Zeruesenay Desta

  • 9317 Citations
  • 43 h-Index
1976 …2019
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Publications 1986 2019

  • 9317 Citations
  • 43 h-Index
  • 162 Article
  • 2 Chapter
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Article
2019

Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2

Dudenkov, T. M., Liu, D., Cairns, J., Devarajan, S., Zhuang, Y., Ingle, J. N., Buzdar, A. U., Robson, M. E., Kubo, M., Batzler, A., Barman, P., Jenkins, G. D., Carlson, E. E., Goetz, M. P., Northfelt, D. W., Moreno-Aspitia, A., Desta, Z., Reid, J. M., Kalari, K. R., Wang, L. & 1 others, Weinshilboum, R. M., Jan 1 2019, In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Open Access
Aromatase Inhibitors
Genome-Wide Association Study
Single Nucleotide Polymorphism
Pharmaceutical Preparations
Breast Neoplasms
1 Citation (Scopus)

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy

Desta, Z., Gammal, R. S., Gong, L., Whirl-Carrillo, M., Gaur, A. H., Sukasem, C., Hockings, J., Myers, A., Swart, M., Tyndale, R. F., Masimirembwa, C., Iwuchukwu, O. F., Chirwa, S., Lennox, J., Gaedigk, A., Klein, T. E. & Haas, D. W., Jan 1 2019, In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Open Access
efavirenz
Pharmacogenetics
Guidelines
Reverse Transcriptase Inhibitors
HIV Infections

CYP2B6 Genotype-Dependent Inhibition of CYP1A2 and Induction of CYP2A6 by the Antiretroviral Drug Efavirenz in Healthy Volunteers

Metzger, I. F., Dave, N., Kreutz, Y., Lu, J. B. L., Galinsky, R. E. & Desta, Z., Jan 1 2019, (Accepted/In press) In : Clinical and translational science.

Research output: Contribution to journalArticle

Open Access
efavirenz
Cytochrome P-450 CYP1A2
Healthy Volunteers
Genotype
Pharmaceutical Preparations

Drug-gene and drug-drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial

Fulton, C. R., Zang, Y., Desta, Z., Rosenman, M., Holmes, A., Decker, B., Zhang, Y., T Callaghan, J., Pratt, V. M., Levy, K., Gufford, B. T., Dexter, P., Skaar, T. & Eadon, M., Apr 1 2019, In : Pharmacogenomics. 20, 6, p. 397-408 12 p.

Research output: Contribution to journalArticle

Tramadol
Codeine
Drug Interactions
Cytochrome P-450 CYP2D6
Pharmaceutical Preparations

Effects of SLCO1B1 polymorphisms on plasma estrogen concentrations in women with breast cancer receiving aromatase inhibitors exemestane and letrozole

Dempsey, J. M., Kidwell, K. M., Gersch, C. L., Pesch, A. M., Desta, Z., Storniolo, A. M., Stearns, V., Skaar, T., Hayes, D. F., Henry, N. L., Rae, J. M. & Hertz, D. L., Jan 1 2019, In : Pharmacogenomics. 20, 8, p. 571-580 10 p.

Research output: Contribution to journalArticle

exemestane
letrozole
Aromatase Inhibitors
Estrogens
Breast Neoplasms

Mechanistic assessment of extrahepatic contributions to glucuronidation of integrase strand transfer inhibitors

Liu, S. N., Lu, J. B. L., Watson, C. J. W., Lazarus, P., Desta, Z. & Gufford, B. T., May 1 2019, In : Drug Metabolism and Disposition. 47, 5, p. 535-544 10 p.

Research output: Contribution to journalArticle

Integrases
Glucuronosyltransferase
Liver Microsomes
Liver
Kidney
2018
1 Citation (Scopus)

CYP2D6 and Endoxifen in Tamoxifen Therapy: A Tribute to David A. Flockhart

Skaar, T. & Desta, Z., Jan 1 2018, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Tamoxifen
Guidelines
Clinical Pharmacology
Pharmacogenetics

DrugMetab: An Integrated Machine Learning and Lexicon Mapping Named Entity Recognition Method for Drug Metabolite

Wu, H. Y., Lu, D., Hyder, M., Zhang, S., Quinney, S., Desta, Z. & Li, L., Jan 1 2018, (Accepted/In press) In : CPT: Pharmacometrics and Systems Pharmacology.

