Zeruesenay Desta

  • 9773 Citations
  • 44 h-Index
1976 …2019

Research output per year

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Abacavir, didanosine and tenofovir do not induce inflammatory, apoptotic or oxidative stress genes in coronary endothelial cells

Kim, C., Gupta, S. K., Green, L., Taylor, B. M., Deuter-Reinhard, M., Desta, Z. & Clauss, M., Dec 19 2011, In : Antiviral Therapy. 16, 8, p. 1335-1339 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine

Stearns, V., Johnson, M. D., Rae, J., Morocho, A., Novielli, A., Bhargava, P., Hayes, D. F., Desta, Z. & Flockhart, D. A., Dec 3 2003, In : Journal of the National Cancer Institute. 95, 23, p. 1758-1764 7 p.

Research output: Contribution to journalArticle

714 Scopus citations

Age-related changes in MicroRNA expression and pharmacogenes in human liver

Burgess, K. S., Philips, S., Benson, E. A., Desta, Z., Gaedigk, A., Gaedigk, R., Segar, M. W., Liu, Y. & Skaar, T. C., Aug 1 2015, In : Clinical Pharmacology and Therapeutics. 98, 2, p. 205-215 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

A mixture model approach in gene-gene and gene-environmental interactions for binary phenotypes

Li, L., Yu, M., Jason, R. D., Shen, C., Azzouz, F., McLeod, H. L., Borges-Gonzales, S., Nguyen, A., Skaar, T., Desta, Z., Sweeney, C. J. & Flockhart, D. A., Nov 1 2008, In : Journal of biopharmaceutical statistics. 18, 6, p. 1150-1177 28 p.

Research output: Contribution to journalArticle

3 Scopus citations

Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2

Dudenkov, T. M., Liu, D., Cairns, J., Devarajan, S., Zhuang, Y., Ingle, J. N., Buzdar, A. U., Robson, M. E., Kubo, M., Batzler, A., Barman, P., Jenkins, G. D., Carlson, E. E., Goetz, M. P., Northfelt, D. W., Moreno-Aspitia, A., Desta, Z., Reid, J. M., Kalari, K. R., Wang, L. & 1 others, Weinshilboum, R. M., Jul 2019, In : Clinical Pharmacology and Therapeutics. 106, 1, p. 219-227 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Anti-inflammatory treatment with pentoxifylline improves HIV-related endothelial dysfunction: A pilot study

Gupta, S. K., Johnson, R. M., Mather, K. J., Clauss, M., Rehman, J., Saha, C., Desta, Z. & Dubé, M. P., Jun 1 2010, In : AIDS. 24, 9, p. 1377-1380 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

A penalized mixture model approach in genotype/phenotype association analysis for quantitative phenotypes

Li, L., Borges, S., Jason, R. D., Shen, C., Desta, Z. & Flockhart, D., Jun 4 2010, In : Cancer Informatics. 9, p. 93-103 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Aromatase inhibitor-induced modulation of breast density: Clinical and genetic effects

Henry, N. L., Chan, H. P., Dantzer, J., Goswami, C. P., Li, L., Skaar, T. C., Rae, J. M., Desta, Z., Khouri, N., Pinsky, R., Oesterreich, S., Zhou, C., Hadjiiski, L., Philips, S., Robarge, J., Nguyen, A. T., Storniolo, A. M., Flockhart, D. A., Hayes, D. F., Helvie, M. A. & 1 others, Stearns, V., Oct 29 2013, In : British Journal of Cancer. 109, 9, p. 2331-2339 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Assessment of rational drug use and prescribing in primary health care facilities in North West Ethiopia

Desta, Z., Abula, T., Beyene, L., Fantahun, M., Yohannes, A. G. & Ayalew, S., Dec 1 1997, In : East African medical journal. 74, 12, p. 758-763 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Assessment of vascular effects of tamoxifen and its metabolites on the rat perfused hindquarter vascular bed

Montenegro, M. F., Pessa, L. R., Gomes, V. A., Desta, Z., Flockhart, D. A. & Tanus-Santos, J. E., May 1 2009, In : Basic and Clinical Pharmacology and Toxicology. 104, 5, p. 400-407 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort

Lynn Henry, N., Rae, J. M., Li, L., Azzouz, F., Skaar, T. C., Desta, Z., Sikora, M. J., Philips, S., Nguyen, A. T., Storniolo, A. M., Hayes, D. F., Flockhart, D. A. & Stearns, V., Jan 21 2009, In : Breast Cancer Research and Treatment. 117, 3, p. 571-575 5 p.

