Yan Liu

  • 1453 Citations
  • 21 h-Index
19952019
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Publications 1995 2019

  • 1453 Citations
  • 21 h-Index
  • 41 Article
  • 3 Letter
  • 1 Editorial
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Article
2019

Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development

Nabinger, S. C., Chen, S., Gao, R., Yao, C., Kobayashi, M., Vemula, S., Fahey, A. C., Wang, C., Daniels, C., Boswell, H., Sandusky, G., Mayo, L., Kapur, R. & Liu, Y., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Leukemia
Cell Self Renewal
2018
1 Citation (Scopus)

Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML

Sayar, H., Liu, Y., Gao, R., Zaid, M. A., Cripe, L., Weisenbach, J., Sargent, K. J., Nassiri, M., Li, L., Konig, H., Suvannasankha, A., Pan, F., Shanmugam, R., Goswami, C., Kapur, R., Xu, M. & Scott Boswell, H., Jan 1 2018, In : Oncotarget. 9, 5, p. 5703-5715 13 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Mutation
Epigenetic Repression
Histone Deacetylase Inhibitors
Chromatin Assembly and Disassembly
10 Citations (Scopus)

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

Cai, Z., Kotzin, J. J., Ramdas, B., Chen, S., Nelanuthala, S., Palam, L. R., Pandey, R., Mali, R. S., Liu, Y., Kelley, M., Sandusky, G., Mohseni, M., Williams, A., Henao-Mejia, J. & Kapur, R., Jan 1 2018, (Accepted/In press) In : Cell Stem Cell.

Research output: Contribution to journalArticle

Hematopoiesis
Hematopoietic Stem Cells
Interleukin-6
Long Noncoding RNA
Myeloid Cells
2017
1 Citation (Scopus)

Necdin modulates leukemia-initiating cell quiescence and chemotherapy response

Yao, C., Kobayashi, M., Chen, S., Nabinger, S. C., Gao, R., Liu, S. Z., Asai, T. & Liu, Y., Jan 1 2017, In : Oncotarget. 8, 50, p. 87607-87622 16 p.

Research output: Contribution to journalArticle

Leukemia
Drug Therapy
Hematopoietic Stem Cells
Acute Myeloid Leukemia
necdin
1 Citation (Scopus)

Pharmacological inhibition of AKT activity in human CD34+ cells enhances their ability to engraft immunodeficient mice

Chen, S., Gao, R., Kobayashi, M., Yu, H., Yao, C., Kapur, R., Yoder, M. & Liu, Y., Jan 1 2017, In : Experimental Hematology. 45, p. 74-84 11 p.

Research output: Contribution to journalArticle

Human Activities
Pharmacology
Fetal Blood
Hematopoietic Stem Cells
Blood Cells
6 Citations (Scopus)

Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors

Kobayashi, M., Nabinger, S. C., Bai, Y., Yoshimoto, M., Gao, R., Chen, S., Yao, C., Dong, Y., Zhang, L., Rodriguez, S., Yashiro-Ohtani, Y., Pear, W. S., Carlesso, N., Yoder, M., Kapur, R., Kaplan, M., Daniel Lacorazza, H., Zhang, Z-Y. & Liu, Y., Apr 1 2017, In : Stem Cells. 35, 4, p. 1053-1064 12 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Hematopoietic Stem Cells
T-Lymphocytes
Cell Differentiation
Stem Cell Factor
2016
14 Citations (Scopus)

S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance

Ghosh, J., Kobayashi, M., Ramdas, B., Chatterjee, A., Ma, P., Mali, R. S., Carlesso, N., Liu, Y., Plas, D. R., Chan, R. & Kapur, R., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2621-2625 5 p.

Research output: Contribution to journalArticle

Ribosomal Protein S6 Kinases
Hematopoietic Stem Cells
Leukemia
Maintenance
Oncogene Fusion
2015
29 Citations (Scopus)

Anoikis resistance is a critical feature of highly aggressive ovarian cancer cells

Cai, Q., Liu, Y. & Xu, Y., Jun 1 2015, In : Oncogene. 34, 25, p. 3315-3324 10 p.

