DETERMINANTS OF BONE MASS/ELDERLY

  • Burr, David (PI)
  • Hui, Siu (PI)
  • Peacock, Munro (PI)
  • Miller, Judy (PI)
  • Longcope, Christopher (PI)
  • Spear, Nathan (PI)
  • Johnston, C. Conrad (PI)
  • Christian, Joe (PI)

Project: Research project

Project Details

Description

The primary determinants of low bone mass in the elderly and the attendant
osteoporotic fractures are bone mass at maturity and subsequent rates of
bone loss. In this project, we will evaluate certain variables which we
feel are important in the development of peak bone mass and/or the
subsequent rates of bone loss, with the hope of identifying high-risk
subjects when prophylactic therapy can be most helpful. Project 1 focuses on changes in estrogen/androgen metabolism around the
menopause as a cause of rapid bone loss. Since bone loss may begin before
menopause, especially from the spine, a group of premenopausal women will
also be evaluated. Project 2 is aimed at studying genetic contributions to the determination
of peak bone mass and subsequent bone loss and possible
genetic-environmental interactions. The twin model will be used for these
studies, and the groups to be evaluated include young twins of known
placental type (to evaluate prenatal environment influences), and older
twins of both sexes (to evaluate differences between the two sexes in
genetic expression), and differences which may occur in trabecular and
cortical bone. Project 3 will explore the concept that Type II diabetes mellitus and
obesity contribute in an additive fashion to slowing of bone loss in
postmenopausal women, and that the mechanism of this effect is through the
production of estrone from its precursors. Project 4 is a placebo-controlled clinical trial of the use of calcium
supplements to increase bone mass in young, growing children. The twin
model will be utilized for this trial because of its proven efficiency. These projects will be supported by two Cores. Core A will provide
biostatistical and epidemiological support for all of the projects. Core B
will provide sex steroid measurements which are critical to Projects 1 and
3.
StatusFinished
Effective start/end date12/1/858/31/02

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)

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