Yuichiro Takagi

  • 1259 Citations
  • 16 h-Index
19942019
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Publications 1994 2019

  • 1259 Citations
  • 16 h-Index
  • 30 Article
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Article
2019
Recombinant Proteins
Methionine
Insects
Toxicity
Proteins

High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity

Zhu, W., Radadiya, A., Bisson, C., Wenzel, S., Nordin, B. E., Martínez-Márquez, F., Imasaki, T., Sedelnikova, S. E., Coricello, A., Baumann, P., Berry, A. H., Nomanbhoy, T. K., Kozarich, J. W., Jin, Y., Rice, D. W., Takagi, Y. & Richards, N. G. J., Dec 1 2019, In : Communications Biology. 2, 1, 345.

Research output: Contribution to journalArticle

Open Access
Aspartate-Ammonia Ligase
aspartate-ammonia ligase
crystal structure
Crystal structure
HCT116 Cells

Parkinson’s disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics

Wu, C. X., Liao, J., Park, Y., Reed, X., Engel, V. A., Hoang, N. C., Takagi, Y., Johnson, S., Wang, M., Federici, M., Jeremy Nichols, R., Sanishvili, R., Cookson, M. R. & Hoang, Q., Jan 1 2019, In : Journal of Biological Chemistry. 294, 15, p. 5907-5913 7 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
ras Proteins
Leucine
Parkinson Disease
Conformations
2018
3 Citations (Scopus)

A protein-protein interaction underlies the molecular basis for substrate recognition by an adenosine-to-inosine RNA-editing enzyme

Rajendren, S., Manning, A. C., Al-Awadi, H., Yamada, K., Takagi, Y. & Hundley, H., Oct 12 2018, In : Nucleic Acids Research. 46, 18, p. 9647-9659 13 p.

Research output: Contribution to journalArticle

RNA Editing
Inosine
Adenosine Deaminase
Adenosine
Double-Stranded RNA
3 Citations (Scopus)

Titer estimation for quality control (TEQC) method: A practical approach for optimal production of protein complexes using the baculovirus expression vector system

Imasaki, T., Wenzel, S., Yamada, K., Bryant, M. L. & Takagi, Y., Apr 1 2018, In : PLoS One. 13, 4, e0195356.

Research output: Contribution to journalArticle

Baculoviridae
Quality Control
quality control
Quality control
control methods
2017
11 Citations (Scopus)

Yeast Hrq1 shares structural and functional homology with the disease-linked human RecQ4 helicase

Rogers, C. M., Wang, J. C. Y., Noguchi, H., Imasaki, T., Takagi, Y. & Bochman, M. L., May 19 2017, In : Nucleic Acids Research. 45, 9, p. 5217-5230 14 p.

Research output: Contribution to journalArticle

RecQ Helicases
Yeasts
Genomic Instability
Telomere
Enzymes
2015
11 Citations (Scopus)

Structures and functions of the multiple KOW domains of transcription elongation factor Spt5

Meyer, P. A., Li, S., Zhang, M., Yamada, K., Takagi, Y., Hartzog, G. A. & Fu, J., 2015, In : Molecular and Cellular Biology. 35, 19, p. 3354-3369 16 p.

Research output: Contribution to journalArticle

Peptide Elongation Factors
Nucleic Acids
Transcription Factors
RNA Polymerase I
RNA Polymerase II
2013
16 Citations (Scopus)

Baculovirus expression: Tackling the complexity challenge

Barford, D., Takagi, Y., Schultz, P. & Berger, I., Jun 2013, In : Current Opinion in Structural Biology. 23, 3, p. 357-364 8 p.

Research output: Contribution to journalArticle

Multiprotein Complexes
Baculoviridae
Eukaryotic Cells
Eukaryota
Health
5 Citations (Scopus)

Expression and purification of functional human glycogen synthase-1 (hGYS1) in insect cells

Khanna, M., Imasaki, T., Chikwana, V. M., Perez-Miller, S., Hunter, G. O., Mosley, A., Takagi, Y. & Hurley, T., 2013, In : Protein Expression and Purification. 90, 2, p. 78-83 6 p.

Research output: Contribution to journalArticle

Glycogen Synthase
Insects
Phosphorylation
Glucose-6-Phosphate
Baculoviridae
2012
26 Citations (Scopus)

Interaction of the mediator head module with RNA polymerase II

Cai, G., Chaban, Y. L., Imasaki, T., Kovacs, J. A., Calero, G., Penczek, P. A., Takagi, Y. & Asturias, F. J., May 9 2012, In : Structure. 20, 5, p. 899-910 12 p.