Research output: Contribution to journalArticle

Anoikis
Ovarian Neoplasms
Autophagy
Neoplasms
Cell Line
9 Citations (Scopus)

Bmi1 promotes erythroid development through regulating ribosome biogenesis

Gao, R., Chen, S., Kobayashi, M., Yu, H., Zhang, Y., Wan, Y., Young, S. K., Soltis, A., Yu, M., Vemula, S., Fraenkel, E., Cantor, A., Antipin, Y., Xu, Y., Yoder, M., Wek, R., Ellis, S. R., Kapur, R., Zhu, X. & Liu, Y., Mar 1 2015, In : Stem Cells. 33, 3, p. 925-938 14 p.

Research output: Contribution to journalArticle

Diamond-Blackfan Anemia
Ribosomes
Erythroid Precursor Cells
Ribosomal Proteins
Hematopoietic Stem Cells
2014
36 Citations (Scopus)

Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbfβ for their development

Kobayashi, M., Shelley, W. C., Seo, W., Vemula, S., Lin, Y., Liu, Y., Kapur, R., Taniuchi, I. & Yoshimoto, M., Aug 19 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 33, p. 12151-12156 6 p.

Research output: Contribution to journalArticle

Core Binding Factor beta Subunit
B-Lymphoid Precursor Cells
Hematopoietic Stem Cells
Embryonic Structures
Liver
11 Citations (Scopus)

Phosphatase of regenerating liver in hematopoietic stem cells and hematological malignancies

Kobayashi, M., Chen, S., Gao, R., Bai, Y., Zhang, Z-Y. & Liu, Y., 2014, In : Cell Cycle. 13, 18, p. 2827-2835 9 p.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Hematopoietic Stem Cells
Phosphoric Monoester Hydrolases
Liver
Dual-Specificity Phosphatases
21 Citations (Scopus)

PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal

Kobayashi, M., Bai, Y., Dong, Y., Yu, H., Chen, S., Gao, R., Zhang, L., Yoder, M., Kapur, R., Zhang, Z-Y. & Liu, Y., 2014, In : Stem Cells. 32, 7, p. 1956-1967 12 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Phosphoric Monoester Hydrolases
Stem Cell Factor
Protein Tyrosine Phosphatases
Cell Proliferation
24 Citations (Scopus)

Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

Chatterjee, A., Ghosh, J., Ramdas, B., Mali, R. S., Martin, H., Kobayashi, M., Vemula, S., Canela, V. H., Waskow, E. R., Visconte, V., Tiu, R. V., Smith, C. C., Shah, N., Bunting, K. D., Boswell, H., Liu, Y., Chan, R. & Kapur, R., Nov 20 2014, In : Cell Reports. 9, 4, p. 1333-1348 16 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Chemical activation
Transcription
Acute Myeloid Leukemia
Neoplasms
21 Citations (Scopus)

Role of OGR1 in myeloid-derived cells in prostate cancer

Liu, Y., Singh, L. S., Zhang, L. & Xu, Y., Jan 9 2014, In : Oncogene. 33, 2, p. 157-164 8 p.

Research output: Contribution to journalArticle

Myeloid Cells
G-Protein-Coupled Receptors
Ovarian Neoplasms
Prostatic Neoplasms
T-Lymphocytes
29 Citations (Scopus)

TRIM3, a tumor suppressor linked to regulation of p21 Waf1/Cip1

Liu, Y., Raheja, R., Yeh, N., Ciznadija, D., Pedraza, A. M., Ozawa, T., Hukkelhoven, E., Erdjument-Bromage, H., Tempst, P., Gauthier, N. P., Brennan, C., Holland, E. C. & Koff, A., Jan 16 2014, In : Oncogene. 33, 3, p. 308-315 8 p.

Research output: Contribution to journalArticle

Neoplasms
Loss of Heterozygosity
Chromosome Mapping
Cyclin D1
Platelet-Derived Growth Factor
2013
4 Citations (Scopus)

Necdin, a p53 target gene, in stem cells

Asai, T., Liu, Y. & Nimer, S. D., Jun 2013, In : Oncotarget. 4, 6, p. 806-807 2 p.

