Yan Liu

  • 1619 Citations
  • 23 h-Index
19952019

Research output per year

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Publications

2019

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, Sun, Y., Wong, T. N., Link, D. C., Liu, Y., Boswell, H. S., Mayo, L. D., Huang, G., Kapur, R., Yoder, M. C., Broxmeyer, H. E., Gao, Z. & Liu, Y., Dec 1 2019, In : Nature communications. 10, 1, 5649.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development

Nabinger, S. C., Chen, S., Gao, R., Yao, C., Kobayashi, M., Vemula, S., Fahey, A. C., Wang, C., Daniels, C., Boswell, H. S., Sandusky, G. E., Mayo, L. D., Kapur, R. & Liu, Y., Jun 1 2019, In : Leukemia. 33, 6, p. 1535-1539 5 p.

Research output: Contribution to journalLetter

3 Scopus citations

P53 involvement in clonal hematopoiesis of indeterminate potential

Chen, S. & Liu, Y., Jul 1 2019, In : Current opinion in hematology. 26, 4, p. 235-240 6 p.

Research output: Contribution to journalReview article

2 Scopus citations
2018

Battle in stem cell niches: Canonical versus noncanonical Wnt signaling

Chen, S. & Liu, Y., Mar 2018, In : Journal of Leukocyte Biology. 103, 3, p. 377-379 3 p.

Research output: Contribution to journalEditorial

Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML

Sayar, S., Liu, Y., Gao, R., Zaid, M. A., Cripe, L. D., Weisenbach, J., Sargent, K. J., Nassiri, M., Li, L., Konig, H., Suvannasankha, A., Pan, F., Shanmugam, R., Goswami, C., Kapur, R., Xu, M. & Scott Boswell, H., 2018, In : Oncotarget. 9, 5, p. 5703-5715 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Genotoxic stresses promote clonal expansion of hematopoietic stem cells expressing mutant p53

Chen, S., Gao, R., Yao, C., Kobayashi, M., Liu, S. Z., Yoder, M. C., Broxmeyer, H., Kapur, R., Boswell, H. S., Mayo, L. D. & Liu, Y., Mar 1 2018, In : Leukemia. 32, 3, p. 850-854 5 p.

Research output: Contribution to journalLetter

9 Scopus citations

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

Cai, Z., Kotzin, J. J., Ramdas, B., Chen, S., Nelanuthala, S., Palam, L. R., Pandey, R., Mali, R. S., Liu, Y., Kelley, M. R., Sandusky, G., Mohseni, M., Williams, A., Henao-Mejia, J. & Kapur, R., Dec 6 2018, In : Cell Stem Cell. 23, 6, p. 833-849.e5

Research output: Contribution to journalArticle

29 Scopus citations
2017

Necdin modulates leukemia-initiating cell quiescence and chemotherapy response

Yao, C., Kobayashi, M., Chen, S., Nabinger, S. C., Gao, R., Liu, S. Z., Asai, T. & Liu, Y., Jan 1 2017, In : Oncotarget. 8, 50, p. 87607-87622 16 p.

Research output: Contribution to journalArticle

1 Scopus citations

Pharmacological inhibition of AKT activity in human CD34+ cells enhances their ability to engraft immunodeficient mice

Chen, S., Gao, R., Kobayashi, M., Yu, H., Yao, C., Kapur, R., Yoder, M. & Liu, Y., Jan 1 2017, In : Experimental Hematology. 45, p. 74-84 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia

Kobayashi, M., Chen, S., Bai, Y., Yao, C., Gao, R., Sun, X. J., Mu, C., Twiggs, T. A., Yu, Z. H., Boswell, H., Yoder, M., Kapur, R., Mulloy, J. C., Zhang, Z-Y. & Liu, Y., Jun 1 2017, In : Leukemia. 31, 6, p. 1453-1457 5 p.

Research output: Contribution to journalLetter

4 Scopus citations

Phosphatase PRL2 promotes oncogenic NOTCH1-Induced T-cell leukemia

Kobayashi, M., Bai, Y., Chen, S., Gao, R., Yao, C., Cai, W., Cardoso, A. A., Croop, J., Zhang, Z. Y. & Liu, Y., Mar 1 2017, In : Leukemia. 31, 3, p. 751-754 4 p.