Research output: Contribution to journalArticle

Named Entity Recognition
Metabolites
Learning systems
Machine Learning
Drugs
1 Citation (Scopus)

Pharmacogenetics and Practice: Tailoring Prescribing for Safety and Effectiveness

Fulton, C. R., Swart, M., De Luca, T., Liu, S. N., Collins, K. S., Desta, Z., Gufford, B. T. & Eadon, M., Nov 1 2018, In : Journal for Nurse Practitioners. 14, 10, p. 697-704.e1

Research output: Contribution to journalArticle

Precision Medicine
Pharmacogenetics
Patient Care
Nurses
Safety
1 Citation (Scopus)

Rifampin modulation of xeno- and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes

Gufford, B. T., Robarge, J. D., Eadon, M., Gao, H., Lin, H., Liu, Y., Desta, Z. & Skaar, T., Apr 1 2018, In : Pharmacology Research and Perspectives. 6, 2, e00386.

Research output: Contribution to journalArticle

Xenobiotics
Rifampin
MicroRNAs
Hepatocytes
Midazolam
2017
2 Citations (Scopus)

Clinical and educational impact of pharmacogenomics testing: A case series from the INGENIOUS trial

Pierson, R. C., Gufford, B. T., Desta, Z. & Eadon, M., Jun 1 2017, In : Pharmacogenomics. 18, 9, p. 835-841 7 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Referral and Consultation
Clinical Pharmacology
Genomics
Drug Interactions
6 Citations (Scopus)

Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment

Marcath, L. A., Deal, A. M., Van Wieren, E., Danko, W., Walko, C. M., Ibrahim, J. G., Weck, K. E., Jones, D. R., Desta, Z., McLeod, H. L., Carey, L. A., Irvin, W. J. & Hertz, D. L., 2017, In : Pharmacogenetics and Genomics. 27, 11, p. 402-409 8 p.

Research output: Contribution to journalArticle

Tamoxifen
Cytochrome P-450 Enzyme System
Cytochrome P-450 CYP2D6
Enzymes
Therapeutics
4 Citations (Scopus)

Population pharmacokinetic modeling to estimate the contributions of genetic and nongenetic factors to efavirenz disposition

Robarge, J. D., Metzger, I. F., Lu, J., Thong, N., Skaar, T., Desta, Z. & Bies, R., Jan 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 1, e01813-16.

Research output: Contribution to journalArticle

efavirenz
Pharmacokinetics
Population
Fats
Body Mass Index
2 Citations (Scopus)

Variable aromatase inhibitor plasma concentrations do not correlate with circulating estrogen concentrations in post-menopausal breast cancer patients

Hertz, D. L., Speth, K. A., Kidwell, K. M., Gersch, C. L., Desta, Z., Storniolo, A. M., Stearns, V., Skaar, T., Hayes, D. F., Henry, N. L. & Rae, J. M., Jun 22 2017, (Accepted/In press) In : Breast Cancer Research and Treatment. p. 1-10 10 p.

Research output: Contribution to journalArticle

exemestane
letrozole
Aromatase Inhibitors
Estrogens
Breast Neoplasms
7 Citations (Scopus)

Variants in the CYP2B6 3′UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs

Burgess, K. S., Ipe, J., Swart, M., Metzger, I. F., Lu, J., Gufford, B. T., Thong, N., Desta, Z., Gaedigk, R., Pearce, R. E., Gaedigk, A., Liu, Y. & Skaar, T., 2017, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

MicroRNAs
efavirenz
Alleles
Binding Sites
Luciferases
2016
6 Citations (Scopus)

Association of variants in candidate genes with lipid profiles in women with early breast cancer on adjuvant aromatase inhibitor therapy

Santa-Maria, C. A., Blackford, A., Nguyen, A. T., Skaar, T., Philips, S., Oesterreich, S., Rae, J. M., Desta, Z., Robarge, J., Henry, N. L., Storniolo, A. M., Hayes, D. F., Blumenthal, R. S., Ouyang, P., Post, W. S., Flockhart, D. A. & Stearns, V., Mar 15 2016, In : Clinical Cancer Research. 22, 6, p. 1395-1402 8 p.

