SPECIFIC REPRESSION OF PROLACTIN GENE EXPRESSION

Project: Research project

Description

DESCRIPTION The objective of
the proposed studies is to identify the critical molecular events that
direct specific repression of PRL gene expression. Aim 1 is to
establish the importance of the alternative splice form of Pit-1 in the
repression of PRL and to determine the molecular events that contribute
to the splice choice. Aim 2 is to determine if specific DNA elements in
the PRL gene are the key determinants of why PRL gene expression is
inhibited in GH3 cell-induced tumors, while GH gene expression is not.
Aim 3 will be to examine the interaction of proteins with the PRL and
GH promoters, and to characterize the proteins that are involved in the
specific repression of the PRL gene.
StatusFinished
Effective start/end date7/11/942/28/15

Funding

  • National Institutes of Health: $252,914.00
  • National Institutes of Health
  • National Institutes of Health: $245,579.00
  • National Institutes of Health: $199,036.00
  • National Institutes of Health: $259,000.00
  • National Institutes of Health: $20,328.00
  • National Institutes of Health: $289,790.00
  • National Institutes of Health: $282,842.00
  • National Institutes of Health: $259,000.00
  • National Institutes of Health
  • National Institutes of Health: $187,892.00
  • National Institutes of Health: $123,482.00
  • National Institutes of Health
  • National Institutes of Health: $283,729.00
  • National Institutes of Health: $250,092.00
  • National Institutes of Health: $87,241.00
  • National Institutes of Health: $291,354.00
  • National Institutes of Health: $132,339.00
  • National Institutes of Health: $290,309.00
  • National Institutes of Health: $194,861.00

Fingerprint

Prolactin
Gene Expression
Proteins
Genes
Protein Interaction Maps
Cell Nucleus
Transcription Factors
Chromatin Assembly and Disassembly
Heterochromatin
Homeodomain Proteins
Mutation
Co-Repressor Proteins
Chromatin
Regulator Genes
Transcription Factor Pit-1
Cell Lineage
Nuclear Proteins
CCAAT-Enhancer-Binding Protein-alpha
Anterior Pituitary Hormones
Repressor Proteins

ASJC

  • Medicine(all)