Research output: Contribution to journalArticle

RNA Polymerase II
Head
Mediator Complex
Transcription Factor TFIIB
Cryoelectron Microscopy
95 Citations (Scopus)

MultiBac: Expanding the research toolbox for multiprotein complexes

Bieniossek, C., Imasaki, T., Takagi, Y. & Berger, I., Feb 2012, In : Trends in Biochemical Sciences. 37, 2, p. 49-57 9 p.

Research output: Contribution to journalArticle

Multiprotein Complexes
Technology
Baculoviridae
Research
Proteins
11 Citations (Scopus)

MultiBac complexomics

Trowitzsch, S., Palmberger, D., Fitzgerald, D., Takagi, Y. & Berger, I., Aug 2012, In : Expert Review of Proteomics. 9, 4, p. 363-373 11 p.

Research output: Contribution to journalArticle

Multiprotein Complexes
Technology
Industrial research
Proteins
Molecular biology
2011
80 Citations (Scopus)

Architecture of the Mediator head module

Imasaki, T., Calero, G., Cai, G., Tsai, K. L., Yamada, K., Cardelli, F., Erdjument-Bromage, H., Tempst, P., Berger, I., Kornberg, G. L., Asturias, F. J., Kornberg, R. D. & Takagi, Y., Jul 14 2011, In : Nature. 475, 7355, p. 240-243 4 p.

Research output: Contribution to journalArticle

Head
Transcription Factor TFIIH
General Transcription Factors
RNA Polymerase II
Gene Expression Regulation
19 Citations (Scopus)

Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src Kinase-associated Protein of 55 kDa Homolog (SKAP-HOM) as a Lyp substrate

Yu, X., Chen, M., Zhang, S., Yu, Z. H., Sun, J. P., Wang, L., Liu, S., Imasaki, T., Takagi, Y. & Zhang, Z-Y., Sep 2 2011, In : Journal of Biological Chemistry. 286, 35, p. 30526-30534 9 p.

Research output: Contribution to journalArticle

src-Family Kinases
Substrate Specificity
Phosphoric Monoester Hydrolases
Tyrosine
Substrates
2010
67 Citations (Scopus)

Mediator Head module structure and functional interactions

Cai, G., Imasaki, T., Yamada, K., Cardelli, F., Takagi, Y. & Asturias, F. J., Mar 2010, In : Nature Structural and Molecular Biology. 17, 3, p. 273-279 7 p.

Research output: Contribution to journalArticle

Head
TATA-Box Binding Protein
RNA Polymerase II
Jaw
Mediator Complex
2009
79 Citations (Scopus)

Mediator Structural Conservation and Implications for the Regulation Mechanism

Cai, G., Imasaki, T., Takagi, Y. & Asturias, F. J., Apr 15 2009, In : Structure. 17, 4, p. 559-567 9 p.

Research output: Contribution to journalArticle

RNA Polymerase II
Yeasts
Mediator Complex
Cytoplasmic and Nuclear Receptors
Sequence Homology
2008
72 Citations (Scopus)

Malleable machines in transcription regulation: The Mediator complex

Tóth-Petróczy, Á., Oldfield, C. J., Simon, I., Takagi, Y., Dunker, A., Uversky, V. N. & Fuxreiter, M., Dec 2008, In : PLoS Computational Biology. 4, 12, e1000243.

Research output: Contribution to journalArticle

Mediator Complex
Mediator
Transcription
Yeast
Saccharomyces cerevisiae
2006
94 Citations (Scopus)

Head Module Control of Mediator Interactions

Takagi, Y., Calero, G., Komori, H., Brown, J. A., Ehrensberger, A. H., Hudmon, A., Asturias, F. & Kornberg, R. D., Aug 4 2006, In : Molecular Cell. 23, 3, p. 355-364 10 p.

Research output: Contribution to journalArticle

RNA Polymerase II
Head
Mediator Complex
Fungal Proteins
Baculoviridae
117 Citations (Scopus)

Mediator as a general transcription factor

Takagi, Y. & Kornberg, R. D., Jan 6 2006, In : Journal of Biological Chemistry. 281, 1, p. 80-89 10 p.

Research output: Contribution to journalArticle

General Transcription Factors
RNA Polymerase II
Transcription
Bearings (structural)
Temperature
2005
12 Citations (Scopus)

Preponderance of free mediator in the yeast Saccharomyces cerevisiae

Takagi, Y., Chadick, J. Z., Davis, J. A. & Asturias, F. J., Sep 2 2005, In : Journal of Biological Chemistry. 280, 35, p. 31200-31207 8 p.

