal Dominant Polycystic Kidney
Cysts
Calcium
Growth
18 Citations (Scopus)

Calcimimetics inhibit renal pathology in rodent nephronophthisis

Chen, N. X., Moe, S. M., Eggleston-Gulyas, T., Chen, X., Hoffmeyer, W. D., Bacallao, R. L., Herbert, B. S. & Gattone, V. H., Sep 2 2011, In : Kidney international. 80, 6, p. 612-619 8 p.

Research output: Contribution to journalArticle

N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine
Cysts
Rodentia
Pathology
Kidney
3 Citations (Scopus)

Calcitriol Suppression of Parathyroid Hormone Fails to Improve Skeletal Properties in an Animal Model of Chronic Kidney Disease

Newman, C. L., Tian, N., Hammond, M. A., Wallace, J. M., Brown, D. M., Chen, X. N., Moe, S. & Allen, M., Feb 17 2016, (Accepted/In press) In : American Journal of Nephrology. p. 20-31 12 p.

Research output: Contribution to journalArticle

Calcitriol
Parathyroid Hormone
Chronic Renal Insufficiency
Animal Models
Bone and Bones
9 Citations (Scopus)

Cellular uptake of β2M and AGE-β2M in synovial fibroblasts and macrophages

O'Neill, K. D., Chen, N. X., Wang, M., Cocklin, R., Zhang, Y. & Moe, S. M., Jan 1 2003, In : Nephrology Dialysis Transplantation. 18, 1, p. 46-53 8 p.

Research output: Contribution to journalArticle

Endosomes
Fibroblasts
Macrophages
Monocytes
Fluorescent Dyes
15 Citations (Scopus)

Changes in skeletal collagen cross-links and matrix hydration in high- and low-turnover chronic kidney disease

Allen, M. R., Newman, C. L., Chen, N., Granke, M., Nyman, J. S. & Moe, S. M., Feb 18 2015, In : Osteoporosis International. 26, 3, p. 977-985 9 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Collagen
Bone and Bones
Bone Remodeling
Kidney
14 Citations (Scopus)

Compromised vertebral structural and mechanical properties associated with progressive kidney disease and the effects of traditional pharmacological interventions

Newman, C. L., Chen, N. X., Smith, E., Smith, M., Brown, D., Moe, S. M. & Allen, M. R., Aug 1 2015, In : Bone. 77, p. 50-56 7 p.

Research output: Contribution to journalArticle

Kidney Diseases
Pharmacology
Anti-Idiotypic Antibodies
Bone and Bones
zoledronic acid
22 Citations (Scopus)

Cortical bone mechanical properties are altered in an animal model of progressive chronic kidney disease

Newman, C. L., Moe, S. M., Chen, N. X., Hammond, M. A., Wallace, J. M., Nyman, J. S. & Allen, M. R., Jun 9 2014, In : PLoS ONE. 9, 6, e99262.

Research output: Contribution to journalArticle

kidney diseases
Chronic Renal Insufficiency
mechanical properties
Bone
Animals
56 Citations (Scopus)

Decreased MicroRNA Is Involved in the Vascular Remodeling Abnormalities in Chronic Kidney Disease (CKD)

Chen, N. X., Kiattisunthorn, K., O'Neill, K. D., Chen, X., Moorthi, R. N., Gattone, V. H., Allen, M. R. & Moe, S. M., May 22 2013, In : PLoS ONE. 8, 5, e64558.

Research output: Contribution to journalArticle

kidney diseases
MicroRNAs
Chronic Renal Insufficiency
microRNA
blood vessels
32 Citations (Scopus)

Development of progressive aortic vasculopathy in a rat model of aging

Miller, S. J., Watson, W. C., Kerr, K. A., Labarrere, C. A., Chen, N. X., Deeg, M. A. & Unthank, J. L., Nov 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 293, 5, p. H2634-H2643

Research output: Contribution to journalArticle

Blood Vessels
Tunica Intima
Pathology
8-epi-prostaglandin F2alpha
Osteopontin
8 Citations (Scopus)

Differential miRNA expression in cells and matrix vesicles in vascular smooth muscle cells from rats with kidney disease

Chaturvedi, P., Chen, N. X., O'Neill, K., McClintick, J. N., Moe, S. M. & Janga, S. C., Jun 26 2015, In : PLoS ONE. 10, 6, e0131589.

