Zeruesenay Desta

  • 9811 Citations
  • 44 h-Index
1976 …2020

Research output per year

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Publications

2020

A randomized placebo-controlled trial of bupropion for Cancer-related fatigue: Study design and procedures

Jim, H. S. L., Hoogland, A. I., Han, H. S., Culakova, E., Heckler, C., Janelsins, M., Williams, G. C., Bower, J., Cole, S., Desta, Z., Babilonia, M. B., Morrow, G. & Peppone, L., Apr 2020, In : Contemporary Clinical Trials. 91, 105976.

Research output: Contribution to journalArticle

Influence of uridine diphosphate glucuronosyltransferase family 1 member A1 and solute carrier organic anion transporter family 1 member B1 polymorphisms and efavirenz on bilirubin disposition in healthy volunteers

Collins, K. S., Metzger, I. F., Gufford, B. T., Lu, J. B., Medeiros, E. B., Pratt, V. M., Skaar, T. C. & Desta, Z., Mar 2020, In : Drug Metabolism and Disposition. 48, 3, p. 169-175 7 p.

Research output: Contribution to journalArticle

Inhibitory Effects of Probenecid on Pharmacokinetics of Tenofovir Disoproxil Fumarate and Emtricitabine for On-Demand HIV Preexposure Prophylaxis

Liu, S. N., Gufford, B. T., Lu, J. B. L., Bushman, L. R., Anderson, P. L., Bergstrom, R. F., Desta, Z. & Gupta, S. K., May 1 2020, In : Clinical Pharmacology and Therapeutics. 107, 5, p. 1200-1208 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation

Al Batran, R., Gopal, K., Capozzi, M. E., Chahade, J. J., Saleme, B., Tabatabaei-Dakhili, S. A., Greenwell, A. A., Niu, J., Almutairi, M., Byrne, N. J., Masson, G., Kim, R., Eaton, F., Mulvihill, E. E., Garneau, L., Masters, A. R., Desta, Z., Velázquez-Martínez, C. A., Aguer, C., Crawford, P. A. & 4 others, Sutendra, G., Campbell, J. E., Dyck, J. R. B. & Ussher, J. R., May 5 2020, In : Cell Metabolism. 31, 5, p. 909-919.e8

Research output: Contribution to journalArticle

1 Scopus citations
Open Access

Translational Knowledge Discovery Between Drug Interactions and Pharmacogenetics

Wu, H. Y., Shendre, A., Zhang, S., Zhang, P., Wang, L., Zeruesenay, D., Rocha, L. M., Shatkay, H., Quinney, S. K., Ning, X. & Li, L., Apr 1 2020, In : Clinical Pharmacology and Therapeutics. 107, 4, p. 886-902 17 p.

Research output: Contribution to journalArticle

2019

Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2

Dudenkov, T. M., Liu, D., Cairns, J., Devarajan, S., Zhuang, Y., Ingle, J. N., Buzdar, A. U., Robson, M. E., Kubo, M., Batzler, A., Barman, P., Jenkins, G. D., Carlson, E. E., Goetz, M. P., Northfelt, D. W., Moreno-Aspitia, A., Desta, Z., Reid, J. M., Kalari, K. R., Wang, L. & 1 others, Weinshilboum, R. M., Jul 2019, In : Clinical Pharmacology and Therapeutics. 106, 1, p. 219-227 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy

Desta, Z., Gammal, R. S., Gong, L., Whirl-Carrillo, M., Gaur, A. H., Sukasem, C., Hockings, J., Myers, A., Swart, M., Tyndale, R. F., Masimirembwa, C., Iwuchukwu, O. F., Chirwa, S., Lennox, J., Gaedigk, A., Klein, T. E. & Haas, D. W., Oct 1 2019, In : Clinical Pharmacology and Therapeutics. 106, 4, p. 726-733 8 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

CYP2B6 Genotype-Dependent Inhibition of CYP1A2 and Induction of CYP2A6 by the Antiretroviral Drug Efavirenz in Healthy Volunteers

Metzger, I. F., Dave, N., Kreutz, Y., Lu, J. B. L., Galinsky, R. E. & Desta, Z., Nov 1 2019, In : Clinical and translational science. 12, 6, p. 657-666 10 p.

