UMBILICAL CORD BLOOD TRANSPLANTATION

Project: Research project

Description

Hematopoietic cells circulating in blood and found in other tissue areas
are produced by stem and progenitor cells. A viable alternative to bone
marrow as a source of stem/progenitor cells is human umbilical cord blood
at least as assessed by in vitro colony assays. Cord blood has recently
been used in an HLA-matched sibling setting in a number of cases and in a
partially HLA-matched sibling setting in one case to successfully engraft
the hematopoietic systems of children with Fanconi anemia and leukemia.
Other disorders including aplastic anemia, Wiskott Aldrich syndrome and
an x-linked lymphoproliferative disorder have also been transplanted with
HLA-matched sibling cord blood, but at the time of this writing
information is not available yet on engraftment. Additionally,
intriguing reports from China mention use of mixtures of unmatched
unrelated cord blood transplants. It is felt that the time is now right
for a full indepth meeting on the biology and transplantation capability
of umbilical cord blood in order to assess the broadness of applicability
of this relatively new form of treatment. It is proposed to have a
conference in this area which includes the following sessions: 1)
Background/History; 2) Clinical Experiences; 3) Cord Blood
Stem/Progenitor Cells which would include growth of these cells in short
vs. long term -cultures, proliferative vs. self-renewal capacity of these
cells, enrichment/purification of the cells, animal models. to study
their growth in vivo, and expansion of these cells in vitro and in vivo;
4) Immunological Reactivity which includes assays to assess graft vs.
host and graft vs. leukemia potential of these cells; and 5) Future of
cord blood transplantation which would include broadness of
applicability, optimization of cord blood collections, in utero tissue
typing and disease markers, and cord blood banking. The conference will
be interactive with ample time for discussions after each oral
presentation and with round table workshop type discussion groups. The
proceedings of this meeting will be published and will serve as a source
book detailing the past, present, and future aspects of this new and very
exciting area of investigation. It is believed that such a meeting will
bring new investigators into this area of research, will intensify the
efforts of those investigators already working in this area, will help to
define the best uses for cord blood, and will hasten the establishments
of allogeneic and autologous cord blood banking.
StatusFinished
Effective start/end date3/1/932/28/94

Funding

  • National Institutes of Health: $27,000.00

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Fetal Blood
Transplantation
Stem Cells
Siblings
Blood Banks
Transplants
Leukemia
Research Personnel
Wiskott-Aldrich Syndrome
Fanconi Anemia
Hematopoietic System
Lymphoproliferative Disorders
Aplastic Anemia
Umbilical Cord
Growth
China
Animal Models
History
Education
Research

ASJC

  • Medicine(all)