Research output: Contribution to journalArticle

Kidney Diseases
kidney diseases
MicroRNAs
microRNA
Vascular Smooth Muscle

Effect of Advanced Glycation End-Products (AGE) Lowering Drug ALT-711 on Biochemical, Vascular, and Bone Parameters in a Rat Model of CKD-MBD

Chen, N. X., Srinivasan, S., O'Neill, K., Nickolas, T. L., Wallace, J. M., Allen, M. R., Metzger, C. E., Creecy, A., Avin, K. G. & Moe, S. M., Jan 1 2019, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Advanced Glycosylation End Products
Blood Vessels
Kidney
Bone and Bones
Pharmaceutical Preparations
1 Citation (Scopus)

Effect of dietary phosphorus intake and age on intestinal phosphorus absorption efficiency and phosphorus balance in male rats

Vorland, C. J., Lachcik, P. J., Aromeh, L. O., Moe, S., Chen, X. N. & Hill Gallant, K. M., Jan 1 2018, In : PLoS One. 13, 11, p. e0207601

Research output: Contribution to journalArticle

Dietary Phosphorus
Intestinal Absorption
Phosphorus
Rats
phosphorus
2 Citations (Scopus)

Effect of ovariectomy on the progression of chronic kidney disease-mineral bone disorder (CKD-MBD) in female Cy/+ rats

Vorland, C. J., Lachcik, P. J., Swallow, E. A., Metzger, C. E., Allen, M., Chen, X. N., Moe, S. & Hill Gallant, K. M., May 28 2019, In : Scientific reports. 9, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Chronic Kidney Disease-Mineral and Bone Disorder
Ovariectomy
Porosity
Kidney Diseases
Phosphorus
3 Citations (Scopus)

Effects of treadmill running in a rat model of chronic kidney disease

Organ, J., Allen, M., Myers-White, A., Elkhatib, W., O'Neill, K. D., Chen, X. N., Moe, S. & Avin, K. G., Dec 1 2018, In : Biochemistry and Biophysics Reports. 16, p. 19-23 5 p.

Research output: Contribution to journalArticle

Exercise equipment
Chronic Renal Insufficiency
Running
Rats
Muscle
46 Citations (Scopus)

Fetuin-A uptake in bovine vascular smooth muscle cells is calcium dependent and mediated by annexins

Chen, N. X., O'Neill, K. D., Chen, X., Duan, D., Wang, E., Sturek, M. S., Edwards, J. M. & Moe, S. M., Feb 1 2007, In : American Journal of Physiology - Renal Physiology. 292, 2, p. F599-F606

Research output: Contribution to journalArticle

alpha-2-HS-Glycoprotein
Annexins
Vascular Smooth Muscle
Smooth Muscle Myocytes
Calcium
3 Citations (Scopus)

Fibroblast growth factor 23 does not directly influence skeletal muscle cell proliferation and differentiation or ex vivo muscle contractility

Avin, K. G., Vallejo, J. A., Chen, N. X., Wang, K., Touchberry, C. D., Brotto, M., Dallas, S. L., Moe, S. M. & Wacker, M. J., Oct 2 2018, In : American Journal of Physiology - Endocrinology and Metabolism. 315, 4, p. E594-E604

Research output: Contribution to journalArticle

Muscle Cells
Cell Differentiation
Skeletal Muscle
Cell Proliferation
Muscles
326 Citations (Scopus)

Fluid shear-induced mechanical signaling in MC3T3-E1 osteoblasts requires cytoskeleton-integrin interactions

