Zeruesenay Desta

  • 9773 Citations
  • 44 h-Index
1976 …2019

Research output per year

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Publications

2009

Rapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [ 13C]pantoprazole breath test

Desta, Z., Modak, A., Nguyen, P. D., Lemler, S. M., Kurogi, Y., Li, L. & Flockhart, D. A., Apr 1 2009, In : Journal of Pharmacology and Experimental Therapeutics. 329, 1, p. 297-305 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
2008

A mixture model approach in gene-gene and gene-environmental interactions for binary phenotypes

Li, L., Yu, M., Jason, R. D., Shen, C., Azzouz, F., McLeod, H. L., Borges-Gonzales, S., Nguyen, A., Skaar, T., Desta, Z., Sweeney, C. J. & Flockhart, D. A., Nov 1 2008, In : Journal of biopharmaceutical statistics. 18, 6, p. 1150-1177 28 p.

Research output: Contribution to journalArticle

3 Scopus citations

Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: Combining inherited and tumor gene markers for prediction of tamoxifen resistance

Goetz, M. P., Suman, V. J., Couch, F. J., Ames, M. M., Rae, J. M., Erlander, M. G., Ma, X. J., Sgroi, D. C., Reynolds, C. A., Lingle, W. L., Weinshilboum, R. M., Flockhart, D. A., Desta, Z., Perez, E. A. & Ingle, J. N., Sep 15 2008, In : Clinical Cancer Research. 14, 18, p. 5864-5868 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Estrogen receptor genotypes, menopausal status, and the lipid effects of tamoxifen

Ntukidem, N. I., Nguyen, A. T., Stearns, V., Rehman, M., Schott, A., Skaar, T., Jin, Y., Blanche, P., Li, L., Lemler, S., Hayden, J., Krauss, R. M., Desta, Z., Flockhart, D. A. & Hayes, D. F., May 30 2008, In : Clinical Pharmacology and Therapeutics. 83, 5, p. 702-710 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

In reply

Desta, Z. & Flockhart, D. A., Sep 15 2008, In : Journal of Clinical Oncology. 26, 10, p. 1765-1766 2 p.

Research output: Contribution to journalLetter

1 Scopus citations
2007

Comparison of duloxetine, escitalopram, and sertraline effects on cytochrome P450 2D6 function in healthy volunteers

Preskorn, S. H., Greenblatt, D. J., Flockhart, D., Luo, Y., Perloff, E. S., Harmatz, J. S., Baker, B., Klick-Davis, A., Desta, Z. & Burt, T., Feb 1 2007, In : Journal of Clinical Psychopharmacology. 27, 1, p. 28-34 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Enhancing race-based prescribing precision with pharmacogenomics

Nguyen, A., Desta, Z. & Flockhart, D. A., Mar 1 2007, In : Clinical Pharmacology and Therapeutics. 81, 3, p. 323-325 3 p.

Research output: Contribution to journalReview article

7 Scopus citations

Estimating a positive false discovery rate for variable selection in pharmacogenetic studies

Li, L., Hui, S., Pennello, G., Desta, Z., Todd, S., Nguyen, A. & Flockhart, D., Sep 1 2007, In : Journal of biopharmaceutical statistics. 17, 5, p. 883-902 20 p.

Research output: Contribution to journalArticle

1 Scopus citations

Germline pharmacogenetics of tamoxifen response: Have we learned enough?

Desta, Z. & Flockhart, D. A., Nov 20 2007, In : Journal of Clinical Oncology. 25, 33, p. 5147-5149 3 p.

Research output: Contribution to journalEditorial

24 Scopus citations

Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro

Destra, Z., Saussele, T., Ward, B., Blievernicht, J., Li, L., Klein, K., Flockhart, D. A. & Zanger, U. M., Jun 1 2007, In : Pharmacogenomics. 8, 6, p. 547-558 12 p.

Research output: Contribution to journalArticle

153 Scopus citations

The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen

Goetz, M. P., Knox, S. K., Suman, V. J., Rae, J. M., Safgren, S. L., Ames, M. M., Visscher, D. W., Reynolds, C., Couch, F. J., Lingle, W. L., Weinshilboum, R. M., Fritcher, E. G. B., Nibbe, A. M., Desta, Z., Nguyen, A., Flockhart, D. A., Perez, E. A. & Ingle, J. N., Jan 1 2007, In : Breast Cancer Research and Treatment. 101, 1, p. 113-121 9 p.