Research output: Contribution to journalArticle

Open Access

Drug-gene and drug-drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial

Fulton, C. R., Zang, Y., Desta, Z., Rosenman, M. B., Holmes, A. M., Decker, B. S., Zhang, Y., T Callaghan, J., Pratt, V. M., Levy, K. D., Gufford, B. T., Dexter, P. R., Skaar, T. C. & Eadon, M. T., Apr 1 2019, In : Pharmacogenomics. 20, 6, p. 397-408 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effects of SLCO1B1 polymorphisms on plasma estrogen concentrations in women with breast cancer receiving aromatase inhibitors exemestane and letrozole

Dempsey, J. M., Kidwell, K. M., Gersch, C. L., Pesch, A. M., Desta, Z., Storniolo, A. M., Stearns, V., Skaar, T. C., Hayes, D. F., Henry, N. L., Rae, J. M. & Hertz, D. L., Jan 1 2019, In : Pharmacogenomics. 20, 8, p. 571-580 10 p.

Research output: Contribution to journalArticle

Mechanistic assessment of extrahepatic contributions to glucuronidation of integrase strand transfer inhibitors

Liu, S. N., Lu, J. B. L., Watson, C. J. W., Lazarus, P., Desta, Z. & Gufford, B. T., May 2019, In : Drug Metabolism and Disposition. 47, 5, p. 535-544 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

CYP2D6 and Endoxifen in Tamoxifen Therapy: A Tribute to David A. Flockhart

Skaar, T. & Desta, Z., Jan 1 2018, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

1 Scopus citations

DrugMetab: An Integrated Machine Learning and Lexicon Mapping Named Entity Recognition Method for Drug Metabolite

Wu, H. Y., Lu, D., Hyder, M., Zhang, S., Quinney, S. K., Desta, Z. & Li, L., Nov 2018, In : CPT: Pharmacometrics and Systems Pharmacology. 7, 11, p. 709-717 9 p.

Research output: Contribution to journalArticle

Pharmacogenetics and Practice: Tailoring Prescribing for Safety and Effectiveness

Fulton, C. R., Swart, M., De Luca, T., Liu, S. N., Collins, K. S., Desta, Z., Gufford, B. T. & Eadon, M. T., Nov 1 2018, In : Journal for Nurse Practitioners. 14, 10, p. 697-704.e1

Research output: Contribution to journalArticle

1 Scopus citations

Rifampin modulation of xeno- and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes

Gufford, B. T., Robarge, J. D., Eadon, M. T., Gao, H., Lin, H., Liu, Y., Desta, Z. & Skaar, T. C., Apr 2018, In : Pharmacology Research and Perspectives. 6, 2, e00386.

Research output: Contribution to journalArticle

3 Scopus citations

Variants in the CYP2B6 3′UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs

Burgess, K. S., Ipe, J., Swart, M., Metzger, I. F., Lu, J., Gufford, B. T., Thong, N., Desta, Z., Gaedigk, R., Pearce, R. E., Gaedigk, A., Liu, Y. & Skaar, T. C., Jul 2018, In : Clinical Pharmacology and Therapeutics. 104, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Clinical and educational impact of pharmacogenomics testing: A case series from the INGENIOUS trial

Pierson, R. C., Gufford, B. T., Desta, Z. & Eadon, M. T., Jun 2017, In : Pharmacogenomics. 18, 9, p. 835-841 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment

Marcath, L. A., Deal, A. M., Van Wieren, E., Danko, W., Walko, C. M., Ibrahim, J. G., Weck, K. E., Jones, D. R., Desta, Z., McLeod, H. L., Carey, L. A., Irvin, W. J. & Hertz, D. L., Jan 1 2017, In : Pharmacogenetics and Genomics. 27, 11, p. 402-409 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Effects of exemestane and letrozole therapy on plasma concentrations of estrogens in a randomized trial of postmenopausal women with breast cancer

Robarge, J. D., Desta, Z., Nguyen, A. T., Li, L., Hertz, D., Rae, J. M., Hayes, D. F., Storniolo, A. M., Stearns, V., Flockhart, D. A., Skaar, T. C. & Henry, N. L., Feb 1 2017, In : Breast Cancer Research and Treatment. 161, 3, p. 453-461 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Pharmacogenetics of Drug Metabolism