Pavalko, F. M., Chen, N. X., Turner, C. H., Burr, D. B., Atkinson, S., Hsieh, Y. F., Qiu, J. & Duncan, R. L., Dec 1 1998, In : American Journal of Physiology - Cell Physiology. 275, 6 44-6, p. C1591-C1601

Research output: Contribution to journalArticle

Osteoblasts
Actinin
Cytoskeleton
Stress Fibers
Integrins
67 Citations (Scopus)

Fluid shear-induced NFκB translocation in osteoblasts is mediated by intracellular calcium release

Chen, N. X., Geist, D. J., Genetos, D. C., Pavalko, F. M. & Duncan, R. L., Sep 1 2003, In : Bone. 33, 3, p. 399-410 12 p.

Research output: Contribution to journalArticle

NF-kappa B
Osteoblasts
Calcium
Type C Phospholipases
Lysine
19 Citations (Scopus)

Glucocorticoid receptor binding in porcine preadipocytes during development.

Chen, N. X., White, B. D. & Hausman, G. J., Mar 1995, In : Journal of animal science. 73, 3, p. 722-727 6 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Swine
swine
gestational age
fetal development
100 Citations (Scopus)

High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells

Chen, N. X., Duan, D., O'Neill, K. D. & Moe, S. M., Dec 1 2006, In : Nephrology Dialysis Transplantation. 21, 12, p. 3435-3442 8 p.

Research output: Contribution to journalArticle

Core Binding Factor Alpha 1 Subunit
Vascular Smooth Muscle
Smooth Muscle Myocytes
Vascular Calcification
Glucose
21 Citations (Scopus)
Insulin-Like Growth Factor Binding Proteins
insulin-like growth factor binding proteins
hormonal regulation
insulin-like growth factor I
Insulin-Like Growth Factor I
11 Citations (Scopus)

Identity and localization of advanced glycation end products on human β2-microglobulin using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Cocklin, R. R., Zhang, Y., O'Neill, K. D., Chen, N. X., Moe, S. M., Bidasee, K. R. & Wang, M., Mar 15 2003, In : Analytical biochemistry. 314, 2, p. 322-325 4 p.

Research output: Contribution to journalArticle

Advanced Glycosylation End Products
Mass Spectrometry
Lasers
18 Citations (Scopus)
Insulin, Regular, Pork
hypophysectomy
Insulin-Like Growth Factor Binding Proteins
Hypophysectomy
IGF Type 1 Receptor
7 Citations (Scopus)

Intracellular calcium increases in vascular smooth muscle cells with progression of chronic kidney disease in a rat model

Rodenbeck, S. D., Zarse, C. A., McKenney-Drake, M. L., Bruning, R. S., Sturek, M., Chen, X. N. & Moe, S., Mar 1 2017, In : Nephrology Dialysis Transplantation. 32, 3, p. 450-458 9 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Vascular Smooth Muscle
Smooth Muscle Myocytes
Calcium
Sarcoplasmic Reticulum

Kidney Disease Progression Does Not Decrease Intestinal Phosphorus Absorption in a Rat Model of Chronic Kidney Disease–Mineral Bone Disorder

Vorland, C. J., Biruete, A., Lachcik, P. J., Srinivasan, S., Chen, N. X., Moe, S. M. & Hill Gallant, K. M., Jan 1 2019, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Intestinal Absorption
Kidney Diseases
Phosphorus
Disease Progression
Kidney
7 Citations (Scopus)

Low bone turnover in chronic kidney disease is associated with decreased VEGF-A expression and osteoblast differentiation

Chen, N. X., O'Neill, K. D., Allen, M. R., Newman, C. L. & Moe, S. M., Aug 25 2015, In : American journal of nephrology. 41, 6, p. 464-473 10 p.