Research output: Contribution to journalArticle

476 Scopus citations

The star-allele nomenclature: Retooling for translational genomics

Robarge, J. D., Li, L., Desta, Z., Nguyen, A. & Flockhart, D. A., Sep 1 2007, In : Clinical Pharmacology and Therapeutics. 82, 3, p. 244-248 5 p.

Research output: Contribution to journalReview article

36 Scopus citations
2006

Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: Major roles for CYP2J2 and CYP3A

Liu, K. H., Kim, M. G., Lee, D. J., Yoon, Y. J., Kim, M. J., Shon, J. H., Chang, S. C., Young, K. C., Desta, Z. & Shin, J. G., Nov 23 2006, In : Drug Metabolism and Disposition. 34, 11, p. 1793-1797 5 p.

Research output: Contribution to journalArticle

62 Scopus citations

Endothelial nitric oxide synthase haplotypes are related to blood pressure elevation, but not to resistance to antihypertensive drug therapy

Sandrim, V. C., Yugar-Toledo, J. C., Desta, Z., Flockhart, D. A., Moreno, H. & Tanus-Santos, J. E., Dec 1 2006, In : Journal of Hypertension. 24, 12, p. 2393-2397 5 p.

Research output: Contribution to journalArticle

47 Scopus citations

Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells

Young, C. L., Li, L., Desta, Z., Zhao, Q., Rae, J. M., Flockhart, D. A. & Skaar, T. C., Jul 20 2006, In : Journal of Pharmacology and Experimental Therapeutics. 318, 2, p. 503-512 10 p.

Research output: Contribution to journalArticle

121 Scopus citations

In reply [2]

Goetz, M. P., Rae, J. M., Safgren, S. L., Ames, M. M., Visscher, D. W., Reynolds, C., Couch, F., Lingle, W. L., Flockhart, D. A., Desta, Z., Perez, E. A. & Ingle, J. N., Aug 1 2006, In : Journal of Clinical Oncology. 24, 22, 1 p.

Research output: Contribution to journalLetter

Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment

Borges, S., Desta, Z., Li, L., Skaar, T. C., Ward, B. A., Nguyen, A., Jin, Y., Storniolo, A. M., Nikoloff, D. M., Wu, L., Hillman, G., Hayes, D. F., Stearns, V. & Flockhart, D. A., Jul 1 2006, In : Clinical Pharmacology and Therapeutics. 80, 1, p. 61-74 14 p.

Research output: Contribution to journalArticle

398 Scopus citations
2005

CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment

Jin, Y., Desta, Z., Stearns, V., Ward, B., Ho, H., Lee, K. H., Skaar, T., Storniolo, A. M., Li, L., Araba, A., Blanchard, R., Nguyen, A., Ullmer, L., Hayden, J., Lemler, S., Weinshilboum, R. M., Rae, J. M., Hayes, D. F. & Flockhart, D. A., Jan 5 2005, In : Journal of the National Cancer Institute. 97, 1, p. 30-39 10 p.

Research output: Contribution to journalArticle

777 Scopus citations

Endothelial nitric oxide synthase gene haplotypes associated with circulating concentrations of nitric oxide products in healthy men

Metzger, I. F., Souza-Costa, D. C., Marroni, A. S., Nagassaki, S., Desta, Z., Flockhart, D. A. & Tanus-Santos, J. E., Aug 2005, In : Pharmacogenetics and Genomics. 15, 8, p. 565-570 6 p.

Research output: Contribution to journalArticle

92 Scopus citations
221 Scopus citations

Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes

Goetz, M. P., Rae, J. M., Suman, V. J., Safgren, S. L., Ames, M. M., Visscher, D. W., Reynolds, C., Couch, F. J., Lingle, W. L., Flockhart, D. A., Desta, Z., Perez, E. A. & Ingle, J. N., Dec 1 2005, In : Journal of Clinical Oncology. 23, 36, p. 9312-9318 7 p.

Research output: Contribution to journalArticle

659 Scopus citations
2004

Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro

Ward, B. A., Morocho, A., Kandil, A., Galinsky, R. E., Flockhart, D. A. & Desta, Z., Sep 1 2004, In : British Journal of Clinical Pharmacology. 58, 3, p. 277-287 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6

Desta, Z., Ward, B. A., Soukhova, N. V. & Flockhart, D. A., Sep 1 2004, In : Journal of Pharmacology and Experimental Therapeutics. 310, 3, p. 1062-1075 14 p.