Research output: Contribution to journalArticle

Aromatase Inhibitors
letrozole
Breast Neoplasms
Lipids
Genes
12 Citations (Scopus)

Chiral plasma pharmacokinetics and urinary excretion of bupropion and metabolites in healthy volunteers

Masters, A. R., Gufford, B. T., Li Lu, J. B., Metzger, I. F., Jones, D. R. & Desta, Z., Aug 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 358, 2, p. 230-238 9 p.

Research output: Contribution to journalArticle

Bupropion
Healthy Volunteers
Pharmacokinetics
Drug Interactions
Cytochrome P-450 CYP2D6
10 Citations (Scopus)

Efavirenz Inhibits the Human Ether-A-Go-Go Related Current (hERG) and Induces QT Interval Prolongation in CYP2B6*6*6 Allele Carriers

Abdelhady, A. M., Shugg, T., Thong, N., Lu, J. B. L., Kreutz, Y., Jaynes, H. A., Robarge, J. D., Tisdale, J. E., Desta, Z. & Overholser, B. R., Oct 1 2016, In : Journal of Cardiovascular Electrophysiology. 27, 10, p. 1206-1213 8 p.

Research output: Contribution to journalArticle

efavirenz
Ether
Alleles
Genotype
Cytochrome P-450 CYP2B6
5 Citations (Scopus)

Effects of exemestane and letrozole therapy on plasma concentrations of estrogens in a randomized trial of postmenopausal women with breast cancer

Robarge, J. D., Desta, Z., Nguyen, A. T., Li, L., Hertz, D., Rae, J. M., Hayes, D. F., Storniolo, A. M., Stearns, V., Flockhart, D. A., Skaar, T. & Henry, N. L., Dec 9 2016, (Accepted/In press) In : Breast Cancer Research and Treatment. p. 1-9 9 p.

Research output: Contribution to journalArticle

exemestane
letrozole
Estrogens
Aromatase Inhibitors
Breast Neoplasms
17 Citations (Scopus)

Implementation of a pharmacogenomics consult service to support the INGENIOUS trial

Eadon, M., Desta, Z., Levy, K., Decker, B., Pierson, R., Pratt, V., Callaghan, J., Rosenman, M., Carpenter, J., Holmes, A., Mcdonald, C., Benson, E., Patil, A., Vuppalanchi, R., Gufford, B., Dave, N., Robarge, J., Hyder, M., Haas, D., Kreutz, R. & 3 others, Dexter, P., Skaar, T. & Flockhart, D., 2016, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Safety-net Providers
Credentialing
Pharmacogenetics
Vulnerable Populations
Poverty
3 Citations (Scopus)

Inhibition of cytochrome P450 2B6 activity by voriconazole profiled using efavirenz disposition in healthy volunteers

Desta, Z., Metzger, I. F., Thong, N., Lu, J. B. L., Callaghan, J., Skaar, T., Flockhart, D. A. & Galinsky, R. E., Nov 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 11, p. 6813-6822 10 p.

Research output: Contribution to journalArticle

efavirenz
Healthy Volunteers
Reverse Transcriptase Inhibitors
Cytochrome P-450 CYP2B6
Voriconazole
21 Citations (Scopus)

Patient-reported outcomes and early discontinuation in aromatase inhibitor-treated postmenopausal women with early stage breast cancer

Kadakia, K. C., Snyder, C. F., Kidwell, K. M., Seewald, N. J., Flockhart, D. A., Skaar, T., Desta, Z., Rae, J. M., Otte, J., Carpenter, J., Storniolo, A. M., Hayes, D. F., Stearns, V. & Lynn Henry, N., Mar 23 2016, In : Oncologist. 21, 5, p. 539-546 8 p.

