Zeruesenay Desta

  • 9773 Citations
  • 44 h-Index
1976 …2019

Research output per year

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Publications

2013

Erratum: Compartment-specific gene regulation of the car inducer efavirenz in vivo (Clinical Pharmacology and Therapeutics (2012) 92 (103-111) DOI: 10.1038/clpt.2012.34)

Meyer Zu Schwabedissen, H. E., Oswald, S., Bresser, C., Nassif, A., Modess, C., Desta, Z., Ogburn, E. T., Marinova, M., Lütjohann, D., Spielhagen, C., Nauck, M., Kroemer, H. K. & Siegmund, W., Jan 1 2013, In : Clinical Pharmacology and Therapeutics. 93, 1, 1 p.

Research output: Contribution to journalComment/debate

Genetic associations with toxicity-related discontinuation of aromatase inhibitor therapy for breast cancer

Henry, N. L., Skaar, T. C., Dantzer, J., Li, L., Kidwell, K., Gersch, C., Nguyen, A. T., Rae, J. M., Desta, Z., Oesterreich, S., Philips, S., Carpenter, J. S., Storniolo, A. M., Stearns, V., Hayes, D. F. & Flockhart, D. A., Apr 1 2013, In : Breast Cancer Research and Treatment. 138, 3, p. 807-816 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Genome-wide discovery of genetic variants affecting tamoxifen sensitivity and their clinical and functional validation

Weng, L., Ziliak, D., Im, H. K., Gamazon, E. R., Philips, S., Nguyen, A. T., Desta, Z., Skaar, T. C., Flockhart, D. A. & Huang, R. S., Jul 1 2013, In : Annals of Oncology. 24, 7, p. 1867-1873 7 p., mdt125.

Research output: Contribution to journalArticle

6 Scopus citations

Histoplasma capsulatum preferentially induces IDO in the lung

Hage, C. A., Horan, D. J., Durkin, M., Connolly, P., Desta, Z., Skaar, T. C., Knox, K. S. & Wheat, L. J., Apr 2013, In : Medical Mycology. 51, 3, p. 270-279 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Inhibition of platelet aggregation by prostaglandin E1 (PGE1) in diabetic patients during therapy with clopidogrel and aspirin

Kreutz, R. P., Nystrom, P., Kreutz, Y., Miao, J., Kovacs, R., Desta, Z., Flockhart, D. A. & Jin, Y., Feb 11 2013, In : Platelets. 24, 2, p. 145-150 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
33 Scopus citations

Is (+)-[13C]-pantoprazole better than (±)-[ 13C]-pantoprazole for the breath test to evaluate CYP2C19 enzyme activity?

Thacker, D. L., Modak, A., Flockhart, D. A. & Desta, Z., Mar 1 2013, In : Journal of Breath Research. 7, 1, 016001.

Research output: Contribution to journalArticle

7 Scopus citations

Pentoxifylline, Inflammation, and Endothelial Function in HIV-Infected Persons: A Randomized, Placebo-Controlled Trial

Gupta, S. K., Mi, D., Dubé, M. P., Saha, C. K., Johnson, R. M., Stein, J. H., Clauss, M. A., Mather, K. J., Desta, Z. & Liu, Z., Apr 9 2013, In : PloS one. 8, 4, e60852.

Research output: Contribution to journalArticle

14 Scopus citations

Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: Genome-wide associations and functional genomics

Ji, Y., Biernacka, J. M., Hebbring, S., Chai, Y., Jenkins, G. D., Batzler, A., Snyder, K. A., Drews, M. S., Desta, Z., Flockhart, D., Mushiroda, T., Kubo, M., Nakamura, Y., Kamatani, N., Schaid, D., Weinshilboum, R. M. & Mrazek, D. A., Oct 1 2013, In : Pharmacogenomics Journal. 13, 5, p. 456-463 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

PharmGKB summary: Tamoxifen pathway, pharmacokinetics

Klein, D. J., Thorn, C. F., Desta, Z., Flockhart, D. A., Altman, R. B. & Klein, T. E., Nov 1 2013, In : Pharmacogenetics and Genomics. 23, 11, p. 643-647 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

Regulation of microRNA expression by rifampin in human hepatocytes

Ramamoorthy, A., Liu, Y., Philips, S., Desta, Z., Lin, H., Goswami, C., Gaedigk, A., Li, L., Flockhart, D. A. & Skaar, T. C., Oct 1 2013, In : Drug Metabolism and Disposition. 41, 10, p. 1763-1768 6 p.