Desta, Z. & Flockhart, D. A., Jan 1 2017, Clinical and Translational Science: Principles of Human Research: Second Edition. Elsevier Inc., p. 327-345 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Polymorphisms in drug-metabolizing enzymes and steady-state exemestane concentration in postmenopausal patients with breast cancer

Hertz, D. L., Kidwell, K. M., Seewald, N. J., Gersch, C. L., Desta, Z., Flockhart, D. A., Storniolo, A. M., Stearns, V., Skaar, T. C., Hayes, D. F., Henry, N. L. & Rae, J. M., Dec 1 2017, In : Pharmacogenomics Journal. 17, 6, p. 521-527 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Population pharmacokinetic modeling to estimate the contributions of genetic and nongenetic factors to efavirenz disposition

Robarge, J. D., Metzger, I. F., Lu, J., Thong, N., Skaar, T. C., Desta, Z. & Bies, R. R., Jan 2017, In : Antimicrobial Agents and Chemotherapy. 61, 1, e01813-16.

Research output: Contribution to journalArticle

15 Scopus citations

Variable aromatase inhibitor plasma concentrations do not correlate with circulating estrogen concentrations in post-menopausal breast cancer patients

Hertz, D. L., Speth, K. A., Kidwell, K. M., Gersch, C. L., Desta, Z., Storniolo, A. M., Stearns, V., Skaar, T. C., Hayes, D. F., Henry, N. L. & Rae, J. M., Oct 1 2017, In : Breast Cancer Research and Treatment. 165, 3, p. 659-668 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Association of variants in candidate genes with lipid profiles in women with early breast cancer on adjuvant aromatase inhibitor therapy

Santa-Maria, C. A., Blackford, A., Nguyen, A. T., Skaar, T. C., Philips, S., Oesterreich, S., Rae, J. M., Desta, Z., Robarge, J., Henry, N. L., Storniolo, A. M., Hayes, D. F., Blumenthal, R. S., Ouyang, P., Post, W. S., Flockhart, D. A. & Stearns, V., Mar 15 2016, In : Clinical Cancer Research. 22, 6, p. 1395-1402 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Chiral plasma pharmacokinetics and urinary excretion of bupropion and metabolites in healthy volunteers

Masters, A. R., Gufford, B. T., Li Lu, J. B., Metzger, I. F., Jones, D. R. & Desta, Z., Aug 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 358, 2, p. 230-238 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Efavirenz Inhibits the Human Ether-A-Go-Go Related Current (hERG) and Induces QT Interval Prolongation in CYP2B6*6*6 Allele Carriers

Abdelhady, A. M., Shugg, T., Thong, N., Lu, J. B. L., Kreutz, Y., Jaynes, H. A., Robarge, J. D., Tisdale, J. E., Desta, Z. & Overholser, B. R., Oct 1 2016, In : Journal of cardiovascular electrophysiology. 27, 10, p. 1206-1213 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Implementation of a pharmacogenomics consult service to support the INGENIOUS trial

Eadon, M. T., Desta, Z., Levy, K. D., Decker, B. S., Pierson, R. C., Pratt, V. M., Callaghan, J. T., Rosenman, M. B., Carpenter, J. S., Holmes, A. M., McDonald, C. A., Benson, E. A., Patil, A. S., Vuppalanchi, R., Gufford, B. T., Dave, N., Robarge, J. D., Hyder, M. A., Haas, D. M., Kreutz, R. P. & 3 others, Dexter, P. R., Skaar, T. C. & Flockhart, D. A., Jul 1 2016, In : Clinical Pharmacology and Therapeutics. 100, 1, p. 63-66 4 p.