Research output: Contribution to journalArticle

475 Scopus citations

Cytochrome P450 pharmacogenetics as a predictor of toxicity and clinical response to pulse cyclophosphamide in lupus nephritis

Takada, K., Arefayene, M., Desta, Z., Yarboro, C. H., Boumpas, D. T., Balow, J. E., Flockhart, D. A. & Illei, G. G., Jul 1 2004, In : Arthritis and Rheumatism. 50, 7, p. 2202-2210 9 p.

Research output: Contribution to journalArticle

132 Scopus citations

Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen

Johnson, M. D., Zuo, H., Lee, K. H., Trebley, J. P., Rae, J. M., Weatherman, R. V., Desta, Z., Flockhart, D. A. & Skaar, T. C., May 1 2004, In : Breast Cancer Research and Treatment. 85, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

355 Scopus citations

QT analysis: A complex answer to a 'simple' problem

Li, L., Desai, M., Desta, Z. & Flockhart, D., Sep 15 2004, In : Statistics in Medicine. 23, 17, p. 2625-2643 19 p.

Research output: Contribution to journalArticle

16 Scopus citations

Re: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine (multiple letters) [1]

Ratliff, B., Dietze, E. C., Bean, G. R., Moore, C., Wanko, S., Seewaldt, V. L., Ponzone, R., Biglia, N., Sismondi, P., Lien, E. A., Ueland, P. M., Løonning, P. E., Stearns, V., Johnson, M. D., Rae, J. M., Novielli, A., Bhargava, P., Hayes, D. F., Desta, Z. & Flockhart, D. A., Jun 2 2004, In : Journal of the National Cancer Institute. 96, 11, p. 883-885 3 p.

Research output: Contribution to journalArticle

Re: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine (multiple letters) [1]

Ratliff, B., Dietze, E. C., Bean, G. R., Moore, C., Wanko, S., Seewaldt, V. L., Ponzone, R., Biglia, N., Sismondi, P., Lien, E. A., Ueland, P. M., Løonning, P. E., Stearns, V., Johnson, M. D., Rae, J. M., Novielli, A., Bhargava, P., Hayes, D. F., Desta, Z. & Flockhart, D. A., Jun 2 2004, In : Journal of the National Cancer Institute. 96, 11, p. 883-885 3 p.

Research output: Contribution to journalArticle

12 Scopus citations
2003

Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine

Stearns, V., Johnson, M. D., Rae, J., Morocho, A., Novielli, A., Bhargava, P., Hayes, D. F., Desta, Z. & Flockhart, D. A., Dec 3 2003, In : Journal of the National Cancer Institute. 95, 23, p. 1758-1764 7 p.

Research output: Contribution to journalArticle

714 Scopus citations

Pharmacokinetics and QT interval pharmacodynamics of oral haloperidol in poor and extensive metabolizers of CYP2D6

Desai, M., Tanus-Santos, J. E., Li, L., Gorski, J. C., Arefayene, M., Liu, Y., Desta, Z. & Flockhart, D. A., Jun 17 2003, In : Pharmacogenomics Journal. 3, 2, p. 105-113 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
84 Scopus citations

Sequence diversity and functional characterization of the 5′-regulatory region of human CYP2C19

Arefayene, M., Skaar, T. C., Zhao, X., Rae, J. M., Tanus-Santos, J. E., Brinkmann, U., Brehm, I., Salat, U., Nguyen, A., Desta, Z. & Flockhart, D. A., Apr 1 2003, In : Pharmacogenetics. 13, 4, p. 199-206 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
467 Scopus citations

Variability of heart rate correction methods for the QT interval

Desai, M., Li, L., Desta, Z., Malik, M. & Flockhart, D., Jun 1 2003, In : British Journal of Clinical Pharmacology. 55, 6, p. 511-517 7 p.

Research output: Contribution to journalArticle

74 Scopus citations
2002

Clinical significance of the cytochrome P450 2C19 genetic polymorphism

Desta, Z., Zhao, X., Shin, J. G. & Flockhart, D. A., Jan 1 2002, In : Clinical Pharmacokinetics. 41, 12, p. 913-958 46 p.