Research output: Contribution to journalArticle

RNA Polymerase II
Yeast
Saccharomyces cerevisiae
Holoenzymes
Yeasts
61 Citations (Scopus)

Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage

Takagi, Y., Masuda, C. A., Chang, W. H., Komori, H., Wang, D., Hunter, T., Joazeiro, C. A. P. & Kornberg, R. D., Apr 15 2005, In : Molecular Cell. 18, 2, p. 237-243 7 p.

Research output: Contribution to journalArticle

RING Finger Domains
Ubiquitin-Protein Ligases
Ligases
Ubiquitin
DNA Repair
2003
32 Citations (Scopus)

Revised Subunit Structure of Yeast Transcription Factor IIH (TFIIH) and Reconciliation with Human TFIIH

Takagi, Y., Komori, H., Chang, W. H., Hudmon, A., Erdjument-Bromage, H., Tempst, P. & Kornberg, R. D., Nov 7 2003, In : Journal of Biological Chemistry. 278, 45, p. 43897-43900 4 p.

Research output: Contribution to journalArticle

Transcription Factor TFIIH
Yeast
Yeasts
General Transcription Factors
Cyclins
2002
162 Citations (Scopus)

Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction

Davis, J. A., Takagi, Y., Kornberg, R. D. & Asturias, F. J., Aug 2002, In : Molecular Cell. 10, 2, p. 409-415 7 p.

Research output: Contribution to journalArticle

Holoenzymes
RNA Polymerase II
Yeasts
Mediator Complex
Electrons
2001
55 Citations (Scopus)

A Multiprotein Complex That Interacts with RNA Polymerase II Elongator

Li, Y., Takagi, Y., Jiang, Y., Tokunaga, M., Erdjument-Bromage, H., Tempst, P. & Kornberg, R. D., Aug 10 2001, In : Journal of Biological Chemistry. 276, 32, p. 29628-29631 4 p.

Research output: Contribution to journalArticle

Multiprotein Complexes
RNA Polymerase II
Gene Deletion
Yeast
Genes
1999
79 Citations (Scopus)

Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein

Ohh, M., Takagi, Y., Aso, T., Stebbins, C. E., Pavletich, N. P., Zbar, B., Conaway, R. C., Conaway, J. W. & Kaelin, W. G., Dec 1999, In : Journal of Clinical Investigation. 104, 11, p. 1583-1591 9 p.

Research output: Contribution to journalArticle

Peptides
Proteins
elongin
Von Hippel-Lindau Tumor Suppressor Protein
Messenger RNA
16 Citations (Scopus)

The Elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C

Brower, C. S., Shilatifard, A., Mather, T., Kamura, T., Takagi, Y., Haque, D., Treharne, A., Foundling, S. I., Conaway, J. W. & Conaway, R. C., May 7 1999, In : Journal of Biological Chemistry. 274, 19, p. 13629-13636 8 p.

Research output: Contribution to journalArticle

Ubiquitin
Tail
elongin
Amino Acids
Peptide Elongation Factors
1997
10 Citations (Scopus)

Identification of elongin C sequences required for interaction with the von Hippel-Lindau tumor suppressor protein

Takagi, Y., Pause, A., Conaway, R. C. & Conaway, J. W., 1997, In : Journal of Biological Chemistry. 272, 43, p. 27444-27449 6 p.

Research output: Contribution to journalArticle

Von Hippel-Lindau Tumor Suppressor Protein
elongin
1996
20 Citations (Scopus)

Characterization of elongin C functional domains required for interaction with Elongin B and activation of Elongin A

Takagi, Y., Conaway, R. C. & Conaway, J. W., 1996, In : Journal of Biological Chemistry. 271, 41, p. 25562-25568 7 p.

Research output: Contribution to journalArticle

Chemical activation
elongin
RNA Polymerase II
Tumor Suppressor Genes
Tumors
1995
12 Citations (Scopus)
Peptide Initiation Factors
RNA Polymerase II
Transcription
DNA
RNA
1994
91 Citations (Scopus)

Phosrestin I undergoes the earliest light-induced phosphorylation by a calcium/calmodulin-dependent protein kinase in drosophila photoreceptors

Matsumoto, H., Kurien, B. T., Takagi, Y., Kahn, E. S., Kinumi, T., Komori, N., Yamada, T., Hayashi, F., Isono, K., Pak, W. L., Jackson, K. W. & Tobin, S. L., 1994, In : Neuron. 12, 5, p. 997-1010 14 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinases
Phosphorylation
Light
Drosophila
Arrestin