Research output: Contribution to journalArticle

Aromatase Inhibitors
exemestane
letrozole
Breast Neoplasms
Visual Analog Scale
7 Citations (Scopus)

Polymorphisms in drug-metabolizing enzymes and steady-state exemestane concentration in postmenopausal patients with breast cancer

Hertz, D. L., Kidwell, K. M., Seewald, N. J., Gersch, C. L., Desta, Z., Flockhart, D. A., Storniolo, A. M., Stearns, V., Skaar, T., Hayes, D. F., Henry, N. L. & Rae, J. M., Aug 23 2016, (Accepted/In press) In : Pharmacogenomics Journal.

Research output: Contribution to journalArticle

exemestane
Cytochrome P-450 CYP3A
Breast Neoplasms
Enzymes
Pharmaceutical Preparations
6 Citations (Scopus)

Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers

Cho, D. Y., Shen, J. H. Q., Lemler, S. M., Skaar, T., Li, L., Blievernicht, J., Zanger, U. M., Kim, K. B., Shin, J. G., Flockhart, D. A. & Desta, Z., Apr 1 2016, In : Drug Metabolism and Pharmacokinetics. 31, 2, p. 107-116 10 p.

Research output: Contribution to journalArticle

efavirenz
Hydroxylation
Rifampin
Healthy Volunteers
Placebos
13 Citations (Scopus)

Rifampin regulation of drug transporters gene expression and the association of microRNAs in human hepatocytes

Benson, E., Eadon, M., Desta, Z., Liu, Y., Lin, H., Burgess, K. S., Segar, M. W., Gaedigk, A. & Skaar, T., Apr 26 2016, In : Frontiers in Pharmacology. 7, APR, 111.

Research output: Contribution to journalArticle

Drug and Narcotic Control
Rifampin
MicroRNAs
Hepatocytes
Gene Expression
14 Citations (Scopus)

Stereoselective glucuronidation of bupropion metabolites in vitro and in vivo

Gufford, B. T., Lu, J. B. L., Metzger, I. F., Jones, D. R. & Desta, Z., Apr 1 2016, In : Drug Metabolism and Disposition. 44, 4, p. 544-553 10 p.

Research output: Contribution to journalArticle

Bupropion
Glucuronides
Urine
Uridine Diphosphate
Subcellular Fractions
12 Citations (Scopus)
Bupropion
Metabolites
High Pressure Liquid Chromatography
Enantiomers
Acetaminophen
14 Citations (Scopus)

Tamoxifen dose escalation in patients with diminished CYP2D6 activity normalizes endoxifen concentrations without increasing toxicity

Hertz, D. L., Deal, A., Ibrahim, J. G., Walko, C. M., Weck, K. E., Anderson, S., Magrinat, G., Olajide, O., Moore, S., Raab, R., Carrizosa, D. R., Corso, S., Schwartz, G., Graham, M., Peppercorn, J. M., Jones, D. R., Desta, Z., Flockhart, D. A., Evans, J. P., McLeod, H. L. & 2 others, Carey, L. A. & Irvin, W. J., Jul 1 2016, In : Oncologist. 21, 7, p. 795-803 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Tamoxifen
Breast Neoplasms
Quality of Life
Genotype
2015
16 Citations (Scopus)

Age-related changes in MicroRNA expression and pharmacogenes in human liver

Burgess, K. S., Philips, S., Benson, E., Desta, Z., Gaedigk, A., Gaedigk, R., Segar, M. W., Liu, Y. & Skaar, T., Aug 1 2015, In : Clinical Pharmacology and Therapeutics. 98, 2, p. 205-215 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Liver
Pediatrics
Pharmaceutical Preparations
RNA Sequence Analysis
13 Citations (Scopus)

Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover

Oesterreich, S., Henry, N. L., Kidwell, K. M., Van Poznak, C. H., Skaar, T., Dantzer, J., Li, L., Hangartner, T. N., Peacock, M., Nguyen, A. T., Rae, J. M., Desta, Z., Philips, S., Storniolo, A. M., Stearns, V., Hayes, D. F. & Flockhart, D. A., Nov 1 2015, In : Breast Cancer Research and Treatment. 154, 2, p. 263-273 11 p.