Research output: Contribution to journalReview article

21 Scopus citations

Inhibition of cytochrome P450 2B6 activity by voriconazole profiled using efavirenz disposition in healthy volunteers

Desta, Z., Metzger, I. F., Thong, N., Lu, J. B. L., Callaghan, J. T., Skaar, T. C., Flockhart, D. A. & Galinsky, R. E., Nov 2016, In : Antimicrobial Agents and Chemotherapy. 60, 11, p. 6813-6822 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Patient-reported outcomes and early discontinuation in aromatase inhibitor-treated postmenopausal women with early stage breast cancer

Kadakia, K. C., Snyder, C. F., Kidwell, K. M., Seewald, N. J., Flockhart, D. A., Skaar, T. C., Desta, Z., Rae, J. M., Otte, J. L., Carpenter, J. S., Storniolo, A. M., Hayes, D. F., Stearns, V. & Lynn Henry, N., Mar 23 2016, In : Oncologist. 21, 5, p. 539-546 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers

Cho, D. Y., Shen, J. H. Q., Lemler, S. M., Skaar, T. C., Li, L., Blievernicht, J., Zanger, U. M., Kim, K. B., Shin, J. G., Flockhart, D. A. & Desta, Z., Apr 2016, In : Drug Metabolism and Pharmacokinetics. 31, 2, p. 107-116 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Rifampin regulation of drug transporters gene expression and the association of microRNAs in human hepatocytes

Benson, E., Eadon, M., Desta, Z., Liu, Y., Lin, H., Burgess, K. S., Segar, M. W., Gaedigk, A. & Skaar, T., Apr 26 2016, In : Frontiers in Pharmacology. 7, APR, 111.

Research output: Contribution to journalArticle

20 Scopus citations

Stereoselective glucuronidation of bupropion metabolites in vitro and in vivo

Gufford, B. T., Lu, J. B. L., Metzger, I. F., Jones, D. R. & Desta, Z., Apr 2016, In : Drug Metabolism and Disposition. 44, 4, p. 544-553 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
15 Scopus citations

Tamoxifen dose escalation in patients with diminished CYP2D6 activity normalizes endoxifen concentrations without increasing toxicity

Hertz, D. L., Deal, A., Ibrahim, J. G., Walko, C. M., Weck, K. E., Anderson, S., Magrinat, G., Olajide, O., Moore, S., Raab, R., Carrizosa, D. R., Corso, S., Schwartz, G., Graham, M., Peppercorn, J. M., Jones, D. R., Desta, Z., Flockhart, D. A., Evans, J. P., McLeod, H. L. & 2 others, Carey, L. A. & Irvin, W. J., Jul 2016, In : Oncologist. 21, 7, p. 795-803 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2015

Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover

Oesterreich, S., Henry, N. L., Kidwell, K. M., Van Poznak, C. H., Skaar, T. C., Dantzer, J., Li, L., Hangartner, T. N., Peacock, M., Nguyen, A. T., Rae, J. M., Desta, Z., Philips, S., Storniolo, A. M., Stearns, V., Hayes, D. F. & Flockhart, D. A., Nov 1 2015, In : Breast Cancer Research and Treatment. 154, 2, p. 263-273 11 p.

Research output: Contribution to journalArticle

15 Scopus citations
1 Scopus citations

Estrogens and their precursors in postmenopausal women with early breast cancer receiving anastrozole

Ingle, J. N., Kalari, K. R., Buzdar, A. U., Robson, M. E., Goetz, M. P., Desta, Z., Barman, P., Dudenkov, T. T., Northfelt, D. W., Perez, E. A., Flockhart, D. A., Williard, C. V., Wang, L. & Weinshilboum, R. M., May 26 2015, In : Steroids. 99, Part A, p. 32-38 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Identification and Mechanistic Investigation of Drug-Drug Interactions Associated with Myopathy: A Translational Approach

Han, X., Quinney, S. K., Wang, Z., Zhang, P., Duke, J., Desta, Z., Elmendorf, J. S., Flockhart, D. A. & Li, L., Sep 1 2015, In : Clinical Pharmacology and Therapeutics. 98, 3, p. 321-327 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

In vitro metabolism of montelukast by cytochrome P450S and UDP-glucuronosyltransferases

De Oliveira Cardoso, J., Oliveira, R. V., Lu, J. B. L. & Desta, Z., Dec 1 2015, In : Drug Metabolism and Disposition. 43, 12, p. 1905-1916 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

In vivo assessment of the metabolic activity of CYP2D6 diplotypes and alleles

Hertz, D. L., Snavely, A. C., McLeod, H. L., Walko, C. M., Ibrahim, J. G., Anderson, S., Weck, K. E., Magrinat, G., Olajide, O., Moore, S., Raab, R., Carrizosa, D. R., Corso, S., Schwartz, G., Peppercorn, J. M., Evans, J. P., Jones, D. R., Desta, Z., Flockhart, D. A., Carey, L. A. & 1 others, Irvin, W. J., Nov 1 2015, In : British Journal of Clinical Pharmacology. 80, 5, p. 1122-1130 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Platelet factor XIIIa release during platelet aggregation and plasma clot strength measured by thrombelastography in patients with coronary artery disease treated with clopidogrel

Kreutz, R. P., Owens, J., Lu, D., Nystrom, P., Jin, Y., Kreutz, Y., Desta, Z. & Flockhart, D. A., Jun 1 2015, In : Platelets. 26, 4, p. 358-363 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
2014

Citalopram and escitalopram plasma drug and metabolite concentrations: Genome-wide associations

Ji, Y., Schaid, D. J., Desta, Z., Kubo, M., Batzler, A. J., Snyder, K., Mushiroda, T., Kamatani, N., Ogburn, E., Hall-Flavin, D., Flockhart, D., Nakamura, Y., Mrazek, D. A. & Weinshilboum, R. M., Aug 2014, In : British Journal of Clinical Pharmacology. 78, 2, p. 373-383 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype dependent

Michaud, V., Kreutz, Y., Skaar, T., Ogburn, E., Thong, N., Flockhart, D. A. & Desta, Z., Apr 2014, In : Pharmacogenomics Journal. 14, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Factor XIII Val34Leu polymorphism and recurrent myocardial infarction in patients with coronary artery disease

Kreutz, R. P., Bitar, A., Owens, J., Desta, Z., Breall, J. A., Von Der Lohe, E., Sinha, A., Vatta, M., Nystrom, P., Jin, Y. & Flockhart, D. A., Oct 2014, In : Journal of Thrombosis and Thrombolysis. 38, 3, p. 380-387 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Genome-Wide Discovery of Drug-Dependent Human Liver Regulatory Elements

Smith, R. P., Eckalbar, W. L., Morrissey, K. M., Luizon, M. R., Hoffmann, T. J., Sun, X., Jones, S. L., Force Aldred, S., Ramamoorthy, A., Desta, Z., Liu, Y., Skaar, T. C., Trinklein, N. D., Giacomini, K. M. & Ahituv, N., Oct 1 2014, In : PLoS Genetics. 10, 10

Research output: Contribution to journalArticle

19 Scopus citations

PharmGKB summary: Ifosfamide pathways, pharmacokinetics and pharmacodynamics

Lowenberg, D., Thorn, C. F., Desta, Z., Flockhart, D. A., Altman, R. B. & Klein, T. E., Feb 1 2014, In : Pharmacogenetics and Genomics. 24, 2, p. 133-138 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Population pharmacogenetic-based pharmacokinetic modeling of efavirenz, 7-hydroxy- and 8-hydroxyefavirenz

Abdelhady, A. M., Desta, Z., Jiang, F., Yeo, C. W., Shin, J. G. & Overholser, B. R., Jan 1 2014, In : Journal of clinical pharmacology. 54, 1, p. 87-96 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Prerequisites to implementing a pharmacogenomics program in a large health-care system

Levy, K. D., Decker, B. S., Carpenter, J. S., Flockhart, D. A., Dexter, P. R., Desta, Z. & Skaar, T. C., Sep 2014, In : Clinical Pharmacology and Therapeutics. 96, 3, p. 307-309 3 p.

Research output: Contribution to journalArticle

21 Scopus citations

Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers

Metzger, I. F., Quigg, T. C., Epstein, N., Aregbe, A. O., Thong, N., Callaghan, J. T., Flockhart, D. A., Nguyen, A. T., Stevens, C. K., Gupta, S. K. & Desta, Z., Dec 1 2014, In : Current Therapeutic Research - Clinical and Experimental. 76, p. 64-69 6 p.

Research output: Contribution to journalArticle

6 Scopus citations