Zhong-Yin Zhang

  • 15604 Citations
  • 72 h-Index
1990 …2020
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  • 13 Similar Profiles
Protein Tyrosine Phosphatases Medicine & Life Sciences
Phosphoric Monoester Hydrolases Medicine & Life Sciences
Non-Receptor Type 1 Protein Tyrosine Phosphatase Medicine & Life Sciences
Catalytic Domain Medicine & Life Sciences
Yersinia Medicine & Life Sciences
Tyrosine Medicine & Life Sciences
Substrates Chemical Compounds
Phosphates Medicine & Life Sciences

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NIH Grants 1996 2019

Protein Tyrosine Phosphatases
Mycobacterium
Tuberculosis
Multidrug-Resistant Tuberculosis
Mycobacterium tuberculosis
Protein Tyrosine Phosphatases
Leukemia
Neoplasms
Salicylic Acid
Noonan Syndrome
Liver Neoplasms
Phosphoric Monoester Hydrolases
Neoplasms
Protein Tyrosine Phosphatases
Therapeutics
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Proteomics
Insulin
Obesity
Proteome

Publications 1990 2020

  • 15604 Citations
  • 72 h-Index
  • 251 Article
  • 6 Chapter
  • 3 Review article
  • 2 Letter

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

Wiede, F., Lu, K. H., Du, X., Liang, S., Hochheiser, K., Dodd, G. T., Goh, P. K., Kearney, C., Meyran, D., Beavis, P. A., Henderson, M. A., Park, S. L., Waithman, J., Zhang, S., Zhang, Z. Y., Oliaro, J., Gebhardt, T., Darcy, P. K. & Tiganis, T., Jan 15 2020, In : EMBO Journal. 39, 2, e103637.

Research output: Contribution to journalArticle

Open Access
T-cells
T-Cell Antigen Receptor
Phosphoric Monoester Hydrolases
Tumors
Immunity

First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors

Li, Y., Gardner, J. J., Fortney, K. R., Leus, I. V., Bonifay, V., Zgurskaya, H. I., Pletnev, A. A., Zhang, S., Zhang, Z-Y., Gribble, G. W., Spinola, S. & Duerfeldt, A. S., Jan 1 2019, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Phosphoric Monoester Hydrolases
Amines
Indoles
Scaffolds

Small Molecules Target the Interaction between Tissue Transglutaminase and Fibronectin

Sima, L. E., Yakubov, B., Zhang, S., Condello, S., Grigorescu, A. A., Nwani, N. G., Chen, L., Schiltz, G. E., Arvanitis, C., Zhang, Z. Y. & Matei, D., Jun 1 2019, In : Molecular cancer therapeutics. 18, 6, p. 1057-1068 12 p.

Research output: Contribution to journalArticle

Fibronectins
Ovarian Neoplasms
Cell-Matrix Junctions
Interferometry
Focal Adhesion Protein-Tyrosine Kinases
4 Citations (Scopus)

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation

Kano, Y., Gebregiworgis, T., Marshall, C. B., Radulovich, N., Poon, B. P. K., St-Germain, J., Cook, J. D., Valencia-Sama, I., Grant, B. M. M., Herrera, S. G., Miao, J., Raught, B., Irwin, M. S., Lee, J. E., Yeh, J. J., Zhang, Z-Y., Tsao, M. S., Ikura, M. & Ohh, M., Dec 1 2019, In : Nature Communications. 10, 1, 224.

Research output: Contribution to journalArticle

phosphorylation
Phosphorylation
GTP Phosphohydrolases
Conformations
switches
5 Citations (Scopus)

Development and characterization of an endotoxemia model in zebra fish

Hsu, A. Y., Gurol, T., Sobreira, T. J. P., Zhang, S., Moore, N., Cai, C., Zhang, Z-Y. & Deng, Q., Mar 29 2018, In : Frontiers in Immunology. 9, MAR, 607.

Research output: Contribution to journalArticle

Endotoxemia
Zebrafish
Inflammation
Myeloid Differentiation Factor 88
Protein Tyrosine Phosphatases