Role of BCL-6 in Allergic Immune Responses

Project: Research project

Description

DESCRIPTION (provided by applicant): The transcriptional repressor protein BCL6
has been implicated in the pathogenesis of non-Hodgkin?s lymphoma, but little
is known about the normal function of BCL6. We have previously shown that the
targeted disruption of the BCL6 gene leads to Th2-mediated inflammation,
suggesting that BCL6 plays an important role in the regulation of T helper type
2 (Th2) subset differentiation. The cytokine IL-4 and the transcription factor
STAT6 are critical mediators of Th2 differentiation. We have found that BCL6
regulates a novel pathway of Th2 differentiation that is independent of IL-4
and STAT6. Our hypothesis is that the cytokine IL-6 has a unique ability to
induce Th2 differentiation via this IL-4/STAT6-independent pathway. In this
proposal, we plan to use mouse genetic, cellular and molecular techniques to
study the mechanisms by which BCL6 regulates this novel pathway of Th2
differentiation. These studies will provide important insights into normal Th2
differentiation, which may lead to new understanding of allergic diseases such
as asthma. These studies will also provide insight into the function of BCL6,
which may help the treatment of B cell lymphoma.
StatusFinished
Effective start/end date9/1/016/30/07

Funding

  • National Institutes of Health: $335,250.00
  • National Institutes of Health: $335,250.00
  • National Institutes of Health: $335,250.00
  • National Institutes of Health: $335,250.00
  • National Institutes of Health: $301,725.00

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Interleukin-4
Cytokines
Repressor Proteins
B-Cell Lymphoma
Non-Hodgkin's Lymphoma
Molecular Biology
Interleukin-6
Lymphoma
Asthma
Inflammation
Genes

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)