Research output: Contribution to journalArticle

Bone Remodeling
Osteoblasts
Chronic Renal Insufficiency
Vascular Endothelial Growth Factor A
Osteogenesis
18 Citations (Scopus)

Matrix vesicles induce calcification of recipient vascular smooth muscle cells through multiple signaling pathways

Chen, X. N., O'Neill, K. D. & Moe, S., 2017, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Ions
Calcium
alpha-2-HS-Glycoprotein
361 Citations (Scopus)

Medial artery calcification in ESRD patients is associated with deposition of bone matrix proteins

Moe, S. M., O'Neill, K. D., Duan, D., Ahmed, S., Chen, N. X., Leapman, S. B., Fineberg, N. & Kopecky, K., Jan 1 2002, In : Kidney international. 61, 2, p. 638-647 10 p.

Research output: Contribution to journalArticle

Bone Matrix
Spiral Computed Tomography
Chronic Kidney Failure
Epigastric Arteries
Vascular Calcification
1 Citation (Scopus)
Chronic Renal Insufficiency
Blood Vessels
Perfusion
Parathyroid Hormone
Therapeutics
19 Citations (Scopus)

Pathogenesis of arrhythmias in a model of CKD

Hsueh, C. H., Chen, N. X., Lin, S. F., Chen, P. S., Gattone, V. H., Allen, M. R., Fishbein, M. C. & Moe, S. M., Dec 1 2014, In : Journal of the American Society of Nephrology. 25, 12, p. 2812-2821 10 p.

Research output: Contribution to journalArticle

Cardiac Arrhythmias
Calcium
MicroRNAs
Action Potentials
Voltage-Sensitive Dye Imaging
34 Citations (Scopus)

Pathophysiology of Vascular Calcification

Chen, X. N. & Moe, S., Sep 26 2015, In : Current Osteoporosis Reports. 13, 6, p. 372-380 9 p.

Research output: Contribution to journalArticle

Vascular Calcification
alpha-2-HS-Glycoprotein
Hyperphosphatemia
Hypercalcemia
Chronic Renal Insufficiency
275 Citations (Scopus)

Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells

Chen, N. X., O'Neill, K. D., Duan, D. & Moe, S. M., Jan 1 2002, In : Kidney international. 62, 5, p. 1724-1731 8 p.

Research output: Contribution to journalArticle

Osteopontin
Vascular Smooth Muscle
Phosphorus
Smooth Muscle Myocytes
Up-Regulation
30 Citations (Scopus)

R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD)

Moe, S. M., Seifert, M. F., Chen, N. X., Sinders, R. M., Chen, X., Duan, D., Henley, C., Martin, D. & Gattone, V. H., Aug 1 2009, In : Nephrology Dialysis Transplantation. 24, 8, p. 2371-2377 7 p.

Research output: Contribution to journalArticle

N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine
Chronic Kidney Disease-Mineral and Bone Disorder
Calcium
Phosphorus
Parathyroid Hormone
8 Citations (Scopus)

Raloxifene improves skeletal properties in an animal model of cystic chronic kidney disease

Newman, C. L., Creecy, A., Granke, M., Nyman, J. S., Tian, N., Hammond, M. A., Wallace, J. M., Brown, D. M., Chen, X. N., Moe, S. & Allen, M., Oct 21 2015, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

Cystic Kidney Diseases
Chronic Renal Insufficiency
Animal Models
Bone Density Conservation Agents
Bone and Bones
8 Citations (Scopus)

Reduced skeletal muscle function is associated with decreased fiber cross-sectional area in the Cy/+ rat model of progressive kidney disease

Organ, J., Srisuwananukorn, A., Price, P., Joll, J. E., Biro, K. C., Rupert, J. E., Chen, X. N., Avin, K. G., Moe, S. & Allen, M., Feb 1 2016, In : Nephrology Dialysis Transplantation. 31, 2, p. 223-230 8 p.