Research output: Contribution to journalLetter

5 Scopus citations

Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors

Kobayashi, M., Nabinger, S. C., Bai, Y., Yoshimoto, M., Gao, R., Chen, S., Yao, C., Dong, Y., Zhang, L., Rodriguez, S., Yashiro-Ohtani, Y., Pear, W. S., Carlesso, N., Yoder, M. C., Kapur, R., Kaplan, M. H., Daniel Lacorazza, H., Zhang, Z. Y. & Liu, Y., Apr 1 2017, In : STEM CELLS. 35, 4, p. 1053-1064 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance

Ghosh, J., Kobayashi, M., Ramdas, B., Chatterjee, A., Ma, P., Mali, R. S., Carlesso, N., Liu, Y., Plas, D. R., Chan, R. & Kapur, R., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2621-2625 5 p.

Research output: Contribution to journalArticle

18 Scopus citations
2015

Anoikis resistance is a critical feature of highly aggressive ovarian cancer cells

Cai, Q., Yan, L. & Xu, Y., Jun 1 2015, In : Oncogene. 34, 25, p. 3315-3324 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Bmi1 promotes erythroid development through regulating ribosome biogenesis

Gao, R., Chen, S., Kobayashi, M., Yu, H., Zhang, Y., Wan, Y., Young, S. K., Soltis, A., Yu, M., Vemula, S., Fraenkel, E., Cantor, A., Antipin, Y., Xu, Y., Yoder, M. C., Wek, R. C., Ellis, S. R., Kapur, R., Zhu, X. & Liu, Y., Mar 1 2015, In : STEM CELLS. 33, 3, p. 925-938 14 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbfβ for their development

Kobayashi, M., Shelley, W. C., Seo, W., Vemula, S., Lin, Y., Liu, Y., Kapur, R., Taniuchi, I. & Yoshimoto, M., Aug 19 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 33, p. 12151-12156 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Phosphatase of regenerating liver in hematopoietic stem cells and hematological malignancies

Kobayashi, M., Chen, S., Gao, R., Bai, Y., Zhang, Z. Y. & Liu, Y., Jan 1 2014, In : Cell Cycle. 13, 18, p. 2827-2835 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal

Kobayashi, M., Bai, Y., Dong, Y., Yu, H., Chen, S., Gao, R., Zhang, L., Yoder, M. C., Kapur, R., Zhang, Z. Y. & Liu, Y., Jul 2014, In : STEM CELLS. 32, 7, p. 1956-1967 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

Chatterjee, A., Ghosh, J., Ramdas, B., Mali, R. S., Martin, H., Kobayashi, M., Vemula, S., Canela, V. H., Waskow, E. R., Visconte, V., Tiu, R. V., Smith, C. C., Shah, N., Bunting, K. D., Boswell, H. S., Liu, Y., Chan, R. J. & Kapur, R., Nov 20 2014, In : Cell Reports. 9, 4, p. 1333-1348 16 p.

Research output: Contribution to journalArticle

30 Scopus citations

Role of OGR1 in myeloid-derived cells in prostate cancer

Yan, L., Singh, L. S., Zhang, L. & Xu, Y., Jan 9 2014, In : Oncogene. 33, 2, p. 157-164 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

TRIM3, a tumor suppressor linked to regulation of p21 Waf1/Cip1

Liu, Y., Raheja, R., Yeh, N., Ciznadija, D., Pedraza, A. M., Ozawa, T., Hukkelhoven, E., Erdjument-Bromage, H., Tempst, P., Gauthier, N. P., Brennan, C., Holland, E. C. & Koff, A., Jan 16 2014, In : Oncogene. 33, 3, p. 308-315 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
2013

Necdin, a p53 target gene, in stem cells

Asai, T., Liu, Y. & Nimer, S. D., Jun 2013, In : Oncotarget. 4, 6, p. 806-807 2 p.

Research output: Contribution to journalEditorial

Open Access
4 Scopus citations

PI3K-Akt pathway regulates polycomb group protein and stem cell maintenance

Liu, Y., Yu, H. & Nimer, S. D., Jan 1 2013, In : Cell Cycle. 12, 2, p. 199-200 2 p.

