HEREDITY OF DYSLEXIA STUDIED THROUGH LINKAGE ANALYSIS

  • Pisoni, David (PI)
  • Wilcox, E. (PI)
  • Fex, J. (PI)
  • Rauch, Steven D. (PI)

Project: Research project

Description

Dyslexia involves difficulties in reading and writing in individuals with
normal or above normal intelligence. It is a serious handicap affecting
about 5-8% of the population, and frequently results in social and
economic problems. Dyslexia has a neurological background with a strong
hereditary basis. Whether the hereditary form of dyslexia is caused by a
major gene or whether it is the additive effect of a number of genes is
not known. Our long-term objective is to determine any genetic factors
involved in dyslexia which will assist in early diagnosis and support and
treatment leading to relatively normal development of reading and writing
skills of affected individuals. A collaboration has been initiated with investigators in Sweden to study
the genetics of dyslexia. Sweden has a relative homogenous population
with a unique church-record system. Families often stay at the same
location for several generations, making Sweden a suitable place for this
study. A current Swedish research project, "Reading Development in
Kronoberg", provides an excellent basis for collaboration. Initially, we
plan to study 15-20 families. We will receive pedigrees and decide from
which family members blood samples shall be taken. Efforts will be made
avoid including study subjects with an attention deficit or/and
hyperactivity disorder. To date we have received blood samples from 3
families and immortal cell lines have been established. Linkage studies
on extracted DNA will be carried out using conventional parametric and
non-parametric linkage methods. Eventually, positional cloning procedures
will be used to clone candidate genes for dyslexia. A collaborative effort with American teams is being established.
StatusFinished
Effective start/end date7/1/796/30/15

Funding

  • National Institutes of Health
  • National Institutes of Health: $103,083.00
  • National Institutes of Health: $625,610.00
  • National Institutes of Health: $227,734.00
  • National Institutes of Health: $506,745.00
  • National Institutes of Health: $475,243.00
  • National Institutes of Health: $602,806.00
  • National Institutes of Health
  • National Institutes of Health: $492,440.00
  • National Institutes of Health: $582,119.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $359,581.00
  • National Institutes of Health: $584,634.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $573,411.00
  • National Institutes of Health: $95,126.00
  • National Institutes of Health: $608,838.00
  • National Institutes of Health: $622,673.00
  • National Institutes of Health: $474,989.00
  • National Institutes of Health: $155,045.00
  • National Institutes of Health: $570,728.00
  • National Institutes of Health
  • National Institutes of Health: $627,287.00

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Hearing
Dyslexia
Communication
Sweden
Reading
Research
Linguistics
Communication Disorders
Cognitive Science
Genes
Social Problems
Pedigree
Speech-Language Pathology
Intelligence
Psychophysics
Audiology
Education
Organism Cloning
Early Diagnosis
Psychology

ASJC

  • Medicine(all)
  • Neuroscience(all)