CENTER ON GENETIC DETERMINANTS OF ALCOHOL INGESTION

Project: Research project

Description

The voluntary ingestion or self-administration of alcohol (ethanol)
in humans and experimental animals is influenced not only by
environmental but also by genetic/biological factors. We
hypothesize that individual differences in response to the
reinforcing/aversive actions of ethanol, in tolerance development,
and in ethanol and acetaldelyde metabolism underlies much of the
individual differences in genetic vulnerability to developing
alcoholism. This applicant institution has unique resources for
this kind of research and proposes to establish an Alcohol
Research Center that will make these resources more accessible
to other investigators. 1) We will establish an Animal Production
Core that will make available for others the genetically selected
P, NP, HAD and LAD lines of rats. The alcohol-preferring P line
of rats has been shown to be a good animal model of alcoholism,
useful in the study of the neurobiological basis of alcohol-seeking
behavior. 2) We will establish a Molecular Biology Core that will
develop methodology to identify the polymorphic alleles of the
human alcohol dehydrogenase (ADH) and aldehyde dehydrogenase
(ALDH) genes. The large collection of human autopsy liver
specimens of known phenotypes will be employed to establish the
validity of the restriction-fragment-length-polymorphism (RFLP)
analyses. The relation of ADH and ALDH polymorphism to
alcoholism and to alcohol-induced liver disease, brain damage, and
other complications will be studied across populations and in
family studies. 3) We will establish a Human Genetics and
Database Core that will develop methodology to estimate the
heritability of various pharmacodynamic actions of ethanol
through comparison studies of monozygotic and dizygotic twins.
A number of behavioral, electrophysiological and neuroendocrine
responses to ethanol will be assessed. The long-term goal of this
core is to enable the testing in humans of hypotheses emerging
from work with experimental animals. An example is that the
rapid development of acute tolerance and its persistence over a
long period of time is an inherited predisposing factor of heavy
drinking and alcoholism. 4) We will establish a Neuroendocrine
Core to perform analysis of neuropeptides and hormones needed in
the proposed human studies, in ongoing animal studies, and in the
proposed Pilot Projects. 5) We propose to support, as part of the
Center activity, Pilot Projects as a way to recruiting new
investigators into the field, and to enhancing collaborative,
interdisciplinary research.
StatusFinished
Effective start/end date9/30/8711/30/17

Funding

  • National Institutes of Health
  • National Institutes of Health: $2,000,000.00
  • National Institutes of Health
  • National Institutes of Health: $1,977,885.00
  • National Institutes of Health
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  • National Institutes of Health: $1,667,612.00
  • National Institutes of Health
  • National Institutes of Health
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  • National Institutes of Health
  • National Institutes of Health: $1,713,802.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,797,423.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $140,808.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,792,590.00
  • National Institutes of Health
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  • National Institutes of Health
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  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $204,578.00
  • National Institutes of Health
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  • National Institutes of Health: $59,970.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,702,588.00
  • National Institutes of Health: $2,096,925.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $156,535.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,906,721.00
  • National Institutes of Health: $1,679,787.00
  • National Institutes of Health
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  • National Institutes of Health
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  • National Institutes of Health
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  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,797,531.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,719,376.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $184,546.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $100,000.00
  • National Institutes of Health
  • National Institutes of Health: $2,077,147.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $107,107.00

Fingerprint

Alcohols
Alcoholism
Ethanol
Eating
Alcohol Drinking
Research
Research Personnel
pilot project
alcohol
Genomics
Alcohol Dehydrogenase
Aldehyde Dehydrogenase
Genes
Molecular Biology
Endophenotypes
Brain
Translational Medical Research
Fetal Alcohol Spectrum Disorders
Self Administration
Drinking

ASJC

  • Medicine(all)