Research output: Contribution to journalEditorial

4 Scopus citations

PRMT4 blocks myeloid differentiation by assembling a Methyl-RUNX1-dependent repressor complex

Vu, L. P., Perna, F., Wang, L., Voza, F., Figueroa, M. E., Tempst, P., Erdjument-Bromage, H., Gao, R., Chen, S., Paietta, E., Deblasio, T., Melnick, A., Liu, Y., Zhao, X. & Nimer, S. D., Dec 26 2013, In : Cell Reports. 5, 6, p. 1625-1638 14 p.

Research output: Contribution to journalArticle

51 Scopus citations
2012

Akt phosphorylates the transcriptional repressor Bmi1 to block its effects on the tumor-suppressing Ink4a-Arf locus

Liu, Y., Liu, F., Yu, H., Zhao, X., Sashida, G., Deblasio, A., Harr, M., She, Q. B., Chen, Z., Lin, H. K., Di Giandomenico, S., Elf, S. E., Yang, Y., Miyata, Y., Huang, G., Menendez, S., Mellinghoff, I. K., Rosen, N., Pandolfi, P. P., Hedvat, C. V. & 1 others, Nimer, S. D., Oct 23 2012, In : Science Signaling. 5, 247, ra77.

Research output: Contribution to journalArticle

32 Scopus citations

Genetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms

Hu, P., Carlesso, N., Xu, M., Liu, Y., Nebreda, A. R., Takemoto, C. & Kapur, R., Jun 8 2012, In : Journal of Biological Chemistry. 287, 24, p. 20258-20269 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells

Asai, T., Liu, Y., Di Giandomenico, S., Bae, N., Ndiaye-Lobry, D., Deblasio, A., Menendez, S., Antipin, Y., Reva, B., Wevrick, R. & Nimer, S. D., Aug 23 2012, In : Blood. 120, 8, p. 1601-1612 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

P38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals

Hu, P., Nebreda, A. R., Liu, Y., Carlesso, N., Kaplan, M. & Kapur, R., Sep 28 2012, In : Journal of Biological Chemistry. 287, 40, p. 33215-33226 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53

Vemula, S., Shi, J., Mali, R. S., Ma, P., Liu, Y., Hanneman, P., Koehler, K. R., Hashino, E., Wei, L. & Kapur, R., Oct 4 2012, In : Blood. 120, 14, p. 2868-2878 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
2011

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

Huang, G., Zhao, X., Wang, L., Elf, S., Xu, H., Zhao, X., Sashida, G., Zhang, Y., Liu, Y., Lee, J., Menendez, S., Yang, Y., Yan, X., Zhang, P., Tenen, D. G., Osato, M., Hsieh, J. J. D. & Nimer, S. D., Dec 15 2011, In : Blood. 118, 25, p. 6544-6552 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

The Mef/Elf4 transcription factor fine tunes the DNA damage response

Sashida, G., Bae, N., Di Giandomenico, S., Asai, T., Gurvich, N., Bazzoli, E., Liu, Y., Huang, G., Zhao, X., Menendez, S. & Nimer, S. D., Jul 15 2011, In : Cancer Research. 71, 14, p. 4857-4865 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

The p53 tumor suppressor protein regulates hematopoietic stem cell fate

Asai, T., Liu, Y., Bae, N. & Nimer, S. D., Sep 1 2011, In : Journal of cellular physiology. 226, 9, p. 2215-2221 7 p.

Research output: Contribution to journalShort survey

55 Scopus citations
2010

Cyclin C regulates human hematopoietic stem/progenitor sell quiescence

Miyata, Y., Liu, Y., Jankovic, V., Sashida, G., Lee, J. M., Shieh, J. H., Naoe, T., Moore, M. & Nimer, S. D., Feb 1 2010, In : STEM CELLS. 28, 2, p. 308-317 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Myelodysplasia: Battle in the bone marrow

Liu, Y., Asai, T. & Nimer, S. D., Jan 1 2010, In : Nature Medicine. 16, 1, p. 30-32 3 p.

Research output: Contribution to journalShort survey

8 Scopus citations

Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents

Zhou, B., He, Y., Zhang, X., Xu, J., Luo, Y., Wang, Y., Franzblau, S. G., Yang, Z., Chan, R. J., Liu, Y., Zheng, J. & Zhang, Z. Y., Mar 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 10, p. 4573-4578 6 p.