Research output: Contribution to journalArticle

Nerve Tissue Proteins
Tumor Suppressor Protein p53
p53 Genes
Nuclear Proteins
Stem Cells
4 Citations (Scopus)

PI3K-Akt pathway regulates polycomb group protein and stem cell maintenance

Liu, Y., Yu, H. & Nimer, S. D., 2013, In : Cell Cycle. 12, 2, p. 199-200 2 p.

Research output: Contribution to journalArticle

Polycomb-Group Proteins
Phosphatidylinositol 3-Kinases
Stem Cells
Maintenance
39 Citations (Scopus)

PRMT4 blocks myeloid differentiation by assembling a Methyl-RUNX1-dependent repressor complex

Vu, L. P., Perna, F., Wang, L., Voza, F., Figueroa, M. E., Tempst, P., Erdjument-Bromage, H., Gao, R., Chen, S., Paietta, E., Deblasio, T., Melnick, A., Liu, Y., Zhao, X. & Nimer, S. D., Dec 26 2013, In : Cell Reports. 5, 6, p. 1625-1638 14 p.

Research output: Contribution to journalArticle

Stem cells
Stem Cells
Methylation
Hematopoiesis
Acute Myeloid Leukemia
2012
30 Citations (Scopus)

Akt phosphorylates the transcriptional repressor Bmi1 to block its effects on the tumor-suppressing Ink4a-Arf locus

Liu, Y., Liu, F., Yu, H., Zhao, X., Sashida, G., Deblasio, A., Harr, M., She, Q. B., Chen, Z., Lin, H. K., Di Giandomenico, S., Elf, S. E., Yang, Y., Miyata, Y., Huang, G., Menendez, S., Mellinghoff, I. K., Rosen, N., Pandolfi, P. P., Hedvat, C. V. & 1 others, Nimer, S. D., Oct 23 2012, In : Science Signaling. 5, 247, ra77.

Research output: Contribution to journalArticle

Phosphorylation
Tumors
Hematopoietic Stem Cells
Polycomb-Group Proteins
Cells
7 Citations (Scopus)

Genetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms

Hu, P., Carlesso, N., Xu, M., Liu, Y., Nebreda, A. R., Takemoto, C. & Kapur, R., Jun 8 2012, In : Journal of Biological Chemistry. 287, 24, p. 20258-20269 12 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Chemotaxis
Mast Cells
Cell Differentiation
Microphthalmia-Associated Transcription Factor
30 Citations (Scopus)

Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells

Asai, T., Liu, Y., Di Giandomenico, S., Bae, N., Ndiaye-Lobry, D., Deblasio, A., Menendez, S., Antipin, Y., Reva, B., Wevrick, R. & Nimer, S. D., Aug 23 2012, In : Blood. 120, 8, p. 1601-1612 12 p.

Research output: Contribution to journalArticle

p53 Genes
Hematopoietic Stem Cells
Stem cells
DNA Damage
Genes
9 Citations (Scopus)

P38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals

Hu, P., Nebreda, A. R., Liu, Y., Carlesso, N., Kaplan, M. & Kapur, R., Sep 28 2012, In : Journal of Biological Chemistry. 287, 40, p. 33215-33226 12 p.

Research output: Contribution to journalArticle

T-cells
T-Cell Antigen Receptor
T-Lymphocytes
Interleukin-4
Ovalbumin
23 Citations (Scopus)

ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53

Vemula, S., Shi, J., Mali, R. S., Ma, P., Liu, Y., Hanneman, P., Koehler, K. R., Hashino, E., Wei, L. & Kapur, R., Oct 4 2012, In : Blood. 120, 14, p. 2868-2878 11 p.

Research output: Contribution to journalArticle

Erythropoiesis
Survival
Stem cells
rho-Associated Kinases
Enhanced recovery
2011
43 Citations (Scopus)

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

Huang, G., Zhao, X., Wang, L., Elf, S., Xu, H., Zhao, X., Sashida, G., Zhang, Y., Liu, Y., Lee, J., Menendez, S., Yang, Y., Yan, X., Zhang, P., Tenen, D. G., Osato, M., Hsieh, J. J. D. & Nimer, S. D., Dec 15 2011, In : Blood. 118, 25, p. 6544-6552 9 p.