Research output: Contribution to journalArticle

26 Scopus citations
2012

Comparison of changes in the lipid profile of postmenopausal women with early stage breast cancer treated with exemestane or letrozole

Bell, L. N., Nguyen, A. T. P., Li, L., Desta, Z., Henry, N. L., Hayes, D. F., Wolff, A. C., Stearns, V., Storniolo, A. M. & Flockhart, D. A., Dec 1 2012, In : Journal of clinical pharmacology. 52, 12, p. 1852-1860 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Compartment-specific gene regulation of the CAR inducer efavirenz in vivo

Meyer Zu Schwabedissen, H. E., Oswald, S., Bresser, C., Nassif, A., Modess, C., Desta, Z., Ogburn, E. T., Marinova, M., Lütjohann, D., Spielhagen, C., Nauck, M., Kroemer, H. K. & Siegmund, W., Jul 2012, In : Clinical Pharmacology and Therapeutics. 92, 1, p. 103-111 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
40 Scopus citations

Impact of efavirenz on intestinal metabolism and transport: Insights from an interaction study with ezetimibe in healthy volunteers

Oswald, S., Meyer Zu Schwabedissen, H. E., Nassif, A., Modess, C., Desta, Z., Ogburn, E. T., Mostertz, J., Keiser, M., Jia, J., Hubeny, A., Ulrich, A., Runge, D., Marinova, M., Lütjohann, D., Kroemer, H. K. & Siegmund, W., Mar 1 2012, In : Clinical Pharmacology and Therapeutics. 91, 3, p. 506-513 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Induction of CYP2C19 and CYP3A activity following repeated administration of efavirenz in healthy volunteers

Michaud, V., Ogburn, E., Thong, N., Aregbe, A. O., Quigg, T. C., Flockhart, D. A. & Desta, Z., Mar 1 2012, In : Clinical Pharmacology and Therapeutics. 91, 3, p. 475-482 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response

Kreutz, R. P., Nystrom, P., Kreutz, Y., Miao, J., Desta, Z., Breall, J. A., Li, L., Chiang, C. W., Kovacs, R., Flockhart, D. A. & Jin, Y., Mar 7 2012, In : Clinical Pharmacology: Advances and Applications. 4, 1, p. 13-20 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Predictors of aromatase inhibitor discontinuation as a result of treatment-emergent symptoms in early-stage breast cancer

Henry, N. L., Azzouz, F., Desta, Z., Li, L., Nguyen, A. T., Lemler, S., Hayden, J., Tarpinian, K., Yakim, E., Flockhart, D. A., Stearns, V., Hayes, D. F. & Storniolo, A. M., Mar 20 2012, In : Journal of Clinical Oncology. 30, 9, p. 936-942 7 p.

Research output: Contribution to journalArticle

185 Scopus citations

Stereoselective and regiospecific hydroxylation of ketamine and norketamine

Desta, Z., Moaddel, R., Ogburn, E. T., Xu, C., Ramamoorthy, A., Venkata, S. L. V., Sanghvi, M., Goldberg, M. E., Torjman, M. C. & Wainer, I. W., Nov 1 2012, In : Xenobiotica. 42, 11, p. 1076-1087 12 p.