Research output: Contribution to journalArticle

exemestane
letrozole
Bone Remodeling
Bone Density
Aromatase Inhibitors
1 Citation (Scopus)

A two-week regimen of high-dose integrase inhibitors does not cause nephrotoxicity in mice

Eadon, M., Zhang, H., Skaar, T., Hato, T., Dagher, P., Gupta, S. & Desta, Z., Jan 1 2015, In : Antiviral Chemistry and Chemotherapy. 24, 2, p. 72-76 5 p.

Research output: Contribution to journalArticle

Integrase Inhibitors
Creatinine
Kidney
Water
Serum
22 Citations (Scopus)

Estrogens and their precursors in postmenopausal women with early breast cancer receiving anastrozole

Ingle, J. N., Kalari, K. R., Buzdar, A. U., Robson, M. E., Goetz, M. P., Desta, Z., Barman, P., Dudenkov, T. T., Northfelt, D. W., Perez, E. A., Flockhart, D. A., Williard, C. V., Wang, L. & Weinshilboum, R. M., May 26 2015, In : Steroids. 99, PA, p. 32-38 7 p.

Research output: Contribution to journalArticle

Estrogens
Breast Neoplasms
Estrone
Metabolites
Hormones
12 Citations (Scopus)

Identification and Mechanistic Investigation of Drug-Drug Interactions Associated with Myopathy: A Translational Approach

Han, X., Quinney, S., Wang, Z., Zhang, P., Duke, J., Desta, Z., Elmendorf, J., Flockhart, D. A. & Li, L., Sep 1 2015, In : Clinical Pharmacology and Therapeutics. 98, 3, p. 321-327 7 p.

Research output: Contribution to journalArticle

Muscular Diseases
Drug Interactions
Simvastatin
Loratadine
Pharmaceutical Preparations
11 Citations (Scopus)

In vitro metabolism of montelukast by cytochrome P450S and UDP-glucuronosyltransferases

De Oliveira Cardoso, J., Oliveira, R. V., Lu, J. B. L. & Desta, Z., Dec 1 2015, In : Drug Metabolism and Disposition. 43, 12, p. 1905-1916 12 p.

Research output: Contribution to journalArticle

montelukast
Glucuronosyltransferase
Cytochromes
Liver Microsomes
Hydroxylation
22 Citations (Scopus)

In vivo assessment of the metabolic activity of CYP2D6 diplotypes and alleles

Hertz, D. L., Snavely, A. C., McLeod, H. L., Walko, C. M., Ibrahim, J. G., Anderson, S., Weck, K. E., Magrinat, G., Olajide, O., Moore, S., Raab, R., Carrizosa, D. R., Corso, S., Schwartz, G., Peppercorn, J. M., Evans, J. P., Jones, D. R., Desta, Z., Flockhart, D. A., Carey, L. A. & 1 others, Irvin, W. J., Nov 1 2015, In : British Journal of Clinical Pharmacology. 80, 5, p. 1122-1130 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Alleles
Tamoxifen
Phenotype
Genotype
5 Citations (Scopus)

Platelet factor XIIIa release during platelet aggregation and plasma clot strength measured by thrombelastography in patients with coronary artery disease treated with clopidogrel

Kreutz, R., Owens, J., Lu, D., Nystrom, P., Jin, Y., Kreutz, Y., Desta, Z. & Flockhart, D. A., Jun 1 2015, In : Platelets. 26, 4, p. 358-363 6 p.

Research output: Contribution to journalArticle

clopidogrel
Factor XIIIa
Thrombelastography
Platelet Aggregation
Coronary Artery Disease
2014
31 Citations (Scopus)

Citalopram and escitalopram plasma drug and metabolite concentrations: Genome-wide associations

Ji, Y., Schaid, D. J., Desta, Z., Kubo, M., Batzler, A. J., Snyder, K., Mushiroda, T., Kamatani, N., Ogburn, E., Hall-Flavin, D., Flockhart, D., Nakamura, Y., Mrazek, D. A. & Weinshilboum, R. M., 2014, In : British Journal of Clinical Pharmacology. 78, 2, p. 373-383 11 p.

Research output: Contribution to journalArticle

Citalopram
Genome
Pharmaceutical Preparations
Major Depressive Disorder
Genome-Wide Association Study
5 Citations (Scopus)

Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype dependent

Michaud, V., Kreutz, Y., Skaar, T., Ogburn, E., Thong, N., Flockhart, D. A. & Desta, Z., 2014, In : Pharmacogenomics Journal. 14, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

efavirenz
Omeprazole
Genotype
Alleles
Cytochrome P-450 CYP3A
6 Citations (Scopus)

Factor XIII Val34Leu polymorphism and recurrent myocardial infarction in patients with coronary artery disease

Kreutz, R., Bitar, A., Owens, J., Desta, Z., Breall, J., von der Lohe, E., Sinha, A., Vatta, M., Nystrom, P., Jin, Y. & Flockhart, D. A., 2014, In : Journal of Thrombosis and Thrombolysis. 38, 3, p. 380-387 8 p.

Research output: Contribution to journalArticle

Factor XIII
Fibrin
Coronary Artery Disease
Myocardial Infarction
Thrombelastography
13 Citations (Scopus)

Genome-Wide Discovery of Drug-Dependent Human Liver Regulatory Elements

Smith, R. P., Eckalbar, W. L., Morrissey, K. M., Luizon, M. R., Hoffmann, T. J., Sun, X., Jones, S. L., Force Aldred, S., Ramamoorthy, A., Desta, Z., Liu, Y., Skaar, T., Trinklein, N. D., Giacomini, K. M. & Ahituv, N., Oct 1 2014, In : PLoS Genetics. 10, 10

Research output: Contribution to journalArticle

rifampicin
Drug Discovery
Rifampin
drug
genome
1 Citation (Scopus)

PharmGKB summary: Ifosfamide pathways, pharmacokinetics and pharmacodynamics

Lowenberg, D., Thorn, C. F., Desta, Z., Flockhart, D. A., Altman, R. B. & Klein, T. E., Feb 2014, In : Pharmacogenetics and Genomics. 24, 2, p. 133-138 6 p.

Research output: Contribution to journalArticle

Alkylating Antineoplastic Agents
Ifosfamide
Pharmacogenetics
Cytochrome P-450 Enzyme System
Signal Transduction
9 Citations (Scopus)

Population pharmacogenetic-based pharmacokinetic modeling of efavirenz, 7-hydroxy- and 8-hydroxyefavirenz

Abdelhady, A. M., Desta, Z., Jiang, F., Yeo, C. W., Shin, J. G. & Overholser, B. R., Jan 2014, In : Journal of Clinical Pharmacology. 54, 1, p. 87-96 10 p.

Research output: Contribution to journalArticle

efavirenz
Pharmacogenetics
Pharmacokinetics
Population
Genotype
19 Citations (Scopus)
Precision Medicine
Pharmacogenetics
Technology
Delivery of Health Care
Research
4 Citations (Scopus)

Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers

Metzger, I. F., Quigg, T. C., Epstein, N., Aregbe, A. O., Thong, N., Callaghan, J., Flockhart, D. A., Nguyen, A. T., Stevens, C. K., Gupta, S. & Desta, Z., Dec 1 2014, In : Current Therapeutic Research - Clinical and Experimental. 76, p. 64-69 6 p.

Research output: Contribution to journalArticle

efavirenz
Bilirubin
Healthy Volunteers
Drug Interactions
Hemoglobins
2013
15 Citations (Scopus)

Aromatase inhibitor-induced modulation of breast density: Clinical and genetic effects

Henry, N. L., Chan, H. P., Dantzer, J., Goswami, C. P., Li, L., Skaar, T., Rae, J. M., Desta, Z., Khouri, N., Pinsky, R., Oesterreich, S., Zhou, C., Hadjiiski, L., Philips, S., Robarge, J., Nguyen, A. T., Storniolo, A. M., Flockhart, D. A., Hayes, D. F., Helvie, M. A. & 1 others, Stearns, V., Oct 29 2013, In : British Journal of Cancer. 109, 9, p. 2331-2339 9 p.

Research output: Contribution to journalArticle

Aromatase Inhibitors
exemestane
letrozole
Therapeutics
Breast Neoplasms
18 Citations (Scopus)

CYP2B6 pharmacogenetics-based in vitro-in vivo extrapolation of efavirenz clearance by physiologically based pharmacokinetic modeling

Xu, C., Quinney, S., Guo, Y., Hall, S. D., Li, L. & Desta, Z., Dec 2013, In : Drug Metabolism and Disposition. 41, 12, p. 2004-2011 8 p.

Research output: Contribution to journalArticle

efavirenz
Pharmacogenetics
Pharmacokinetics
Alleles
Genotype
17 Citations (Scopus)

CYP2D6 genotypes, endoxifen levels, and disease recurrence in 224 Filipino and Vietnamese women receiving adjuvant tamoxifen for operable breast cancer

Love, R. R., Desta, Z., Flockhart, D., Skaar, T., Ogburn, E. T., Ramamoorthy, A., Uy, G. B., Laudico, A. V., van Dinh, N., Quang, L. H., van To, T., Young, G. S., Hade, E. & Jarjoura, D., 2013, In : SpringerPlus. 2, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Tamoxifen
Genotype
Breast Neoplasms
Recurrence
12 Citations (Scopus)

Cytochrome P450 3A4*22, PPAR-α, and ARNT polymorphisms and clopidogrel response

Kreutz, R., Owens, J., Jin, Y., Nystrom, P., Desta, Z., Kreutz, Y., Breall, J., Li, L., Chiang, C. W., Kovacs, R. & Flockhart, D. A., Dec 9 2013, In : Clinical Pharmacology: Advances and Applications. 5, p. 185-192 8 p.

Research output: Contribution to journalArticle

clopidogrel
Cytochrome P-450 CYP3A
Peroxisome Proliferator-Activated Receptors
Cytoplasmic and Nuclear Receptors
Platelet Aggregation
17 Citations (Scopus)

Effects of clopidogrel and itraconazole on the disposition of efavirenz and its hydroxyl metabolites: Exploration of a novel CYP2B6 phenotyping index

Jiang, F., Desta, Z., Shon, J. H., Yeo, C. W., Kim, H. S., Liu, K. H., Bae, S. K., Lee, S. S., Flockhart, D. A. & Shin, J. G., Jan 2013, In : British Journal of Clinical Pharmacology. 75, 1, p. 244-253 10 p.

Research output: Contribution to journalArticle

efavirenz
clopidogrel
Itraconazole
Hydroxyl Radical
Area Under Curve

Erratum: Compartment-specific gene regulation of the car inducer efavirenz in vivo (Clinical Pharmacology and Therapeutics (2012) 92 (103-111) DOI: 10.1038/clpt.2012.34)

Meyer Zu Schwabedissen, H. E., Oswald, S., Bresser, C., Nassif, A., Modess, C., Desta, Z., Ogburn, E. T., Marinova, M., Lütjohann, D., Spielhagen, C., Nauck, M., Kroemer, H. K. & Siegmund, W., Jan 2013, In : Clinical Pharmacology and Therapeutics. 93, 1, p. 129 1 p.

Research output: Contribution to journalArticle

efavirenz
Clinical Pharmacology
Genes
Therapeutics