Research output: Contribution to journalArticle

144 Scopus citations

The oncogenic role of the ETS transcription factors MEF and ERG

Sashida, G., Bazzoli, E., Menendez, S., Liu, Y. & Nimer, S. D., Sep 1 2010, In : Cell Cycle. 9, 17, p. 3457-3459 3 p.

Research output: Contribution to journalReview article

14 Scopus citations
2009

ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation

Sashida, G., Liu, Y., Elf, S., Miyata, Y., Ohyashiki, K., Izumi, M., Menendez, S. & Nimer, S. D., Jul 1 2009, In : Molecular and cellular biology. 29, 13, p. 3687-3699 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

p53 Regulates Hematopoietic Stem Cell Quiescence

Liu, Y., Elf, S. E., Miyata, Y., Sashida, G., Liu, Y., Huang, G., Di Giandomenico, S., Lee, J. M., Deblasio, A., Menendez, S., Antipin, J., Reva, B., Koff, A. & Nimer, S. D., Jan 9 2009, In : Cell Stem Cell. 4, 1, p. 37-48 12 p.

Research output: Contribution to journalArticle

343 Scopus citations

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

Lin, H. K., Wang, G., Chen, Z., Teruya-Feldstein, J., Liu, Y., Chan, C. H., Yang, W. L., Erdjument-Bromage, H., Nakayama, K. I., Nimer, S., Tempst, P. & Pandolfi, P. P., Mar 9 2009, In : Nature Cell Biology. 11, 4, p. 420-432 13 p.

Research output: Contribution to journalArticle

180 Scopus citations

The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior

Liu, Y., Elf, S. E., Asai, T., Miyata, Y., Liu, Y., Sashida, G., Huang, G., Di Giandomenico, S., Koff, A. & Nimer, S. D., Oct 1 2009, In : Cell Cycle. 8, 19, p. 3120-3124 5 p.

Research output: Contribution to journalReview article

Open Access
48 Scopus citations

The role of p53 in limiting somatic cell reprogramming

Liu, Y., Hoya-Arias, R. & Nimer, S. D., Nov 1 2009, In : Cell Research. 19, 11, p. 1227-1228 2 p.

Research output: Contribution to journalArticle

12 Scopus citations
2008

DNA damage signaling in hematopoietic cells: A role for Mre11 complex repair of topoisomerase lesions

Morales, M., Liu, Y., Laiakis, E. C., Morgan, W. F., Nimer, S. D. & Petrini, J. H. J., Apr 1 2008, In : Cancer Research. 68, 7, p. 2186-2193 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
2007

Tumor promoting properties of the ETS protein MEF in ovarian cancer

Yao, J. J., Liu, Y., Lacorazza, H. D., Soslow, R. A., Scandura, J. M., Nimer, S. D. & Hedvat, C. V., Jun 7 2007, In : Oncogene. 26, 27, p. 4032-4037 6 p.

Research output: Contribution to journalArticle

26 Scopus citations
2006

The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2

Liu, Y., Hedvat, C. V., Mao, S., Zhu, X. H., Yao, J., Nguyen, H., Koff, A. & Nimer, S. D., Apr 1 2006, In : Molecular and cellular biology. 26, 8, p. 3114-3123 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells

Lacorazza, H. D., Yamada, T., Liu, Y., Miyata, Y., Sivina, M., Nunes, J. & Nimer, S. D., Mar 1 2006, In : Cancer Cell. 9, 3, p. 175-187 13 p.

Research output: Contribution to journalArticle

102 Scopus citations
2003

Simplification of finite element models for thermal fatigue life prediction of PBGA packages

Akay, H. U., Liu, Y. & Rassaian, M., Sep 1 2003, In : Journal of Electronic Packaging, Transactions of the ASME. 125, 3, p. 347-353 7 p.

Research output: Contribution to journalArticle

31 Scopus citations
1995

Intragenic suppression among CDC34 (UBC3) mutations defines a class of ubiquitin-conjugating catalytic domains

Liu, Y., Mathias, N., Steussy, C. N. & Goebl, M. G., Oct 1995, In : Molecular and cellular biology. 15, 10, p. 5635-5644 10 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations