Zeruesenay Desta

  • 9811 Citations
  • 44 h-Index
1976 …2020

Research output per year

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Publications

Stereoselective glucuronidation of bupropion metabolites in vitro and in vivo

Gufford, B. T., Lu, J. B. L., Metzger, I. F., Jones, D. R. & Desta, Z., Apr 2016, In : Drug Metabolism and Disposition. 44, 4, p. 544-553 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: Major role of CYP3A

Desta, Z., Soukhova, N., Morocho, A. M. & Flockhart, D. A., Aug 2 2001, In : Journal of Pharmacology and Experimental Therapeutics. 298, 2, p. 508-520 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
15 Scopus citations

Stereoselective pharmacokinetics of cisapride in healthy volunteers and the effect of repeated administration of grapefruit juice

Desta, Z., Kivistö, K. T., Lilja, J. J., Backman, J. T., Soukhova, N., Neuvonen, P. J. & Flockhart, D. A., Oct 18 2001, In : British Journal of Clinical Pharmacology. 52, 4, p. 399-407 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Stereoselective pharmacokinetics of stable isotope (+/-)-[ 13C]-pantoprazole: Implications for a rapid screening phenotype test of CYP2C19 activity

Thacker, D. L., Modak, A., Nguyen, P. D., Flockhart, D. A. & Desta, Z., Nov 1 2011, In : Chirality. 23, 10, p. 904-909 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers

Metzger, I. F., Quigg, T. C., Epstein, N., Aregbe, A. O., Thong, N., Callaghan, J. T., Flockhart, D. A., Nguyen, A. T., Stevens, C. K., Gupta, S. K. & Desta, Z., Dec 1 2014, In : Current Therapeutic Research - Clinical and Experimental. 76, p. 64-69 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Tamoxifen and its metabolites cause acute vasorelaxation of aortic rings by inducing vasodilator prostanoid synthesis

Montenegro, M. F., Ceron, C. S., Salgado, M. C. O., Desta, Z., Flockhart, D. A. & Tanus-Santos, J. E., Dec 1 2011, In : Journal of cardiovascular pharmacology. 58, 6, p. 647-653 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Tamoxifen dose escalation in patients with diminished CYP2D6 activity normalizes endoxifen concentrations without increasing toxicity

Hertz, D. L., Deal, A., Ibrahim, J. G., Walko, C. M., Weck, K. E., Anderson, S., Magrinat, G., Olajide, O., Moore, S., Raab, R., Carrizosa, D. R., Corso, S., Schwartz, G., Graham, M., Peppercorn, J. M., Jones, D. R., Desta, Z., Flockhart, D. A., Evans, J. P., McLeod, H. L. & 2 others, Carey, L. A. & Irvin, W. J., Jul 2016, In : Oncologist. 21, 7, p. 795-803 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Tamoxifen metabolites as active inhibitors of aromatase in the treatment of breast cancer

Lu, W. J., Desta, Z. & Flockhart, D. A., Jan 1 2012, In : Breast Cancer Research and Treatment. 131, 2, p. 473-481 9 p.

Research output: Contribution to journalArticle

49 Scopus citations
467 Scopus citations

The dual role of pharmacogenetics in HIV treatment: Mutations and polymorphisms regulating antiretroviral drug resistance and disposition

Michaud, V., Bar-Magen, T., Turgeon, J., Flockhart, D., Desta, Z. & Wainberg, M. A., Jul 2012, In : Pharmacological Reviews. 64, 3, p. 803-833 31 p.

Research output: Contribution to journalArticle

66 Scopus citations

The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6

Wu, G. M., Desta, Z., Morocho, A. M. & Flockhart, D. A., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P71

Research output: Contribution to journalArticle

The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6

Desta, Z., Wu, G. M., Morocho, A. M. & Flockhart, D. A., Mar 7 2002, In : Drug Metabolism and Disposition. 30, 3, p. 336-343 8 p.

Research output: Contribution to journalArticle

85 Scopus citations

The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen

Goetz, M. P., Knox, S. K., Suman, V. J., Rae, J. M., Safgren, S. L., Ames, M. M., Visscher, D. W., Reynolds, C., Couch, F. J., Lingle, W. L., Weinshilboum, R. M., Fritcher, E. G. B., Nibbe, A. M., Desta, Z., Nguyen, A., Flockhart, D. A., Perez, E. A. & Ingle, J. N., Jan 1 2007, In : Breast Cancer Research and Treatment. 101, 1, p. 113-121 9 p.

Research output: Contribution to journalArticle

477 Scopus citations

The star-allele nomenclature: Retooling for translational genomics

Robarge, J. D., Li, L., Desta, Z., Nguyen, A. & Flockhart, D. A., Sep 1 2007, In : Clinical Pharmacology and Therapeutics. 82, 3, p. 244-248 5 p.

Research output: Contribution to journalReview article

36 Scopus citations

Translational Knowledge Discovery Between Drug Interactions and Pharmacogenetics

Wu, H. Y., Shendre, A., Zhang, S., Zhang, P., Wang, L., Zeruesenay, D., Rocha, L. M., Shatkay, H., Quinney, S. K., Ning, X. & Li, L., Apr 1 2020, In : Clinical Pharmacology and Therapeutics. 107, 4, p. 886-902 17 p.

Research output: Contribution to journalArticle

Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: Implications for cyclophosphamide metabolism

Rae, J. M., Soukhova, N. V., Flockhart, D. A. & Desta, Z., May 11 2002, In : Drug Metabolism and Disposition. 30, 5, p. 525-530 6 p.

Research output: Contribution to journalArticle

103 Scopus citations

Variability of heart rate correction methods for the QT interval

Desai, M., Li, L., Desta, Z., Malik, M. & Flockhart, D., Jun 1 2003, In : British Journal of Clinical Pharmacology. 55, 6, p. 511-517 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

Variable aromatase inhibitor plasma concentrations do not correlate with circulating estrogen concentrations in post-menopausal breast cancer patients

Hertz, D. L., Speth, K. A., Kidwell, K. M., Gersch, C. L., Desta, Z., Storniolo, A. M., Stearns, V., Skaar, T. C., Hayes, D. F., Henry, N. L. & Rae, J. M., Oct 1 2017, In : Breast Cancer Research and Treatment. 165, 3, p. 659-668 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Variants in the CYP2B6 3′UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs

Burgess, K. S., Ipe, J., Swart, M., Metzger, I. F., Lu, J., Gufford, B. T., Thong, N., Desta, Z., Gaedigk, R., Pearce, R. E., Gaedigk, A., Liu, Y. & Skaar, T. C., Jul 2018, In : Clinical Pharmacology and Therapeutics. 104, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Variation in anastrozole metabolism and pharmacodynamics in women with early breast cancer

Ingle, J. N., Buzdar, A. U., Schaid, D. J., Goetz, M. P., Batzler, A., Robson, M. E., Northfelt, D. W., Olson, J. E., Perez, E. A., Desta, Z., Weintraub, R. A., Williard, C. V., Flockhart, D. A. & Weinshilboum, R. M., Apr 15 2010, In : Cancer Research. 70, 8, p. 3278-3286 9 p.

Research output: Contribution to journalArticle

56 Scopus citations