Research output: Contribution to journalArticle

Nucleic Acid Regulatory Sequences
Leukemia
Genes
Protein Methyltransferases
Mutation
9 Citations (Scopus)

The Mef/Elf4 transcription factor fine tunes the DNA damage response

Sashida, G., Bae, N., Di Giandomenico, S., Asai, T., Gurvich, N., Bazzoli, E., Liu, Y., Huang, G., Zhao, X., Menendez, S. & Nimer, S. D., Jul 15 2011, In : Cancer Research. 71, 14, p. 4857-4865 9 p.

Research output: Contribution to journalArticle

DNA Damage
Transcription Factors
Phosphorylation
Double-Stranded DNA Breaks
Radio
48 Citations (Scopus)

The p53 tumor suppressor protein regulates hematopoietic stem cell fate

Asai, T., Liu, Y., Bae, N. & Nimer, S. D., Sep 2011, In : Journal of Cellular Physiology. 226, 9, p. 2215-2221 7 p.

Research output: Contribution to journalArticle

Tumor Suppressor Protein p53
Hematopoietic Stem Cells
Stem cells
Genes
Chemical activation
2010
29 Citations (Scopus)

Cyclin C regulates human hematopoietic stem/progenitor sell quiescence

Miyata, Y., Liu, Y., Jankovic, V., Sashida, G., Lee, J. M., Shieh, J. H., Naoe, T., Moore, M. & Nimer, S. D., Feb 2010, In : Stem Cells. 28, 2, p. 308-317 10 p.

Research output: Contribution to journalArticle

Cyclin C
Hematopoietic Stem Cells
Cell Cycle
Cyclin-Dependent Kinases
G1 Phase
6 Citations (Scopus)

Myelodysplasia: Battle in the bone marrow

Liu, Y., Asai, T. & Nimer, S. D., Jan 2010, In : Nature Medicine. 16, 1, p. 30-32 3 p.

Research output: Contribution to journalArticle

Mammalian Chromosomes
Chromosomes, Human, Pair 5
Myelodysplastic Syndromes
Hematopoiesis
MicroRNAs
139 Citations (Scopus)

Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents

Zhou, B., He, Y., Zhang, X., Xu, J., Luo, Y., Wang, Y., Franzblau, S. G., Yang, Z., Chan, R., Liu, Y., Zheng, J. & Zhang, Z-Y., Mar 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 10, p. 4573-4578 6 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Mycobacterium
Phosphoric Monoester Hydrolases
Macrophages
Click Chemistry
13 Citations (Scopus)

The oncogenic role of the ETS transcription factors MEF and ERG

Sashida, G., Bazzoli, E., Menendez, S., Liu, Y. & Nimer, S. D., Sep 1 2010, In : Cell Cycle. 9, 17, p. 3457-3459 3 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-ets
Genes
Oncogenes
Neoplasms
Genetic Translocation
2009
23 Citations (Scopus)

ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation

Sashida, G., Liu, Y., Elf, S., Miyata, Y., Ohyashiki, K., Izumi, M., Menendez, S. & Nimer, S. D., Jul 2009, In : Molecular and Cellular Biology. 29, 13, p. 3687-3699 13 p.

Research output: Contribution to journalArticle

Oncogenes
Fibroblasts
Neoplasms
Carcinogenesis
Transcription Factors
319 Citations (Scopus)

p53 Regulates Hematopoietic Stem Cell Quiescence

Liu, Y., Elf, S. E., Miyata, Y., Sashida, G., Liu, Y., Huang, G., Di Giandomenico, S., Lee, J. M., Deblasio, A., Menendez, S., Antipin, J., Reva, B., Koff, A. & Nimer, S. D., Jan 9 2009, In : Cell Stem Cell. 4, 1, p. 37-48 12 p.

Research output: Contribution to journalArticle

Gene Knockdown Techniques
Neoplastic Stem Cells
p53 Genes
Hematopoiesis
Hematopoietic Stem Cells
173 Citations (Scopus)

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

Lin, H. K., Wang, G., Chen, Z., Teruya-Feldstein, J., Liu, Y., Chan, C. H., Yang, W. L., Erdjument-Bromage, H., Nakayama, K. I., Nimer, S., Tempst, P. & Pandolfi, P. P., 2009, In : Nature Cell Biology. 11, 4, p. 420-432 13 p.

Research output: Contribution to journalArticle

S-Phase Kinase-Associated Proteins
Proto-Oncogene Proteins c-akt
Ubiquitin-Protein Ligases
Ubiquitination
Phosphorylation
46 Citations (Scopus)

The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior

Liu, Y., Elf, S. E., Asai, T., Miyata, Y., Liu, Y., Sashida, G., Huang, G., Di Giandomenico, S., Koff, A. & Nimer, S. D., Oct 1 2009, In : Cell Cycle. 8, 19, p. 3120-3124 5 p.

Research output: Contribution to journalArticle

Tumor Suppressor Protein p53
Hematopoietic Stem Cells
Apoptosis
Cell Cycle Checkpoints
Ribosomes
11 Citations (Scopus)

The role of p53 in limiting somatic cell reprogramming

Liu, Y., Hoya-Arias, R. & Nimer, S. D., Nov 2009, In : Cell Research. 19, 11, p. 1227-1228 2 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-mdm2
Neoplastic Cell Transformation
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor p21
Tumor Suppressor Protein p53
2008
15 Citations (Scopus)

DNA damage signaling in hematopoietic cells: A role for Mre11 complex repair of topoisomerase lesions

Morales, M., Liu, Y., Laiakis, E. C., Morgan, W. F., Nimer, S. D. & Petrini, J. H. J., Apr 1 2008, In : Cancer Research. 68, 7, p. 2186-2193 8 p.

Research output: Contribution to journalArticle

DNA Damage
Ataxia Telangiectasia
Topoisomerase I Inhibitors
Camptothecin
Double-Stranded DNA Breaks
2007
24 Citations (Scopus)

Tumor promoting properties of the ETS protein MEF in ovarian cancer

Yao, J. J., Liu, Y., Lacorazza, H. D., Soslow, R. A., Scandura, J. M., Nimer, S. D. & Hedvat, C. V., Jun 7 2007, In : Oncogene. 26, 27, p. 4032-4037 6 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Neoplasms
Proteins
Nude Mice
Cell Line
2006
25 Citations (Scopus)

The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2

Liu, Y., Hedvat, C. V., Mao, S., Zhu, X. H., Yao, J., Nguyen, H., Koff, A. & Nimer, S. D., Apr 2006, In : Molecular and Cellular Biology. 26, 8, p. 3114-3123 10 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Proteolysis
Cell Cycle
Phosphorylation
G1 Phase
100 Citations (Scopus)

The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells

Lacorazza, H. D., Yamada, T., Liu, Y., Miyata, Y., Sivina, M., Nunes, J. & Nimer, S. D., Mar 2006, In : Cancer Cell. 9, 3, p. 175-187 13 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Transcription Factors
Radiation Effects
Bromodeoxyuridine
Acute Myeloid Leukemia
2003
29 Citations (Scopus)

Simplification of finite element models for thermal fatigue life prediction of PBGA packages

Akay, H. U., Liu, Y. & Rassaian, M., Sep 2003, In : Journal of Electronic Packaging, Transactions of the ASME. 125, 3, p. 347-353 7 p.

Research output: Contribution to journalArticle

Ball grid arrays
Thermal fatigue
Fatigue of materials
Plastics
Surface mount technology
1995
31 Citations (Scopus)

Intragenic suppression among CDC34 (UBC3) mutations defines a class of ubiquitin-conjugating catalytic domains

Liu, Y., Mathias, N., Steussy, C. N. & Goebl, M., 1995, In : Molecular and Cellular Biology. 15, 10, p. 5635-5644 10 p.

Research output: Contribution to journalArticle

Ubiquitin
Catalytic Domain
Mutation
Enzymes
S 0139