Yasuyoshi Ueki

  • 1286 Citations
  • 15 h-Index
19952020

Research output per year

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Publications

  • 1286 Citations
  • 15 h-Index
  • 35 Article
  • 4 Review article
2020

Alveolar Bone Protection by Targeting the SH3BP2-SYK Axis in Osteoclasts

Kittaka, M., Yoshimoto, T., Schlosser, C., Rottapel, R., Kajiya, M., Kurihara, H., Reichenberger, E. J. & Ueki, Y., Feb 1 2020, In : Journal of Bone and Mineral Research. 35, 2, p. 382-395 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Investigating global gene expression changes in a murine model of cherubism

Sharma, T., Cotney, J., Singh, V., Sanjay, A., Reichenberger, E. J., Ueki, Y. & Maye, P., Jun 2020, In : Bone. 135, 115315.

Research output: Contribution to journalArticle

Optineurin regulates osteoblastogenesis through STAT1

Mizuno, N., Iwata, T., Ohsawa, R., Ouhara, K., Matsuda, S., Kajiya, M., Matsuda, Y., Kume, K., Tada, Y., Morino, H., Yoshimoto, T., Ueki, Y., Mihara, K., Sotomaru, Y., Takeda, K., Munenaga, S., Fujita, T., Kawaguchi, H., Shiba, H., Kawakami, H. & 1 others, Kurihara, H., May 14 2020, In : Biochemical and Biophysical Research Communications. 525, 4, p. 889-894 6 p.

Research output: Contribution to journalArticle

RANKL-independent osteoclastogenesis in the SH3BP2 cherubism mice

Kittaka, M., Yoshimoto, T., Hoffman, H., Levitan, M. E. & Ueki, Y., Jun 2020, In : Bone Reports. 12, 100258.

Research output: Contribution to journalArticle

Open Access
2019

Epigenetic regulation of NfatC1 transcription and osteoclastogenesis by nicotinamide phosphoribosyl transferase in the pathogenesis of arthritis

Li, X., Islam, S., Xiong, M., Nsumu, N. N., Lee, M. W., Zhang, L. Q., Ueki, Y., Heruth, D. P., Lei, G. & Ye, S. Q., Dec 1 2019, In : Cell Death Discovery. 5, 1, 62.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts

Kittaka, M., Mayahara, K., Mukai, T., Yoshimoto, T., Yoshitaka, T., Gorski, J. P. & Ueki, Y., Jan 2018, In : Journal of Bone and Mineral Research. 33, 1, p. 167-181 15 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Mouse Cre Models for the Study of Bone Diseases

Dallas, S. L., Xie, Y., Shiflett, L. A. & Ueki, Y., Aug 1 2018, In : Current Osteoporosis Reports. 16, 4, p. 466-477 12 p.

Research output: Contribution to journalReview article

10 Scopus citations

Pharmacological inhibition of tankyrase induces bone loss in mice by increasing osteoclastogenesis

Fujita, S., Mukai, T., Mito, T., Kodama, S., Nagasu, A., Kittaka, M., Sone, T., Ueki, Y. & Morita, Y., Jan 2018, In : Bone. 106, p. 156-166 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Rescue of a cherubism bone marrow stromal culture phenotype by reducing TGFβ signaling

Liu, Y., Sharma, T., Chen, I. P., Reichenberger, E., Ueki, Y., Arif, Y., Parisi, D. & Maye, P., Jun 2018, In : Bone. 111, p. 28-35 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Second-Generation SYK Inhibitor Entospletinib Ameliorates Fully Established Inflammation and Bone Destruction in the Cherubism Mouse Model

Yoshimoto, T., Hayashi, T., Kondo, T., Kittaka, M., Reichenberger, E. J. & Ueki, Y., Aug 2018, In : Journal of Bone and Mineral Research. 33, 8, p. 1513-1519 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Molecular and Cellular Pathogenesis of Cherubism

Ueki, Y., Jun 1 2016, In : Clinical calcium. 26, 6, p. 918-926 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Bone marrow transplantation improves autoinflammation and inflammatory bone loss in SH3BP2 knock-in cherubism mice

Yoshitaka, T., Kittaka, M., Ishida, S., Mizuno, N., Mukai, T. & Ueki, Y., Feb 1 2015, In : Bone. 71, p. 201-209 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-driven and collagen-induced arthritis in mice

Mukai, T., Gallant, R., Ishida, S., Kittaka, M., Yoshitaka, T., Fox, D. A., Morita, Y., Nishida, K., Rottapel, R. & Ueki, Y., Mar 1 2015, In : Arthritis and Rheumatology. 67, 3, p. 656-667 12 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations
2014

Enhanced TLR-MYD88 signaling stimulates autoinflammation in SH3BP2 cherubism mice and defines the etiology of cherubism