Research output: Contribution to journalArticle

52 Scopus citations

Tamoxifen metabolites as active inhibitors of aromatase in the treatment of breast cancer

Lu, W. J., Desta, Z. & Flockhart, D. A., Jan 1 2012, In : Breast Cancer Research and Treatment. 131, 2, p. 473-481 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

The dual role of pharmacogenetics in HIV treatment: Mutations and polymorphisms regulating antiretroviral drug resistance and disposition

Michaud, V., Bar-Magen, T., Turgeon, J., Flockhart, D., Desta, Z. & Wainberg, M. A., Jul 2012, In : Pharmacological Reviews. 64, 3, p. 803-833 31 p.

Research output: Contribution to journalArticle

66 Scopus citations
2011

Abacavir, didanosine and tenofovir do not induce inflammatory, apoptotic or oxidative stress genes in coronary endothelial cells

Kim, C., Gupta, S. K., Green, L., Taylor, B. M., Deuter-Reinhard, M., Desta, Z. & Clauss, M., Dec 19 2011, In : Antiviral Therapy. 16, 8, p. 1335-1339 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Contribution of N-glucuronidation to efavirenz elimination in vivo in the basal and rifampin-induced metabolism of efavirenz

Cho, D. Y., Ogburn, E. T., Jones, D. & Desta, Z., Apr 1 2011, In : Antimicrobial Agents and Chemotherapy. 55, 4, p. 1504-1509 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Genotype-guided tamoxifen dosing increases active metabolite exposure in women with reduced CYP2D6 metabolism: A multicenter study

Irvin, W. J., Walko, C. M., Weck, K. E., Ibrahim, J. G., Chiu, W. K., Dees, E. C., Moore, S. G., Olajide, O. A., Graham, M. L., Canale, S. T., Raab, R. E., Corso, S. W., Peppercorn, J. M., Anderson, S. M., Friedman, K. J., Ogburn, E. T., Desta, Z., Flockhart, D. A., McLeod, H. L., Evans, J. P. & 1 others, Carey, L. A., Aug 20 2011, In : Journal of Clinical Oncology. 29, 24, p. 3232-3239 8 p.

Research output: Contribution to journalArticle

145 Scopus citations

In vitro cytochrome P450-mediated metabolism of exemestane

Kamdem, L. K., Flockhart, D. A. & Desta, Z., Jan 1 2011, In : Drug Metabolism and Disposition. 39, 1, p. 98-105 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

Plasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age

Desta, Z., Kreutz, Y., Nguyen, A. T., Li, L., Skaar, T., Kamdem, L. K., Henry, N. L., Hayes, D. F., Storniolo, A. M., Stearns, V., Hoffmann, E., Tyndale, R. F. & Flockhart, D. A., Nov 1 2011, In : Clinical Pharmacology and Therapeutics. 90, 5, p. 693-700 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Rapid and simultaneous determination of efavirenz, 8-hydroxyefavirenz, and 8,14-dihydroxyefavirenz using LC-MS-MS in human plasma and application to pharmacokinetics in healthy volunteers

Kim, K. B., Kim, H., Jiang, F., Yeo, C. W., Bae, S. K., Desta, Z., Shin, J. G. & Liu, K. H., Feb 1 2011, In : Chromatographia. 73, 3-4, p. 263-271 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Stereoselective pharmacokinetics of stable isotope (+/-)-[ 13C]-pantoprazole: Implications for a rapid screening phenotype test of CYP2C19 activity

Thacker, D. L., Modak, A., Nguyen, P. D., Flockhart, D. A. & Desta, Z., Nov 1 2011, In : Chirality. 23, 10, p. 904-909 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Tamoxifen and its metabolites cause acute vasorelaxation of aortic rings by inducing vasodilator prostanoid synthesis

Montenegro, M. F., Ceron, C. S., Salgado, M. C. O., Desta, Z., Flockhart, D. A. & Tanus-Santos, J. E., Dec 1 2011, In : Journal of cardiovascular pharmacology. 58, 6, p. 647-653 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
2010

Anti-inflammatory treatment with pentoxifylline improves HIV-related endothelial dysfunction: A pilot study

Gupta, S. K., Johnson, R. M., Mather, K. J., Clauss, M., Rehman, J., Saha, C., Desta, Z. & Dubé, M. P., Jun 1 2010, In : AIDS. 24, 9, p. 1377-1380 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

A penalized mixture model approach in genotype/phenotype association analysis for quantitative phenotypes

Li, L., Borges, S., Jason, R. D., Shen, C., Desta, Z. & Flockhart, D., Jun 4 2010, In : Cancer Informatics. 9, p. 93-103 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients.