Research output: Contribution to journalArticle

Kidney Diseases
Chronic Renal Insufficiency
Skeletal Muscle
Torque
Muscles
19 Citations (Scopus)

RhoA/Rho kinase (ROCK) alters fetuin-A uptake and regulates calcification in bovine vascular smooth muscle cells (BVSMC)

Chen, N. X., Chen, X., O'Neill, K. D., Atkinson, S. J. & Moe, S. M., Sep 1 2010, In : American Journal of Physiology - Renal Physiology. 299, 3, p. F674-F680

Research output: Contribution to journalArticle

alpha-2-HS-Glycoprotein
rho-Associated Kinases
Vascular Smooth Muscle
Smooth Muscle Myocytes
Vascular Calcification
287 Citations (Scopus)

Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease (CKD)

Moe, S. M., Reslerova, M., Ketteler, M., O'Neill, K., Duan, D., Koczman, J., Westenfeld, R., Jahnen-Dechent, W. & Chen, N. X., Jun 2005, In : Kidney international. 67, 6, p. 2295-2304 10 p.

Research output: Contribution to journalArticle

alpha-2-HS-Glycoprotein
Vascular Calcification
Osteoprotegerin
Chronic Renal Insufficiency
Vascular Smooth Muscle
18 Citations (Scopus)

Signal transduction of β2m-induced expression of VCAM-1 and COX-2 in synovial fibroblasts

Chen, N. X., O’Neill, K. D., Niwa, T. & Moe, S. M., Jan 1 2002, In : Kidney international. 61, 2, p. 414-424 11 p.

Research output: Contribution to journalArticle

Vascular Cell Adhesion Molecule-1
Cyclooxygenase 2
Signal Transduction
Fibroblasts
Phosphatidylinositol 3-Kinase
1 Citation (Scopus)

Skeletal accumulation of fluorescently tagged zoledronate is higher in animals with early stage chronic kidney disease

Swallow, E. A., Aref, M. W., Chen, X. N., Byiringiro, I., Hammond, M. A., McCarthy, B. P., Territo, P., Kamocka, M., Winfree, S., Dunn, K., Moe, S. & Allen, M., Jun 11 2018, (Accepted/In press) In : Osteoporosis International. p. 1-8 8 p.

Research output: Contribution to journalArticle

zoledronic acid
Chronic Renal Insufficiency
Tibia
Kidney
Bone and Bones
24 Citations (Scopus)

Skeletal effects of zoledronic acid in an animal model of chronic kidney disease

Allen, M. R., Chen, N. X., Gattone, V. H., Chen, X., Carr, A. J., Leblanc, P., Brown, D. & Moe, S. M., Apr 1 2013, In : Osteoporosis International. 24, 4, p. 1471-1481 11 p.

Research output: Contribution to journalArticle

zoledronic acid
Chronic Renal Insufficiency
Animal Models
Kidney Diseases
Diphosphonates

Skeletal levels of bisphosphonate in the setting of chronic kidney disease are independent of remodeling rate and lower with fractionated dosing

Swallow, E. A., Aref, M. W., Metzger, C. E., Sacks, S., Lehmkuhler, D. R., Chen, X. N., Hammond, M. A., Territo, P., Nickolas, T. L., Moe, S. & Allen, M., Oct 1 2019, In : Bone. 127, p. 419-426 8 p.

Research output: Contribution to journalArticle

zoledronic acid
Diphosphonates
Chronic Renal Insufficiency
Ulna
Bone Remodeling
15 Citations (Scopus)

Skeletal muscle regeneration and oxidative stress are altered in chronic kidney disease

Avin, K. G., Chen, N. X., Organ, J. M., Zarse, C., O'Neill, K., Conway, R. G., Konrad, R. J., Bacallao, R. L., Allen, M. R. & Moe, S. M., Aug 1 2016, In : PLoS ONE. 11, 8, e0159411.

Research output: Contribution to journalArticle

Oxidative stress
muscle development
kidney diseases
Chronic Renal Insufficiency
Muscle