Kidney Multiphoton Analysis of Therapeutic Agents

Project: Research project

Description

DESCRIPTION (provided by applicant): The integrated scientific team of INphoton, LLC will develop standard operating procedures for intravital multiphoton microscopy assays quantifying fluorescent drug delivery, cellular uptake, intracellular distribution, metabolism, and physiologic/therapeutic effects within the kidney of live rats. Refinement of some existing assays will be necessary for commercial utilization. The resulting products will enable INphoton to extend commercial services to pharmaceutical and biotech companies to enhance preclinical evaluation of potential products. INphoton, LLC will commercialize multiphoton microscopy for preclinical drug evaluation in the kidney. This will greatly aid evaluation of a potential therapeutic agent's cellular location, functional effects and adverse affects. Since this is not possible with other imaging modalities, this approach complements and extends existing imaging technologies.
StatusFinished
Effective start/end date7/1/067/31/14

Funding

  • National Institutes of Health: $418,705.00
  • National Institutes of Health: $417,462.00
  • National Institutes of Health: $100,000.00

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Kidney
Pharmaceutical Preparations
Therapeutics
Preclinical Drug Evaluations
Pharmaceutical Services
Therapeutic Uses
Physiological Effects of Drugs
Microscopy
Contract Services
Technology
Research
Acute Kidney Injury
Intravital Microscopy
Cultured Cells
Neoplasms

ASJC

  • Medicine(all)