Research output: Contribution to journalArticle

59 Scopus citations

Association of variants in candidate genes with lipid profiles in women with early breast cancer on adjuvant aromatase inhibitor therapy

Santa-Maria, C. A., Blackford, A., Nguyen, A. T., Skaar, T. C., Philips, S., Oesterreich, S., Rae, J. M., Desta, Z., Robarge, J., Henry, N. L., Storniolo, A. M., Hayes, D. F., Blumenthal, R. S., Ouyang, P., Post, W. S., Flockhart, D. A. & Stearns, V., Mar 15 2016, In : Clinical Cancer Research. 22, 6, p. 1395-1402 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover

Oesterreich, S., Henry, N. L., Kidwell, K. M., Van Poznak, C. H., Skaar, T. C., Dantzer, J., Li, L., Hangartner, T. N., Peacock, M., Nguyen, A. T., Rae, J. M., Desta, Z., Philips, S., Storniolo, A. M., Stearns, V., Hayes, D. F. & Flockhart, D. A., Nov 1 2015, In : Breast Cancer Research and Treatment. 154, 2, p. 263-273 11 p.

Research output: Contribution to journalArticle

15 Scopus citations
1 Scopus citations

Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: Major roles for CYP2J2 and CYP3A

Liu, K. H., Kim, M. G., Lee, D. J., Yoon, Y. J., Kim, M. J., Shon, J. H., Chang, S. C., Young, K. C., Desta, Z. & Shin, J. G., Nov 23 2006, In : Drug Metabolism and Disposition. 34, 11, p. 1793-1797 5 p.

Research output: Contribution to journalArticle

62 Scopus citations

Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro

Ward, B. A., Morocho, A., Kandil, A., Galinsky, R. E., Flockhart, D. A. & Desta, Z., Sep 1 2004, In : British Journal of Clinical Pharmacology. 58, 3, p. 277-287 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Characterization of tamoxifen metabolism to a novel, putative active metabolite

Morocho, A. M., Desta, Z., Wu, G. M., Soukova, N. V., Rae, J. M. & Flockhart, D. A., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P68

Research output: Contribution to journalArticle

2 Scopus citations

Chiral plasma pharmacokinetics and urinary excretion of bupropion and metabolites in healthy volunteers

Masters, A. R., Gufford, B. T., Li Lu, J. B., Metzger, I. F., Jones, D. R. & Desta, Z., Aug 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 358, 2, p. 230-238 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Circadian time-dependent kinetics of theophylline and its modulation by phenobarbital pretreatment in rats

Zeruesenay, D., Siegmund, W., Franke, G. & Zschiesche, M., Jan 1 1993, In : Chronobiology International. 10, 2, p. 81-86 6 p.

Research output: Contribution to journalArticle

Citalopram and escitalopram plasma drug and metabolite concentrations: Genome-wide associations

Ji, Y., Schaid, D. J., Desta, Z., Kubo, M., Batzler, A. J., Snyder, K., Mushiroda, T., Kamatani, N., Ogburn, E., Hall-Flavin, D., Flockhart, D., Nakamura, Y., Mrazek, D. A. & Weinshilboum, R. M., Aug 2014, In : British Journal of Clinical Pharmacology. 78, 2, p. 373-383 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Clinical and educational impact of pharmacogenomics testing: A case series from the INGENIOUS trial

Pierson, R. C., Gufford, B. T., Desta, Z. & Eadon, M. T., Jun 2017, In : Pharmacogenomics. 18, 9, p. 835-841 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy

Desta, Z., Gammal, R. S., Gong, L., Whirl-Carrillo, M., Gaur, A. H., Sukasem, C., Hockings, J., Myers, A., Swart, M., Tyndale, R. F., Masimirembwa, C., Iwuchukwu, O. F., Chirwa, S., Lennox, J., Gaedigk, A., Klein, T. E. & Haas, D. W., Oct 1 2019, In : Clinical Pharmacology and Therapeutics. 106, 4, p. 726-733 8 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Comparison of changes in the lipid profile of postmenopausal women with early stage breast cancer treated with exemestane or letrozole

Bell, L. N., Nguyen, A. T. P., Li, L., Desta, Z., Henry, N. L., Hayes, D. F., Wolff, A. C., Stearns, V., Storniolo, A. M. & Flockhart, D. A., Dec 1 2012, In : Journal of clinical pharmacology. 52, 12, p. 1852-1860 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Comparison of duloxetine, escitalopram, and sertraline effects on cytochrome P450 2D6 function in healthy volunteers

Preskorn, S. H., Greenblatt, D. J., Flockhart, D., Luo, Y., Perloff, E. S., Harmatz, J. S., Baker, B., Klick-Davis, A., Desta, Z. & Burt, T., Feb 1 2007, In : Journal of Clinical Psychopharmacology. 27, 1, p. 28-34 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Compartment-specific gene regulation of the CAR inducer efavirenz in vivo

Meyer Zu Schwabedissen, H. E., Oswald, S., Bresser, C., Nassif, A., Modess, C., Desta, Z., Ogburn, E. T., Marinova, M., Lütjohann, D., Spielhagen, C., Nauck, M., Kroemer, H. K. & Siegmund, W., Jul 2012, In : Clinical Pharmacology and Therapeutics. 92, 1, p. 103-111 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients.

Borges, S., Desta, Z., Jin, Y., Faouzi, A., Robarge, J. D., Philips, S., Nguyen, A., Stearns, V., Hayes, D., Rae, J. M., Skaar, T. C., Flockhart, D. A. & Li, L., Apr 2010, In : Journal of clinical pharmacology. 50, 4, p. 450-458 9 p.

Research output: Contribution to journalArticle

86 Scopus citations

Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment

Marcath, L. A., Deal, A. M., Van Wieren, E., Danko, W., Walko, C. M., Ibrahim, J. G., Weck, K. E., Jones, D. R., Desta, Z., McLeod, H. L., Carey, L. A., Irvin, W. J. & Hertz, D. L., Jan 1 2017, In : Pharmacogenetics and Genomics. 27, 11, p. 402-409 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6

Desta, Z., Ward, B. A., Soukhova, N. V. & Flockhart, D. A., Sep 1 2004, In : Journal of Pharmacology and Experimental Therapeutics. 310, 3, p. 1062-1075 14 p.

Research output: Contribution to journalArticle

475 Scopus citations
81 Scopus citations

Contribution of N-glucuronidation to efavirenz elimination in vivo in the basal and rifampin-induced metabolism of efavirenz

Cho, D. Y., Ogburn, E. T., Jones, D. & Desta, Z., Apr 1 2011, In : Antimicrobial Agents and Chemotherapy. 55, 4, p. 1504-1509 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

CYP2B6 Genotype-Dependent Inhibition of CYP1A2 and Induction of CYP2A6 by the Antiretroviral Drug Efavirenz in Healthy Volunteers

Metzger, I. F., Dave, N., Kreutz, Y., Lu, J. B. L., Galinsky, R. E. & Desta, Z., Nov 1 2019, In : Clinical and translational science. 12, 6, p. 657-666 10 p.

Research output: Contribution to journalArticle

Open Access

CYP2B6 pharmacogenetics-based in vitro-in vivo extrapolation of efavirenz clearance by physiologically based pharmacokinetic modeling

Xu, C., Quinney, S. K., Guo, Y., Hall, S. D., Li, L. & Desta, Z., Dec 1 2013, In : Drug Metabolism and Disposition. 41, 12, p. 2004-2011 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

CYP2D6 and Endoxifen in Tamoxifen Therapy: A Tribute to David A. Flockhart

Skaar, T. & Desta, Z., Jan 1 2018, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

1 Scopus citations

CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment

Jin, Y., Desta, Z., Stearns, V., Ward, B., Ho, H., Lee, K. H., Skaar, T., Storniolo, A. M., Li, L., Araba, A., Blanchard, R., Nguyen, A., Ullmer, L., Hayden, J., Lemler, S., Weinshilboum, R. M., Rae, J. M., Hayes, D. F. & Flockhart, D. A., Jan 5 2005, In : Journal of the National Cancer Institute. 97, 1, p. 30-39 10 p.

Research output: Contribution to journalArticle

777 Scopus citations

CYP2D6 genotypes, endoxifen levels, and disease recurrence in 224 Filipino and Vietnamese women receiving adjuvant tamoxifen for operable breast cancer

Love, R. R., Desta, Z., Flockhart, D., Skaar, T., Ogburn, E. T., Ramamoorthy, A., Uy, G. B., Laudico, A. V., van Dinh, N., Quang, L. H., van To, T., Young, G. S., Hade, E. & Jarjoura, D., Jan 1 2013, In : SpringerPlus. 2, 1, p. 1-5 5 p., 52.

Research output: Contribution to journalArticle

20 Scopus citations

Cytochrome P450 2D6 activity predicts discontinuation of tamoxifen therapy in breast cancer patients

Rae, J. M., Sikora, M. J., Henry, N. L., Li, L., Kim, S., Oesterreich, S., Skaar, T. C., Nguyen, A. T., Desta, Z., Storniolo, A. M., Flockhart, D. A., Hayes, D. F. & Stearns, V., May 7 2009, In : Pharmacogenomics Journal. 9, 4, p. 258-264 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: Combining inherited and tumor gene markers for prediction of tamoxifen resistance

Goetz, M. P., Suman, V. J., Couch, F. J., Ames, M. M., Rae, J. M., Erlander, M. G., Ma, X. J., Sgroi, D. C., Reynolds, C. A., Lingle, W. L., Weinshilboum, R. M., Flockhart, D. A., Desta, Z., Perez, E. A. & Ingle, J. N., Sep 15 2008, In : Clinical Cancer Research. 14, 18, p. 5864-5868 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Cytochrome P450 3A4*22, PPAR-α, and ARNT polymorphisms and clopidogrel response

Kreutz, R. P., Owens, J., Jin, Y., Nystrom, P., Desta, Z., Kreutz, Y., Breall, J. A., Li, L., Chiang, C. W., Kovacs, R. J. & Flockhart, D. A., Dec 9 2013, In : Clinical Pharmacology: Advances and Applications. 5, p. 185-192 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Cytochrome P450 pharmacogenetics as a predictor of toxicity and clinical response to pulse cyclophosphamide in lupus nephritis

Takada, K., Arefayene, M., Desta, Z., Yarboro, C. H., Boumpas, D. T., Balow, J. E., Flockhart, D. A. & Illei, G. G., Jul 1 2004, In : Arthritis and Rheumatism. 50, 7, p. 2202-2210 9 p.

Research output: Contribution to journalArticle

132 Scopus citations

Drug-gene and drug-drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial

Fulton, C. R., Zang, Y., Desta, Z., Rosenman, M. B., Holmes, A. M., Decker, B. S., Zhang, Y., T Callaghan, J., Pratt, V. M., Levy, K. D., Gufford, B. T., Dexter, P. R., Skaar, T. C. & Eadon, M. T., Apr 1 2019, In : Pharmacogenomics. 20, 6, p. 397-408 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

DrugMetab: An Integrated Machine Learning and Lexicon Mapping Named Entity Recognition Method for Drug Metabolite

Wu, H. Y., Lu, D., Hyder, M., Zhang, S., Quinney, S. K., Desta, Z. & Li, L., Nov 2018, In : CPT: Pharmacometrics and Systems Pharmacology. 7, 11, p. 709-717 9 p.

Research output: Contribution to journalArticle

Efavirenz directly modulates the oestrogen receptor and induces breast cancer cell growth

Sikora, M. J., Rae, J. M., Johnson, M. D. & Desta, Z., Oct 1 2010, In : HIV Medicine. 11, 9, p. 603-607 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Efavirenz Inhibits the Human Ether-A-Go-Go Related Current (hERG) and Induces QT Interval Prolongation in CYP2B6*6*6 Allele Carriers

Abdelhady, A. M., Shugg, T., Thong, N., Lu, J. B. L., Kreutz, Y., Jaynes, H. A., Robarge, J. D., Tisdale, J. E., Desta, Z. & Overholser, B. R., Oct 1 2016, In : Journal of cardiovascular electrophysiology. 27, 10, p. 1206-1213 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype dependent

Michaud, V., Kreutz, Y., Skaar, T., Ogburn, E., Thong, N., Flockhart, D. A. & Desta, Z., Apr 2014, In : Pharmacogenomics Journal. 14, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Efavirenz primary and secondary metabolism in vitro and in vivo: Identification of novel metabolic pathways and cytochrome P450 2A6 as the principal catalyst of efavirenz 7-hydroxylation

Ogburn, E. T., Jones, D. R., Masters, A. R., Xu, C., Guo, Y. & Desta, Z., Jul 2010, In : Drug Metabolism and Disposition. 38, 7, p. 1218-1229 12 p.

Research output: Contribution to journalArticle

110 Scopus citations
99 Scopus citations

Effect of grapefruit juice (GFJ) on the stereo-selective pharmacokinetics (PK) of cisapride (CIS) and cardiac qtc interval in healthy volunteers

Desta, Z., Kivistö, K. T., Lilja, J. J., Backman, J. T., Neuvonen, P. J., Soukhova, N. & Flockhart, D. A., Jan 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P82

Research output: Contribution to journalArticle

3 Scopus citations

Effects of clopidogrel and itraconazole on the disposition of efavirenz and its hydroxyl metabolites: Exploration of a novel CYP2B6 phenotyping index

Jiang, F., Desta, Z., Shon, J. H., Yeo, C. W., Kim, H. S., Liu, K. H., Bae, S. K., Lee, S. S., Flockhart, D. A. & Shin, J. G., Jan 1 2013, In : British Journal of Clinical Pharmacology. 75, 1, p. 244-253 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Effects of exemestane and letrozole therapy on plasma concentrations of estrogens in a randomized trial of postmenopausal women with breast cancer

Robarge, J. D., Desta, Z., Nguyen, A. T., Li, L., Hertz, D., Rae, J. M., Hayes, D. F., Storniolo, A. M., Stearns, V., Flockhart, D. A., Skaar, T. C. & Henry, N. L., Feb 1 2017, In : Breast Cancer Research and Treatment. 161, 3, p. 453-461 9 p.

Research output: Contribution to journalArticle

7 Scopus citations