CORNEAL INNERVATION AND WOUND HEALING

Project: Research project

Description

Corneal sensory nerve fibers exert important trophic effects on the
corneal epithelium, stimulate epithelial mitogenesis, and accelerate
wound healing after corneal injuries. The mechanisms by which the nerves
exert these effects are unknown; however, the release of axonally
transported neuropeptides has been hypothesized. In the current
application, we propose: 1) to study the ability of six different
neuropeptides, calcitonin gene-related peptide (CGRP), substance P (SP),
galanin (GAL), neuropeptide Y (NPY), vasoactive intestinal polypeptide
(VIP), and met-enkephalin (met-ENK) to stimulate epithelial mitogenesis
in normal rat corneas, 2) to study the ability of the aforementioned
neuropeptides to stimulate epithelial mitogenesis in wounded rat corneas,
3) to determine the effects of unilateral corneal injury on neuropeptide
expression (up-regulation, down-regulation, or alteration) in ipsilateral
corneal nerve fibers, and 4) to determine the effects of unilateral
corneal injury on neuropeptide expression in contralateral corneal nerve
fibers. The long term objectives of this continuing research program are
to increase our understanding of the neurochemistry, plasticity, an
trophic functions of corneal nerves and to test the hypothesis that
certain neuropeptides synthesized and transported within corneal nerves
may be used therapeutically to stimulate wound healing following corneal
injuries.
StatusFinished
Effective start/end date7/1/846/30/97

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $134,855.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $159,501.00

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Wound Healing
Neuropeptides
Agglutinins
Nerve Fibers
Cornea
Peroxidase
Substance P
Calcitonin Gene-Related Peptide
Neuropeptide Y
Afferent Neurons
Superior Cervical Ganglion
Efferent Neurons
Adrenergic Fibers
Neurochemistry
Eye Injuries
Leucine Enkephalin
Galanin
Brain Stem
Methionine Enkephalin
Vasoactive Intestinal Peptide

Keywords

  • Medicine(all)