Yoshitaka, T., Mukai, T., Kittaka, M., Alford, L. M., Masrani, S., Ishida, S., Yamaguchi, K., Yamada, M., Mizuno, N., Olsen, B. R., Reichenberger, E. J. & Ueki, Y., Sep 25 2014, In : Cell Reports. 8, 6, p. 1752-1766 15 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Etanercept administration to neonatal SH3BP2 knock-in cherubism mice prevents TNF-α-induced inflammation and bone loss

Yoshitaka, T., Ishida, S., Mukai, T., Kittaka, M., Reichenberger, E. J. & Ueki, Y., May 2014, In : Journal of Bone and Mineral Research. 29, 5, p. 1170-1182 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss

Mukai, T., Ishida, S., Ishikawa, R., Yoshitaka, T., Kittaka, M., Gallant, R., Lin, Y. L., Rottapel, R., Brotto, M., Reichenberger, E. J. & Ueki, Y., Dec 1 2014, In : Journal of Bone and Mineral Research. 29, 12, p. 2618-2635 18 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

SH3BP2 gain-of-function mutation exacerbates inflammation and bone loss in a murine collagen-induced arthritis model

Mukai, T., Gallant, R., Ishida, S., Yoshitaka, T., Kittaka, M., Nishida, K., Fox, D. A., Morita, Y. & Ueki, Y., Aug 21 2014, In : PloS one. 9, 8, e105518.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
2011

Clonal overgrowth of esophageal smooth muscle cells in diffuse leiomyomatosis-Alport syndrome caused by partial deletion in COL4A5 and COL4A6 genes

Oohashi, T., Naito, I., Ueki, Y., Yamatsuji, T., Permpoon, R., Tanaka, N., Naomoto, Y. & Ninomiya, Y., Jan 2011, In : Matrix Biology. 30, 1, p. 3-8 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism

Levaot, N., Voytyuk, O., Dimitriou, I., Sircoulomb, F., Chandrakumar, A., Deckert, M., Krzyzanowski, P. M., Scotter, A., Gu, S., Janmohamed, S., Cong, F., Simoncic, P. D., Ueki, Y., La Rose, J. & Rottapel, R., Dec 9 2011, In : Cell. 147, 6, p. 1324-1339 16 p.

Research output: Contribution to journalArticle

Open Access
115 Scopus citations
2010

Cherubism gene Sh3bp2 is important for optimal bone formation, osteoblast differentiation, and function

Mukherjee, P. M., Wang, C. J., Chen, I. P., Jafarov, T., Olsen, B. R., Ueki, Y. & Reichenberger, E. J., Aug 2010, In : American Journal of Orthodontics and Dentofacial Orthopedics. 138, 2, p. 140.e1-140.e11

Research output: Contribution to journalArticle

12 Scopus citations

Pro416Arg cherubism mutation in Sh3bp2 knock-in mice affects osteoblasts and alters bone mineral and matrix properties

Wang, C. J., Chen, I. P., Koczon-Jaremko, B., Boskey, A. L., Ueki, Y., Kuhn, L. & Reichenberger, E. J., May 1 2010, In : Bone. 46, 5, p. 1306-1315 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
2009

SH3BP2 is a critical regulator of macrophage and osteoclast response to M-CSF and RANKL stimulation

McMahon, M. S. & Ueki, Y., Feb 2009, In : HSS Journal. 5, 1, p. 49-50 2 p.

Research output: Contribution to journalArticle

1 Scopus citations
2008

Does anti-TNF-alpha have a role in the treatment of osteoporosis?

McMahon, M. S. & Ueki, Y., Dec 1 2008, In : Bulletin of the NYU Hospital for Joint Diseases. 66, 4, p. 280-281 2 p.

Research output: Contribution to journalArticle

10 Scopus citations

NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism

Aliprantis, A. O., Ueki, Y., Sulyanto, R., Park, A., Sigrist, K. S., Sharma, S. M., Ostrowski, M. C., Olsen, B. R. & Glimcher, L. H., Nov 3 2008, In : Journal of Clinical Investigation. 118, 11, p. 3775-3789 15 p.

Research output: Contribution to journalArticle

Open Access
198 Scopus citations
2007

Increased Myeloid Cell Responses to M-CSF and RANKL Cause Bone Loss and Inflammation in SH3BP2 "Cherubism" Mice

Ueki, Y., Lin, C. Y., Senoo, M., Ebihara, T., Agata, N., Onji, M., Saheki, Y., Kawai, T., Mukherjee, P. M., Reichenberger, E. & Olsen, B. R., Jan 12 2007, In : Cell. 128, 1, p. 71-83 13 p.

Research output: Contribution to journalArticle

Open Access
124 Scopus citations

On the horizon from the ORS

Chu, C. R., McMahon, M. S., Ueki, Y. & Fyhrie, D. P., Oct 2007, In : Journal of the American Academy of Orthopaedic Surgeons. 15, 10, p. 636-638 3 p.

Research output: Contribution to journalArticle

2002

Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23

Nomoto, H., Oohashi, T., Hirakawa, S., Ueki, Y., Ohtsuki, H. & Ninomiya, Y., 2002, In : Acta Medica Okayama. 56, 1, p. 25-29 5 p.