Research output: Contribution to journalReview article

694 Scopus citations

In vitro inhibition of pimozide N-dealkylation by selective serotonin reuptake inhibitors and azithromycin

Desta, Z., Soukhova, N. & Flockhart, D. A., Apr 18 2002, In : Journal of Clinical Psychopharmacology. 22, 2, p. 162-168 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6

Desta, Z., Wu, G. M., Morocho, A. M. & Flockhart, D. A., Mar 7 2002, In : Drug Metabolism and Disposition. 30, 3, p. 336-343 8 p.

Research output: Contribution to journalArticle

84 Scopus citations

Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: Implications for cyclophosphamide metabolism

Rae, J. M., Soukhova, N. V., Flockhart, D. A. & Desta, Z., May 11 2002, In : Drug Metabolism and Disposition. 30, 5, p. 525-530 6 p.

Research output: Contribution to journalArticle

103 Scopus citations
2001

Characterization of tamoxifen metabolism to a novel, putative active metabolite

Morocho, A. M., Desta, Z., Wu, G. M., Soukova, N. V., Rae, J. M. & Flockhart, D. A., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P68

Research output: Contribution to journalArticle

2 Scopus citations

Effect of grapefruit juice (GFJ) on the stereo-selective pharmacokinetics (PK) of cisapride (CIS) and cardiac qtc interval in healthy volunteers

Desta, Z., Kivistö, K. T., Lilja, J. J., Backman, J. T., Neuvonen, P. J., Soukhova, N. & Flockhart, D. A., Jan 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P82

Research output: Contribution to journalArticle

3 Scopus citations

Inhibition of cytochrome P450 (CYP450) isoforms by isoniazid: Potent inhibition of CYP2C19 and CYP3A

Desta, Z., Soukhova, N. V. & Flockhart, D. A., Feb 8 2001, In : Antimicrobial Agents and Chemotherapy. 45, 2, p. 382-392 11 p.

Research output: Contribution to journalArticle

132 Scopus citations

In vitro inhibition of pimozide N-dealkylation by selective serotonin reuptake inhibitors (SSRIS) antidepressants and azithromycin

Desta, Z., Soukhova, N. V. & Flockhart, D. A., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P9

Research output: Contribution to journalArticle

Mechanism-based inactivation of CYP2C19 and CYP2D6 by tamoxifen (TAM) and its metabolite n-desmethyltamoxifen (NDTAM)

Desta, Z., Park, J., Soukhova, N. & Flockhart, D. A., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P9

Research output: Contribution to journalArticle

1 Scopus citations

Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: Major role of CYP3A

Desta, Z., Soukhova, N., Morocho, A. M. & Flockhart, D. A., Aug 2 2001, In : Journal of Pharmacology and Experimental Therapeutics. 298, 2, p. 508-520 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Stereoselective pharmacokinetics of cisapride in healthy volunteers and the effect of repeated administration of grapefruit juice

Desta, Z., Kivistö, K. T., Lilja, J. J., Backman, J. T., Soukhova, N., Neuvonen, P. J. & Flockhart, D. A., Oct 18 2001, In : British Journal of Clinical Pharmacology. 52, 4, p. 399-407 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6

Wu, G. M., Desta, Z., Morocho, A. M. & Flockhart, D. A., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P71

Research output: Contribution to journalArticle

2000

Interaction of cisapride with the human cytochrome P450 system: Metabolism and inhibition studies

Desta, Z., Soukhova, N., Mahal, S. K. & Flockhart, D. A., Aug 2 2000, In : Drug Metabolism and Disposition. 28, 7, p. 789-800 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: Potent effect on CYP2C19 and CYP2D6

Ko, J. W., Desta, Z., Soukhova, N. V., Tracy, T. & Flockhart, D. A., Apr 20 2000, In : British Journal of Clinical Pharmacology. 49, 4, p. 343-351 9 p.

Research output: Contribution to journalArticle

92 Scopus citations

Selection of drugs to treat gastro-oesophageal reflux disease: The role of drug interactions

Flockhart, D. A., Desta, Z. & Mahal, S. K., Jan 1 2000, In : Clinical Pharmacokinetics. 39, 4, p. 295-309 15 p.

Research output: Contribution to journalReview article

54 Scopus citations