Borges, S., Desta, Z., Jin, Y., Faouzi, A., Robarge, J. D., Philips, S., Nguyen, A., Stearns, V., Hayes, D., Rae, J. M., Skaar, T. C., Flockhart, D. A. & Li, L., Apr 2010, In : Journal of clinical pharmacology. 50, 4, p. 450-458 9 p.

Research output: Contribution to journalArticle

86 Scopus citations

Efavirenz directly modulates the oestrogen receptor and induces breast cancer cell growth

Sikora, M. J., Rae, J. M., Johnson, M. D. & Desta, Z., Oct 1 2010, In : HIV Medicine. 11, 9, p. 603-607 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Efavirenz primary and secondary metabolism in vitro and in vivo: Identification of novel metabolic pathways and cytochrome P450 2A6 as the principal catalyst of efavirenz 7-hydroxylation

Ogburn, E. T., Jones, D. R., Masters, A. R., Xu, C., Guo, Y. & Desta, Z., Jul 2010, In : Drug Metabolism and Disposition. 38, 7, p. 1218-1229 12 p.

Research output: Contribution to journalArticle

110 Scopus citations

Erratum: Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients (Journal of Clinical Pharmacology (2010) 50: 4 (450-458) DOI: 10.1177/0091270009359182)

Borges, S., Desta, Z., Jin, Y., Faouzi, A., Robarge, J. D., Philip, S., Nguyen, A., Stearns, V., Hayes, D., Rae, J. M., Skaar, T. C., Flockhart, D. A. & Li, L., Jun 1 2010, In : Journal of Clinical Pharmacology. 50, 6, 1 p.

Research output: Contribution to journalComment/debate

Estrogen receptor genotypes, menopausal status, and the effects of tamoxifen on lipid levels: Revised and updated results

Hayes, D. F., Skaar, T. C., Rae, J. M., Henry, N. L., Nguyen, A. T., Stearns, V., Li, L., Philips, S., Desta, Z. & Flockhart, D. A., Nov 1 2010, In : Clinical Pharmacology and Therapeutics. 88, 5, p. 626-629 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Impact of proton pump inhibitors on the effectiveness of clopidogrel after coronary stent placement: The clopidogrel Medco outcomes study

Kreutz, R. P., Stanek, E. J., Aubert, R., Yao, J., Breall, J. A., Desta, Z., Skaar, T. C., Teagarden, J. R., Frueh, F. W., Epstein, R. S. & Flockhart, D. A., Aug 1 2010, In : Pharmacotherapy. 30, 8, p. 787-796 10 p.

Research output: Contribution to journalArticle

111 Scopus citations

In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole

Kamdem, L. K., Liu, Y., Stearns, V., Kadlubar, S. A., Ramirez, J., Jeter, S., Shahverdi, K., Ward, B. A., Ogburn, E., Ratain, M. J., Flockhart, D. A. & Desta, Z., Dec 1 2010, In : British Journal of Clinical Pharmacology. 70, 6, p. 854-869 16 p.

Research output: Contribution to journalArticle

54 Scopus citations

Methadone: A substrate and mechanism-based inhibitor of CYP19 (aromatase)

Lu, W. J., Bies, R., Kamden, L. K., Desta, Z. & Flockhart, D. A., Aug 1 2010, In : Drug Metabolism and Disposition. 38, 8, p. 1308-1313 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients

Kiyotani, K., Mushiroda, T., Imamura, C. K., Hosono, N., Tsunoda, T., Kubo, M., Tanigawara, Y., Flockhart, D. A., Desta, Z., Skaar, T. C., Aki, F., Hirata, K., Takatsuka, Y., Okazaki, M., Ohsumi, S., Yamakawa, T., Sasa, M., Nakamura, Y. & Zembutsu, H., Mar 10 2010, In : Journal of Clinical Oncology. 28, 8, p. 1287-1293 7 p.

Research output: Contribution to journalArticle

176 Scopus citations

Variation in anastrozole metabolism and pharmacodynamics in women with early breast cancer

Ingle, J. N., Buzdar, A. U., Schaid, D. J., Goetz, M. P., Batzler, A., Robson, M. E., Northfelt, D. W., Olson, J. E., Perez, E. A., Desta, Z., Weintraub, R. A., Williard, C. V., Flockhart, D. A. & Weinshilboum, R. M., Apr 15 2010, In : Cancer Research. 70, 8, p. 3278-3286 9 p.

Research output: Contribution to journalArticle

55 Scopus citations
2009

Antiestrogen pathway (aromatase inhibitor)

Desta, Z., Nguyen, A., Flockhart, D., Skaar, T., Fletcher, R., Weinshilboum, R., Berlin, D. S., Klein, T. E. & Altman, R. B., Jul 1 2009, In : Pharmacogenetics and Genomics. 19, 7, p. 554-555 2 p.

Research output: Contribution to journalShort survey

6 Scopus citations

Assessment of vascular effects of tamoxifen and its metabolites on the rat perfused hindquarter vascular bed

Montenegro, M. F., Pessa, L. R., Gomes, V. A., Desta, Z., Flockhart, D. A. & Tanus-Santos, J. E., May 1 2009, In : Basic and Clinical Pharmacology and Toxicology. 104, 5, p. 400-407 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort

Lynn Henry, N., Rae, J. M., Li, L., Azzouz, F., Skaar, T. C., Desta, Z., Sikora, M. J., Philips, S., Nguyen, A. T., Storniolo, A. M., Hayes, D. F., Flockhart, D. A. & Stearns, V., Jan 21 2009, In : Breast Cancer Research and Treatment. 117, 3, p. 571-575 5 p.

Research output: Contribution to journalArticle

59 Scopus citations
81 Scopus citations

Cytochrome P450 2D6 activity predicts discontinuation of tamoxifen therapy in breast cancer patients

Rae, J. M., Sikora, M. J., Henry, N. L., Li, L., Kim, S., Oesterreich, S., Skaar, T. C., Nguyen, A. T., Desta, Z., Storniolo, A. M., Flockhart, D. A., Hayes, D. F. & Stearns, V., May 7 2009, In : Pharmacogenomics Journal. 9, 4, p. 258-264 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

Evaluating the role of serotonin in hot flashes after breast cancer using acute tryptophan depletion

Carpenter, J. S., Yu, M., Wu, J., Von Ah, D., Milata, J., Otte, J. L., Johns, S., Schneider, B., Storniolo, A. M., Salomon, R., Desta, Z., Cao, D., Jin, Y., Philips, S. & Skaar, T. C., Jul 1 2009, In : Menopause. 16, 4, p. 644-652 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Identification of genetic variants in the human indoleamine 2,3-dioxygenase (IDO1) gene, which have altered enzyme activity

Arefayene, M., Philips, S., Cao, D., Mamidipalli, S., Desta, Z., Flockhart, D. A., Wilkes, D. S. & Skaar, T. C., Jun 1 2009, In : Pharmacogenetics and Genomics. 19, 6, p. 464-476 13 p.

Research output: Contribution to journalArticle

28 Scopus citations
29 Scopus citations

Pharmacogenetics of Drug Metabolism

Flockhart, D. A. & Desta, Z., Dec 1 2009, Clinical and Translational Science. Elsevier Inc., p. 301-317 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations