Zeruesenay Desta

  • 9811 Citations
  • 44 h-Index
1976 …2020

Research output per year

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Pharmacogenetics and Practice: Tailoring Prescribing for Safety and Effectiveness

Fulton, C. R., Swart, M., De Luca, T., Liu, S. N., Collins, K. S., Desta, Z., Gufford, B. T. & Eadon, M. T., Nov 1 2018, In : Journal for Nurse Practitioners. 14, 10, p. 697-704.e1

Research output: Contribution to journalArticle

1 Scopus citations

Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes

Goetz, M. P., Rae, J. M., Suman, V. J., Safgren, S. L., Ames, M. M., Visscher, D. W., Reynolds, C., Couch, F. J., Lingle, W. L., Flockhart, D. A., Desta, Z., Perez, E. A. & Ingle, J. N., Dec 1 2005, In : Journal of Clinical Oncology. 23, 36, p. 9312-9318 7 p.

Research output: Contribution to journalArticle

661 Scopus citations

Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: Genome-wide associations and functional genomics

Ji, Y., Biernacka, J. M., Hebbring, S., Chai, Y., Jenkins, G. D., Batzler, A., Snyder, K. A., Drews, M. S., Desta, Z., Flockhart, D., Mushiroda, T., Kubo, M., Nakamura, Y., Kamatani, N., Schaid, D., Weinshilboum, R. M. & Mrazek, D. A., Oct 1 2013, In : Pharmacogenomics Journal. 13, 5, p. 456-463 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Pharmacokinetic Interactions Between Isoniazid and Theophylline in Rats

Zeruesenay, D., Siegmund, W., Zschiesche, M., Franke, G., Walter, R. & Bleyer, H., Nov 1992, In : Journal of Pharmacy and Pharmacology. 44, 11, p. 893-897 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Pharmacokinetics and QT interval pharmacodynamics of oral haloperidol in poor and extensive metabolizers of CYP2D6

Desai, M., Tanus-Santos, J. E., Li, L., Gorski, J. C., Arefayene, M., Liu, Y., Desta, Z. & Flockhart, D. A., Jun 17 2003, In : Pharmacogenomics Journal. 3, 2, p. 105-113 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen

Johnson, M. D., Zuo, H., Lee, K. H., Trebley, J. P., Rae, J. M., Weatherman, R. V., Desta, Z., Flockhart, D. A. & Skaar, T. C., May 1 2004, In : Breast Cancer Research and Treatment. 85, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

356 Scopus citations

PharmGKB summary: Tamoxifen pathway, pharmacokinetics

Klein, D. J., Thorn, C. F., Desta, Z., Flockhart, D. A., Altman, R. B. & Klein, T. E., Nov 1 2013, In : Pharmacogenetics and Genomics. 23, 11, p. 643-647 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

PharmGKB summary: Ifosfamide pathways, pharmacokinetics and pharmacodynamics

Lowenberg, D., Thorn, C. F., Desta, Z., Flockhart, D. A., Altman, R. B. & Klein, T. E., Feb 1 2014, In : Pharmacogenetics and Genomics. 24, 2, p. 133-138 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation

Al Batran, R., Gopal, K., Capozzi, M. E., Chahade, J. J., Saleme, B., Tabatabaei-Dakhili, S. A., Greenwell, A. A., Niu, J., Almutairi, M., Byrne, N. J., Masson, G., Kim, R., Eaton, F., Mulvihill, E. E., Garneau, L., Masters, A. R., Desta, Z., Velázquez-Martínez, C. A., Aguer, C., Crawford, P. A. & 4 others, Sutendra, G., Campbell, J. E., Dyck, J. R. B. & Ussher, J. R., May 5 2020, In : Cell Metabolism. 31, 5, p. 909-919.e8

Research output: Contribution to journalArticle

1 Scopus citations

Plasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age

Desta, Z., Kreutz, Y., Nguyen, A. T., Li, L., Skaar, T., Kamdem, L. K., Henry, N. L., Hayes, D. F., Storniolo, A. M., Stearns, V., Hoffmann, E., Tyndale, R. F. & Flockhart, D. A., Nov 1 2011, In : Clinical Pharmacology and Therapeutics. 90, 5, p. 693-700 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Platelet factor XIIIa release during platelet aggregation and plasma clot strength measured by thrombelastography in patients with coronary artery disease treated with clopidogrel

Kreutz, R. P., Owens, J., Lu, D., Nystrom, P., Jin, Y., Kreutz, Y., Desta, Z. & Flockhart, D. A., Jun 1 2015, In : Platelets. 26, 4, p. 358-363 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Polymorphisms in drug-metabolizing enzymes and steady-state exemestane concentration in postmenopausal patients with breast cancer

Hertz, D. L., Kidwell, K. M., Seewald, N. J., Gersch, C. L., Desta, Z., Flockhart, D. A., Storniolo, A. M., Stearns, V., Skaar, T. C., Hayes, D. F., Henry, N. L. & Rae, J. M., Dec 1 2017, In : Pharmacogenomics Journal. 17, 6, p. 521-527 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Population pharmacogenetic-based pharmacokinetic modeling of efavirenz, 7-hydroxy- and 8-hydroxyefavirenz

Abdelhady, A. M., Desta, Z., Jiang, F., Yeo, C. W., Shin, J. G. & Overholser, B. R., Jan 1 2014, In : Journal of clinical pharmacology. 54, 1, p. 87-96 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Population pharmacokinetic modeling to estimate the contributions of genetic and nongenetic factors to efavirenz disposition

Robarge, J. D., Metzger, I. F., Lu, J., Thong, N., Skaar, T. C., Desta, Z. & Bies, R. R., Jan 2017, In : Antimicrobial Agents and Chemotherapy. 61, 1, e01813-16.

Research output: Contribution to journalArticle

15 Scopus citations

Predictors of aromatase inhibitor discontinuation as a result of treatment-emergent symptoms in early-stage breast cancer

Henry, N. L., Azzouz, F., Desta, Z., Li, L., Nguyen, A. T., Lemler, S., Hayden, J., Tarpinian, K., Yakim, E., Flockhart, D. A., Stearns, V., Hayes, D. F. & Storniolo, A. M., Mar 20 2012, In : Journal of Clinical Oncology. 30, 9, p. 936-942 7 p.

Research output: Contribution to journalArticle

185 Scopus citations

Prerequisites to implementing a pharmacogenomics program in a large health-care system

Levy, K. D., Decker, B. S., Carpenter, J. S., Flockhart, D. A., Dexter, P. R., Desta, Z. & Skaar, T. C., Sep 2014, In : Clinical Pharmacology and Therapeutics. 96, 3, p. 307-309 3 p.

Research output: Contribution to journalArticle

21 Scopus citations

Prescription writing in Gondar outpatient teaching hospital, Ethiopia

Desta, Z. & Abdulwhab, M., Feb 1 1996, In : East African medical journal. 73, 2, p. 115-119 5 p.

Research output: Contribution to journalArticle

10 Scopus citations
Open Access

QT analysis: A complex answer to a 'simple' problem

Li, L., Desai, M., Desta, Z. & Flockhart, D., Sep 15 2004, In : Statistics in Medicine. 23, 17, p. 2625-2643 19 p.

Research output: Contribution to journalArticle

16 Scopus citations
84 Scopus citations

Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment

Borges, S., Desta, Z., Li, L., Skaar, T. C., Ward, B. A., Nguyen, A., Jin, Y., Storniolo, A. M., Nikoloff, D. M., Wu, L., Hillman, G., Hayes, D. F., Stearns, V. & Flockhart, D. A., Jul 1 2006, In : Clinical Pharmacology and Therapeutics. 80, 1, p. 61-74 14 p.

Research output: Contribution to journalArticle

399 Scopus citations

Rapid and simultaneous determination of efavirenz, 8-hydroxyefavirenz, and 8,14-dihydroxyefavirenz using LC-MS-MS in human plasma and application to pharmacokinetics in healthy volunteers

Kim, K. B., Kim, H., Jiang, F., Yeo, C. W., Bae, S. K., Desta, Z., Shin, J. G. & Liu, K. H., Feb 1 2011, In : Chromatographia. 73, 3-4, p. 263-271 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Rapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [ 13C]pantoprazole breath test

Desta, Z., Modak, A., Nguyen, P. D., Lemler, S. M., Kurogi, Y., Li, L. & Flockhart, D. A., Apr 1 2009, In : Journal of Pharmacology and Experimental Therapeutics. 329, 1, p. 297-305 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Re: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine (multiple letters) [1]

Ratliff, B., Dietze, E. C., Bean, G. R., Moore, C., Wanko, S., Seewaldt, V. L., Ponzone, R., Biglia, N., Sismondi, P., Lien, E. A., Ueland, P. M., Løonning, P. E., Stearns, V., Johnson, M. D., Rae, J. M., Novielli, A., Bhargava, P., Hayes, D. F., Desta, Z. & Flockhart, D. A., Jun 2 2004, In : Journal of the National Cancer Institute. 96, 11, p. 883-885 3 p.

Research output: Contribution to journalArticle

Re: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine (multiple letters) [1]

Ratliff, B., Dietze, E. C., Bean, G. R., Moore, C., Wanko, S., Seewaldt, V. L., Ponzone, R., Biglia, N., Sismondi, P., Lien, E. A., Ueland, P. M., Løonning, P. E., Stearns, V., Johnson, M. D., Rae, J. M., Novielli, A., Bhargava, P., Hayes, D. F., Desta, Z. & Flockhart, D. A., Jun 2 2004, In : Journal of the National Cancer Institute. 96, 11, p. 883-885 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

Regulation of microRNA expression by rifampin in human hepatocytes

Ramamoorthy, A., Liu, Y., Philips, S., Desta, Z., Lin, H., Goswami, C., Gaedigk, A., Li, L., Flockhart, D. A. & Skaar, T. C., Oct 1 2013, In : Drug Metabolism and Disposition. 41, 10, p. 1763-1768 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers

Cho, D. Y., Shen, J. H. Q., Lemler, S. M., Skaar, T. C., Li, L., Blievernicht, J., Zanger, U. M., Kim, K. B., Shin, J. G., Flockhart, D. A. & Desta, Z., Apr 2016, In : Drug Metabolism and Pharmacokinetics. 31, 2, p. 107-116 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Rifampin modulation of xeno- and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes

Gufford, B. T., Robarge, J. D., Eadon, M. T., Gao, H., Lin, H., Liu, Y., Desta, Z. & Skaar, T. C., Apr 2018, In : Pharmacology Research and Perspectives. 6, 2, e00386.

Research output: Contribution to journalArticle

3 Scopus citations

Rifampin regulation of drug transporters gene expression and the association of microRNAs in human hepatocytes

Benson, E., Eadon, M., Desta, Z., Liu, Y., Lin, H., Burgess, K. S., Segar, M. W., Gaedigk, A. & Skaar, T., Apr 26 2016, In : Frontiers in Pharmacology. 7, APR, 111.

Research output: Contribution to journalArticle

20 Scopus citations

Sensitive assay for pimozide in human plasma using high-performance liquid chromatography with fluorescence detection: Application to pharmacokinetic studies

Kerbusch, T., Desta, Z., Soukhova, N. V., Thacker, D. & Flockhart, D. A., Jun 20 1997, In : Journal of Chromatography B: Biomedical Applications. 694, 1, p. 163-168 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Sequence diversity and functional characterization of the 5′-regulatory region of human CYP2C19

Arefayene, M., Skaar, T. C., Zhao, X., Rae, J. M., Tanus-Santos, J. E., Brinkmann, U., Brehm, I., Salat, U., Nguyen, A., Desta, Z. & Flockhart, D. A., Apr 1 2003, In : Pharmacogenetics. 13, 4, p. 199-206 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients

Kiyotani, K., Mushiroda, T., Imamura, C. K., Hosono, N., Tsunoda, T., Kubo, M., Tanigawara, Y., Flockhart, D. A., Desta, Z., Skaar, T. C., Aki, F., Hirata, K., Takatsuka, Y., Okazaki, M., Ohsumi, S., Yamakawa, T., Sasa, M., Nakamura, Y. & Zembutsu, H., Mar 10 2010, In : Journal of Clinical Oncology. 28, 8, p. 1287-1293 7 p.

Research output: Contribution to journalArticle

177 Scopus citations

Stereoselective and regiospecific hydroxylation of ketamine and norketamine

Desta, Z., Moaddel, R., Ogburn, E. T., Xu, C., Ramamoorthy, A., Venkata, S. L. V., Sanghvi, M., Goldberg, M. E., Torjman, M. C. & Wainer, I. W., Nov 1 2012, In : Xenobiotica. 42, 11, p. 1076-1087 12 p.

Research output: Contribution to journalArticle

53 Scopus citations
15 Scopus citations

Stereoselective glucuronidation of bupropion metabolites in vitro and in vivo

Gufford, B. T., Lu, J. B. L., Metzger, I. F., Jones, D. R. & Desta, Z., Apr 2016, In : Drug Metabolism and Disposition. 44, 4, p. 544-553 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: Major role of CYP3A

Desta, Z., Soukhova, N., Morocho, A. M. & Flockhart, D. A., Aug 2 2001, In : Journal of Pharmacology and Experimental Therapeutics. 298, 2, p. 508-520 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
15 Scopus citations

Stereoselective pharmacokinetics of stable isotope (+/-)-[ 13C]-pantoprazole: Implications for a rapid screening phenotype test of CYP2C19 activity

Thacker, D. L., Modak, A., Nguyen, P. D., Flockhart, D. A. & Desta, Z., Nov 1 2011, In : Chirality. 23, 10, p. 904-909 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers

Metzger, I. F., Quigg, T. C., Epstein, N., Aregbe, A. O., Thong, N., Callaghan, J. T., Flockhart, D. A., Nguyen, A. T., Stevens, C. K., Gupta, S. K. & Desta, Z., Dec 1 2014, In : Current Therapeutic Research - Clinical and Experimental. 76, p. 64-69 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Tamoxifen and its metabolites cause acute vasorelaxation of aortic rings by inducing vasodilator prostanoid synthesis

Montenegro, M. F., Ceron, C. S., Salgado, M. C. O., Desta, Z., Flockhart, D. A. & Tanus-Santos, J. E., Dec 1 2011, In : Journal of cardiovascular pharmacology. 58, 6, p. 647-653 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Tamoxifen dose escalation in patients with diminished CYP2D6 activity normalizes endoxifen concentrations without increasing toxicity

Hertz, D. L., Deal, A., Ibrahim, J. G., Walko, C. M., Weck, K. E., Anderson, S., Magrinat, G., Olajide, O., Moore, S., Raab, R., Carrizosa, D. R., Corso, S., Schwartz, G., Graham, M., Peppercorn, J. M., Jones, D. R., Desta, Z., Flockhart, D. A., Evans, J. P., McLeod, H. L. & 2 others, Carey, L. A. & Irvin, W. J., Jul 2016, In : Oncologist. 21, 7, p. 795-803 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Tamoxifen metabolites as active inhibitors of aromatase in the treatment of breast cancer

Lu, W. J., Desta, Z. & Flockhart, D. A., Jan 1 2012, In : Breast Cancer Research and Treatment. 131, 2, p. 473-481 9 p.

Research output: Contribution to journalArticle

49 Scopus citations
467 Scopus citations

The dual role of pharmacogenetics in HIV treatment: Mutations and polymorphisms regulating antiretroviral drug resistance and disposition

Michaud, V., Bar-Magen, T., Turgeon, J., Flockhart, D., Desta, Z. & Wainberg, M. A., Jul 2012, In : Pharmacological Reviews. 64, 3, p. 803-833 31 p.

Research output: Contribution to journalArticle

66 Scopus citations

The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6

Wu, G. M., Desta, Z., Morocho, A. M. & Flockhart, D. A., Dec 1 2001, In : Clinical Pharmacology and Therapeutics. 69, 2, p. P71

Research output: Contribution to journalArticle

The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6

Desta, Z., Wu, G. M., Morocho, A. M. & Flockhart, D. A., Mar 7 2002, In : Drug Metabolism and Disposition. 30, 3, p. 336-343 8 p.

Research output: Contribution to journalArticle

85 Scopus citations

The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen

Goetz, M. P., Knox, S. K., Suman, V. J., Rae, J. M., Safgren, S. L., Ames, M. M., Visscher, D. W., Reynolds, C., Couch, F. J., Lingle, W. L., Weinshilboum, R. M., Fritcher, E. G. B., Nibbe, A. M., Desta, Z., Nguyen, A., Flockhart, D. A., Perez, E. A. & Ingle, J. N., Jan 1 2007, In : Breast Cancer Research and Treatment. 101, 1, p. 113-121 9 p.

Research output: Contribution to journalArticle

477 Scopus citations

Translational Knowledge Discovery Between Drug Interactions and Pharmacogenetics

Wu, H. Y., Shendre, A., Zhang, S., Zhang, P., Wang, L., Zeruesenay, D., Rocha, L. M., Shatkay, H., Quinney, S. K., Ning, X. & Li, L., Apr 1 2020, In : Clinical Pharmacology and Therapeutics. 107, 4, p. 886-902 17 p.

Research output: Contribution to journalArticle

Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: Implications for cyclophosphamide metabolism

Rae, J. M., Soukhova, N. V., Flockhart, D. A. & Desta, Z., May 11 2002, In : Drug Metabolism and Disposition. 30, 5, p. 525-530 6 p.

Research output: Contribution to journalArticle

103 Scopus citations

Variability of heart rate correction methods for the QT interval

Desai, M., Li, L., Desta, Z., Malik, M. & Flockhart, D., Jun 1 2003, In : British Journal of Clinical Pharmacology. 55, 6, p. 511-517 7 p.

Research output: Contribution to journalArticle

74 Scopus citations