Project: Research project

Project Details


DESCRIPTION Prior support through the
Publication Grant Program of the National Library of Medicine enabled
an initial evaluation of the Denny-Brown collection of research material,
including the videotaping and editing of 500 of the approximately 2200
films depicting the behavior of monkeys with lesion of many major CNS
structures. The project began 12/01/92 and was granted a no cost
extension for a second year. The current proposal requests an additional 2
years of funding. There are 11 other series of primate lesion experiments.
Additionally, there are about 22,000 histological slides, which were sorted
and catalogued as part of the initial project, that show the extent of the
lesions in almost all of these animals. Since the NLM Publication Grant
Program does not support Competing Continuation applications, the PI's
are seeking continued funding of the project by NINDS. The proposed 2-
Year project will: 1) continue the process of verbally annotating each
videotape. This annotation by the Co-PI, completed for the first ten
animals, describes Denny-Brown's methodology and the behavior being
exhibited by the animal in each film sequence; 2) continue the process of
typing all the handwritten records for the DC series of animals (completed
for the first six animals); 3) videotape the remaining 1700 films; 4)
arrange for transfer of the entire collection to the National Museum of
Health and Medicine at the Armed Forces Institute of Pathology, which
has agreed to maintain it as a research collection; 5) publicize via reports
and presentations the availability of the collection; and 6) seek
evaluations of the DC series of annotated videotapes to determine of the
videotapes of the other series should undergo a similar process of editing
and annotation. In addition to the films of monkeys with CNS lesions, the
Denny-Brown collection includes approximately 500 films of some of the
patients under Denny-Brown's care at Boston City and Long Island
Hospitals between 1946 and 1967. These films have potential clinical
and/or research value because they depict a group of patients with end-
stage disease (e.g., Parkinson's, Huntington's, Wilson's) and non-
contemporary diseases (e.g., post-encephalitic parkinsonism), and because
they typify the neurological examination process that was used at the
time, e.g., that of trying to elicit reflexes that were released as a
consequence of CNS damage. Thus, the proposed project will also
involve selecting, videotaping, editing and annotating some of the films
Denny-Brown made of humans with neurological diseases.
Effective start/end date1/1/9512/31/01


  • National Institutes of Health
  • National Institutes of Health: $27,499.00
  • National Institutes of Health: $43,419.00
  • National Institutes of Health: $40,188.00
  • National Institutes of Health


  • Medicine(all)
  • Neuroscience(all)

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