LONGITUDINAL STUDIES OF OSTEOPOROSIS IN AGING

Project: Research project

Description

DESCRIPTION: The overall goals of
this competing continuation application are to: 1) obtain precise estimate
of the lifetime risk of fractures for women, and 2) identify geographical
differences in fracture risks in the U.S. for all race sex groups and
relate them to risk factors. The long-term goals are to develop more
rational strategies for prevention of osteoporosis in women and to
identify new risk factors for osteoporosis. The specific aims are to
develop statistical methods and apply them to existing datasets to achieve
these goals. The first goal will be achieved through four specific aims:
1) estimating the correlation of baseline radius bone mass measurement
with subsequent measurement at other sites, 2) predicting non-spine
fracture from the presence of early spine fractures and early rates of
bone loss, 3) estimating the correlation of an individual's radius bone
mass measurement over time, and 4) formulating a model to predict lifetime
fracture risks based on the first three findings. These analyses will be
based on data collected from a longitudinal study of 521 healthy women
recruited between 1971 and 1983. Multiple measurements of radius bone
mass and fracture occurrences have been recorded on all subjects, and bone
mass at all sites will be made on the 150 active subjects within the next
year. Reports from spine x-rays on the first 300 recruits are also
available and the original films saved on 120 subjects will be re-read
uniformly by a radiologist. Standard statistical procedures will be used
or new ones will be developed and applied to the data for each of the 4
aims. The second goal will be addressed through 2 specific aims: 1) to improve
the estimation of fracture incidence at the county level in the U.S. using
Medicare claims data, and 2) identify potential risk factors at the county
level which are associated with incidence of hip fracture. Fractures will
be identified from Medicare and VA hospital claims databases. The rate
estimates based on denominators from the U.S. censuses and Medicare
enrollee files will be compared. Verification of hip fractures will be
based on 2 algorithms developed independently by two research groups.
Empirical Bayes estimates of the county-level hip fracture incidence rates
will be calculated.The stabilized rate estimates will be correlated with
potential risk factors from other public use datasets such as the Area
Resource File and NHANES III when the data become available.
StatusFinished
Effective start/end date2/1/848/31/98

Funding

  • National Institutes of Health: $110,500.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $106,773.00
  • National Institutes of Health
  • National Institutes of Health: $52,159.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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Aging of materials
Bone
Longitudinal Studies
Hip Fractures
Quality control
Osteoporosis
Bone and Bones
Medicare
Incidence
Spine
Nutrition Surveys
Censuses
X-Rays
Databases

ASJC

  • Medicine(all)