Zeruesenay Desta

  • 9816 Citations
  • 44 h-Index
1976 …2020

Research output per year

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Publications

2001

Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: Major role of CYP3A

Desta, Z., Soukhova, N., Morocho, A. M. & Flockhart, D. A., Aug 2 2001, In : Journal of Pharmacology and Experimental Therapeutics. 298, 2, p. 508-520 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Stereoselective pharmacokinetics of cisapride in healthy volunteers and the effect of repeated administration of grapefruit juice

Desta, Z., Kivistö, K. T., Lilja, J. J., Backman, J. T., Soukhova, N., Neuvonen, P. J. & Flockhart, D. A., Oct 18 2001, In : British Journal of Clinical Pharmacology. 52, 4, p. 399-407 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6

Wu, G. M., Desta, Z., Morocho, A. M. & Flockhart, D. A., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P71

Research output: Contribution to journalArticle

2000

Interaction of cisapride with the human cytochrome P450 system: Metabolism and inhibition studies

Desta, Z., Soukhova, N., Mahal, S. K. & Flockhart, D. A., Aug 2 2000, In : Drug Metabolism and Disposition. 28, 7, p. 789-800 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: Potent effect on CYP2C19 and CYP2D6

Ko, J. W., Desta, Z., Soukhova, N. V., Tracy, T. & Flockhart, D. A., Apr 20 2000, In : British Journal of Clinical Pharmacology. 49, 4, p. 343-351 9 p.

Research output: Contribution to journalArticle

92 Scopus citations

Selection of drugs to treat gastro-oesophageal reflux disease: The role of drug interactions

Flockhart, D. A., Desta, Z. & Mahal, S. K., Jan 1 2000, In : Clinical Pharmacokinetics. 39, 4, p. 295-309 15 p.

Research output: Contribution to journalReview article

54 Scopus citations
15 Scopus citations
1999

A fatality involving moclobemide, sertraline and pimozide [2]

Desta, Z. & Flockhart, D. A., Jan 1 1999, In : Journal of Forensic Sciences. 44, 1, p. 231-232 2 p.

Research output: Contribution to journalLetter

2 Scopus citations
99 Scopus citations

Identification and characterization of human cytchrome P450 (CYP) isoforms interacting with cisapride

Desta, Z., Thacker, D., Soukhova, N., Shin, J. G. & Flockhart, D. A., Jan 1 1999, In : Clinical Pharmacology and Therapeutics. 65, 2, 1 p.

Research output: Contribution to journalArticle

3 Scopus citations
1998

Human N-demethylation of (S)-mephenytoin by cytochrome P450S 2C9 and 2B6

Ko, J. W., Desta, Z. & Flockhart, D. A., Aug 1 1998, In : Drug Metabolism and Disposition. 26, 8, p. 775-778 4 p.

Research output: Contribution to journalArticle

60 Scopus citations

Identification and characterization of human cytochrome P450 isoforms interacting with pimozide

Desta, Z., Kerbusch, T., Soukhova, N., Richard, E., Ko, J. W. & Flockhart, D. A., Jan 1 1998, In : Journal of Pharmacology and Experimental Therapeutics. 285, 2, p. 428-437 10 p.

Research output: Contribution to journalArticle

66 Scopus citations
1997

Assessment of rational drug use and prescribing in primary health care facilities in North West Ethiopia

Desta, Z., Abula, T., Beyene, L., Fantahun, M., Yohannes, A. G. & Ayalew, S., Dec 1 1997, In : East African medical journal. 74, 12, p. 758-763 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Sensitive assay for pimozide in human plasma using high-performance liquid chromatography with fluorescence detection: Application to pharmacokinetic studies

Kerbusch, T., Desta, Z., Soukhova, N. V., Thacker, D. & Flockhart, D. A., Jun 20 1997, In : Journal of Chromatography B: Biomedical Applications. 694, 1, p. 163-168 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
1996

Prescription writing in Gondar outpatient teaching hospital, Ethiopia

Desta, Z. & Abdulwhab, M., Feb 1 1996, In : East African medical journal. 73, 2, p. 115-119 5 p.

Research output: Contribution to journalArticle

10 Scopus citations
1995

Prescribing pattern of antibacterial drugs in a teaching hospital in Gondar, Ethiopia

Aseffa, A., Desta, Z. & Tadesse, I., Jan 1 1995, In : East African medical journal. 72, 1, p. 56-59 4 p.

Research output: Contribution to journalArticle

11 Scopus citations
1993

Circadian time-dependent kinetics of theophylline and its modulation by phenobarbital pretreatment in rats

Zeruesenay, D., Siegmund, W., Franke, G. & Zschiesche, M., Jan 1 1993, In : Chronobiology International. 10, 2, p. 81-86 6 p.

Research output: Contribution to journalArticle

1992

Effects of isoniazid on hepatic drug oxidation and N-acetylation capacities in rats

Desta, Z., Siegmund, W., Franke, G., Beyrich, A. & Bleyer, H., Jan 1 1992, In : Pharmazie. 47, 6, p. 448-451 4 p.

Research output: Contribution to journalArticle

Pharmacodynamic interactions between isoniazid and theophylline in mice and rats, and the influence of pyridoxine

Desta, Z. & Steingruber, M., Jan 1 1992, In : Pharmazie. 47, 7, p. 525-528 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pharmacokinetic Interactions Between Isoniazid and Theophylline in Rats

Zeruesenay, D., Siegmund, W., Zschiesche, M., Franke, G., Walter, R. & Bleyer, H., Nov 1992, In : Journal of Pharmacy and Pharmacology. 44, 11, p. 893-897 5 p.

Research output: Contribution to journalArticle

11 Scopus citations
1986

Methodological prerequisites for drug utilisation studies.

Sittner, W. D., Desta, Z. & Wiezorek, W. D., Apr 1 1986, In : Ethiopian medical journal. 24, 2, p. 101-102 2 p.

Research output: Contribution to journalLetter