Research output: Contribution to journalArticle

7 Scopus citations
2001

Autosomal dominant craniometaphyseal dysplasia is caused by mutations in the transmembrane protein ANK

Reichenberger, E., Tiziani, V., Watanabe, S., Park, L., Ueki, Y., Santanna, C., Baur, S. T., Shiang, R., Grange, D. K., Beighton, P., Gardner, J., Hamersma, H., Sellars, S., Ramesar, R., Lidral, A. C., Sommer, A., Raposo do Amaral, C. M., Gorlin, R. J., Mulliken, J. B. & Olsen, B. R., 2001, In : American Journal of Human Genetics. 68, 6, p. 1321-1326 6 p.

Research output: Contribution to journalArticle

Open Access
139 Scopus citations

Genetic alteration of penicillin non-susceptible Streptococcus pneumoniae observed throughout recurrence of acute otitis media detected by amplified fragment length polymorphism analysis

Sugata, K. I., Fukushima, K., Ogawa, T., Nakashima, T., Sugata, A., Kasai, N., Gunduz, M., Ueki, Y. & Nishizaki, K., Dec 1 2001, In : Acta Medica Okayama. 55, 3, p. 167-174 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Genomic structures of SCN2A and SCN3A - Candidate genes for deafness at the DFNA16 locus

Kasai, N., Fukushima, K., Ueki, Y., Prasad, S., Nosakowski, J., Sugata, K. I., Sugata, A., Nishizaki, K., Meyer, N. C. & Smith, R. J. H., Feb 7 2001, In : Gene. 264, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism

Ueki, Y., Tiziani, V., Santanna, C., Fukai, N., Maulik, C., Garfinkle, J., Ninomiya, C., Doamaral, C., Peters, H., Habal, M., Rhee-Morris, L., Doss, J. B., Kreiborg, S., Olsen, B. R. & Reichenberger, E., Jun 26 2001, In : Nature genetics. 28, 2, p. 125-126 2 p.

Research output: Contribution to journalArticle

244 Scopus citations

Random amplified polymorphic DNA analysis applied to acute otitis media caused by penicillin non-susceptible Streptococcus pneumoniae

Nakashima, T., Fukushima, K., Tahara, M., Sugata, K., Ogawa, T., Sugata, A., Gunduz, M., Ueki, Y., Uno, Y. & Nishizaki, K., Jan 1 2001, In : Journal of Infection and Chemotherapy. 7, 4, p. 239-242 4 p.

Research output: Contribution to journalArticle

3 Scopus citations
2000
3 Scopus citations
1999

A gene for fluctuating, progressive autosomal dominant nonsyndromic hearing loss, DFNA16, maps to chromosome 2q23-24.3

Fukushima, K., Kasai, N., Ueki, Y., Nishizaki, K., Sugata, K., Hirakawa, S., Masuda, A., Gunduz, M., Ninomiya, Y., Masuda, Y., Sato, M., McGuirt, W. T., Coucke, P., Van Camp, G. & Smith, R. J. H., Jan 1 1999, In : American Journal of Human Genetics. 65, 1, p. 141-150 10 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations
1998

Ehlers-Danlos syndrome

Ueki, Y., Yoshino, T. & Yoshioka, H., 1998, In : Ryōikibetsu shōkōgun shirīzu. 19 Pt 2, p. 514-517 4 p.

Research output: Contribution to journalReview article

Organization and expression of basement membrane collagen IV genes and their roles in human disorders

Sado, Y., Kagawa, M., Naito, I., Ueki, Y., Seki, T., Momota, R., Oohashi, T. & Ninomiya, Y., May 1998, In : Journal of Biochemistry. 123, 5, p. 767-776 10 p.

Research output: Contribution to journalReview article

124 Scopus citations

Topoisomerase I and II consensus sequences in a 17-kB deletion junction of the COL4A5 and COL4A6 genes and immunohistochemical analysis of esophageal leiomyomatosis associated with Alport syndrome

Ueki, Y., Naito, I., Oohashi, T., Sugimoto, M., Seki, T., Yoshioka, H., Sado, Y., Sato, H., Sawai, T., Sasaki, F., Matsuoka, M., Fukuda, S. & Ninomiya, Y., Feb 1998, In : American Journal of Human Genetics. 62, 2, p. 253-261 9 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations
1997

Structure of the human type XIX collagen (COL19A1) gene, which suggests it has arisen from an ancestor gene of the FACIT family

Khaleduzzaman, M., Sumiyoshi, H., Ueki, Y., Inoguchi, K., Ninomiya, Y. & Yoshioka, H., Jan 1 1997, In : Genomics. 45, 2, p. 304-312 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
1995

Isolation and structure of the COL4A6 gene encoding the human α6(IV) collagen chain and comparison with other type IV collagen genes

Oohashi, T., Ueki, Y., Sugimoto, M. & Ninomiya, Y., Jan 1 1995, In : Journal of Biological Chemistry. 270, 45, p. 26863-26867 5 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations