Zeruesenay Desta

  • 9811 Citations
  • 44 h-Index
1976 …2020

Research output per year

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Publications

Article

Effects of isoniazid on hepatic drug oxidation and N-acetylation capacities in rats

Desta, Z., Siegmund, W., Franke, G., Beyrich, A. & Bleyer, H., Jan 1 1992, In : Pharmazie. 47, 6, p. 448-451 4 p.

Research output: Contribution to journalArticle

Effects of SLCO1B1 polymorphisms on plasma estrogen concentrations in women with breast cancer receiving aromatase inhibitors exemestane and letrozole

Dempsey, J. M., Kidwell, K. M., Gersch, C. L., Pesch, A. M., Desta, Z., Storniolo, A. M., Stearns, V., Skaar, T. C., Hayes, D. F., Henry, N. L., Rae, J. M. & Hertz, D. L., Jan 1 2019, In : Pharmacogenomics. 20, 8, p. 571-580 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Endothelial nitric oxide synthase gene haplotypes associated with circulating concentrations of nitric oxide products in healthy men

Metzger, I. F., Souza-Costa, D. C., Marroni, A. S., Nagassaki, S., Desta, Z., Flockhart, D. A. & Tanus-Santos, J. E., Aug 2005, In : Pharmacogenetics and Genomics. 15, 8, p. 565-570 6 p.

Research output: Contribution to journalArticle

92 Scopus citations

Endothelial nitric oxide synthase haplotypes are related to blood pressure elevation, but not to resistance to antihypertensive drug therapy

Sandrim, V. C., Yugar-Toledo, J. C., Desta, Z., Flockhart, D. A., Moreno, H. & Tanus-Santos, J. E., Dec 2006, In : Journal of Hypertension. 24, 12, p. 2393-2397 5 p.

Research output: Contribution to journalArticle

48 Scopus citations

Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells

Young, C. L., Li, L., Desta, Z., Zhao, Q., Rae, J. M., Flockhart, D. A. & Skaar, T. C., Jul 20 2006, In : Journal of Pharmacology and Experimental Therapeutics. 318, 2, p. 503-512 10 p.

Research output: Contribution to journalArticle

121 Scopus citations
221 Scopus citations

Estimating a positive false discovery rate for variable selection in pharmacogenetic studies

Li, L., Hui, S., Pennello, G., Desta, Z., Todd, S., Nguyen, A. & Flockhart, D., Sep 1 2007, In : Journal of biopharmaceutical statistics. 17, 5, p. 883-902 20 p.

Research output: Contribution to journalArticle

1 Scopus citations

Estrogen receptor genotypes, menopausal status, and the effects of tamoxifen on lipid levels: Revised and updated results

Hayes, D. F., Skaar, T. C., Rae, J. M., Henry, N. L., Nguyen, A. T., Stearns, V., Li, L., Philips, S., Desta, Z. & Flockhart, D. A., Nov 1 2010, In : Clinical Pharmacology and Therapeutics. 88, 5, p. 626-629 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Estrogen receptor genotypes, menopausal status, and the lipid effects of tamoxifen

Ntukidem, N. I., Nguyen, A. T., Stearns, V., Rehman, M., Schott, A., Skaar, T., Jin, Y., Blanche, P., Li, L., Lemler, S., Hayden, J., Krauss, R. M., Desta, Z., Flockhart, D. A. & Hayes, D. F., May 30 2008, In : Clinical Pharmacology and Therapeutics. 83, 5, p. 702-710 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Estrogens and their precursors in postmenopausal women with early breast cancer receiving anastrozole

Ingle, J. N., Kalari, K. R., Buzdar, A. U., Robson, M. E., Goetz, M. P., Desta, Z., Barman, P., Dudenkov, T. T., Northfelt, D. W., Perez, E. A., Flockhart, D. A., Williard, C. V., Wang, L. & Weinshilboum, R. M., May 26 2015, In : Steroids. 99, Part A, p. 32-38 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Evaluating the role of serotonin in hot flashes after breast cancer using acute tryptophan depletion

Carpenter, J. S., Yu, M., Wu, J., Von Ah, D., Milata, J., Otte, J. L., Johns, S., Schneider, B., Storniolo, A. M., Salomon, R., Desta, Z., Cao, D., Jin, Y., Philips, S. & Skaar, T. C., Jul 1 2009, In : Menopause. 16, 4, p. 644-652 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Factor XIII Val34Leu polymorphism and recurrent myocardial infarction in patients with coronary artery disease

Kreutz, R. P., Bitar, A., Owens, J., Desta, Z., Breall, J. A., Von Der Lohe, E., Sinha, A., Vatta, M., Nystrom, P., Jin, Y. & Flockhart, D. A., Oct 2014, In : Journal of Thrombosis and Thrombolysis. 38, 3, p. 380-387 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Genetic associations with toxicity-related discontinuation of aromatase inhibitor therapy for breast cancer

Henry, N. L., Skaar, T. C., Dantzer, J., Li, L., Kidwell, K., Gersch, C., Nguyen, A. T., Rae, J. M., Desta, Z., Oesterreich, S., Philips, S., Carpenter, J. S., Storniolo, A. M., Stearns, V., Hayes, D. F. & Flockhart, D. A., Apr 1 2013, In : Breast Cancer Research and Treatment. 138, 3, p. 807-816 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Genome-Wide Discovery of Drug-Dependent Human Liver Regulatory Elements

Smith, R. P., Eckalbar, W. L., Morrissey, K. M., Luizon, M. R., Hoffmann, T. J., Sun, X., Jones, S. L., Force Aldred, S., Ramamoorthy, A., Desta, Z., Liu, Y., Skaar, T. C., Trinklein, N. D., Giacomini, K. M. & Ahituv, N., Oct 1 2014, In : PLoS Genetics. 10, 10

Research output: Contribution to journalArticle

19 Scopus citations

Genome-wide discovery of genetic variants affecting tamoxifen sensitivity and their clinical and functional validation

Weng, L., Ziliak, D., Im, H. K., Gamazon, E. R., Philips, S., Nguyen, A. T., Desta, Z., Skaar, T. C., Flockhart, D. A. & Huang, R. S., Jul 1 2013, In : Annals of Oncology. 24, 7, p. 1867-1873 7 p., mdt125.

Research output: Contribution to journalArticle

6 Scopus citations

Genotype-guided tamoxifen dosing increases active metabolite exposure in women with reduced CYP2D6 metabolism: A multicenter study

Irvin, W. J., Walko, C. M., Weck, K. E., Ibrahim, J. G., Chiu, W. K., Dees, E. C., Moore, S. G., Olajide, O. A., Graham, M. L., Canale, S. T., Raab, R. E., Corso, S. W., Peppercorn, J. M., Anderson, S. M., Friedman, K. J., Ogburn, E. T., Desta, Z., Flockhart, D. A., McLeod, H. L., Evans, J. P. & 1 others, Carey, L. A., Aug 20 2011, In : Journal of Clinical Oncology. 29, 24, p. 3232-3239 8 p.

Research output: Contribution to journalArticle

146 Scopus citations

Histoplasma capsulatum preferentially induces IDO in the lung

Hage, C. A., Horan, D. J., Durkin, M., Connolly, P., Desta, Z., Skaar, T. C., Knox, K. S. & Wheat, L. J., Apr 2013, In : Medical Mycology. 51, 3, p. 270-279 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Human N-demethylation of (S)-mephenytoin by cytochrome P450S 2C9 and 2B6

Ko, J. W., Desta, Z. & Flockhart, D. A., Aug 1 1998, In : Drug Metabolism and Disposition. 26, 8, p. 775-778 4 p.

Research output: Contribution to journalArticle

60 Scopus citations

Identification and characterization of human cytchrome P450 (CYP) isoforms interacting with cisapride

Desta, Z., Thacker, D., Soukhova, N., Shin, J. G. & Flockhart, D. A., Jan 1 1999, In : Clinical Pharmacology and Therapeutics. 65, 2, 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

Identification and characterization of human cytochrome P450 isoforms interacting with pimozide

Desta, Z., Kerbusch, T., Soukhova, N., Richard, E., Ko, J. W. & Flockhart, D. A., Jan 1 1998, In : Journal of Pharmacology and Experimental Therapeutics. 285, 2, p. 428-437 10 p.

Research output: Contribution to journalArticle

66 Scopus citations

Identification and Mechanistic Investigation of Drug-Drug Interactions Associated with Myopathy: A Translational Approach

Han, X., Quinney, S. K., Wang, Z., Zhang, P., Duke, J., Desta, Z., Elmendorf, J. S., Flockhart, D. A. & Li, L., Sep 1 2015, In : Clinical Pharmacology and Therapeutics. 98, 3, p. 321-327 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Identification of genetic variants in the human indoleamine 2,3-dioxygenase (IDO1) gene, which have altered enzyme activity

Arefayene, M., Philips, S., Cao, D., Mamidipalli, S., Desta, Z., Flockhart, D. A., Wilkes, D. S. & Skaar, T. C., Jun 1 2009, In : Pharmacogenetics and Genomics. 19, 6, p. 464-476 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro

Destra, Z., Saussele, T., Ward, B., Blievernicht, J., Li, L., Klein, K., Flockhart, D. A. & Zanger, U. M., Jun 1 2007, In : Pharmacogenomics. 8, 6, p. 547-558 12 p.

Research output: Contribution to journalArticle

153 Scopus citations

Impact of efavirenz on intestinal metabolism and transport: Insights from an interaction study with ezetimibe in healthy volunteers

Oswald, S., Meyer Zu Schwabedissen, H. E., Nassif, A., Modess, C., Desta, Z., Ogburn, E. T., Mostertz, J., Keiser, M., Jia, J., Hubeny, A., Ulrich, A., Runge, D., Marinova, M., Lütjohann, D., Kroemer, H. K. & Siegmund, W., Mar 1 2012, In : Clinical Pharmacology and Therapeutics. 91, 3, p. 506-513 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Impact of proton pump inhibitors on the effectiveness of clopidogrel after coronary stent placement: The clopidogrel Medco outcomes study

Kreutz, R. P., Stanek, E. J., Aubert, R., Yao, J., Breall, J. A., Desta, Z., Skaar, T. C., Teagarden, J. R., Frueh, F. W., Epstein, R. S. & Flockhart, D. A., Aug 1 2010, In : Pharmacotherapy. 30, 8, p. 787-796 10 p.

Research output: Contribution to journalArticle

111 Scopus citations

Induction of CYP2C19 and CYP3A activity following repeated administration of efavirenz in healthy volunteers

Michaud, V., Ogburn, E., Thong, N., Aregbe, A. O., Quigg, T. C., Flockhart, D. A. & Desta, Z., Mar 1 2012, In : Clinical Pharmacology and Therapeutics. 91, 3, p. 475-482 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response

Kreutz, R. P., Nystrom, P., Kreutz, Y., Miao, J., Desta, Z., Breall, J. A., Li, L., Chiang, C. W., Kovacs, R., Flockhart, D. A. & Jin, Y., Mar 7 2012, In : Clinical Pharmacology: Advances and Applications. 4, 1, p. 13-20 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Influence of uridine diphosphate glucuronosyltransferase family 1 member A1 and solute carrier organic anion transporter family 1 member B1 polymorphisms and efavirenz on bilirubin disposition in healthy volunteers

Collins, K. S., Metzger, I. F., Gufford, B. T., Lu, J. B., Medeiros, E. B., Pratt, V. M., Skaar, T. C. & Desta, Z., Mar 2020, In : Drug Metabolism and Disposition. 48, 3, p. 169-175 7 p.

Research output: Contribution to journalArticle

Inhibition of cytochrome P450 (CYP450) isoforms by isoniazid: Potent inhibition of CYP2C19 and CYP3A

Desta, Z., Soukhova, N. V. & Flockhart, D. A., Feb 8 2001, In : Antimicrobial Agents and Chemotherapy. 45, 2, p. 382-392 11 p.

Research output: Contribution to journalArticle

133 Scopus citations

Inhibition of cytochrome P450 2B6 activity by voriconazole profiled using efavirenz disposition in healthy volunteers

Desta, Z., Metzger, I. F., Thong, N., Lu, J. B. L., Callaghan, J. T., Skaar, T. C., Flockhart, D. A. & Galinsky, R. E., Nov 2016, In : Antimicrobial Agents and Chemotherapy. 60, 11, p. 6813-6822 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
29 Scopus citations

Inhibition of platelet aggregation by prostaglandin E1 (PGE1) in diabetic patients during therapy with clopidogrel and aspirin

Kreutz, R. P., Nystrom, P., Kreutz, Y., Miao, J., Kovacs, R., Desta, Z., Flockhart, D. A. & Jin, Y., Feb 11 2013, In : Platelets. 24, 2, p. 145-150 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Inhibitory Effects of Probenecid on Pharmacokinetics of Tenofovir Disoproxil Fumarate and Emtricitabine for On-Demand HIV Preexposure Prophylaxis

Liu, S. N., Gufford, B. T., Lu, J. B. L., Bushman, L. R., Anderson, P. L., Bergstrom, R. F., Desta, Z. & Gupta, S. K., May 1 2020, In : Clinical Pharmacology and Therapeutics. 107, 5, p. 1200-1208 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Interaction of cisapride with the human cytochrome P450 system: Metabolism and inhibition studies

Desta, Z., Soukhova, N., Mahal, S. K. & Flockhart, D. A., Aug 2 2000, In : Drug Metabolism and Disposition. 28, 7, p. 789-800 12 p.

Research output: Contribution to journalArticle

44 Scopus citations
33 Scopus citations

In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole

Kamdem, L. K., Liu, Y., Stearns, V., Kadlubar, S. A., Ramirez, J., Jeter, S., Shahverdi, K., Ward, B. A., Ogburn, E., Ratain, M. J., Flockhart, D. A. & Desta, Z., Dec 1 2010, In : British Journal of Clinical Pharmacology. 70, 6, p. 854-869 16 p.

Research output: Contribution to journalArticle

55 Scopus citations

In vitro cytochrome P450-mediated metabolism of exemestane

Kamdem, L. K., Flockhart, D. A. & Desta, Z., Jan 1 2011, In : Drug Metabolism and Disposition. 39, 1, p. 98-105 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

In vitro inhibition of pimozide N-dealkylation by selective serotonin reuptake inhibitors (SSRIS) antidepressants and azithromycin

Desta, Z., Soukhova, N. V. & Flockhart, D. A., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P9

Research output: Contribution to journalArticle

In vitro inhibition of pimozide N-dealkylation by selective serotonin reuptake inhibitors and azithromycin

Desta, Z., Soukhova, N. & Flockhart, D. A., Apr 18 2002, In : Journal of Clinical Psychopharmacology. 22, 2, p. 162-168 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: Potent effect on CYP2C19 and CYP2D6

Ko, J. W., Desta, Z., Soukhova, N. V., Tracy, T. & Flockhart, D. A., Apr 20 2000, In : British Journal of Clinical Pharmacology. 49, 4, p. 343-351 9 p.

Research output: Contribution to journalArticle

92 Scopus citations

In vitro metabolism of montelukast by cytochrome P450S and UDP-glucuronosyltransferases

De Oliveira Cardoso, J., Oliveira, R. V., Lu, J. B. L. & Desta, Z., Dec 1 2015, In : Drug Metabolism and Disposition. 43, 12, p. 1905-1916 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

In vivo assessment of the metabolic activity of CYP2D6 diplotypes and alleles

Hertz, D. L., Snavely, A. C., McLeod, H. L., Walko, C. M., Ibrahim, J. G., Anderson, S., Weck, K. E., Magrinat, G., Olajide, O., Moore, S., Raab, R., Carrizosa, D. R., Corso, S., Schwartz, G., Peppercorn, J. M., Evans, J. P., Jones, D. R., Desta, Z., Flockhart, D. A., Carey, L. A. & 1 others, Irvin, W. J., Nov 1 2015, In : British Journal of Clinical Pharmacology. 80, 5, p. 1122-1130 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Is (+)-[13C]-pantoprazole better than (±)-[ 13C]-pantoprazole for the breath test to evaluate CYP2C19 enzyme activity?

Thacker, D. L., Modak, A., Flockhart, D. A. & Desta, Z., Mar 1 2013, In : Journal of Breath Research. 7, 1, 016001.

Research output: Contribution to journalArticle

7 Scopus citations

Mechanism-based inactivation of CYP2C19 and CYP2D6 by tamoxifen (TAM) and its metabolite n-desmethyltamoxifen (NDTAM)

Desta, Z., Park, J., Soukhova, N. & Flockhart, D. A., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P9

Research output: Contribution to journalArticle

1 Scopus citations

Mechanistic assessment of extrahepatic contributions to glucuronidation of integrase strand transfer inhibitors

Liu, S. N., Lu, J. B. L., Watson, C. J. W., Lazarus, P., Desta, Z. & Gufford, B. T., May 2019, In : Drug Metabolism and Disposition. 47, 5, p. 535-544 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Methadone: A substrate and mechanism-based inhibitor of CYP19 (aromatase)

Lu, W. J., Bies, R., Kamden, L. K., Desta, Z. & Flockhart, D. A., Aug 1 2010, In : Drug Metabolism and Disposition. 38, 8, p. 1308-1313 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Patient-reported outcomes and early discontinuation in aromatase inhibitor-treated postmenopausal women with early stage breast cancer

Kadakia, K. C., Snyder, C. F., Kidwell, K. M., Seewald, N. J., Flockhart, D. A., Skaar, T. C., Desta, Z., Rae, J. M., Otte, J. L., Carpenter, J. S., Storniolo, A. M., Hayes, D. F., Stearns, V. & Lynn Henry, N., Mar 23 2016, In : Oncologist. 21, 5, p. 539-546 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Pentoxifylline, Inflammation, and Endothelial Function in HIV-Infected Persons: A Randomized, Placebo-Controlled Trial

Gupta, S. K., Mi, D., Dubé, M. P., Saha, C. K., Johnson, R. M., Stein, J. H., Clauss, M. A., Mather, K. J., Desta, Z. & Liu, Z., Apr 9 2013, In : PloS one. 8, 4, e60852.

Research output: Contribution to journalArticle

14 Scopus citations

Pharmacodynamic interactions between isoniazid and theophylline in mice and rats, and the influence of pyridoxine

Desta, Z. & Steingruber, M., Jan 1 1992, In : Pharmazie. 47, 7, p. 525-528 4 p.

Research output: Contribution to journalArticle

2 Scopus citations